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Actions Of (1s,3r)-1-Aminocyclopentane-1,3-Dicarboxylic Acid (1s,3r-Acpd) In Retinal On Bipolar Cells Indicate That It Is An Agonist At L-Ap4 Receptors., Wallace B. Thoreson, R. F. Miller

Journal Articles: Ophthalmology

Metabotropic glutamate receptors (mGluRs) include receptors sensitive to L-2-amino-4-phosphonobutyrate (L-AP4) and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). To determine whether 1S,3R-ACPD is an agonist at retinal L-AP4 receptors, whole cell voltage clamp recordings were obtained from mudpuppy ON bipolar cells in a superfused retinal slice and L-AP4 and 1S,3R-ACPD were bath applied. Both compounds evoked similar outward currents which reversed near 0 mV and were accompanied by an increased input resistance. Responses to both agonists washed out in parallel suggesting they act through the same second messenger pathway(s). Inhibitors of cGMP-PDE activity suppressed responses to both L-AP4 and 1SR,3RS-ACPD, suggesting that both compounds …

Bulletin Of The University Of Nebraska: Annual Catalog Of The College Of Medicine, 1994-1995, University Of Nebraska Medical Center

Bulletin of the University of Nebraska: Annual Catalog of the College of Medicine

•Governance of the University of Nebraska

•College of Medicine Administration

•The University of Nebraska

•General Information

•Learning Facilities

•Admissions

•Curriculum

•Academic Calendar 1994-95

•Evaluation of Student Performance

•Requirements for Graduation

•General Policies

•Fees and Expenses

•Financial Assistance

•Departments of Instruction

•Faculty Listing

•Index

The University Of Nebraska Hospital, The First Seventy-Five Years, 1917-1992, F Miles Skultety

University of Nebraska Medical Center: Books

This all began in the summer of 1991. I had been retired from the College of Medicine for four years when I received a copy of a memo to a fairly large group asking us to serve on a committee for the 75th Anniversary of the University of Nebraska Hospital and the University of Nebraska College of Nursing. Having elected to do so, I eventually ended up as chairman of the subcommittee on history. The other members of that committee were Alice Friedlander, retired Director of Volunteer Services; Kathy McConnell, President of the Hospital Auxiliary; Sharon Redding from the College …

Bulletin Of The College Of Dentistry, 1994-1996, University Of Nebraska Medical Center

Bulletin of the University of Nebraska College of Dentistry

•The University of Nebraska

•The College of Dentistry

•Predental Requirements

•Transfer of Credits

•Rural Health Opportunities Program

•Admission Guidelines

•Technical Standards for Admission

•Application Procedure

•Costs at the College of Dentistry

•Scholarships and Financial Aid

•Textbooks, Instruments, and Materials

•Housing Facilities

•Degrees

•Advanced Training

•Dean's Advisory Council

•Conduct Regulations

•Scholarship Regulations

•Professional Courses of Instruction

•Program in Dental Hygiene

•College Administrative Officers and Teaching Faculty

•College of Dentistry Calendar

•University Governance