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- Adenosine; Anxiety; Autism; ATP; Ketogenic diet; Metabolism (1)
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Articles 1 - 13 of 13
Full-Text Articles in Medicine and Health Sciences
A Person-Centered Approach To Understanding Negative Reinforcement Drinking Among First Year College Students [Post-Print], Laura Holt, Stephen Armeli, Howard Tennen, Carol S. Austad, Sarah Raskin, Carolyn Fallahi, Rebecca Wood, Rivkah I. Rosen, Meredith Ginley, Godfrey D. Pearlson
A Person-Centered Approach To Understanding Negative Reinforcement Drinking Among First Year College Students [Post-Print], Laura Holt, Stephen Armeli, Howard Tennen, Carol S. Austad, Sarah Raskin, Carolyn Fallahi, Rebecca Wood, Rivkah I. Rosen, Meredith Ginley, Godfrey D. Pearlson
Faculty Scholarship
The current study used a person-centered approach (i.e. latent profile analysis) to identify distinct types of college student drinkers based on the predictions of motivational, social learning, and stress and coping theories of maladaptive drinking. A large sample (N = 844; 53% female) of first-year undergraduates from two institutions, public and private, who reported consuming one or more drinks in the last three months completed measures of depressive and anxiety symptoms, positive alcohol-outcome expectancies, negative life events, social support, drinking motives, drinking level and drinking-related problems. Latent profile analysis revealed a small subgroup of individuals (n = 81, …
Active Prospective Control Is Required For Effective Sensorimotor Learning, Winona Snapp-Childs, Elizabeth Casserly, Mark Mon-Williams, Geoffrey Bingham
Active Prospective Control Is Required For Effective Sensorimotor Learning, Winona Snapp-Childs, Elizabeth Casserly, Mark Mon-Williams, Geoffrey Bingham
Faculty Scholarship
Passive modeling of movements is often used in movement therapy to overcome disabilities caused by stroke or other disorders (e.g. Developmental Coordination Disorder or Cerebral Palsy). Either a therapist or, recently, a specially designed robot moves or guides the limb passively through the movement to be trained. In contrast, action theory has long suggested that effective skill acquisition requires movements to be actively generated. Is this true? In view of the former, we explicitly tested the latter. Previously, a method was developed that allows children with Developmental Coordination Disorder to produce effective movements actively, so as to improve manual performance …
The Isolation And Morphology Of Imp48, Maura Griffith
The Isolation And Morphology Of Imp48, Maura Griffith
The First-Year Papers (2010 - present)
No abstract provided.
Ketogenic Diets And Pain [Post-Print], Susan A. Masino, David N. Ruskin
Ketogenic Diets And Pain [Post-Print], Susan A. Masino, David N. Ruskin
Faculty Scholarship
Ketogenic diets are well established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain.
2013 Summer Research Symposium Abstract Book, Trinity College
2013 Summer Research Symposium Abstract Book, Trinity College
Science Symposia Abstracts
2013 Summer volume of abstracts for science research projects conducted by students at Trinity College.
Homeostatic Control Of Brain Function – New Approaches To Understand Epileptogenesis, Detlev Boison, Ursula S. Sandau, David N. Ruskin, Masahito Kawamura Jr., Susan A. Masino
Homeostatic Control Of Brain Function – New Approaches To Understand Epileptogenesis, Detlev Boison, Ursula S. Sandau, David N. Ruskin, Masahito Kawamura Jr., Susan A. Masino
Faculty Scholarship
Neuronal excitability of the brain and ongoing homeostasis depend not only on intrinsic neuronal properties, but also on external environmental factors; together these determine the functionality of neuronal networks. Homeostatic factors become critically important during epileptogenesis, a process that involves complex disruption of self-regulatory mechanisms. Here we focus on the bioenergetic homeostatic network regulator adenosine, a purine nucleoside whose availability is largely regulated by astrocytes. Endogenous adenosine modulates complex network function through multiple mechanisms including adenosine receptor-mediated pathways, mitochondrial bioenergetics, and adenosine receptor-independent changes to the epigenome. Accumulating evidence from our laboratories shows that disruption of adenosine homeostasis plays a …
Ketogenic Diet Improves Core Symptoms Of Autism In Btbr Mice, David N. Ruskin, Julia Svedova, Jessica Cote, Ursula Sandau, Jong M. Rho, Masahito Kawamura Jr., Detlev Boison, Susan A. Masino
Ketogenic Diet Improves Core Symptoms Of Autism In Btbr Mice, David N. Ruskin, Julia Svedova, Jessica Cote, Ursula Sandau, Jong M. Rho, Masahito Kawamura Jr., Detlev Boison, Susan A. Masino
Faculty Scholarship
Autism spectrum disorders share three core symptoms: impaired sociability, repetitive behaviors and communication deficits. Incidence is rising, and current treatments are inadequate. Seizures are a common comorbidity, and since the 1920’s a high-fat, low-carbohydrate ketogenic diet has been used to treat epilepsy. Evidence suggests the ketogenic diet and analogous metabolic approaches may benefit diverse neurological disorders. Here we show that a ketogenic diet improves autistic behaviors in the BTBR mouse. Juvenile BTBR mice were fed standard or ketogenic diet for three weeks and tested for sociability, self-directed repetitive behavior, and communication. In separate experiments, spontaneous intrahippocampal EEGs and tests of …
Adenosine And Autism: A Spectrum Of Opportunities [Post-Print], Susan A. Masino, Masahito Kawamura Jr., Jessica Cote, Rebecca Williams, David N. Ruskin
Adenosine And Autism: A Spectrum Of Opportunities [Post-Print], Susan A. Masino, Masahito Kawamura Jr., Jessica Cote, Rebecca Williams, David N. Ruskin
Faculty Scholarship
In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine's influence might be a new therapeutic target for autism with multiple beneficial effects.
Ketogenic Diets And Thermal Pain: Dissociation Of Hypoalgesia, Elevated Ketones, And Lowered Glucose In Rats [Post-Print], David N. Ruskin, Tracy A.C.S. Suter, Jessica Ross, Susan A. Masino
Ketogenic Diets And Thermal Pain: Dissociation Of Hypoalgesia, Elevated Ketones, And Lowered Glucose In Rats [Post-Print], David N. Ruskin, Tracy A.C.S. Suter, Jessica Ross, Susan A. Masino
Faculty Scholarship
Ketogenic diets (KDs) are high-fat, low-carbohydrate formulations effective in treating medically refractory epilepsy, and recently we demonstrated lowered sensitivity to thermal pain in rats fed a KD for 3 to 4 weeks. Regarding anticonvulsant and hypoalgesic mechanisms, theories are divided as to direct effects of increased ketones and/or decreased glucose, metabolic hallmarks of these diets. To address this point, we characterized the time course of KD-induced thermal hypoalgesia, ketosis, and lowered glucose in young male rats fed ad libitum on normal chow or KDs. A strict 6.6:1 (fat:[carbohydrates + protein], by weight) KD increased blood ketones and reduced blood glucose …
2013 Annual Research Symposium Abstract Book, Trinity College
2013 Annual Research Symposium Abstract Book, Trinity College
Science Symposia Abstracts
2013 annual volume of abstracts for science research projects conducted by students at Trinity College.
Prospective Memory In Schizophrenia: Relationship To Medication Management Skills, Neurocognition And Symptoms In Individuals With Schizophrenia [Pre-Print], Sarah Raskin, Jacqueline Maye, Alexandra Rogers, David Correll, Marta Zamroziewicz, Matthew Kurtz
Prospective Memory In Schizophrenia: Relationship To Medication Management Skills, Neurocognition And Symptoms In Individuals With Schizophrenia [Pre-Print], Sarah Raskin, Jacqueline Maye, Alexandra Rogers, David Correll, Marta Zamroziewicz, Matthew Kurtz
Faculty Scholarship
Objective: Impaired adherence to medication regimens is a serious concern for individuals with schizophrenia
linked to relapse and poorer outcomes. One possible reason for poor adherence to medication is
poor ability to remember future intentions, labeled prospective memory skills. It has been demonstrated
in several studies that individuals with schizophrenia have impairments in prospective memory that are
linked to everyday life skills. However, there have been no studies, to our knowledge, examining the
relationship of a clinical measure of prospective memory to medication management skills, a key element
of successful adherence. Methods: In this Study 41 individuals with schizophrenia and …
Terrifying Our Soldiers: Stimulant- Induced Ptsd In The Armed Forces, David Correll
Terrifying Our Soldiers: Stimulant- Induced Ptsd In The Armed Forces, David Correll
The Trinity Papers (2011 - present)
No abstract provided.
Using Neurotechnologies To Develop Virtues: A Buddhist Approach To Cognitive Enhancement [Pre-Print], James J. Hughes
Using Neurotechnologies To Develop Virtues: A Buddhist Approach To Cognitive Enhancement [Pre-Print], James J. Hughes
Faculty Scholarship
Recently, Fenton (2009) has argued that Buddhist ethics can accommodate the use of attention-enhancing drugs, and Walker (2006 , 2009) has argued that future neurotechnologies may be used to enhance happiness and virtue. This paper uses a Western Buddhist perspective, drawing on many Buddhist traditions, to explore how emerging neurotechnologies may be used to suppress vices and enhance happiness and virtue. A Buddhist approach to the authenticity of technologically-mediated spiritual progress is discussed. The potential utility and dangers of mood manipulation for a Buddhist understanding of liberation are outlined. Then the ten paramitas of Theravadan Buddhism are explored to frame …