Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (19)
- Medical Sciences (16)
- Oncology (15)
- Medical Pharmacology (12)
- Pharmacy and Pharmaceutical Sciences (6)
-
- Public Health (3)
- Surgery (3)
- Translational Medical Research (3)
- Gastroenterology (2)
- Medical Genetics (2)
- Pathology (2)
- Amino Acids, Peptides, and Proteins (1)
- Chemicals and Drugs (1)
- Family Medicine (1)
- Medical Biochemistry (1)
- Medical Education (1)
- Medical Microbiology (1)
- Medical Neurobiology (1)
- Neurology (1)
- Other Pharmacy and Pharmaceutical Sciences (1)
- Radiology (1)
- Publication Year
Articles 31 - 31 of 31
Full-Text Articles in Medicine and Health Sciences
Plant-Derived Epcam Antigen Induces Protective Anti-Cancer Response., Robert Brodzik, Sergei Spitsin, Max Golovkin, Katarzyna Bandurska, Carla Portocarrero, Monika Okulicz, Zenon Steplewski, Hilary Koprowski
Plant-Derived Epcam Antigen Induces Protective Anti-Cancer Response., Robert Brodzik, Sergei Spitsin, Max Golovkin, Katarzyna Bandurska, Carla Portocarrero, Monika Okulicz, Zenon Steplewski, Hilary Koprowski
Department of Cancer Biology Faculty Papers
Immunotherapy holds great promise for treatment of infectious and malignant diseases and might help to prevent the occurrence and recurrence of cancer. We produced a plant-derived tumor-associated colorectal cancer antigen EpCAM (pGA733) at high yields using two modern plant expression systems. The full antigenic domain of EpCAM was efficiently purified to confirm its antigenic and immunogenic properties as compared to those of the antigen expressed in the baculovirus system (bGA733). Recombinant plant-derived antigen induced a humoral immune response in BALB/c mice. Sera from those mice efficiently inhibited the growth of SW948 colorectal carcinoma cells xenografted in nude mice, as compared …