Medicine and Health Sciences Commons^™

Understanding The Role Of Epstein - Barr Virus Encoded Rnas (Ebers) In Ebv Biology, Waqar Ahmed

Medical Education Dissertations

Epstein Barr virus (EBV) is an oncogenic herpesvirus aetiologically linked to several human malignancies of epithelial and lymphoid origins. An accumulating body of data indicates that EBV-infected cells release specific viral components in nano-vesicles called exosomes. Epstein-Barr virus encoded RNAs (EBER1 and EBER2) are two highly abundant, non-protein coding RNAs that are consistently expressed in all EBV latency programs. Conventional in situ hybridization (ISH) studies have indicated that these RNAs are typically found in the nucleus of EBV-infected cells. Recently, it was reported that EBERs are released out of the infected cells. However, the mechanism by which these highly abundant …

The Role Of Human Α7-Nicotinic Acetylcholine Receptors In Mediating Neuroprotective Action Of Curcumin, Eslam Mohammed Gaber Elnebrisi

Medical Education Dissertations

Curcumin is a polyphenolic compound isolated from the rhizomes of Curcuma longa. Curcumin has been demonstrated to have antioxidant, anti-inflammatory, and anticancer properties. Moreover, it has been shown to exhibit beneficial effects in the treatment of several neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases. However, the molecular and cellular targets mediating the pharmacological actions of curcumin remain largely unknown. In this study, the effects of curcumin application on the functional properties of the nicotinic acetylcholine receptor, a prototype for ligand-gated ion channels were investigated. Using the two-electrode voltage clamp technique, the results showed that curcumin co-application caused a significant potentiation …

Prevalence Of And Factors Associated With Overweight, Obesity And Metabolic Syndrome Among School Children And Adolescents In Ras Alkhaimah, United Arab Emirates – 2016-2017, Mouza Mohammed Yahed Al Zaabi

Medical Education Dissertations

Introduction: The prevalence of childhood obesity is reported to be increasing rapidly in the United Arab Emirates (UAE). Excess adiposity is a key independent risk factor for the future development of cardiometabolic disorders such as metabolic syndrome. Population-based studies using representative samples are required to provide accurate and valid estimates of obesity and metabolic syndrome. Currently, there is a dearth of pediatric obesity research conducted in the emirate of Ras Al Khaimah.

Aims: The aim of this study was to estimate the prevalence and factors associated with obesity and metabolic syndrome among school children in Ras Al Khaimah, UAE.

Method: …

Emergence Of Carbapenem Resistant Enterobacteriaceae In Abu Dhabi, 2009-2015, Aqdas Bilal Butt

Theses

The rapid emergence of carbapenem resistant Enterobacteriaceae (CRE) is a global phenomenon that has not spared the United Arab Emirates. However, unlike in most Western countries with similarly developed health care system, very little data have been available locally on the rate and dynamics of antimicrobial resistance in general, and that of CRE, in particular. Our laboratory has been collecting CRE isolates from Abu Dhabi hospitals since 2009. In the current study we subjected 394 such independent strains, representing 34.0% of the total CRE encountered, to a detailed analysis that included the determination of their antibiotic susceptibility profile, of the …

Health Supplement Use And Related Adverse Events In Dubai, United Arab Emirates: A Cross-Study, Naseem Mohammed Rafee Abdulla

Philosophy Dissertations

Health supplement products contain ingredients of more than a thousand chemicals. Several of these chemicals may adversely affect human health. Previous studies have found that consumers are generally unaware of the risks of health supplements and their associated adverse events. In addition, they are unaware of the appropriate reporting process to relevant authorities should adverse events occur. Moreover, many healthcare professionals have inadequate knowledge, attitude, and practice in health supplement consumption-related adverse events and their reporting. The purpose of this research was to measure the health supplement consumption in the population of Dubai, the adverse events thereof, and the level …

The Effect Of Β-Caryophyllene On Doxorubicin-Induced Cardiotoxicity, Hasan Al-Taee

Theses

Doxorubicin is an effective and widely used chemotherapeutic drug. However, its clinical use is limited due to cardiotoxicity which it causes that appears in the form of dilated cardiomyopathy. Many efforts have been devoted to developing/discovering agents which can counter DOX-induced cardiotoxicity. The present study was undertaken to evaluate the cardioprotective potential of β Caryophyllene (BCP), a dietary phytocannabinoid, in a rat model of DOX-induced acute and chronic cardiotoxicity. BCP is widely found in various herbs and spices and is a full agonist of the cannabinoid receptor type 2 (CB₂) and exhibits potent anti-inflammatory effects. In the present …

Biochemical And Biological Effects Of Irisin In A Model Of Diabetes Mellitus, Mohamed Omer Sirelkhatim Mahgoub

Dissertations

Diabetes mellitus (DM) is a highly prevalent health problem affecting more than 425 million people worldwide. It is associated with several detrimental complications such as neuropathy, nephropathy, retinopathy and cardiovascular diseases. Irisin is a novel hormone that plays a role in metabolism by stimulating the browning of white adipose tissue (WAT) into beige adipose tissue which acquires properties that are similar to those of brown adipose tissue (BAT). Several studies have attempted to characterize the roles of irisin in DM and obesity, however, contradictory results have been reported and physiological roles of irisin have been questioned by several researchers. In …

Role Of The Snf2 Homolog, Irc20, In Yeast Genome Maintenance, Deena Mohamed Galal Eldin Ahmed

Theses

In eukaryotes, DNA is wrapped around histone proteins forming a highly compact structure, the chromatin. All DNA-based processes must occur within the complex organization of the chromatin, and this requires modulation of its structure when needed. This is accomplished by covalent histone modifications that alter histone-DNA contacts, as well as through the actions of ATP-dependent chromatin remodelers. These multi-subunit complexes play major roles in transcription regulation, replication and repairing DNA damage. This thesis aims to characterize a poorly studied member of the SWI/SNF family of ATPases/helicases, Irc20, from Saccharomyces cerevisiae. Previously, Irc20 has been shown to be involved in …

Genomic And Cellular Studies Establish The Pathogenesis And Cellular Mechanisms Of Disease-Causing Mutations In Families With Autosomal Recessive Disorders, Nesreen Khalid Ahmad Al Jezawi

Dissertations

The majority of the reported genetic disorders in the UAE population are of the autosomal recessive type, which is mainly due to high rates of consanguinity within the UAE national population, and within a significant proportion of other UAE expatriate communities; such as Arabs and Pakistanis. It is estimated that more than 50% of all marriages among Emiratis occur between biologically related couples, with first cousin marriages being the highest. That could be attributed to sociocultural values in the region. Successful management of genetic diseases can be achieved by the implementation of effective preventative programs that could help reduce the …

Prevalence, Characteristics And Correlates Of Prediabetes In Al Ain And Dubai, The Uae: Cross Sectional Study, Layla Mohamed Hassan Ali Al Marzooqi

Health and Physical Education Dissertations

The United Arab Emirates (UAE) has one of the highest rates of type 2 diabetes mellitus in the world. Prior to the onset of type 2 diabetes mellitus, a period of moderate hyperglycemia is often present, referred to as prediabetes. This is associated with a significant loss of pancreatic beta cells, an increased risk of cardiovascular disease and other serious health issues. There are gaps in the literature concerning the prevalence of prediabetes and its associated correlates, as well as correlations between the conversion rates from prediabetes to type 2 diabetes mellitus. The primary objective of this study was to …