Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Doctor of Philosophy (PhD) Heersink School of Medicine (57)
- Doctor of Philosophy (PhD) School of Public Health (15)
- Doctor of Philosophy (PhD) School of Health Professions (12)
- Doctor of Philosophy (PhD) School of Nursing (9)
- Master of Science in Dentistry (MScD) School of Dentistry (7)
-
- Doctor of Public Health (DrPH) School of Public Health (6)
- Doctor of Science in Physical Therapy (DScPT) School of Health Professions (6)
- Doctor of Philosophy (PhD) School of Optometry (5)
- Master of Dentistry (MDent) School of Dentistry (4)
- Mitochondria (4)
- Obesity (4)
- Apoptosis (3)
- Autophagy (3)
- Executive Doctor of Science (DSc) School of Health Professions (3)
- Master of Science (MS) School of Optometry (3)
- Master of Science in Public Health (MSPH) School of Public Health (3)
- Ozone (3)
- Physical activity (3)
- Adolescents (2)
- African American (2)
- Asthma (2)
- Bioenergetics (2)
- Body composition (2)
- CD8 T cells (2)
- Capsule (2)
- Cathepsin D (2)
- Central scotoma (2)
- Cytochrome P450 (2)
- ER stress (2)
- Epigenetics (2)
Articles 31 - 60 of 135
Full-Text Articles in Medicine and Health Sciences
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
All ETDs from UAB
Ozone (O3) is a primary component of photochemical smog and represents a serious public health concern as more than 50% of the U.S. population lives in areas exceeding national ambient air quality standards for this toxic pollutant. Recent findings indicate that the effects of inhaled O3 extend to extra-pulmonary tissues like the heart and liver. We hypothesize that inhaled O3 exposure-related events in the lung will cause downstream alterations in the liver proteome. To test this, we exposed male Sprague-Dawley rats to 0.5 ppm ozone for 8 hr a day for 5 days. After exposures, livers were removed and proteomic …
Distribution/Localization And Relative Quantitation Of C-Terminal Αa-Crystallin Truncation Products Within Lenses Of Icr/F Rats Treated With Dietary Supplemented Genistein, Kyle Anthony Floyd
Distribution/Localization And Relative Quantitation Of C-Terminal Αa-Crystallin Truncation Products Within Lenses Of Icr/F Rats Treated With Dietary Supplemented Genistein, Kyle Anthony Floyd
All ETDs from UAB
The ocular lens functions to focus light coming into the eye onto the retina. Lens development begins in utero, and continues over an individual's lifetime. Lens fiber cells and their proteins are only synthesized once and have no repair mechanisms, so they remain for an individual's lifetime. The α-crystallins, the most abundant lens proteins, act as chaperones to keep damaged/unfolded proteins in-solution. Cataract disease is associated with protein damage, leading to a light scattering opacity. It has been suggested that truncation of αA-crystallin leads to a loss of chaperone function. Cataract disease is the leading cause of blindness in the …
Predictors Of Vaginal Douching Behavior And Sexual Risk Taking Among A Population Of Women In The South: The Influence Of Sexual Concurrency And Partner Incarceration, Keri J. Griffin
All ETDs from UAB
In the United States, adolescent women between the ages of 14 and 19 are estimated to bear the largest burden of sexually transmitted infections. Left untreated, these infections have the potential to result in several adverse reproductive health outcomes. Sexually risky behaviors, including early sexual initiation, sexual partner concurrency, and the use of vaginal douche products increase the risk for the contraction of sexually transmitted infections. Further, having a sexual relationship with a male partner who is known to have other partners or a history of contact with the justice system might put a woman at additional risk. Utilizing a …
The Role Of Histone Methylation In The Medial Temporal Lobe During Long-Term Memory Formation, Swati Gupta
The Role Of Histone Methylation In The Medial Temporal Lobe During Long-Term Memory Formation, Swati Gupta
All ETDs from UAB
Several studies have established the importance of epigenetic regulation of gene transcription in the brain during memory consolidation. Epigenetic mechanisms involve modifying the DNA or the associated histone proteins to determine the transcriptional outcome of a gene. The work encompassed in this dissertation serves as an initial investigation for the role of histone lysine methylation mechanisms in regulating gene activation and suppression in the medial temporal lobe that includes entorhinal cortex (EC), hippocampus, and amygdala during memory consolidation. To this end, we found that di-methylation of histone H3 at lysine 9 (H3K9me2) which promotes gene suppression was specific to associative …
The Effect Of Structured Background On Smooth Pursuit With Real And Simulated Central Scotoma, Thomas Keith
The Effect Of Structured Background On Smooth Pursuit With Real And Simulated Central Scotoma, Thomas Keith
All ETDs from UAB
The purpose of the study was to better understand the role of the fovea in smooth pursuit eye movements in human subjects. The research entailed a systematical study of a previously unstudied condition where the foveal inputs of both the background and the pursuit target were eliminated through simulation but the anatomic fovea was intact; and a comprehensive study of smooth pursuit eye movements of human subjects with real central scotoma. Ten normally sighted subjects (NS) and three central scotoma subjects (CS) were asked to visually pursuit a 0.87o yellow dot moving along either a horizontal or a vertical trajectory …
A Study Of The Genetic Mechanisms Used To Regulate The Third Complementarity Determining Region Of The Immunoglobulin H Chain, Mohamed Khass
A Study Of The Genetic Mechanisms Used To Regulate The Third Complementarity Determining Region Of The Immunoglobulin H Chain, Mohamed Khass
All ETDs from UAB
Developing B cells exhibit sequential changes in the representation of immunoglobulin (Ig) heavy (H) chain sequences with excess hydrophobic or charged amino acids in complementarity determining region 3 (CDR-H3). To begin to elucidate the mechanisms by which this process occurs, we used Bromodeoxy Uridine (BrdU) incorporation and Annexin V binding to quantify B cell turnover and cell cycle progression in developing B cell subsets in the bone marrow, spleen and peritoneal cavity of wild-type BALB/c mice. To magnify the effects of hydrophobicity and charge, we included in this analysis mice limited to the use of an IgH allele with a …
Screening For Medical Referral: Determining Variables That Influence Accuracy, Heather Ellis Mount
Screening For Medical Referral: Determining Variables That Influence Accuracy, Heather Ellis Mount
All ETDs from UAB
SCREENING FOR MEDICAL REFERRAL: DETERMINING VARIABLES THAT INFLUENCE ACCURACY HEATHER E. MOUNT DOCTOR OF SCIENCE IN PHYSICAL THERAPY ABSTRACT Background: Screening for medical referral is essential to autonomous practice; however, no studies have examined the medical screening abilities of physical therapists in various settings. Objective: The purpose of this study was to determine if physical therapists in various practice settings could appropriately screen for medical referral, given brief clinical vignettes. Methods: A Delphi study was performed to enhance the content validity of the vignettes. After reviewing the vignettes, survey participants determined if they would provide intervention, provide intervention and refer, …
Childhood Obesity: The Role Of Genetic Admixture, Parental Feeding Practices, And The School Food Environment, Michelle Cardel
Childhood Obesity: The Role Of Genetic Admixture, Parental Feeding Practices, And The School Food Environment, Michelle Cardel
All ETDs from UAB
Disentangling the etiology of pediatric obesity continues to challenge researchers due to the interconnecting of behavioral, physiological, environmental, and genetic factors. Studies have focused on the role of the obesogenic environment, characterized by excess energy intake and sedentary behavior, as it relates to weight and fat gain in children. Although these factors certainly have an impact on fat accumulation, increased energy intake and decreased physical activity do not solely account for the increasing trends in obesity prevalence. Less explored genetic and environmental factors may contribute independently and/or synergistically to the current obesity epidemic, and that, these factors could vary in …
Are Enabling Services In Federally Qualified Health Centers Associated With Women Receiving Prenatal Care In The First Trimester?, Forrest A. Daniels
Are Enabling Services In Federally Qualified Health Centers Associated With Women Receiving Prenatal Care In The First Trimester?, Forrest A. Daniels
All ETDs from UAB
The purpose of this study was to examine whether enabling services in federally qualified health centers (FQHCs) were associated with women receiving prenatal care services in the first trimester. The population for this study included FQHCs providing prenatal care services for the years 2008, 2009, and 2010. Data for this study were derived from two sources: Uniform Data System (UDS) and the Area Resource File (ARF). This study adopted the Andersen's (1973) Behavioral Model of Health Services Use. The study consisted of longitudinal panel data analysis. Univariate and bivariate statistics were calculated using PASW/SPSS statistical software, version 18. For the …
Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn
Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn
All ETDs from UAB
Bacteriophage can mediate the transfer of unrelated mobile genetic elements (MGE) from a carrier bacterial cell to the susceptible population around it. This transfer results in the spread of virulence or other accessory genes encoded on the MGE. During viral particle assembly, the MGE can discourage the formation of viable bacteriophage progeny by limiting the size of the particles to those large enough to encapsidate the MGE, but too small to fit the complete bacteriophage genome which is three times larger. Here, I present models for size determination by an external scaffolding protein which is independent of and dominant over …
Structural And Molecular Studies Of Nucleic Acid Chaperones, Lei Ding
Structural And Molecular Studies Of Nucleic Acid Chaperones, Lei Ding
All ETDs from UAB
Nucleic acids are the storage of genetic information that needs to be expressed and inherited. As abundant cellular macromolecules they are also major players of a wide variety of biological processes. They usually undergo post-transcriptional modifications and/or fold into higher order structures in order to accomplish their distinct functions. Most biological events involving nucleic acids are achieved by proteins that interact with them. The functionality requires specific recognition of nucleic acids by proteins at molecular level. Nucleic acid chaperones are a group of nucleic acids binding proteins that associate with structured RNAs or DNAs and assist correct folding of their …
Proteomic Clues To The Pathogenesis Of Alexander Disease, Daniel L. Flint
Proteomic Clues To The Pathogenesis Of Alexander Disease, Daniel L. Flint
All ETDs from UAB
Since the initial report identifying mutations in GFAP as the primary genetic defect in the astrogliopathy Alexander Disease (AxD) much progress has been made in elucidating the molecular details underpinning the pathogenic role of mutant GFAP in astrocytes. In particular, data collected from mouse, fly, and cell culture models of AxD have isolated several prominent cellular changes that are associated with mutant GFAP expression including oxidative stress, proteasome inhibition, reduced expression of the astrocyte glutamate transporter GLT-1, and loss of neurons; these models have also successfully recapitulated the pathological hallmark of AxD--protein aggregates known as Rosenthal fibers (RFs). To date, …
Functional Collaboration Between Igf-1 Receptor And Growth Hormone Signaling Pathway, Yujun Gan
Functional Collaboration Between Igf-1 Receptor And Growth Hormone Signaling Pathway, Yujun Gan
All ETDs from UAB
GH receptor (GHR) binds GH in its extracellular domain (ECD) to activate the GHR-associated cytoplasmic tyrosine kinase, JAK2. IGF-1 binds IGF-1R, a disulfide-linked heterotetramer with tyrosine kinase activity in its intracellular domain (ICD). Classically, IGF-1 is a GH effector in a “linear” GH→GHR→IGF-1→IGF-1R pathway. Our recent studies suggest IGF-1R also subserves GH signaling in several novel ways: 1) GH induces a GHR-JAK2-IGF-1R complex, whose formation is independent of tyrosine phosphorylation of any of the partners; 2) Cotreatment with IGF-1 augments acute GH signaling; 3) deletion of IGF-1R in primary osteoblasts or human prostate cancer cells blunts acute GH signaling. In …
Development And Content Validity Of The Military Concussion Readiness Inventory For Service Members, Michelle L. Gutierrez
Development And Content Validity Of The Military Concussion Readiness Inventory For Service Members, Michelle L. Gutierrez
All ETDs from UAB
The aim of this study was to develop and establish content validity of a new questionnaire entitled the Military Concussion Readiness Inventory (MCRI). The MCRI was designed to identify functional impairments and predict readiness for return-to-duty in service members (SM) who experienced mild traumatic brain injury (mTBI) due to a blast. The items on the MCRI were linked to the The International Classification of Functioning, Disability and Health (ICF) classifications. Nineteen male SM participated in a nominal group technique process to generate items for the MCRI. The items were classified according to the ICF before sending items to the Delphi …
Diagnostic Classifications For Bipedal Locomotion, Lois Deming Hedman
Diagnostic Classifications For Bipedal Locomotion, Lois Deming Hedman
All ETDs from UAB
Background: Analysis of and intervention for movement dysfunction, especially walking dysfunction, is the central expertise of physical therapists (PTs). PTs are called to establish a diagnosis prior to making patient management decisions yet no valid classification system for walking exists. Objectives: The purpose of this study was to determine if locomotor experts could arrive at consensus on the validity, mutual exclusivity and understandability of diagnostic classifications for bipedal locomotion. Methods: An electronic mail Delphi survey methodology was utilized. Experts were recruited purposefully through research and clinical leaders in the PT profession. Identified experts were then asked for their recommendations in …
The Role Of Endoplasmic Reticulum Stress Response In Glioma Cell Death, G Johnson
The Role Of Endoplasmic Reticulum Stress Response In Glioma Cell Death, G Johnson
All ETDs from UAB
Malignant gliomas, including glioblastomas, are the main primary adult brain tumor. Even with current therapies, the median survival time for patients diagnosed with glioblastomas is only about 12 months. Therefore, it is imperative to identify pathways that can induce glioma cell death. This dissertation provides evidence defining how Endoplasmic Reticulum Stress Response (ERSR) induction promotes cell death selectively in malignant glioma cells (MGCs). I present data showing a correlation between ER Ca2+ storage abnormalities, ER ribosome-translocon expression and activity, ERSR intensity and cell death in MGCs. These data show ERSR induction with thapsigargin (THAP) results in a larger loss of …
Application Of The Social Cognitive Theory To A Web-Based Physical Activity Intervention For Overweight African American Female College Students, Rodney Joseph
All ETDs from UAB
Background.African American women report low levels of physical activity and share a disproportionate burden of many health conditions associated with being insufficiently active, indicating the need for innovative approaches to promote physical activity in this population. The purpose of the current study was to evaluate changes in physical activity and associated Social Cognitive Theory constructs of outcome expectations, enjoyment, self-regulation, and social support following the completion of a six month, culturally-adapted, Social Cognitive Theory-based website-delivered weight loss and physical activity intervention for young African-American women. Methods.A secondary data analysis was performed on African-American female college students (N=34) enrolled in a …
Influence Of Surface Treatment Of Y-Tzp And Luting Cements On Retention Of Y-Tzp Crown, Mehdi Karimipour-Saryazdi
Influence Of Surface Treatment Of Y-Tzp And Luting Cements On Retention Of Y-Tzp Crown, Mehdi Karimipour-Saryazdi
All ETDs from UAB
Clinicians for a single tooth restoration, due to improved esthetics, often select all ceramic crowns. Zirconium Oxide has been utilized for many years to full fill the requirement of esthetics, high mechanical properties and biocompatibility. The purpose of this study is to evaluate the effect of different surface treatments and luting agents on retention of a zirconium oxide crown. Material and Methods: Ninety extracted teeth were obtained. Teeth were mounted in Ortho JetTM resin (Lang Dental Manufacturing Co., Inc. IL, USA). Occlusal surface was cut flat using Isomet (Buhler Ltd). Diamond burs were used to cut axial walls under water …
The Effects Of Direct To Consumer Advertising On Healthcare Utilization Among Medicaid Children With Asthma, Luceta C. Mcroy
The Effects Of Direct To Consumer Advertising On Healthcare Utilization Among Medicaid Children With Asthma, Luceta C. Mcroy
All ETDs from UAB
National guidelines recommend treatment of asthma with preventive long term medication, but adherence remains low, resulting in high healthcare utilization among those affected by the chronic disease. The increase in DTCA since the easing of restrictions by the FDA in 1997 has prompted much debate on the effects of the DTCA, with critics arguing that it is harmful while proponents see many benefits such as increased medication adherence. This study examines the impact of DTCA on healthcare utilization and asthma medication use by combining Medicaid administrative data and a national advertising data set on asthma medication from 1999 to 2002. …
The Effect Of A Topical Ocular Preparation On Performance Of Simulated Driving In Cases Of Symptomatic Dry Eye, Chandra Venise Mickles
The Effect Of A Topical Ocular Preparation On Performance Of Simulated Driving In Cases Of Symptomatic Dry Eye, Chandra Venise Mickles
All ETDs from UAB
Dry eye is a common complaint of millions of people worldwide with a significant impact on quality of life. In particular, it could have a significant impact on vision-related activities of daily living such as driving. The purpose of this investigation was to determine if 30 days of active topical dry eye treatment (Systane® Balance, Alcon Laboratories; Ft. Worth, TX) has an impact on the simulated night-time driving performance in mild or moderate dry eye compared to a topical saline (Sensitive Eyes®, Bausch & Lomb; Rochester NY). Dry eye symptoms and signs were also assessed to corroborate our findings. Forty …
Innate Immune Mechanisms Against The Atypical Fungal Pathogen Pneumocystis Murina, Michael Paul Nelson
Innate Immune Mechanisms Against The Atypical Fungal Pathogen Pneumocystis Murina, Michael Paul Nelson
All ETDs from UAB
Pneumonia caused by the fungal pathogen Pneumocystis continues to be the leading cause of morbidity and mortality in AIDS patients. In addition, there are a number of other non-HIV-associated diseases that render an individual susceptible to Pneumocystis infection, including chronic obstructive pulmonary disease. Innate immune mechanisms are important for controlling Pneumocystis lung infection. As alveolar macrophages serve the front lines of lung host defense, our goal was to elucidate their responses during lung Pneumocystis infection. Here, we established a role for Src family kinases in the lung immune response to Pneumocystis, which uncovered a role for alternatively activated alveolar macrophages. …
The Influence Of Growth Factors Applied During Socket Conversion, On The Incidence Of Spontaneous Early Dental Implant Exposure, Michael Anh Minh Nguyen
The Influence Of Growth Factors Applied During Socket Conversion, On The Incidence Of Spontaneous Early Dental Implant Exposure, Michael Anh Minh Nguyen
All ETDs from UAB
Spontaneous early exposure of a dental implant's cover screw can result in a nidus for plaque accumulation, which may result in inflammation, damage to the peri-implant mucosa, and possible peri-implant bone loss. This study aims to investigate the effect of the addition of growth factors, specifically recombinant human platelet-derived growth factor, and platelet-rich plasma, at the time of socket conversion, on the incidence of early implant exposures. This retrospective study utilized data from a study involving a total of 80 implants that were placed in 4 different types of sites (Groups 1,2,3, and 4). Group 1 sites were extraction sites …
Measuring Disease Activity And Use Of Complementary And Alternative Medicine In African-Americans With Rheumatoid Arthritis, Ashutosh Tamhane
Measuring Disease Activity And Use Of Complementary And Alternative Medicine In African-Americans With Rheumatoid Arthritis, Ashutosh Tamhane
All ETDs from UAB
The aims of this project were to: 1) compare disease activity scores 28 joints (DAS28) based on erythrocyte sedimentation rate (ESR) versus that based on C-reactive protein (CRP), and 2) describe prevalence of complementary and alternative medicine (CAM) use and examine differences of CAM use stratified by disease duration and sex. This analysis included participants from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry. Using tender and swollen joint counts separate ESR-based and CRP-based DAS28 scores (DAS28-ESR3 and DAS28-CRP3) were calculated, as were DAS28-ESR4 and DAS28-CRP4, which included the patient¡¯s assessment of disease …
The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor
The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor
All ETDs from UAB
THE IMPACT OF COMMUNITY HEALTH CENTERS ON PROSTATE CANCER SCREENING BEHAVIORS OF AFRICAN AMERICAN MALES: A MIXED METHODS STUDY MICHAEL C. TAYLOR UAB SCHOOL OF PUBLIC HEALTH DEPARTMENT OF HEALTH BEHAVIOR ABSTRACT Federally qualified community health centers have a significant impact upon uninsured and low income populations in the United States by providing low cost primary care and preventive services. The purpose of this mixed methods study was to determine the impact of community health centers (CHCs) on African American males' prostate cancer screening behavior in a major Southern city. A sequential explanatory mixed method model was used to assess …
Three Dimensional Comparison Of Facial Morphology Of A Caucasian American Population And A Native Brazilian Population, William N. Turner
Three Dimensional Comparison Of Facial Morphology Of A Caucasian American Population And A Native Brazilian Population, William N. Turner
All ETDs from UAB
The aim of this study was to assess the use of 3-dimensional facial averages in determining facial morphologic differences in a Caucasian North American population and a native Brazilian population. Methods and Materials: Three-dimensional images were acquired through a commercially available stereo-photogrammetric camera system (The 3dMDfaceTM system). A total of 200 images from two population groups (Caucasian American and Native Brazilian) were taken. Each image was acquired as a facial mesh and orientated along a triangulated axis. All facial images were overlaid and superimposed, using Rapid Form 6 software to create a composite facial average of one man and one …
Adaptation To A Simulated Central Scotoma With Visual Search Tasks, Dave Walsh
Adaptation To A Simulated Central Scotoma With Visual Search Tasks, Dave Walsh
All ETDs from UAB
This study characterized the perceptual and oculomotor adaptation to a simulated central scotoma in normally-sighted subjects and characterized the effects of two different scotoma profiles on the adaptation process. Twelve normally-sighted subjects, 6 for each type of scotoma profile, prac-ticed a search task (finding an "O" target among "C" distracters) for 11 blocks (162 trials per block). Search reaction time (RT) and eye movement data were collected. A head-mounted eye tracker was used to simulate two 10 deg circular central scotomas (CS), one with a sharp change from seeing to unseeing (S-CS) and the other with a gradual transition (G-CS). …
Suppression Of A Nonsense Mutation In A Mouse Model Of Hurler Syndrome, Dan Wang
Suppression Of A Nonsense Mutation In A Mouse Model Of Hurler Syndrome, Dan Wang
All ETDs from UAB
Nonsense suppression therapy utilizes compounds that suppress translation termination at disease-causing premature termination codons (PTCs) to restore full-length, functional protein synthesis. This approach may provide a treatment for many diseases caused by nonsense mutations including Hurler syndrome (mucopolysaccharidosis type I - Hurler, MPS I-H). MPS I-H is a lysosomal storage disease caused by severe &alpha-L-iduronidase deficiency and subsequent lysosomal glycosaminoglycan (GAG) accumulation. In this work, we investigated the effectiveness of nonsense suppression therapy as a treatment for MPS I-H. We first generated a targeted knock-in mouse model that carries the Idua-W392X nonsense mutation homologous to the human IDUA-W402X mutation frequently …
Facilitating The Use Of Implicit Memory And Learning In The Physical Therapy Management Of Individuals With Alzheimer's Disease; A Case Series., Laura White
All ETDs from UAB
Background and Purpose: Physical rehabilitation of individuals with Alzheimer's disease (AD) is often complicated by impairments in explicit memory and learning. Rehabilitation strategies that facilitate use of the preserved implicit memory system may be effective in treating patients with AD. The purpose of this case series is to describe the application of these strategies, including high-repetition practice, errorless learning (EL), and spaced retrieval (SR), to the physical therapy management of individuals with moderate AD. Case Description: Three women aged 89 to 95 years old with moderate AD who resided in an assisted living facility participated in physical therapy to address …
Biochemical And Cellular Mechanisms For The Antineoplastic Properties Of Sulindac, Jason Derek Whitt
Biochemical And Cellular Mechanisms For The Antineoplastic Properties Of Sulindac, Jason Derek Whitt
All ETDs from UAB
ABSTRACT The nonsteroidal anti-inflammatory drug (NSAID) sulindac has displayed the ability to inhibit the proliferation of colorectal cancer (CRC) cells and to increase the sensitivity of multidrug resistant (MDR) cancer cells to a wide variety of chemotherapeutic agents. The antineoplastic activity of sulindac has been attributed to inhibition of the prostaglandin producing enzyme COX-2, but the exact mechanism remains elusive and the inhibition of prostaglandin synthesis can result in gastrointestinal, hepatic, and cardiovascular toxicities. Enzymatic, cellular, and imaging assays were used to identify mechanisms that could contribute to the antiproliferative and apoptotic activity of sulindac. Screening of more than 500 …
Evaluating The Efficacy Of Radiofrequency Amplitude-Modulated Electromagnetic Fields As A Novel Treatment For Hepatocellular Carcinoma, Jacquelyn Winifred Zimmerman
Evaluating The Efficacy Of Radiofrequency Amplitude-Modulated Electromagnetic Fields As A Novel Treatment For Hepatocellular Carcinoma, Jacquelyn Winifred Zimmerman
All ETDs from UAB
Hepatocellular carcinoma (HCC) incidence in the US is dramatically increasing. Five-year survival has remained 3-5% for the past several decades, demonstrating urgent need for additional therapies. Intrabuccal administration of amplitude-modulated radiofrequency electromagnetic fields (RF EMF) is a novel, minimally invasive treatment modality. Clinical evidence demonstrates this treatment approach elicits therapeutic responses in cancer patients. In vitro we have described a phenotype in HCC cells following RF EMF exposure that included proliferative inhibition, modulation of gene expression, and disruption of the mitotic spindle. This phenotype was specific for HCC cells exposed to HCC-specific RF EMF. We have demonstrated similar efficacy in …