Medicine and Health Sciences Commons^™

Tetramethylenedisulfotetramine Neurotoxicity: In Vivo Validation Of In Vitro Screen To Identify Potential Countermeasures, Marcela Laukova, Sundas Pervez, Fatim Sannoh, Jana Veliskova, Libor Velisek, Michael Shakarjian

NYMC Faculty Posters

Tetramethylenedisulfotetramine (TMDT), a synthetic neurotoxin, induces a seizure syndrome by blocking Cl- influx through the GABAA channel. This process leads to uncontrolled depolarization followed by excessive Ca2+ entry into neurons and potential excitotoxicity. No standardized, effective treatment for TMDT poisoning currently exists. Primary neuronal cultures were used to screen candidate countermeasures for alleviation of TMDT-provoked hyperexcitability by monitoring changes in intracellular Ca2+ levels ([Ca2+]i). Agents antagonizing NMDA or β-adrenergic receptors reversed TMDT-induced increases in [Ca2+]i and displayed the best counteracting potential. We have commenced testing these in vitro leads in vivo. Adult male mice were injected with 0.25 mg/kg TMDT …

Risk Factors Associated With Poor Health Outcomes For Children Under The Age Of 5 With Moderate Acute Malnutrition In Rural Fagita Lekoma District, Awi Zone, Amhara, Ethiopia, 2016, W/Amilak Adamu, Dube Jara, Mulunesh Alemayehu, Sahai Burrowes

Background: Left untreated, moderate acute malnutrition (MAM) in children can lead to severe acute malnutrition, stunting, developmental delays, and death. Despite recent progress the prevalence of malnutrition remains high throughout Ethiopia. The ability to make accurate prognoses and develop effective treatment strategies for children with MAM is currently limited and, as result, a significant proportion of children with MAM fail to recover even with treatment. We seek to address this limitation by assessing the risk factors for poor outcomes among children under the age of 5 with MAM in a rural area of Ethiopia’s Amhara Region. This region is …

Is Gene Therapy A Viable Option For Cancer Treatment?, Aliza Applebaum

The Science Journal of the Lander College of Arts and Sciences

The use of gene therapy as a medical treatment option was first introduced to the world in 1990, when a four-year-old girl became its first patient. Since then gene therapy has met great success but also severe drawback. Incidences with severely negative outcomes on patients gave gene therapy a bad name and many began skeptical towards its use, but the constant work and progress on the safety and effectiveness of gene therapy is making it a more viable route of treatment. This paper focuses on gene therapy as a form of cancer treatment. Viral insertion of the modified genetic material …