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Articles 1 - 30 of 180
Full-Text Articles in Medicine and Health Sciences
Minimally Invasive Therapies In The Treatment Of Arthropathy, Steven Bateman
Minimally Invasive Therapies In The Treatment Of Arthropathy, Steven Bateman
Physician Assistant Scholarly Project Papers
It is estimated that 27% of adults over 45 years of age suffer from osteoarthritis of the hip secondary to articular cartilage damage over the lifespan. Joint pain diminishes life quality, limits range of motion and overall activity, and frequently impairs basic ambulation. These functional deficits worsen the progression of comorbidities that are often referred to as lifestylerelated chronic disease as physical activity subsequently declines. This literature review explores the efficacy of minimally invasive therapies that precede and delay surgical intervention in adult patients experiencing functional limitations and pain in major joints. The study examines the effectiveness of various interventions, …
Blood-Based Versus Stool-Based Biomarker Accuracy In Detection Of Colorectal Cancer And Impact Of Non-Invasive Tests On Patient Participation, Allison Obritsch
Blood-Based Versus Stool-Based Biomarker Accuracy In Detection Of Colorectal Cancer And Impact Of Non-Invasive Tests On Patient Participation, Allison Obritsch
Physician Assistant Scholarly Project Papers
Colorectal cancer is a very treatable cancer when detected early, therefore patient adherence and colorectal cancer screening is key to decrease mortality. The purpose of this research and systematic literature review was to determine how the accuracy of blood-based and stool-based biomarkers compared in the detection of colorectal cancer and how noninvasive testing modalities influence patient participation in colorectal cancer screening. Only articles published within the past 10 years were included. A combination of keywords and MeSH phrases to include but not limited to “adherence,” “SEPT9,” “colonoscopy,” “multitarget stool,” and “colorectal cancer” were used to find relevant articles for each …
Corticosteriod Injection Vs Therapy Vs Combination For Shoulder Rotator Cuff Injuries, Rodney Guy Palmer Jr.
Corticosteriod Injection Vs Therapy Vs Combination For Shoulder Rotator Cuff Injuries, Rodney Guy Palmer Jr.
Physician Assistant Scholarly Project Papers
Rotator cuff pathologies seen in a primary care setting ranks third for musculoskeletal complaints seen by primary care providers. Rotator cuff pathologies can cause significant dysfunction in activities of daily living (ADLs), work tasks, and daily life. Current treatment recommendations are intra-articular steroid injections, therapy only rehabilitation, or the combination of the two. This literature review researched articles comparing the effectiveness of steroid only treatments, therapy only treatments, and the combination of the two. There was conflicting evidence regarding which treatment was the most effective. Significant side effects for steroid injections were discovered which included rotator cuff rupture. Therapy demonstrated …
Alternative Treatment Modalities For Plantar Fasciitis, Chelsey Clark
Alternative Treatment Modalities For Plantar Fasciitis, Chelsey Clark
Physician Assistant Scholarly Project Papers
Plantar Fasciitis is a common and frequent condition in adult patients. The purpose of this literature review is to determine whether evidence exists for alternative treatments in the regimen of plantar fasciitis that has not been resolved with the standard treatment. The review was done using Pubmed, CINAHL and SportDiscus. Research was included on the following alternative treatments of PF: corticosteroid injections, extracorporeal shockwave, dry needling, Platelet-Rich Plasma (PRP), Autologous Blood Injection (ABI), cupping, custom insoles, and ultrasound therapy. A total of 12 research articles were included in this review. The alternative treatments considered within this literature review had some …
A Comparison Of Common Treatment Modalities For Veterans Diagnosed With Post-Traumatic Stress Disorder Versus Low-Dose Ketamine Therapy, Kristopher Flynt
A Comparison Of Common Treatment Modalities For Veterans Diagnosed With Post-Traumatic Stress Disorder Versus Low-Dose Ketamine Therapy, Kristopher Flynt
Physician Assistant Scholarly Project Papers
The purpose of this research and systematic literature review is to compare the drug ketamine’s efficacy at treating post-traumatic stress disorder for veterans and active-duty military compared to approved Food and Drug Administration (FDA) options and combination medication/psychotherapy. In this review, three databases were searched including Pubmed, ClinicalKey, and PsycInfo from October 3 to January 9, 2023. Additionally, the Veterans Affairs (VA)/Department of Defense (DOD) Clinical Practice Guidelines was utilized. A variety of key and mesh terms were utilized when database searching. Chosen works for review included randomized control trials, systematic reviews, meta-analysis, and retro-perspective studies. Sources that were excluded …
Proning Versus Respiratory Pharmacotherapeutics In Hospitalized Covid-19 Patients, Sasha Marie Hopfauf
Proning Versus Respiratory Pharmacotherapeutics In Hospitalized Covid-19 Patients, Sasha Marie Hopfauf
Physician Assistant Scholarly Project Papers
The purpose of this research and literature review is to compare the use of prone positioning and respiratory pharmacotherapeutics within hospitalized COVID-19 patients and the outcomes associated with each. A literature review was performed using the databases PubMed, Clinical Key, DynaMed, and CINAHL. A variety of key terms were used when searching. Studies chosen were retrospective reviews, a cross sectional study, an interventional study, and a pilot study. Articles within the last three years were utilized after exclusion criteria was applied. A total of thirteen articles were included within this project. The research shows that pulmonary vasodilators such as inhaled …
The Effectiveness Of The Gut-Brain-Axis Versus Ssri For Treatment And Management Of Depression, Jenni Hetleved
The Effectiveness Of The Gut-Brain-Axis Versus Ssri For Treatment And Management Of Depression, Jenni Hetleved
Physician Assistant Scholarly Project Papers
Major Depressive Disorder (MDD) is a crippling condition that affects millions of people worldwide. Serotonin reuptake inhibitors (SSRIs) are the staple treatment adjunct to psychotherapy. Recently, the connection between gut health, specifically the gut brain axis, has been researched to look at the connection between gut microbiota and it’s effect on depressive symptoms. A literature review was performed using electronic databases such as PubMed, PsychINFO, and embase. This meta-analysis evaluates the connection between gut microbiota and depression as well as the effectiveness of SSRI therapy on depression. Results show a significant change in gut microbiota with short term change to …
Fertility Treatment In Pcos: Metformin Vs. Inositol, Kaylina Kelley
Fertility Treatment In Pcos: Metformin Vs. Inositol, Kaylina Kelley
Physician Assistant Scholarly Project Papers
The most common endocrine disorder affecting women is polycystic ovary syndrome (PCOS) (Pourghasem, 2019). Metformin is commonly used to decrease insulin resistance and increase fertility in these women. However, it is known to cause many side effects, which are mostly gastrointestinal related. Myoinositol is a B-vitamin that is thought to also decrease insulin resistance and increase fertility with few side effects. The purpose of this literature review is to determine whether myoinositol is a comparable substitute for metformin in patients with PCOS suffering with infertility. This was done by evaluating pregnancy rates, insulin resistance, and side effects of metformin and …
Pregnancy Planning: Hormonal Contraception Versus Natural Family Planning, Melanie Loehrer
Pregnancy Planning: Hormonal Contraception Versus Natural Family Planning, Melanie Loehrer
Physician Assistant Scholarly Project Papers
Statement of the problem: Natural family planning methods provide women with an opportunity to use natural methods to plan pregnancy. This is done through daily monitoring of symptoms and biomarker fluctuation in accordance with hormonal changes throughout the menstrual cycle to identify the fertile window. Through the identification of the fertile window and ovulation, one can determine appropriate days for sexual intercourse. This format allows participants to develop a greater understanding and in-depth knowledge of reproductive health to avoid or achieve pregnancy. The use of natural family planning has greatly increased over the last two decades, growing the demand for …
A Comparison Of Pharmacotherapy Versus Complementary Medicine In The Treatment Of Migraines, Samantha Braaten
A Comparison Of Pharmacotherapy Versus Complementary Medicine In The Treatment Of Migraines, Samantha Braaten
Physician Assistant Scholarly Project Papers
Migraine headache is a common, universal neurological disorder that can be complicated to treat. Despite the wide availability of treatments used as prophylactic agents against migraines, outcomes have been inconsistent, and a number of patients do not respond to prophylactic medications. Therefore, it is important to investigate new non-pharmacological modalities accompanied with less adverse effects and maximal efficacy. To determine if complementary medicine modalities such as acupuncture, botulinum toxin-A, or cognitive behavioral therapy can be as effective as traditional pharmacotherapy for the treatment of migraines, a literature review was completed using meta-analyses and clinical trial reviews. Despite the fact there …
Evaluating And Comparing The Safety And Efficacy Of Rimegepant Versus Lasmiditan In Aborting Acute Migraine Headaches In The Adult Migraineur, Anthony Douthit
Evaluating And Comparing The Safety And Efficacy Of Rimegepant Versus Lasmiditan In Aborting Acute Migraine Headaches In The Adult Migraineur, Anthony Douthit
Physician Assistant Scholarly Project Papers
Migraine headaches are one of the most common causes of primary headaches. Worldwide, migraines are one of the leading causes of disability and while the mechanism of migraines are not entirely understood, they result in significant disability for those who experience them. Dihydroergotamine was introduced for migraine treatment in the 1920s and in the 1990s triptans were introduced and have been the mainstay of acute migraine treatment since their introduction. In recent years, there have been several developments in the acute treatment and prophylaxis of migraine headaches. Some of the more widely studied and recently developed interventions include calcitonin gene …
Chronic Exertional Compartment Syndrome: Surgical Treatment Vs Conservative Care, Molly Ruebke
Chronic Exertional Compartment Syndrome: Surgical Treatment Vs Conservative Care, Molly Ruebke
Physician Assistant Scholarly Project Papers
Chronic exertional compartment syndrome (CECS) is a relatively rare pathology characterized by pain, tightness, and/or numbness in the affected calf upon performance of repetitive physical activity, most commonly with running or serving in the military. CECS usually has a delay in diagnosis due to low levels of awareness among clinicians and a wide range of differential diagnoses for chronic exertional leg pain. The natural course of CECS is often not self-limiting and therefore requires intervention, as symptoms can be severely debilitating and eventually force patients to avoid any provoking activity. The purpose of this literature review is to take a …
Platelet-Rich Plasma Vs Corticosteroid: Osteoarthritis Symptoms, Joshua Zetocha
Platelet-Rich Plasma Vs Corticosteroid: Osteoarthritis Symptoms, Joshua Zetocha
Physician Assistant Scholarly Project Papers
Osteoarthritis (OA) is a disease that hundreds of millions of people suffer from across the world (Palazzo et al., 2016). Currently, corticosteroid intra-articular injections are frequently administered to help with pain and inflammation related to OA (Pereira et al, 2015). A relatively new treatment option is Platelet-Rich Plasma (PRP) intra-articular injections. PRP injections use the patient’s own plasma, injected into the affected joint space, to reduce inflammation and potentially improve both pain and functionality. This literature review will investigate whether the newer PRP injections relieve pain and improve functionality of OA patients better than corticosteroid injections. The literature review was …
Benzimidazole Adjuvant Therapy: A Review Of Efficacy And Safety In Patients With Cancer, Jared Mouw
Benzimidazole Adjuvant Therapy: A Review Of Efficacy And Safety In Patients With Cancer, Jared Mouw
Physician Assistant Scholarly Project Papers
This literature review aims to compile previous studies’ data and explore the effects of benzimidazoles as an adjuvant therapy and its relationship to a patient’s cancer biomarkers, tumor progression, and quality of life. In addition to the aforementioned, we will attempt to review data to identify the safety and toxicity profile of benzimidazoles within a population of patients currently diagnosed with cancer to determine if this class of medications could be implemented along with current cancer treatment regimens to increase efficacy and tolerance. To determine this, the databases of CINAHL, ClinicalKey, and PubMed were searched with the keywords mentioned below. …
Gabapentin As An Effective Treatment Option For Alcohol Use Disorder, Monica Hurst
Gabapentin As An Effective Treatment Option For Alcohol Use Disorder, Monica Hurst
Physician Assistant Scholarly Project Papers
The purpose of this literature review is to determine whether gabapentin is an effective treatment option for alcohol use disorder (AUD). Utilizing data sourced primarily from published clinical trials, gabapentin’s effect on heavy drinking, abstinence, withdrawal symptoms and alcohol cravings will be explored. This review will also compare gabapentin’s efficacy against currently approved AUD treatment options, along with what dosages are most efficacious while contributing the fewest adverse effects. The data presented in this literature review undeniably demonstrates a positive effect of gabapentin on alcohol use disorder; Specifically, the data shows that gabapentin at multiple dosages helps to decrease heavy …
A Comparison Of Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies And Standard Migraine Prophylaxis In Those With Episodic Migraines, Alexie Harms
Physician Assistant Scholarly Project Papers
The purpose of this research study is to determine if anti-calcitonin gene related peptide monoclonal antibodies (CGRP mAbs) more effective and tolerable in reducing the number of migraine days in comparison to conventional migraine prophylactic use of Propranolol, Amitriptyline, and Topiramate. Migraines are debilitating and a frequent reason for primary care visits interfering with an individual’s work, school, and daily life. Standard of care treatment options for migraine prophylaxis are drugs initially developed for other diseases and can lead to unnecessary and unwanted side effects decreasing treatment adherence in the prevention of migraines. In this literature review, electronic search databases …
Effectiveness Of Knee Joint Injury Treatments In The Prevention Of Post-Traumatic Osteoarthritis, Jenna Zaeske
Effectiveness Of Knee Joint Injury Treatments In The Prevention Of Post-Traumatic Osteoarthritis, Jenna Zaeske
Physician Assistant Scholarly Project Papers
The purpose of this research and systematic literature review is to determine the effectiveness of rest, physical therapy, and/or surgical intervention following either anterior cruciate ligament (ACL) or meniscus injuries in short- and long- term osteoarthritis outcomes. The short- and longterm outcomes were evaluated to compare the prevalence and progression of osteoarthritis after joint injury. In this literature review, the electronic database PubMed was used to find relevant research. Many keywords were used when searching for articles. Sources included for review had research on ACL or meniscus injuries specifically. Other knee injuries, non-knee injuries and non-human subjects were excluded. Articles …
Weight Loss For Bariatric Patients: Arterial Embolization Versus Gastric Bypass, Morgan Bernhardt
Weight Loss For Bariatric Patients: Arterial Embolization Versus Gastric Bypass, Morgan Bernhardt
Physician Assistant Scholarly Project Papers
The primary aim of this systematic literature review is to determine the safety and efficacy of left gastric artery embolization (LGAE) in comparison to Roux-en-Y gastric bypass (RYGB) for bariatric patients. A total of four prospective studies focusing on left gastric artery embolization were selected and reviewed. A total of five studies were selected that discussed Roux-en-Y gastric bypass. All studies used have a publication date of 10 years or less. The research shows evidence that RYGB, an invasive surgical operation, has been proven to result in long-term efficacy of weight loss but can be associated with a higher risk …
Efficacy Of Transcutaneous Electrical Nerve Stimulation Vs. Calcitonin Gene Related Peptides In The Application Of Migraine Prophylaxis, Matthew Davis
Efficacy Of Transcutaneous Electrical Nerve Stimulation Vs. Calcitonin Gene Related Peptides In The Application Of Migraine Prophylaxis, Matthew Davis
Physician Assistant Scholarly Project Papers
Worldwide migraines affect millions of people everyday causing significant impact on patient’s lives. Oftentimes, these patients have failed several first-line therapies for migraine prophylaxis causing pharmaceutical companies to develop newer therapies. The purpose of this systematic literature review is to evaluate the effectiveness and tolerability of transcutaneous electrical nerve stimulator (TENS) devices versus calcitonin gene related peptide (CGRP) antagonists in the application of migraine prophylaxis. PubMed and ClinicalKey were searched with key terms, 17 sources were selected that were published after 2016. Sources included meta-analysis, literature review, and randomized control trials. The data showed that TENS devices as well as …
Comparison Of Urethral Bulking Injection Therapy And Surgical Midurethral Sling Placement For Treatment Of Stress Urinary Incontinence In Women, Ashley Black
Physician Assistant Scholarly Project Papers
This literature review aims to assess the comparative efficacy and safety of urethral bulking injection therapy and surgical midurethral sling intervention in the treatment of stress incontinence in women. A comprehensive search of the existing literature was conducted and includes studies from PubMed, an electronic search databases. The findings indicate that both urethral bulking injection therapy and surgical midurethral sling intervention are suitable interventions to be considered for the treatment of stress incontinence in women. Current research available regarding the efficacy of urethral bulking agents versus midurethral slings suggests that the placement of a miduerthral sling has the highest incidence …
Liraglutide Versus Semaglutide: Long Term Weight Loss Management In Obese Individuals, Mckenzie Burke
Liraglutide Versus Semaglutide: Long Term Weight Loss Management In Obese Individuals, Mckenzie Burke
Physician Assistant Scholarly Project Papers
Obesity has been a source of complications affecting multiple aspects from a physiological and psychological standpoint which has been steadily growing. There are a multitude of weight loss programs and medications with the idea of sustaining consistent weight loss to include use of the pharmaceuticals discussed within this review. The purpose of this literature review is to compare the efficacy and safety with use of liraglutide versus semaglutide (GLP-1 receptor agonists) in respect to long term weight loss management while in conjunction to lifestyle modifications within the obese population. Thorough research has been done with the aid of health science …
The Effects Of Food On Mood: Implications Of Mediterranean And Plant-Based Diets On Depression Symptom Prevalence And Severity, Kaitlyn Prochnow
The Effects Of Food On Mood: Implications Of Mediterranean And Plant-Based Diets On Depression Symptom Prevalence And Severity, Kaitlyn Prochnow
Physician Assistant Scholarly Project Papers
The purpose of this research and systematic literature review is to determine whether adherence to a Mediterranean diet or a plant-based diet has better effects on decreasing depression prevalence and/or symptom severity. A variety of keywords were used to search the online database, PubMed. Clinical trials and randomized controlled trials conducted within the last 20 years were included in the initial search. Exclusions were made if studies were not specific to Mediterranean or plant-based diets, or if they were focused on other psychiatric illnesses besides depression. For the final review, ten articles were selected. After thorough analyses and comparisons of …
Aspirin Vs. Pravastatin For Prevention Of Preterm Delivery In Patients At Risk For Pre-Eclampsia, Mary Weisberg
Aspirin Vs. Pravastatin For Prevention Of Preterm Delivery In Patients At Risk For Pre-Eclampsia, Mary Weisberg
Physician Assistant Scholarly Project Papers
This literature review is an examination of the use of low-dose aspirin therapy versus the use of pravastatin therapy to prevent preterm delivery in women at risk of developing preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks of gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Preeclampsia is a serious condition that affects pregnant women and their growing fetuses which may lead to maternal or fetal demise. The Prevention of preeclampsia with the use of low-dose aspirin in the first 12-16 weeks is currently the mainstay of treatment for women with moderate to severe …
Long-Term Control Of Type Ii Diabetes Mellitus And Weight Through Roux-En-Y Gastric Bypass Surgery Versus Weight Loss Medication, Alexandra Laber
Long-Term Control Of Type Ii Diabetes Mellitus And Weight Through Roux-En-Y Gastric Bypass Surgery Versus Weight Loss Medication, Alexandra Laber
Physician Assistant Scholarly Project Papers
Type II diabetes mellitus (T2DM) affects hundreds of millions of individuals in the United States and is only becoming more common. The disease can damage organs all throughout the body and even lead to death. The goal of treatment is to lower blood glucose, but since T2DM tends to be associated with obesity, another common goal in treatment is weight loss. However, this is difficult for many people to achieve, and intense medical treatment is sometimes needed. Since T2DM is a lifelong disease, interventions must be considered in the long term. The purpose of this project is to compare long-term …
Home-Based Cardiac Rehab Vs. Center-Based Cardiac Rehab In Rural Areas, Timothy Fresonke
Home-Based Cardiac Rehab Vs. Center-Based Cardiac Rehab In Rural Areas, Timothy Fresonke
Physician Assistant Scholarly Project Papers
Cardiac rehabilitation in rural areas can present unique challenges. The main challenge is the locations patients must travel to receive such care. Some patients are expected to travel more then an hour away, on multiple occasions during the week, to undergo therapy. This can be an issue for many patients and something that has been studied and is starting to be addressed in various countries. A literature review was done to see if there was a safe and effective alternative to the traditional center-based cardiac rehabilitation. The electronic search databases PubMed, Embase and CINAHL Complete were utilized to search for …
Safety And Efficacy Of Apixaban Vs Rivaroxaban: In Nonvalvular Atrial Fibrillation, Cody Dewitt
Safety And Efficacy Of Apixaban Vs Rivaroxaban: In Nonvalvular Atrial Fibrillation, Cody Dewitt
Physician Assistant Scholarly Project Papers
Nonvalvular atrial fibrillation, the most common cardiac arrhythmia in developed countries, warrants anticoagulation for stroke prevention. Updated guidelines recommend direct oral anticoagulants (DOACs) over historically used warfarin. The purpose of this review is to compare clinical safety and efficacy outcomes between apixaban and rivaroxaban. In patients with nonvalvular atrial fibrillation on a direct oral anticoagulant, is there a significant difference in safety and efficacy between apixaban and rivaroxaban? Does decreased kidney function change safety and efficacy? Does varying BMI such as low weight or obesity change safety and efficacy? A retrospective literature review was conducted utilizing PubMed databases. Articles included …
Active Toxoplasmosis Infection: Efficacy And Safety Of Treatment Options, Daniele Krouse
Active Toxoplasmosis Infection: Efficacy And Safety Of Treatment Options, Daniele Krouse
Physician Assistant Scholarly Project Papers
This literature review intends to investigate the safety and efficacy of two different drug treatment regimens, pyrimethamine versus trimethoprim-sulfamethoxazole, for active toxoplasmosis infections. Affecting nearly 11% of the United States population and up to 80% of the populations of tropical countries, Toxoplasmosis infection is the second leading cause of death from food borne illness. Current classic management of active infection with pyrimethamine is correlated with numerous undesirable side effects, high cost and need for complex use of adjunctive medications. It is necessary to identify alternative treatment options with fewer side effects, less complex regimens, lower cost, and easier access for …
Manual Vs. Mechanical Chest Compressions In Adult Cardiac Arrest, Brittany Ann Almquist
Manual Vs. Mechanical Chest Compressions In Adult Cardiac Arrest, Brittany Ann Almquist
Physician Assistant Scholarly Project Papers
The purpose of this literature review is to compare the use of manual versus mechanical chest compressions during cardiopulmonary resuscitation (CPR) in the treatment of adult cardiac arrest patients. A literature review was performed using the databases CINAHL, Embase, and PubMed. Studies chosen were peer reviewed randomized controlled trials, respective reviews, a cross-over controlled trial, and an experimental trial. Only articles from the last seven years were included in this review. After exclusion criteria were applied, ten articles were relevant and utilized. Four themes were identified in the literature review specific to studies of cardiac arrest with utilization of CPR …
The Effect Of Metformin Vs Lifestyle Modifications On The Prevention Of Prediabetes Progressing To Type Ii Diabetes, Brittany Mcpherson
The Effect Of Metformin Vs Lifestyle Modifications On The Prevention Of Prediabetes Progressing To Type Ii Diabetes, Brittany Mcpherson
Physician Assistant Scholarly Project Papers
Prediabetes is a common disease among American adults that is the predecessor to type 2 diabetes (T2D). T2D is a serious disease that causes long term damage to the heart, blood vessels, and kidneys if uncontrolled. This literature review looks at the effectiveness of medication (metformin), diet alone, exercise alone, and diet and exercise in combination in preventing the progression from prediabetes to a diagnosis of T2D. The literature review was performed using an electronic search database to identify literature related to preventing the conversion of prediabetes to T2D using either lifestyle modifications or metformin within the past five years. …
Associations Between Screen Use And Depression In The Youth Population, David Franta
Associations Between Screen Use And Depression In The Youth Population, David Franta
Physician Assistant Scholarly Project Papers
The association between depression in the youth population and screen use has remained largely unclear. Depression is a common finding in children and adolescents, and as mobile phones, computers, and television are becoming more readily available to young populations, evaluation of the relationship between the two could likely be very important. Unfortunately, little concrete evidence has been established regarding the direct effects of screen time and the presence or development of depression. A literature review comprised of both cross-sectional and longitudinal studies was performed to evaluate the current literature regarding screen use and depression in the youth population, including differences …