Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Reduced Intestinal Colonization Of Adult Beef Cattle By Escherichia Coli O157:H7 Tir Deletion And Nalidixic-Acid-Resistant Mutants Lacking Flagellar Expression, Gustavo Bretschneider, Emil M. Berberov, Rodney A. Moxley
Reduced Intestinal Colonization Of Adult Beef Cattle By Escherichia Coli O157:H7 Tir Deletion And Nalidixic-Acid-Resistant Mutants Lacking Flagellar Expression, Gustavo Bretschneider, Emil M. Berberov, Rodney A. Moxley
School of Veterinary and Biomedical Sciences: Faculty Publications
The importance of the Escherichia coli O157:H7 translocated intimin receptor (Tir) protein in intestinal colonization and the effect of infection with Tir+ strains on protection against subsequent challenge was studied in adult beef cattle. Cattle were orally inoculated (C1) with a Shiga toxin-2++ E. coli O157:H7 strain that was Tir+ or Tir-, and 42 days later were re-challenged (C2) with the nalidixic acid (Nal) R parent strain to test whether prior infection had any effect on fecal shedding. During the first 14 days post-C1, the NalS wildtype (WT) strain was shed at significantly …
Isotype-Specific Antibody Responses Against Escherichia Coli O157:H7 Locus Of Enterocyte Effacement Proteins In Adult Beef Cattle Following Experimental Infection, G. Bretschneider, E. M. Berberov, Rodney A. Moxley
Isotype-Specific Antibody Responses Against Escherichia Coli O157:H7 Locus Of Enterocyte Effacement Proteins In Adult Beef Cattle Following Experimental Infection, G. Bretschneider, E. M. Berberov, Rodney A. Moxley
School of Veterinary and Biomedical Sciences: Faculty Publications
Escherichia coli O157:H7 is an important food-borne pathogen and cause of hemorrhagic colitis and hemolytic uremic syndrome in humans. Cattle are an important reservoir of E. coli O157:H7, in which the organism colonizes the intestinal tract and is shed in the feces. Vaccination of cattle has significant potential as a pre-harvest intervention strategy for E. coli O157:H7; however, basic information about the bovine immune responses to important bacterial colonization factors resulting from infection has not been reported. The serum and fecal IgG and IgA antibody responses of adult cattle to E. coli O157:H7 intimin, translocated intimin receptor (Tir), E. coli …