Medicine and Health Sciences Commons^™

Motor And Sensory Characterization Of A Mouse Model Of Charcot-Marie-Tooth Type 2o Disease, Swaran Nandini

Electronic Theses and Dissertations

Dynein is an essential motor protein required for the maintenance and survival of cells. Dynein forms a motor complex to carry intracellular cargoes like organelles, growth factors, peptides, and hormones along the microtubules inside the cells. In neurons, the dynein is the retrograde motor protein that moves cargoes from the neuronal tip to the neuronal soma along the length of an axon. Dynein has an established role in neuronal nuclear migration, transport of neuronal survival signals and growth factors, organelle positioning inside neurons etc. Hence, it is not very surprising that numerous mutations in dynein have been reported in association …

Factors Influencing Unmet Medical Need Among U.S. Adults: Disparities In Access To Health Services, Ahmad Khanijahani

Electronic Theses and Dissertations

Inequities in access to health services has negative consequences on individual well-being, and imposes financial and emotional burden on patients, families, health care systems, and the public. Inequities engendered from differences in socioeconomic status, health insurance coverage, race, and other characteristics can engender disparities. This study aimed to identify the potential predictors of unmet medical need among the civilian noninstitutionalized U.S. adults. Inability to receive needed medical care or receiving medical care after a delay, due to the associated costs, constructed unmet medical need. This study used a four-year (2014-2017) National Health Interview Survey (NHIS) data (sample size: 296,301 adults) …

Readability Of Patient-Reported Outcome Measures For Persons With Aphasia, Sara Gray

Electronic Theses and Dissertations

The relationship between positive health outcomes in persons with aphasia (PWA) and personcentered care is highlighted by personally relevant information obtained directly from the PWA. Such is often facilitated via patient reported outcome measures (PROMs). In order to provide accurate responses to PROMs, PWAs must to read, comprehend, formulate and generate answers to a variety of questions. PROMs designed for other clinical populations assessed/treated by speech-language pathologists have been found to be largely unreadable. Despite the significant role of PROMs in assessment and management of aphasia, no study to date has examined the readability of these measures. Four readability formulae …

Implementation Of The Roles And Responsibilities Of Speech Language Pathologists In The Schools, Tamar Nir

Electronic Theses and Dissertations

The purpose of this study was to determine how the roles and responsibilities of speech-language pathologists (SLPs) in schools are being implemented, whether speech-language pathologists in schools feel comfortable with their roles, and whether they are willing to engage in professional learning activities to hone knowledge and skills in role areas in order to inform pre-service and in-service learning This study utilized an online survey to collect responses. The survey included questions related to the rate of implementation, comfort level, and desire for further professional learning with regards to the roles and responsibilities prescribed by American Speech-Language Hearing Association (ASHA) …

A Deep Learning Approach To Diagnosing Schizophrenia, Justin Barry

Electronic Theses and Dissertations

In this article, the investigators present a new method using a deep learning approach to diagnose schizophrenia. In the experiment presented, the investigators have used a secondary dataset provided by National Institutes of Health. The aforementioned experimentation involves analyzing this dataset for existence of schizophrenia using traditional machine learning approaches such as logistic regression, support vector machine, and random forest. This is followed by application of deep learning techniques using three hidden layers in the model. The results obtained indicate that deep learning provides state-of-the-art accuracy in diagnosing schizophrenia. Based on these observations, there is a possibility that deep learning …

Factors Influencing Nurse Practitioners' Weight Management Practices In Primary Care, Suzanne Hyer

Electronic Theses and Dissertations

More American adults are overweight or obese than ever before. Nurse practitioners (NPs) play a critical and expanding role in primary care, which is an ideal setting for the assessment and management of weight loss. NPs can make a significant contribution to tackling the obesity crisis. The study presented here seeks to close the gap in data related to how NPs approach weight management with their primary care patients. This study focused on a comprehensive examination of the current practice patterns of NPs related to weight management, a theoretical concept analysis of weight bias among healthcare providers, along with the …

Predictors Of Hospital Quality And Efficiency, Hoda Fotovvat

Electronic Theses and Dissertations

American hospitals have made serious efforts to implement and expand their health information technology capabilities and to integrate different specialized care or high-tech services in order to maximize the efficiency and quality of care. In providing a variety of HIT-related services, these hospitals expanded their national reputation in line with integrated care goals. As a result, hospitals are encouraged to establish effective communication channels to facilitate patient-physician sharing of the patient care experience, to enhance effective pain management, and to transform patient-centered care modalities to solidify the adequacy of patient care processes. By analyzing national data sets publicly available, this …

Motivational Factors And Barriers Affecting Seniors' Decision To Relocate To A Senior Living Facility, Suja Chaulagain

Electronic Theses and Dissertations

This study aimed to explore factors affecting seniors' intention to relocate to a senior living facility. More specifically, the purpose of this study was to examine the influence of push and pull motivational factors and perceived barriers on seniors' intention to relocate to a senior living facility (SLF). In addition, the mediating role of perceived barriers on the relationships between push motivational factors and intention to relocate and pull motivational factors and intention to relocate were explored. The data of the study was collected from 363 seniors. Structural equation modeling (SEM) analysis was conducted to test the study hypotheses. The …

Ab Toxins: Recovery From Intoxication And Relative Potencies, Patrick Cherubin

Electronic Theses and Dissertations

AB-type protein toxins have a catalytic A subunit attached to a cell-binding B subunit. Ricin, Shiga toxin (Stx), exotoxin A, and diphtheria toxin are AB toxins that act within the host cytosol and kill the host cell through pathways involving the inhibition of protein synthesis. Our overall goal is to help elucidate the cellular basis of intoxication for therapeutic development. According to the current model of intoxication, the effect of AB toxins is irreversible. To test this model, we developed a system that uses flow cytometry and a fluorescent reporter to examine the cellular potency of toxins that inhibit protein …

Unraveling Pdi And Its Interaction With Ab Toxins, Jessica Guyette

Electronic Theses and Dissertations

Protein disulfide isomerase (PDI) is an essential endoplasmic reticulum (ER) protein that acts as both an oxidoreductase and chaperone. It exhibits substantial flexibility and undergoes cycles of unfolding and refolding in its interaction with cholera toxin (Ctx), which is a unique property of PDI. This unfolding allows PDI to disassemble the Ctx holotoxin, which is required for Ctx activity. Here, we investigated the unfolding and refolding property of PDI and how this affects its interaction with bacterial toxins. PDI showed remarkable redox-linked conformational resilience that allows it to refold after being thermally stressed. Deletion constructs of PDI showed that both …

Modeling Disease Impact Of Vibrio-Phage Interactions, Christopher Botelho

Electronic Theses and Dissertations

Since the work of John Snow, scientists and medical professionals have understood that individuals develop cholera by means of consuming contaminated water. Despite the knowledge of cholera's route of infection, many countries have experienced and still experience endemic cholera. Cholera is caused by the Vibrio cholerae (V. cholerae) bacterium and presents with acute diarrhea and vomiting. If untreated, infected individuals may die due to dehydration. Cholera is a disease that most commonly affects countries with poor infrastructure and water sanitation. Despite efforts to control cholera in such countries, the disease persists. One such example is Haiti which has been experiencing …

A Complete Approach To Predict Biodistribution Of Nanomaterials Within Animal Species From In-Vitro Data, Edward Price

Electronic Theses and Dissertations

Smart drug-design for antibody and nanomaterial-based therapies allows for optimization of drug efficacy and more efficient early-stage pre-clinical trials. The ideal drug must display maximum efficacy at target tissue sites, but to track and predict distribution to these sites, one must have a mechanistic understanding of the kinetics involved with the individual cells of the tissue itself. This process can be tracked through biological simulations coupled with in-vitro approaches, which result in a rapid and efficient in-depth understanding of drug transport within tissue vasculature and cellular environment. As a result, it becomes possible to predict drug biodistribution within live animal …

The Envelope Stress Response In Sedimentation-Resistant Escherichia Coli, Neel K. Shah

Honors Undergraduate Theses

Previous research discovered the existence of sedimentation-resistant mutants of E. coli. Genomic studies revealed that these mutants resisted sedimentation due to independent modifications to genes that influenced the Rcs signal transduction pathway, causing increased secretion of an exopolysaccharide capsule comprised primarily of colanic acid. The Rcs system is responsible for detecting envelope stressors; consequently, ampicillin and osmotic stress were used to perturb the cellular envelope and study the response of the mutants compared to wild-type cells. It was found that the overproduction of colanic acid in the mutants confers some resistance to envelope stress; however, the mutants still behaved …

Overview Of Direct Thrombin Inhibitors For Use In Staphylococcus Aereus Infections, Joseph C. Risler

Honors Undergraduate Theses

The pathogenicity and intractable nature of the microorganism Staphylococcus aureus (SA) has been long documented and highlighted by many health care agencies, with emphasis on its ability to exploit the human coagulation system to deadly effect. Two drugs from a class of inhibitors known as Direct Thrombin Inhibitors (DTI) have been shown to have a substantial effect on the enzyme secreted by SA known as Staphylocoagulase (SC), but up until now the application of this potential treatment has been limited. This paper strives to supply an overview of these clinical studies and propose a novel protocol for testing DTI's on …

Factors Contributing To The Negative And Unhealthy Psychological Conditions In The Ed Rn, Ariana M. Nieves

Honors Undergraduate Theses

The emergency department is a stressful environment. Emergency department registered nurses (ED RNs) are at an increased risk of development of negative and unhealthy psychological conditions due to their frequent exposure to stress and traumatic events. These conditions include post-traumatic stress disorder, compassion fatigue, and burnout syndrome, which are already known to be common in the emergency department registered nurse population. It is important to understand the factors that influence the development of these psychological conditions in order to provide better education to nurses regarding prevention of the development of these psychological conditions. This literature review aimed to identify articles …

The Effect Of Nursing Interventions And Health Promotion On Childhood Obesity: A Literature Review, Grace N. Mageloff

Honors Undergraduate Theses

Childhood obesity is a growing epidemic in the United States that has short-term and long-term health consequences for the children affected. Nurses are patient advocates and are responsible for speaking up for the patient; in the pediatric population, a nurse must act as an advocate on behalf of the child. The purpose of this literature review is to look at different barriers to nursing interventions in regard to childhood obesity. A literature review was done by using different databases, with 11 articles having similar themes and interventions used. The main themes from the literature review were parental willingness and involvement …

Barriers And Facilitators To Accessing And Utilizing Mental Health Services For Homeless Youth: A Systematic Review, Abbygail P. Lapinski

Honors Undergraduate Theses

Homelessness in the youth population is associated with elevated rates of mental illness, substance abuse, and suicidality compared to the housed population in the United States (Berdahl, Hoyt, and Whitbeck, 2005; Hodgson, Shelton, Van den Bree, 2014; Hughes et al., 2010). With a survival-focused perspective, exacerbating issues, stigmatization, and transience housing; homeless youth require special consideration to meet their diverse health needs. When barriers impede homeless youth's access to necessary health resources, their health concerns are left untreated and impound until emergency services are required. This review of literature is focused on identifying and synthesizing barriers and facilitators for homeless …

Assessing The Impact Of Digital Health Technologies On Maternal Health Care In Sub-Saharan Africa, Samerawit Tadele

Honors Undergraduate Theses

Maternal morbidity and mortality are prevalent issues worldwide that profoundly affects low- and middle-income countries (LMICs) in Africa. Estimates vary, but by the end of 2015, at least 300,000 women died in LMICs due to preventable pregnancy and childbirth conditions. Pregnant women die from complications that could be detected and managed if they were able to receive early access to necessary health interventions. Mobile technology is increasingly common across the globe, including LMICs, and incorporating digital health technologies, especially mobile phone (mHealth) programs, can offer a possible solution to morbidity and mortality related to pregnancy. A literature review analyzing the …

Associations Between Low-Carbohydrate Diet Score And Prognostic Factors Among Adults With Diabetes Mellitus: An Analysis Of The Nhanes 2005-2016, Elta N. Charles

Honors Undergraduate Theses

Background: Type 2 diabetes mellitus is one of the leading chronic diseases affecting Americans. There is a lack of literature discussing the link between diet and prognosis of those already diagnosed with DM. Objective: To provide insight into which diet is better for the outlook of diabetes mellitus by examining the associations between the low-carbohydrate diet (LCD) score and three diabetes-related health indicators: blood hemoglobin (HbA1c), triglycerides, and retinopathy. Methods: A total of 3,313 U.S. adults with DM were selected from the National Health and Nutrition Examination Survey 2005-2016. Presence of retinopathy was ascertained through self-reporting. Dietary intake was measured …

Should Athletes Receive Sleep Hygiene Education? A Systematic Literature Review, Ines L. Contreras

Honors Undergraduate Theses

Previous studies show the need to find a solution to improve the athlete's recovery and help overcome their sleep disorders. Sleep hygiene is a list of habits and recommendation that enhance sleep quality. Sleep hygiene education has been used in some research to fill the need of the athletes. Still, a lack of information exists on the development of sleep hygiene programs and related impacts. This thesis aims to perform a systematic review of the literature of scholarly journals articles from 2007 to 2018, focusing on the relationship between sleep hygiene education and athletes sleep quality and quantity. The investigation …

The Efficacy Of Meditation-Based Treatments In Relapse Prevention For Persons With Substance Use Disorders, Florence C. Bates

Honors Undergraduate Theses

Substance abuse is a global problem that has contributed to a variety of societal, financial, health, and familial strains. An increasing prevalence of illicit drug, prescription opioids, and alcohol abuse has created a need for re-evaluation of recovery and relapse treatments. This literature review examines the efficacy of meditation-based treatments for relapse prevention in persons recovering from Substance Use Disorders (SUDs). A comparative analysis of Mindfulness Based Relapse Programs (MBRP), an adapted MBRP-W program, and a Transcendental Meditation (TM) intervention was used to examine the success of meditation-based interventions. Research supports improvements associated with the meditation-based interventions including significant reductions …

Using The Ketogenic Diet As An Adjuvant To Cancer Therapy: A Systematic Review, Melanie L. Risola

Honors Undergraduate Theses

Cancer is the second leading cause of death in the United States. Evidence shows that a conventional western diet may contribute to the proliferation of cancer cells, affecting their prognosis. The aim of this review is to examine the efficacy and safety of using the ketogenic diet as an adjuvant to traditional cancer therapy. The systematic literature search was performed in October 2018 on two search engines: EBSCOhost (Medline, CINHAL, Cochrane Central Register of Controlled Trials) and Web of Science using the following key terms: ketogenic diet, high fat & low-carbohydrate diet, Atkins diet, cancer or neoplasms+. The search limitations …

An Exploration Of Public Misconceptions Of Municipal Water Fluoridation Relating To Oral And Public Health, Thomas A. Hawkins

Honors Undergraduate Theses

Municipal water fluoridation began in 1945, and in the past 70 years, it appears to have decreased the rate of dental caries nationwide. Despite being deemed one of the top ten innovations of the 20th century, there continues to be misconceptions with this controversial practice. The intent of this thesis is to address some of the misconceptions with water fluoridation, and what possible solutions could be provided to alleviate the concerns. This was accomplished through a literature review of current research articles. Two main topics were explored: the public health and oral health concerns and how they contribute to the …

Development Of A Spanish Version Of The Main Concept Analysis For Analyzing Oral Disordered Discourse, Karla Simonet

Honors Undergraduate Theses

Aphasia is an acquired language impairment caused by damage in the regions of the brain that support language. The Main Concept Analysis (MCA) is a published formal assessment battery that allows the quantification of the presence, accuracy, completeness, and efficiency of content in spoken discourse produced by persons with aphasia (PWA). It utilizes a sequential picture description task (with four sets of pictures) for language sample elicitation. The MCA results can also be used clinically for targeting appropriate interventions of aphasic output. The purpose of this research is to develop a Spanish adaptation of the MCA by establishing normative data …

The Mediating Role Of Resilience In The Relationship Between Attachment Style And Symptoms Of Depression And Anxiety, Melanie Jurgensen

Honors Undergraduate Theses

Although previous research has identified a relationship between insecure attachment styles and symptoms of depression and anxiety, evidence regarding the mechanisms of action driving this relationship has been lacking. Consequently, the current study examined the mediating role of resilience in the relationship between insecure attachment styles (i.e. anxious-avoidant, anxious-ambivalent, helpless-disorganized and frightened-disorganized) and symptoms of depression and anxiety. The current study included a sample of 182 participants (i.e., 87 men and 95 women) who completed six questionnaires that assessed each participants' relationship with their caregivers during their childhood, present symptoms of depression and anxiety, and their resilience. Correlational analyses indicated …

Fear Of Falling Assessment And Interventions In Community-Dwelling Older Adults: A Mixed Methods Case Study, Amanda S. Cappleman

Honors Undergraduate Theses

Background: Fear of falling has significant adverse physical and psychological effects for the community-dwelling older adult. Objective: The purpose of this study was to assess fear of falling in community-dwelling older adults and explore participant perceptions of fear of falling assessments and interventions. Methods: A mixed methods case study was utilized to gain an in-depth understanding of older adults' perceptions. It consisted of quantitative data collection by objective measures and qualitative data collection by four individual in-depth interviews. A sample of four community-dwelling adults aged 65 years and older and living in Orlando, Florida, completed the study in their home …

Fall Risk Assessment In Community- Dwelling Older Adults: An Explanatory Sequential Mixed Methods Study, Maryann Dool

Honors Undergraduate Theses

Abstract

Aims: 1) To determine fall risk assessment using subjective and objective measures; 2) To understand older adults' perception on fall risk assessment.

Methodology: An explanatory sequential mixed methods design was used and consisted of two phases. Phase 1, the quantitative data was collected from nineteen older adults at an independent living facility in Orlando, Florida. Phase 2, the qualitative data was collected from three participants of Phase 1. After obtaining Institutional Review Board approval, the study was conducted at Lutheran Towers an independent living facility located in the downtown area of Orlando, Florida. Three measurement tools were used: demographic …

Sepsis Knowledge In Undergraduate Nursing Students, Kelsey E. Tilton

Honors Undergraduate Theses

Background: Sepsis is the most common cause of death in critically ill patients in settings other than cardiovascular intensive care units (ICUs). Research shows that early detection is the best way to prevent sepsis progression and improve patient outcomes. Nurses can play a critical role in the treatment of sepsis using their knowledge and resources to detect the presence of sepsis at the earliest possible point in the progression of the syndrome. Baccalaureate nursing students were surveyed to assess students' beliefs and knowledge of sepsis and to examine the gaps in students' abilities to identify sepsis. Methodology: An …

Artful Bionics: Pushing The Limits Of Visual Expression In Prosthetic Design, Anna Kester

Honors Undergraduate Theses

Traditional prosthetic design revolves around functionality, aiming to hide and downplay an individual's limb difference as much as possible. This may not only negatively affect the user's desire to wear their prosthetic but may also negatively affect their self-confidence and sense of identity. Expression is a primary way to communicate identity, yet some traditional prosthetics may deny expression, leaving users without an immediate means to express themselves apart from the stigmatizing label of 'disability'. This study examines the ability of art when combined with bionic prosthetic technology to change the perception of disability, empower self confidence in prosthetics users, and …

Long-Term Outcomes Of Neonatal Herpes Simplex Virus Infection And Treatment, Genesis M. Brador

Honors Undergraduate Theses

The prevalence of herpes simplex virus (HSV) infection globally is high, and although there is no cure for it, the antiviral drug acyclovir is used to alleviate symptoms. There are two types of HSV: HSV-1, which typically infects the oral area, and HSV-2, which is associated with genital infections. A mother who carries the infection may transmit it to a neonate in different ways, most commonly via vaginal delivery in the presence of active lesions. There are three types of HSV disease that affect newborns: skin, eyes or mouth (SEM) disease, central nervous system (CNS) disease, or disseminated disease. The …