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University of Nebraska - Lincoln
Addiction; Drug Abuse; Learning; Motivation; Occasion setting; Pavlovian conditioning
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Facilitation By Drug States Does Not Depend On Acquired Excitatory Strength, Matthew I. Palmatier, Rick A. Bevins
Facilitation By Drug States Does Not Depend On Acquired Excitatory Strength, Matthew I. Palmatier, Rick A. Bevins
Department of Psychology: Faculty Publications
Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug-state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal-tracking conditioned response …