Medicine and Health Sciences Commons^™

Atp-Site Binding Inhibitor Effectively Targets Mtorc1 And Mtorc2 Complexes In Glioblastoma, Jayson Neil, Craig Shannon, Avinash Mohan, Dimitri Laurent, Raj Murali, Meena Jhanwar-Uniyal

NYMC Faculty Publications

The PI3K-AKT-mTOR signaling axis is central to the transformed phenotype of glioblastoma (GBM) cells, due to frequent loss of tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10). The mechanistic target of rapamycin (mTOR) kinase is present in two cellular multi-protein complexes, mTORC1 and mTORC2, which have distinct subunit composition, substrates and mechanisms of action. Targeting the mTOR protein is a promising strategy for GBM therapy. However, neither of these complexes is fully inhibited by the allosteric inhibitor of mTOR, rapamycin or its analogs. Herein, we provide evidence that the combined inhibition of mTORC1/2, using the ATP-competitive binding …

Week Of December 14, 2015, New York Medical College

InTouch

• Summer Fellowship Pays Off in the Form of Published Research
• Department of Surgery Hosts Twelfth Annual Louis R.M. Del Guercio, M.D., Distinguished Visiting Professorship and Research Day
• D.P.T. Students Share Their Community Service Projects
• Department of Pediatrics Hosts Fifth Annual Assistant Professor Pediatric Research Symposium
• NYMC Serves Up International Food and Handicrafts
• P2P Committee Recognizes Role Models at NYMC

Week Of December 7, 2015, New York Medical College

InTouch

• NYMC Honored at WCA Annual Fall Leadership Dinner
• NYMC Hosts Music and Medicine
• HSL Hosts Shakespeare and the Four Humors Presentation
• Meet the Doctor Lecture Series Addresses Concussions in Youth Sports
• New York Blood Center Recognizes NYMC
• StuHE Hosts Public Health Career Mentor Session

"I Have Chicken Fat In My Urine!" A Case Of Candida Tropicalis Induced Emphysematous Pyelitis, Ahmed Alansari, Manuel D. Borras, Noella Boma

NYMC Faculty Publications

A patient with uncontrolled diabetes mellitus presented with fever and flank pain. A computed tomography scan showed free air within both collecting systems. A diagnosis of emphysematous pyelitis was made after other alternative diagnoses were ruled out. Urine culture grew Candida tropicalis. The emphysematous pyelitis resolved with conservative management using antifungal therapy.

Week Of November 16, 2015, New York Medical College

InTouch

• Amy S. Kahn Named Vice President for Development and Alumni Affairs
• BioInc@NYMC Welcomes Two New Clients
• Three High School Students Named Siemens Competition Semi-Finalists

Week Of November 9, 2015, New York Medical College

InTouch

• Penghua Wang, Ph.D., Identifies Protein that Fights Intestinal Bugs
• Changes are Coming to NYMC's Open Enrollment and Payroll
• The Flu Vaccine is Now Available in Health Services

Week Of November 2, 2015, New York Medical College

InTouch

• NYMC Supporters Gather at Founder's Dinner
• School of Medicine Hosts Cardiovascular Translational Research Workshop
• Medical Student, Adrian Romero, is the Recipient of 2015 AMA Foundation
• SHSP Hosts Two-Day Asthma Institute
• NYMC Hosts Second Annual Pre-Medical and Pre-Health Mentoring Program
• More NYMC History Adorns Walls of BSB
• Speech-Language Pathology Students Lead Disabilities Awareness Challenge at Local Boy Scout Event
• Peer to Peer Committee Recognizes Role Models at NYMC

Week Of October 26, 2015, New York Medical College

InTouch

• William Campbell, Ph.D., Longtime, Celebrated NYMC Adjunct Professor, Wins Nobel
• Steven A. Wartman, M.D., Ph.D., M.A.C.P., Announced as 2016 NYMC Commencement Speaker
• Dean Miller Reports on LCME Mock Site Visit
• School of Medicine Launches Personal Accolades and Incidents Reporting (PAIR)
• Medical Student Brian Yum Selected Semi-Finalist in Essay Program
• D.P.T. Students Host Successful Race for Rehab
• NYMC Welcomes BOCES New Visions Health Students
• NYMC Sends Support to Liberia
• SHSP Welcomes New Cohort of Dr.P.H. Candidates

Week Of October 19, 2015, New York Medical College

InTouch

• NYMC Set to Honor Three at 2015 Founder's Dinner
• School of Medicine Announces New Administrative Appointments
• School of Medicine Retreat Highlights Quality Improvement, Patient Safety and the Education of Medical Learners
• NYMC Mourns the Death of Former Chancellor Rev. Msgr. James P. Cassidy, Ph.D.
• NYMC Steps Out to Fight Heart Disease
• NYMC Hosts 8th Annual Community Health Fair
• Good Food Farmers Network Deliveries to Campus Begin

Week Of October 5, 2015, New York Medical College

InTouch

• School of Medicine Retreat Focuses on Diversity and Inclusion
• Late 19th Century Prize Microscopes Return to NYMC
• Historic Finds Now on Display in Sunshine Heritage Hall
• NYMC Seeds Selected for the Flu Vaccine
• NYMC Recognizes Three Decades of TB and HIV Lectures
• Meet the Farmers of the Good Food Farmers Network

Week Of September 28, 2015, New York Medical College

InTouch

• NYMC Celebrates Wellness Week
• NYMC Welcomes Claudette Killian, M.B.A., as Purchasing Specialist
• Be Part of the Farm-to-Campus Initiative

Week Of September 14, 2015, New York Medical College

InTouch

• Dean Miller Hosts School of Medicine Retreat
• Adam D. Hammerman Named VP for Financial Operations
• NYMC Joins the Good Food Farmers Network

Week Of September 8, 2015, New York Medical College

InTouch

• 7 Dana Road Gets the Gold
• Medical Students Share Their Summer Service Learning Experiences
• NYMC Joins the Good Food Farmers Network
• Save the Date for the 2015 Westchester County Heart Walk
• TouroOne Finance is Successfully Implemented
• Dr. Amler Briefs Albany on Recent Asthma Achievements

How Clinicians Feel About Working With Spouses Of The Chronically Ill, Douglas Ingram

NYMC Faculty Publications

Clinicians who provide psychotherapy to spouses or partners of the chronically ill were solicited through listserves of psychodynamic and other organizations. The current report excluded those therapists working with spouses of dementia patients. Interviews were conducted with clinicians who responded. The interviews highlight the challenges commonly encountered by psychotherapeutic work with this cohort of therapy patients. A comparison is drawn that shows both overlap and distinctions between the experiences of those therapists engaging with spouses of chronically ill patients without a dementing process and those working with spouses of chronically ill patients who do suffer from a dementing process.

Week Of August 31, 2015, New York Medical College

InTouch

• NYMC Achieves Top ACCME Accreditation
• CrisisManager Makes Campus Debut
• GSBMS Hosts Fourth Annual STAR Student Research Forum
• Karen Sanders, M.D. '77, deputy chief academic affiliations officer of the U.S. Department of Veterans Affairs, Visits NYMC
• NYMC Joins the Good Food Farmers Network
• High Schoolers Visit NYMC for Insider's View of Medicine

Week Of August 24, 2015, New York Medical College

InTouch

• School of Medicine Class of 2019 Embarks on their Journey to Medicine at the White Coat Ceremony
• NYMC Celebrates Walkway Ribbon Cutting
• NYMC Celebrates Faculty Authorship
• D.P.T. Class of 2015 Achieves 100 Percent First-Time Passing Rate on the National Licensure Exam
• GSBMS Welcomes New Cohort of Ph.D. Candidates

Change In Overactive Bladder Symptoms After Surgery For Stress Urinary Incontinence In Women, Halina Zyczynski, Michael E Albo, Howard B Goldman, Clifford Y Wai, Larry T Sirls, Linda Brubaker, Peggy Norton, R E Varner, Maude Carmel, Hae-Young Kim

NYMC Faculty Publications

OBJECTIVE: To assess change in overactive bladder (OAB) symptoms up to 5 years after surgery and to identify associated predictors of change from baseline.

METHODS: This is a secondary analysis of data from three multicenter urinary incontinence (UI) surgical trials of women with stress-predominant mixed UI assigned to Burch colposuspension, autologous fascial sling, or retropubic or transobturator midurethral slings. The primary outcome was improvement of 70% or greater from baseline in symptoms measured by the Urinary Distress Inventory-Irritative subscale. Surgical groups were compared within respective trials. Generalized linear models were fit using 1-year and up to 5-year data.

RESULTS: Significant …

Missing Data Frequency And Correlates In Two Randomized Surgical Trials For Urinary Incontinence In Women, Linda Brubaker, Heather J Litman, Hae-Young Kim, Philippe Zimmern, Keisha Dyer, John W Kusek, Holly E Richter, Anne Stoddard

NYMC Faculty Publications

INTRODUCTION AND HYPOTHESIS: Missing data is frequently observed in clinical trials; high rates of missing data may jeopardize trial outcome validity.

PURPOSE: We determined the rates of missing data over time, by type of data collected and compared demographic and clinical factors associated with missing data among women who participated in two large randomized clinical trials of surgery for stress urinary incontinence, the Stress Incontinence Surgical Treatment Efficacy Trial (SISTEr) and the Trial of Midurethral Sling (TOMUS).

METHODS: The proportions of subjects who attended and missed each follow-up visit were calculated. The chi-squared test, Fisher's exact test and t test …

Week Of July 27, 2015, New York Medical College

InTouch

• Public Health Program Passes the Test... with Flying Colors
• School of Medicine Class of 2017 Transitions to the Clinical Years
• NYMC Hosts 16th Pediatric Cancer Research Foundation Memorial Lectureship
• NYMC Reaches Out to Nepal
• NYMC Hosts Open Door Family Medical Centers Summer Students
• Lawrence Shapiro, M.D., Is Named Professor Emeritus of Pediatrics

Chironian Summer/Fall 2015, New York Medical College

The Chironian

No abstract provided.

Beta-Blocker Use And 30-Day All-Cause Readmission In Medicare Beneficiaries With Systolic Heart Failure, Vikas Bhatia, Kumar Sanam, Taimoor Hashim, Prakash Deedwania, Wilbert S. Aronow, Ross Fletcher, Ali Ahmed

NYMC Faculty Publications

BACKGROUND: Beta-blockers improve outcomes in patients with systolic heart failure. However, it is unknown whether their initial negative inotropic effect may increase 30-day all-cause readmission, a target outcome for Medicare cost reduction and financial penalty for hospitals under the Affordable Care Act.

METHODS: Of the 3067 Medicare beneficiaries discharged alive from 106 Alabama hospitals (1998-2001) with a primary discharge diagnosis of heart failure and ejection fraction

RESULTS: Beta-blocker use was not associated with 30-day all-cause readmission (hazard ratio [HR] 0.87; 95% confidence interval [CI], 0.64-1.18) or heart failure readmission (HR 0.95; 95% CI, 0.57-1.58), but was significantly associated with lower …

Week Of June 29, 2015, New York Medical College

InTouch

• New Campus Walkway is Now Open
• NYMC School of Medicine Pilots "The Healer's Art" Program
• Dr. Halperin Hosts Chancellor's Circle Reception
• Dr. Miller Hosts Special Dean's Lecture
• Department of Family and Community Medicine Hosts Annual Faculty Development and Appreciation Dinner
• Office of Medical Education Hosts Preceptor Appreciation Banquet
• NYMC Welcomes Class of 2018 D.P.T. Students
• Students Take a Study Break with Leonard

Orexin Receptor Activation Generates Gamma Band Input To Cholinergic And Serotonergic Arousal System Neurons And Drives An Intrinsic Ca(2+)-Dependent Resonance In Ldt And Ppt Cholinergic Neurons, Masaru Ishibashi, Iryna Gumenchuk, Bryan Kang, Catherine Steger, Elizabeth Lynn, Nancy Molina, Leonard M. Eisenberg, Christopher S. Leonard

NYMC Faculty Publications

A hallmark of the waking state is a shift in EEG power to higher frequencies with epochs of synchronized intracortical gamma activity (30-60 Hz) - a process associated with high-level cognitive functions. The ascending arousal system, including cholinergic laterodorsal (LDT) and pedunculopontine (PPT) tegmental neurons and serotonergic dorsal raphe (DR) neurons, promotes this state. Recently, this system has been proposed as a gamma wave generator, in part, because some neurons produce high-threshold, Ca(2+)-dependent oscillations at gamma frequencies. However, it is not known whether arousal-related inputs to these neurons generate such oscillations, or whether such oscillations are ever transmitted to neuronal …

Dysregulated Arginine Metabolism And Cardiopulmonary Dysfunction In Patients With Thalassaemia, Claudia Morris, Hae-Young Kim, Elizabeth Klings, John Wood, John B. Porter, Felicia Trachtenberg, Frans Kuypers, Elliott P Vichinsky, Frans A Kuypers

NYMC Faculty Publications

Pulmonary hypertension (PH) commonly develops in thalassaemia syndromes, but is poorly characterized. The goal of this study was to provide a comprehensive description of the cardiopulmonary and biological profile of patients with thalassaemia at risk for PH. A case-control study of thalassaemia patients at high versus low PH-risk was performed. A single cross-sectional measurement for variables reflecting cardiopulmonary status and biological pathophysiology were obtained, including Doppler-echocardiography, 6-min-walk-test, Borg Dyspnoea Score, New York Heart Association functional class, cardiac magnetic resonance imaging (MRI), chest-computerized tomography, pulmonary function testing and laboratory analyses targeting mechanisms of coagulation, inflammation, haemolysis, adhesion and the arginine-nitric oxide …

Week Of June 1, 2015, New York Medical College

InTouch

• NYMC Bids Farewell to the Class of 2015
• AOA Iota Chapter Hosts Annual Lecture and Induction Ceremony
• School of Medicine Class of 2018 Hosts 27th Annual Convocation of Thanks
• SHSP Hosts Third Annual Research and Scholarship Day
• Department of Family and Community Medicine Presents Third Annual Research Day
• Department of Pediatrics Hosts Fifth Annual Paul K. Woolf, M.D., Pediatric Trainee Research Day
• NYMC Inducts Inaugural Members of Delta Omega Honorary Society in Public Health
• LEND Graduates 19 From Interdisciplinary Leadership Program
• NYMC Hosts AHA Research Reception
• Students Host Annual Health Fair
• NYMC Shows Support for the National Alliance on Mental …

Week Of May 18, 2015, New York Medical College

InTouch

• Dr. Jan K. Richardson Will Address the Class of 2015
• NYMC Celebrates 27th Annual Employee Recognition Program
• View the NYMC Corporate Citizenship Award Video
• NYMC Ranks in Top Ten Med Schools with the Most Applicants

Week Of May 11, 2015, New York Medical College

InTouch

• Office of the Registrar Rolls Out Self-Service Portal for Students
• Peer to Peer Committee Recognizes Role Models at NYMC
• NYMC Unveils Historic Letter by Charles Darwin
• Four Faculty Members are 2015 Healthcare Heroes

Week Of April 27, 2015, New York Medical College

InTouch

• NYMC Receives the Business Council of Westchester Corporate Citizenship Award
• NYMC Celebrates Earth Day
• Doctoral Projects Demonstrate Breadth and Depth of Physical Therapy
• New York Mets Tickets Raffle Winner

Week Of April 20, 2015, New York Medical College

InTouch

• NYMC Welcomes New BioInc Client
• Town Hall Meeting Keeps NYMC Community Informed about Project Enterprise
• FCM and PT Team Up for an Interprofessional Education Opportunity
• Construction is Set to Commence for New Walkway to Provide Better Campus Connectivity
• College Community Rallies to Help Medical Students Displaced by Off-Campus Fire
• LCME Standard of the Week

The Minimum Important Difference For The International Consultation On Incontinence Questionnaire-Urinary Incontinence Short Form In Women With Stress Urinary Incontinence, Larry Sirls, Sharon Tennstedt, Linda Brubaker, Hae-Young Kim, Ingrid Nygaard, David Rahn, Jonathan Shepherd, Holly Richter

NYMC Faculty Publications

INTRODUCTION: Minimum important difference (MID) estimates the minimum degree of change in an instrument's score that correlates with a patient's subjective sense of improvement. We aimed to determine the MID for the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) using both anchor based and distribution based methods derived using data from the Trial of Midurethral Slings (TOMUS).

MATERIALS AND METHODS: Instruments for the anchor-based analyses included the urogenital distress inventory (UDI), incontinence impact questionnaire (IIQ), patient global impression of improvement (PGI-I), incontinence episodes (IE) on 7-day bladder diary, and satisfaction with surgical results. After confirming moderate correlation …