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Articles 31 - 60 of 135
Full-Text Articles in Medicine and Health Sciences
Retinoids And Abnormal Alveolar Development, Masheika L. James
Retinoids And Abnormal Alveolar Development, Masheika L. James
All ETDs from UAB
Extremely preterm infants are at high risk for a form of chronic lung disease called bronchopulmonary dysplasia (BPD), which is characterized by impaired alveolar development. Exposure to hyperoxia and deficiency of vitamin A (VA) contribute to the development of BPD in preterm infants. Randomized controlled trials indicate VA supplementation decreases BPD and/or death. However, 25% of preterm infants continue to remain VA deficient despite supplementation, probably due to impairment in VA transport, VA is stored in the liver as retinyl esters which are transported to the lung and irreversibly metabolized into all-trans-retinoic acid (ATRA), the active metabolite. A combination of …
Structural Investigations Of Retinoid X Receptor Transcriptional Activation By Anti-Cancer Rexinoids, Leeann J. Boerma
Structural Investigations Of Retinoid X Receptor Transcriptional Activation By Anti-Cancer Rexinoids, Leeann J. Boerma
All ETDs from UAB
Nuclear receptor (NR) protein retinoid X receptor (RXR) is a ligand-inducible transcription factor that binds retinoids for regulation of target genes. Agonist binding induces a major structural rearrangement in the ligand binding domain (LBD) and formation of the coactivator binding interface. RXR-signaling pathways control proliferation, differentiation, and growth in epithelial tissues. To understand how RXR agonists enhance signaling at the molecular level requires an understanding of how agonists induce structural and dynamical changes in the LBD to recruit coactivators for activation of anti-cancer relevant transcription. While most studies of NR activation center on the position of Helix 12 (H12)/activation function-2 …
Proteomic Clues To The Pathogenesis Of Alexander Disease, Daniel L. Flint
Proteomic Clues To The Pathogenesis Of Alexander Disease, Daniel L. Flint
All ETDs from UAB
Since the initial report identifying mutations in GFAP as the primary genetic defect in the astrogliopathy Alexander Disease (AxD) much progress has been made in elucidating the molecular details underpinning the pathogenic role of mutant GFAP in astrocytes. In particular, data collected from mouse, fly, and cell culture models of AxD have isolated several prominent cellular changes that are associated with mutant GFAP expression including oxidative stress, proteasome inhibition, reduced expression of the astrocyte glutamate transporter GLT-1, and loss of neurons; these models have also successfully recapitulated the pathological hallmark of AxD--protein aggregates known as Rosenthal fibers (RFs). To date, …
Finding A Cure For Venezuelan Equine Encephalitis Virus (Veev) Infection: The Search For The Antiviral Genes And Vaccine Development., Svetlana Atasheva
Finding A Cure For Venezuelan Equine Encephalitis Virus (Veev) Infection: The Search For The Antiviral Genes And Vaccine Development., Svetlana Atasheva
All ETDs from UAB
Venezuelan equine encephalitis virus (VEEV) is a re-emerging virus that causes a severe and often fatal disease in equids and humans. To date, despite a continuous public health threat, no vaccines or antiviral drugs against VEEV infection have been developed for human use. In this study we took advantage of accumulated knowledge of capsid protein function in viral replication, assembly and virus-host interactions. Besides being an integral part of the virion, capsid protein is the major determinant of VEEV pathogenesis. This protein is cytotoxic and induces cellular transcriptional shutoff as a countermeasure to the cellular antiviral response. We introduced targeted …
Regulation Of Membrane Traffic By The Big2 Member Of Guanine Nucleotide Exchange Factors, Jason Lowery
Regulation Of Membrane Traffic By The Big2 Member Of Guanine Nucleotide Exchange Factors, Jason Lowery
All ETDs from UAB
Vesicular transport is an essential cellular process that facilitates the movement of molecules within a cell. The importance of vesicular transport is highlighted by numerous human diseases that result from mutations affecting protein trafficking. The Brefeldin A-inhibited guanine nucleotide exchange factor 2 (BIG2) has emerged as a key regulator of protein trafficking within the late secretory pathway, between the trans-Golgi Network (TGN) and endosomal compartments and within the recycling endosomal pathway. Mutations in BIG2 lead to Autosomal Recessive Periventricular Heterotopia with Microcephly (ARPHM), a disorder characterized by severe brain malformations. BIG2 stimulates nucleotide exchange of GDP for GTP on ADP-ribosylation …
Real-Time Quantitative Pcr For Evaluation Of Mutans Streptococci And Dental Caries, Chanika Manmontri
Real-Time Quantitative Pcr For Evaluation Of Mutans Streptococci And Dental Caries, Chanika Manmontri
All ETDs from UAB
Mutans streptococci (MS), e.g., Streptococcus mutans (Sm) and Streptococcus sobrinus (Ss), are associated with dental caries. Quantification of MS has been shown to predict caries risk. A new technology using PCR may streamline quantification compared to traditional culture methods. Purpose: To use real-time quantitative PCR (qPCR) and standard plate counting (SPC) for detection and quantification of levels of Sm, Ss and total streptococci (TS) in clinical samples from high-caries-risk children with no regular access to dental care and to study correlation of these bacterial levels and ratios to caries prevalence. Methods: Saliva and plaque samples were collected from school-aged children …
An Investigation Of The Effect Of Misspecifying The Random Effect Distribution And The Incorrect Assumption Of Equal Intraclass Correlation Coefficients Among Treatment Groups In The Analyses Of Data From Cluster Randomized Trials, Omar B. Mbowe
All ETDs from UAB
Generalized linear mixed models (GLMM) are among the commonly used statistical methods for the analyses of binary data from cluster randomized trials (CRT). GLMMs extend the linear mixed models to accommodate, among others, binary outcomes. The linear predictor of GLMMs contains fixed effects and random effects to model the correlation among responses in a cluster. These random effects are usually assumed to be normally distributed but this assumption may not hold in practice. Also, the cluster sizes may vary within a trial for several reasons including loss to follow-up. This variation in cluster sizes can result in unequal cluster sizes. …
Molar Distalization To Resolve Class Ii Malocclusion: A Cephalometric Study Utilizing The Carriere Distalizer, Careybeth Hayes Rivers
Molar Distalization To Resolve Class Ii Malocclusion: A Cephalometric Study Utilizing The Carriere Distalizer, Careybeth Hayes Rivers
All ETDs from UAB
Objective: The purpose of this study is to determine the short-term skeletal and dental effects that occur as a result of Class II malocclusion correction utilizing the Carrière Distalizer as compared to best-matched controls. Methods: This is a retrospective cohort cephalometric study using lateral cephalometric films of 25 (14 male, 11 female, average age 13y 6m) class II patients consecutively treated with the Carrière Distalizer compared with 36 (19 male, 17 female, 13y 2m) untreated class II control subjects from a historical database best-matched based upon age, sex and skeletal classifications. Pretreatment and posttreatment lateral head films were analyzed with …
Mitochondrial Morphology And Function In Neuronal Cells Under Stress, Lonnie Schneider
Mitochondrial Morphology And Function In Neuronal Cells Under Stress, Lonnie Schneider
All ETDs from UAB
Neurodegenerative disease encompasses a wide range of conditions and pathologies that can manifest at any age depending on the etiology. A major factor in both early onset and age-related neurodegeneration is mitochondrial dysfunction. To investigate how mitochondrial bioenergetics is affected by cellular stress, we used an in vitro culture system to examine mitochondrial function in response to oxidative stress. We also studied an in vivo model of neuronal ceroid lipofuscinosis to determine the impact of deficient autophagy-lysosomal activity on mitochondrial morphology, composition and function. In vitro we found that retinoic acid-induced differentiation of dopaminergic neuroblastoma SH-SY5Y cells exhibited increased mitochondrial …
A Histologic And Radiologic Analysis Of Bone Formation Under The Elevated Maxillary Sinus Using Venous Coagulum As The Sole Filling Material, Kathleen Ann Beaudry
A Histologic And Radiologic Analysis Of Bone Formation Under The Elevated Maxillary Sinus Using Venous Coagulum As The Sole Filling Material, Kathleen Ann Beaudry
All ETDs from UAB
Insufficient bone height is a common obstacle to placing dental implants in the posterior maxilla. Sinus lift procedures using various grafting materials have been shown to be a highly predictable way to increase bone height in the posterior maxilla (Jensen 1998). Given the wide range of materials that have proven successful in augmenting the sinus, the argument could be made that the presence of graft is not critical. Instead, the creation and maintenance of space, provided by two implants, along with the osteoinductive properties of the membrane, the periosteum, and growth factors provided by a blood clot are the only …
The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand
The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand
All ETDs from UAB
Environmental ozone exposure remains a major public health concern with over one-third of the United States population experiencing unhealthful levels. Epidemiological studies indicate exposure increases morbidity in those with pre-existing disease such as asthma, though the biological mechanisms underlying this phenomenon remain elusive. CD11c+ cells within the respiratory tract include dendritic cells (DCs), which are the most efficient antigen presenters and play major roles controlling immune responses. In addition, DCs are thought necessary for asthma pathogenesis and exacerbation. Therefore the link between ozone associated asthma morbidity may be DCs. We hypothesize ozone exposure may site specifically alter DC phenotypes, numbers, …
Sleep Duration And Obesity: Longitudinal Study Of Adolescents, Herpreet Kaur Thind
Sleep Duration And Obesity: Longitudinal Study Of Adolescents, Herpreet Kaur Thind
All ETDs from UAB
Prevalence of obesity continues to be high in the United States with about one-third adults being overweight or obese. Among adolescents the rates of overweight/obesity have increased by three times in the past two decades. Moreover, the rates of obesity are disproportionately high among the minority population. Recently, sleep duration has emerged as an independent risk factor for obesity. Several cross-sectional and longitudinal studies worldwide have shown an inverse relationship between sleep duration and obesity. However, some studies do not support this association. Majority of the studies in the United States have been conducted on predominantly White populations. African Americans …
Glutamate Release And Uptake At Cerebellar Synapses, Ming-Chi Tsai
Glutamate Release And Uptake At Cerebellar Synapses, Ming-Chi Tsai
All ETDs from UAB
Glutamate mediates excitatory synaptic transmission in the central nervous system (CNS). Regulation of glutamate release and uptake shapes the spatiotemporal dynamics of glutamate at and around synapses to influence information transfer between neural cells. This dissertation focuses on the modulation of glutamate release and uptake at excitatory synapses of cerebellar Purkinje cells (PC). In the first project we show that differential expression of PC glutamate transporters controls the amount of glutamate entering the extrasynaptic space, thereby influencing the excitatory responses in surrounding Bergmann glia. This work provides the first evidence that neuronal glutamate uptake affects glial glutamatergic signaling. In the …
The Effect Of Environmental Ozone Exposure On The Postnatal Lung, Katherine Leah Tuggle Stringer
The Effect Of Environmental Ozone Exposure On The Postnatal Lung, Katherine Leah Tuggle Stringer
All ETDs from UAB
In the U.S., approximately 37 million children reside in geographic locales that experience unhealthy ozone levels. This population is of great concern as they are undergoing active lung growth and cellular differentiation which may alter their susceptibility to inhaled toxicants. Epidemiological and animal studies indicate that early life ozone exposure results in altered lung development, potentially facilitating predisposition to chronic pulmonary conditions in adulthood. The goal of this dissertation was to evaluate short and long-term effects of ozone exposure in the developing lung. The first study evaluated acute effects of ozone exposure in the postnatal and adult lung. The results …
Three Dimensional Comparison Of Facial Morphology Of A Caucasian American Population And A Native Brazilian Population, William N. Turner
Three Dimensional Comparison Of Facial Morphology Of A Caucasian American Population And A Native Brazilian Population, William N. Turner
All ETDs from UAB
The aim of this study was to assess the use of 3-dimensional facial averages in determining facial morphologic differences in a Caucasian North American population and a native Brazilian population. Methods and Materials: Three-dimensional images were acquired through a commercially available stereo-photogrammetric camera system (The 3dMDfaceTM system). A total of 200 images from two population groups (Caucasian American and Native Brazilian) were taken. Each image was acquired as a facial mesh and orientated along a triangulated axis. All facial images were overlaid and superimposed, using Rapid Form 6 software to create a composite facial average of one man and one …
Modulation Of Alpha-Synuclein Metabolism And Toxicity By Cathepsin D, Donna Marlana Crabtree
Modulation Of Alpha-Synuclein Metabolism And Toxicity By Cathepsin D, Donna Marlana Crabtree
All ETDs from UAB
Parkinson's disease (PD) is the most commonly occurring neurodegenerative movement disorder, and aberrant accumulation of the protein α-synuclein is thought to be a major contributing factor in disease development. Dysfunction of the autophagy lysosome pathway (ALP) has been implicated in PD pathogenesis. Our lab and others have shown that the lysosomal enzyme cathepsin D (CD) is an important regulator of α-synuclein degradation. The primary focus of this thesis is probing the structure/function dynamic that exists between α-synuclein and CD. We have found that lentiviral-mediated over expression of wild type CD (wtCD) leads to subtle alterations in the ALP in a …
Are Enabling Services In Federally Qualified Health Centers Associated With Women Receiving Prenatal Care In The First Trimester?, Forrest A. Daniels
Are Enabling Services In Federally Qualified Health Centers Associated With Women Receiving Prenatal Care In The First Trimester?, Forrest A. Daniels
All ETDs from UAB
The purpose of this study was to examine whether enabling services in federally qualified health centers (FQHCs) were associated with women receiving prenatal care services in the first trimester. The population for this study included FQHCs providing prenatal care services for the years 2008, 2009, and 2010. Data for this study were derived from two sources: Uniform Data System (UDS) and the Area Resource File (ARF). This study adopted the Andersen's (1973) Behavioral Model of Health Services Use. The study consisted of longitudinal panel data analysis. Univariate and bivariate statistics were calculated using PASW/SPSS statistical software, version 18. For the …
Regulation Of Cell Death By Autophagy In Glial Neoplasms, Latika R. Kohli
Regulation Of Cell Death By Autophagy In Glial Neoplasms, Latika R. Kohli
All ETDs from UAB
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive malignancies of the peripheral nervous system. The majority of MPNSTs arise in patients of the autosomal dominant genetic disorder neurofibromatosis type I (NF1) although they also arise sporadically. In the absence of any effective chemotherapeutic options and with surgery constituting the mainstay of treatment, MPNST patients face an extremely poor prognosis. This underscores the need to develop novel therapeutic strategies against this tumor type. It is well accepted that the crosstalk between autophagy and apoptosis can be exploited to derive maximal therapeutic benefit, especially through combinatorial therapies. However, this interaction is extremely …
Stress And Job Performance: The Roles Of Salivary Cortisol And Social Support, Tracy Shamburger
Stress And Job Performance: The Roles Of Salivary Cortisol And Social Support, Tracy Shamburger
All ETDs from UAB
Perceived stress may negatively affect job performance. Perceived stress is known to alter physiological responses, including cortisol response. Cortisol affects working memory and may explain how stress affects performance. Aeromedical crewmembers transport wounded soldiers in the austere aeromedical environment. The demands of the Aeromedical Evacuation (AE) may lead to stress and impact job performance. The AE training mission simulates real world operational missions and this setting was used to examine the effects of perceived stress on job performance among aeromedical crewmembers at different time points during the mission (Time 1- baseline, Time 2 - pre-flight, Time 3 - in-flight, Time …
High-Risk Human Papillomavirus And Cervical Intraepithelial Neoplasia Among Foreign-Born Latinas At Colposcopy, Bertha Hidalgo
High-Risk Human Papillomavirus And Cervical Intraepithelial Neoplasia Among Foreign-Born Latinas At Colposcopy, Bertha Hidalgo
All ETDs from UAB
Although the literature is quite extensive with regard to the human papillomavirus (HPV) among many racial/ethnic populations, there continues to be a paucity of information regarding the prevalence of HPV types as well as of cervical intraepithelial neoplasia (CIN among Latinas, specifically foreign-born Latinas. Some studies have reported prevalence of HPV among Latinas, but very few have differentiated between US- and foreign-born Latinas. This nuance is essential to understanding the true effect contributed by each group to HPV and CIN incidence and prevalence rates. Therefore, this dissertation aimed to assess differences in the prevalence of high- and low-risk types and …
Diagnostic Classifications For Bipedal Locomotion, Lois Deming Hedman
Diagnostic Classifications For Bipedal Locomotion, Lois Deming Hedman
All ETDs from UAB
Background: Analysis of and intervention for movement dysfunction, especially walking dysfunction, is the central expertise of physical therapists (PTs). PTs are called to establish a diagnosis prior to making patient management decisions yet no valid classification system for walking exists. Objectives: The purpose of this study was to determine if locomotor experts could arrive at consensus on the validity, mutual exclusivity and understandability of diagnostic classifications for bipedal locomotion. Methods: An electronic mail Delphi survey methodology was utilized. Experts were recruited purposefully through research and clinical leaders in the PT profession. Identified experts were then asked for their recommendations in …
Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore
Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore
All ETDs from UAB
Objectives: The purpose of this study was to expand upon what has been observed in literature about obesity and its ties to socioeconomic status (SES) among African American Women (AAW) participants of the Jackson Heart Study (JHS). Methods: This secondary analysis was a sub-study of the JHS and focused on four SES variables: education, income, occupation and wealth; and five outcome variables: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Two analytic samples were created in order to examine data collected during Exam 1 (2000-2004) and Exam 2 (2005-2008). …
Factors Associated With Participant Retention In A Behavioral Weight Loss Study, Cathy C. Roche
Factors Associated With Participant Retention In A Behavioral Weight Loss Study, Cathy C. Roche
All ETDs from UAB
Participant retention in longitudinal research is gaining increasing attention. By identifying factors associated with participant retention, programs can be better designed to promote effective weight loss. This study examines factors associated with participant retention. The Anderson Behavioral Model provided the conceptual framework for the study. The sample consisted of secondary data abstracted from the research records of 316 participants in the University of Alabama at Birmingham cohort of the Look Action for Health in Diabetes (AHEAD) trial. The Look AHEAD trial is a randomized controlled trial designed to investigate the long-term effects of interventions aimed at producing weight loss in …
An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee
An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee
All ETDs from UAB
Pre-diabetes is a major contributor to increased morbidity and mortality in the US. Without proper and timely intervention the majority of individuals with pre-diabetes will develop Type 2 diabetes. African Americans (AA) and people living in the Stroke Belt have increased odds of developing pre-diabetes compared to Whites and people living outside the Stroke Belt. While several covariates have been identified as contributors to the increased odds of pre-diabetes there is little consensus on which covariates may be responsible for the disparities of pre-diabetes. The reasons for disparities in pre-diabetes are complex and require further investigation. This study explored the …
The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein
The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein
All ETDs from UAB
In recent years, hydrogen sulfide (H2S) has been identified as a ubiquitous cell signaling molecule. In addition to its diverse physiological roles, H2S has emerged as a possible drug therapy, with a wide range of applications. Along with cytoprotective effects in pathological states such as ischemia-reperfusion injury, H2S has been shown to decrease aerobic metabolism in a reversible manner. This dissertation is focused on exploring H2S-induced hypometabolism and the implications therein for human health and disease. We have shown that rats exposed to 80 ppm H2S gas in combination with low oxygen (10.5% O2) for 6 hr exhibit decreases in …
Apolipoprotein E Mimetic Peptide Improves Hdl Functionality And Inhibits Atherosclerosis Progression In Mouse Models Of Atherosclerosis, Gaurav Nayyar
Apolipoprotein E Mimetic Peptide Improves Hdl Functionality And Inhibits Atherosclerosis Progression In Mouse Models Of Atherosclerosis, Gaurav Nayyar
All ETDs from UAB
Despite major advances in diagnosis and treatment, coronary artery disease (CAD) is still the number one cause of morbidity and mortality in United States. An ideal treatment for lipid-mediated inflammatory disorders would not only reduce plasma cholesterol dramatically but also improve high density lipoproteins (HDL) function. Apolipoprotein E (apo E), a protein component of HDL and very low density lipoprotein (VLDL), is necessary for the receptor mediated hepatic uptake of apolipoprotein-B (apo B) containing remnant lipoproteins and also possesses strong anti-inflammatory properties. We hypothesized that a synthetic dual domain apo E mimetic peptide, Ac-hE18A-NH2 (a 28-residue peptide) containing receptor binding …
Neuropharmacology Of The Α2a Adrenergic Receptor In Disorders Of Mood And Cognition, Christopher Cottingham
Neuropharmacology Of The Α2a Adrenergic Receptor In Disorders Of Mood And Cognition, Christopher Cottingham
All ETDs from UAB
Depressive disorders carry relatively high lifetime risks of greater than 10%, and the antidepressant drugs used in the pharmacotherapy of these mood/cognitive disorders are among the most-prescribed pharmacological agents. However, a detailed understanding of both depressive etiology and the pharmacological mechanisms of action for antidepressant drugs remain elusive. The overall goal of this dissertation research is to provide novel in-sights through a detailed study of the neuropharmacology of the α2A adrenergic receptor (AR). α2ARs, as key regulators of noradrenergic neurotransmission, have been broadly understood to have some ill-defined role in both the neurobiology and neuropharmacology of depressive disorders. The studies …
Three-Dimensional Magnetic Resonance Imaging Of The Natural Dentition, Ryan Jeffery Cox
Three-Dimensional Magnetic Resonance Imaging Of The Natural Dentition, Ryan Jeffery Cox
All ETDs from UAB
The purpose of this study was to determine if ultra short echo time magnetic resonance imaging (UTE-MRI) technology could be used to image teeth in orthodontics. The objectives of this study were to determine the accuracy and resolution of UTE-MRI on dental morphology and its application to the field of orthodontics with respect to appliance affect on morphology. Teeth were collected from the Orthodontic clinic at the University of Alabama at Birmingham and the Institutional Review Board of the University of Alabama at Birmingham approved the study. High-resolution 3-Tesla UTE-MRI was preformed on sixty extracted human premolar teeth with fixed …
Social Connectedness And Its Association With Violence Commission In Adolescents Living In Low-Income Inner-City Neighborhoods, Thomas Norton Creger
Social Connectedness And Its Association With Violence Commission In Adolescents Living In Low-Income Inner-City Neighborhoods, Thomas Norton Creger
All ETDs from UAB
ABSTRACT For nearly two decades, violence has been viewed as a major public health issue. According to the Centers for Disease Control and Prevention, 4,141 young people between the ages of 10 and 19 were murdered in 2008, and over 480,238 young people were treated for violence-related injuries in U.S. emergency rooms that same year. That translates to an average of 11 young people murdered each day, and a daily average of 1,315 young people who sustained violence-related injuries so severe that they required treatment at a hospital. The purpose of this study was to test a multilevel model linking …
Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn
Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn
All ETDs from UAB
Bacteriophage can mediate the transfer of unrelated mobile genetic elements (MGE) from a carrier bacterial cell to the susceptible population around it. This transfer results in the spread of virulence or other accessory genes encoded on the MGE. During viral particle assembly, the MGE can discourage the formation of viable bacteriophage progeny by limiting the size of the particles to those large enough to encapsidate the MGE, but too small to fit the complete bacteriophage genome which is three times larger. Here, I present models for size determination by an external scaffolding protein which is independent of and dominant over …