Medicine and Health Sciences Commons^™

Postoperative Breath-Holding Spells Requiring Cardiopulmonary Resuscitation After Cardiopulmonary Bypass, Rebecca Kreis, Jeffrey A. Robinson, Ali N. Ibrahimiye, Laura Ortmann

Journal Articles: Pediatrics

Breath-holding spells are common in childhood and can be associated with bradycardia and pulselessness. This report details severe breath-holding spells complicating postoperative management after atrial septal defect closure. The patient required cardiopulmonary resuscitation despite the use of a temporary pacemaker to prevent bradycardia. After multiple episodes of chest compressions, the decision was made to not intervene immediately to pulselessness and the patient was able to recover without further intervention.

Nutrition Support Practices For Infants Born <750 Grams Or <25 Weeks Gestation: A Call For More Research, Melissa K. Thoene, Ann Anderson-Berry

Journal Articles: Pediatrics

With advances in medical care and efforts to care for continually smaller and younger preterm infants, the gestational age of viability has decreased, including as young as 21 or 22 weeks of gestation [...].

Week 96 Extension Results Of A Phase 3 Study Evaluating Long-Acting Cabotegravir With Rilpivirine For Hiv-1 Treatment, Susan Swindells, Thomas Lutz, Lelanie Van Zyl, Norma Porteiro, Matthias Stoll, Essack Mitha, Alyssa Shon, Paul Benn, Jenny O. Huang, Conn M. Harrington, Kai Hove, Susan L. Ford, Christine L. Talarico, Vasiliki Chounta, Herta Crauwels, Rodica Van Solingen-Ristea, Simon Vanveggel, David A. Margolis, Kimberly Y. Smith, Kati Vandermeulen, William R. Spreen

Journal Articles: Infectious Diseases

BACKGROUND: ATLAS (NCT02951052), a phase 3, multicenter, open-label study, demonstrated that switching to injectable cabotegravir (CAB) with rilpivirine (RPV) long-acting dosed every 4 weeks was noninferior at week (W) 48 to continuing three-drug daily oral current antiretroviral therapy (CAR). Results from the W 96 analysis are presented.

METHODS AND DESIGN: Participants completing W 52 of ATLAS were given the option to withdraw, transition to ATLAS-2M (NCT03299049), or enter an Extension Phase to continue long-acting therapy (Long-acting arm) or switch from CAR to long-acting therapy (Switch arm). Endpoints assessed at W 96 included proportion of participants with plasma HIV-1 RNA less …

Covid-19 Patients With Documented Alcohol Use Disorder Or Alcohol-Related Complications Are More Likely To Be Hospitalized And Have Higher All-Cause Mortality, Kristina L. Bailey, Harlan Sayles, James Campbell, Neha Khalid, Madyson Anglim, Jana Ponce, Todd A. Wyatt, James C. Mcclay, Ellen L. Burnham, Alfred Anzalone, Corrine K. Hanson

Journal Articles: Environmental, Agricultural & Occupational Health

BACKGROUND: Coronavirus Disease 2019 (COVID-19) has affected every country globally, with hundreds of millions of people infected with the SARS-CoV-2 virus and over 6 million deaths to date. It is unknown how alcohol use disorder (AUD) affects the severity and mortality of COVID-19. AUD is known to increase the severity and mortality of bacterial pneumonia and the risk of developing acute respiratory distress syndrome. Our objective is to determine whether individuals with AUD have increased severity and mortality from COVID-19.

METHODS: We utilized a retrospective cohort study of inpatients and outpatients from 44 centers participating in the National COVID Cohort …

Physical Activity For Adl Performance In Older Adults With Dementia: A Systematic Review, Clancy Hesseltine, Josiah Heun, Murphy Porter, Sam Wyrick, Stacy Smallfield, Molly Whitlow

Student Systematized Reviews: Occupational Therapy

PURPOSE: An estimated 5.8 million people in the United States live with dementia. By the year 2060, this number is expected to climb as high as 14 million people (CDC, 2019). Performance and participation in activities of daily living (ADLs) is a primary goal of occupational therapy. Exercise intervention is an occupational therapy approach for individuals with dementia that will increase ADL performance (Giebel et al., 2015). The present study examined the effects of physical exercise to maintain or improve activities of daily living performance for adults with dementia.

DESIGN: This systematic review of systematic reviews examined whether physical activity …

Occupational Therapy Interventions For Adls In Adults Post-Tbi With Visual Symptoms: A Systematic Review, Connor Jarman Bs, Olivia Vander Haar Bms, Lauren Wobken Bs, Stacy Smallfield Drot, Msot, Otr/L, Bcg, Faota, Molly Whitlow Phd, Mph

Student Systematized Reviews: Occupational Therapy

PURPOSE: Traumatic brain injury (TBI) is a leading cause of death and injury in the United States. In fact, it is estimated that 1.5 million Americans experience them every year (CDC, 2022). Visual impairments may be a symptom following TBI (Richman, 2014). This affects an individual’s ability to perform activities of daily living (ADLs) such as dressing, hygiene, and functional mobility, including the reading required for these activities. The purpose of this systematic review was to synthesize the evidence and intervention options within the scope of occupational therapy for adults post-TBI experiencing visual symptoms.

DESIGN: We conducted a systematic review …

Effectiveness Of Functional Cognition Intervention For Adults With Traumatic Brain Injuries: A 
Systematic Review, Lauren Mccormick, Madison Otte, Delaney Hill, Emily Leahy, Stacy Smallfield, Molly Whitlow

Student Systematized Reviews: Occupational Therapy

Purpose: An estimated 5.3 million Americans are living with a permanent disability due to having a traumatic brain injury (TBI) (CDC, 1999). A common deficit seen in this population includes impaired functional cognition, which is the ability to use and integrate thinking and processing skills to complete complex instrumental activities of daily living (IADLs) (Giles et al., 2017). Occupational therapy practitioners support individuals post-TBI by creating and implementing occupation-based interventions during rehabilitation to optimize functional cognition and improve individuals' ability to complete IADLs. This study aims to identify the effectiveness of interventions within the scope of occupational therapy practice …

Ubiquitous Aberration In Cholesterol Metabolism Across Pancreatic Ductal Adenocarcinoma, Venugopal Gunda, Thiago C. Genaro-Mattos, Jyoti B. Kaushal, Ramakanth C. Venkata, Gopalakrishnan Natarajan, Kavita Mallya, Paul M. Grandgenett, Karoly Mirnics, Surinder K. Batra, Zeljka Korade, Satyanarayana Rachagani

Journal Articles: Biochemistry & Molecular Biology

Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models. Cholesterol is one of the critical metabolites supporting PC, synthesized or acquired by PC cells. Nevertheless, the significance of the de novo cholesterol synthesis pathway has been controversial in PC, indicating the need to reassess this pathway in PC. We utilized preclinical models and clinical specimens of PC patients and cell lines and utilized mass spectrometry-based sterol analysis. Further, we also performed in silico analysis to corroborate the significance …

The Gsk3 Kinase And Lztr1 Protein Regulate The Stability Of Ras Family Proteins And The Proliferation Of Pancreatic Cancer Cells, Chitra Palanivel, Neha Chaudhary, Parthasarathy Seshacharyulu, Jesse L. Cox, Ying Yan, Surinder K. Batra, Michel M. Ouellette

Journal Articles: Biochemistry & Molecular Biology

Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene. In pancreatic cancer (PC), more than 90% of tumors carry an activating mutation in KRAS. Mutations in components of the Ras signaling pathway can also be the cause of RASopathies, a group of developmental disorders. In a subset of RASopathies, the causal mutations are in the LZTR1 protein, a substrate adaptor for E3 ubiquitin ligases that promote the degradation of Ras proteins. Here, we show that the function of LZTR1 is regulated …

Tumor Microenvironment Enriches The Stemness Features: The Architectural Event Of Therapy Resistance And Metastasis, Palanisamy Nallasamy, Rama Krishna Nimmakayala, Seema Parte, Abhirup C. Are, Surinder K. Batra, Moorthy P. Ponnusamy

Journal Articles: Biochemistry & Molecular Biology

Cancer divergence has many facets other than being considered a genetic term. It is a tremendous challenge to understand the metastasis and therapy response in cancer biology; however, it postulates the opportunity to explore the possible mechanism in the surrounding tumor environment. Most deadly solid malignancies are distinctly characterized by their tumor microenvironment (TME). TME consists of stromal components such as immune, inflammatory, endothelial, adipocytes, and fibroblast cells. Cancer stem cells (CSCs) or cancer stem-like cells are a small sub-set of the population within cancer cells believed to be a responsible player in the self-renewal, metastasis, and therapy response of …

Rapid Student Assessment And Review Program (R-Star) Training Manual ©, Nicole M. Sleddens

Manuals: Physical Therapy

No abstract provided.

Palliative Care For The Pandemic ; Zoom New World-Skills I Learned During The Pandemic, Krysten Vance

The Art of Medicine

No abstract provided.

Isolation, Chloe Olson, Teresa Eberhart

The Art of Medicine

No abstract provided.

Untitled, Nate Singh

The Art of Medicine

No abstract provided.

Numb, Anonymous -

The Art of Medicine

No abstract provided.

Sherman's Shakes: A Story About Living With Epilepsy, Garrett Sacco

The Art of Medicine

No abstract provided.

Untitled, Sophie Cemaj

The Art of Medicine

No abstract provided.

The Unfortunate Case Of Dr. Silvan, Tom Schroeder

The Art of Medicine

No abstract provided.

Medicine's No Longer Healing, Natasha Hongsermeier-Graves

The Art of Medicine

No abstract provided.

Self Portrait, Tiffany Truong

The Art of Medicine

No abstract provided.

1000 Cuts ; Difficult, Stephanie Hartman

The Art of Medicine

No abstract provided.

Ethics Consults, Rebecca Anderson

The Art of Medicine

No abstract provided.

Good Morning Covid Nation, Gillian Rolfe

The Art of Medicine

No abstract provided.

Untitled, Keely Reidlberger

The Art of Medicine

No abstract provided.

Ephemeral, Alicia Phillips

The Art of Medicine

No abstract provided.

We'll Get Through This, Ben Mcintire

The Art of Medicine

No abstract provided.

Art Of Medicine - 2022

The Art of Medicine

No abstract provided.

Occupational Therapy Interventions To Optimize Functional Use Of The Upper Extremity After Peripheral Nerve Injury: A Systematic Review, Shayleigh Clarkson, Allison Fisher, Sean Mcfadden, Payton Swanson, Molly Whitlow, Stacy Smallfield

Student Systematized Reviews: Occupational Therapy

PURPOSE: Peripheral nerve injuries are a distinct group of injuries that are commonly caused by motor vehicle accidents, falls, industrial accidents, household accidents, and penetrating trauma (Kamble et al., 2019). A peripheral nerve injury can affect an individual’s daily occupations and routines due to unrelenting pain, loss of sensation, and/or burning sensations. Peripheral nerve injuries can result in motor loss and subsequent muscle imbalance which can create functional loss (Chae et al., 2020). The purpose of this systematic review was to provide occupational therapists with evidence supporting the use of interventions to increase the functional use of the upper extremity …

Climbing The Anki Mountain, One (Review) Step At A Time: A Written And Video-Based Guide On Using Anki In Medical School To Enhance Knowledge Acquisition And Retention, Alexander Tu, Tiffany Truong, Avi Prajapati

EMET Projects

No abstract provided.

Longs Peak Overlooking Bear Lake In Rocky Mountain National Park, David Wessling

Graduate Medical Education Research Journal

No abstract provided.