Medicine and Health Sciences Commons^™

Induction Of Protective Immunity Against Larval Onchocerca Volvulus In A Mouse Model., A. M. Lange, W. Yutanawiboonchai, J. B. Lok, M. Trpis, D. Abraham

Department of Microbiology and Immunology Faculty Papers

BALB/cBYJ mice were immunized against larval Onchocerca volvulus by subcutaneous injection of normal, irradiated, or freeze-thaw-killed Onchocerca sp. larvae. The mice received challenge infections of O. volvulus third-stage larva (L3) contained in diffusion chambers implanted subcutaneously. At two-weeks postinfection, the diffusion chambers were removed and larval survival was assessed. When mice were immunized a single time with 35-krad-irradiated or normal O. volvulus L3, there was a significant reduction in the survival of challenge parasites. However, there was little or no reduction in challenge worm survival when mice were immunized a single time with freeze-thaw-killed O. volvulus L3 or fourth-stage larva …

A Clustering Of Childhood Meningococcal Disease: A Challenge For Physicians, Press And Community., Michael S. Dreyer, Stephen C. Eppes, Joel D. Klein

Department of Pediatrics Faculty Papers

The Delaware Division of Public Health reported only two cases of documented meningococcal infection in the pediatric population in 1992. As of March 1, 1993, the Morbidity and Mortality Weekly Report indicated only one case of meningococcal disease in the state of Delaware for 1993. However, from the end of February to early April 1993, approximately six weeks, there were seven cases of documented meningococcal infection in the pediatric population that either presented or were transferred to one of the pediatric care facilities in the Wilmington, Delaware area. Notification of these cases to the Delaware Division of Public Health prompted …

Jefferson Alumni Bulletin – Volume Xlii, Number 1, Fall 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLII, Number 1, Fall 1993

House staff receive a comprehensive preparation, page 2

Rectal cancer management arrives on the threshold of synergy with basic research, page 6

Fry is the first marks professor, page 8

Funding completed for the kind professorship, page 9

Bibbo is the first Lang professor, page 10

Institute for dermatopathology, page 11

Joslin center for diabetes, page 11

$54 million in awards in 1993, page 12

Blood substitute is refined, page 12

Study suggests site of alcohol and anesthesia action, page 13

Computers assist drug design, page 13

Clinton aide discusses …

Nurses Alumni Association Bulletin, Fall 1993, Alice C. Boehret, Alice Drumm, Vivian Moyer, Joyce Shaffer, Nancy Powell, Betty Piersol, Margaret Summers, Lorraine Mccall, Doris E. Bowman, Paula J. Levine

Nursing Alumni Bulletins

Annual Meeting Calendar

Inside Front & Back Cover 1994 Annual Luncheon-Meeting Notice.

Inside Front & Back Cover 1993-1994 Meeting Dates

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

News About and From Our Graduates

Seize the Day

Psychology and Nursing

Fiftieth Anniversary

Resume of Minutes of Alumni Association Meetings

Tribute to Mabel C. Prevost

The Decade Fund Nursing Scholarship

Happy Birthday

Alumni Office News

Jefferson Alumni Identification Card

Committee Reports

Bulletin

Social

Relief Fund

Scholarship

Finance

In Memoriam, Names of Deceased Graduates

Luncheon Photos

Class News

Relief Fund Application

Scholarship Application

Membership Application

Pins, Transcripts, Class …

Ochrobactrum Anthropi Bacteremia In A Child., Joel D. Klein, Stephen C. Eppes

Department of Pediatrics Faculty Papers

Children undergoing chemotherapy for cancer are at increased risk of supervening infection, including bacteremia. This may be due to immunosuppression as well as the presence of intravascular devices such as central venous catheters. Bacteria responsible for these infections include those found in the child's endogenous flora as well as in environmental sources. We report the case of a child with acute lymphoblastic leukemia (ALL) who developed bacteremia secondary to Ochrobactrum anthropi. Details of this extremely rare infection are the focus of this report.

A Curriculum Based On Systems Theory., Ruth L. Schemm, Mary Corcoran, Ellen Kolodner, Roseann C Schaaf

Department of Occupational Therapy Faculty Papers

This paper describes an entry-level curriculum based on systems theory that was designed to promote integrated thinking and a shared image of practice among all of the members of an educational community that included students, faculty, and clinicians. Initiated in 1983, the program integrates occupational therapy theory, critical thinking, and knowledge about person-environmental transactions with traditional medical, biological, psychological, and sociological course work to create a unique educational experience. The curriculum model is based on a spiral learning process that encourages integrated thinking. Furthermore, all concepts are systematically tied to the occupation core, the central theme of the program. Fieldwork …

Jefferson Alumni Bulletin – Volume Xlii, Number 4, Summer 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLII, Number 4, Summer 1993

The development of surgery for heart disease, page 6

Refining the heart-lung machine, page 9

Training surgical residents, page 10

Counseling in family medicine, page 10

Volunteer care in Swaziland, page 10

Paleoradiology of the prehistoric Australian aborigines, page 11

Vaccine therapy of melanoma, page 12

Biliary radiology and T tube design, page 13

Familial patterns of ovarian carcinoma, page 15

The importance of treating diabetic retinopathy, page 16

Investigators identify key protein causing heart muscle damage after heart attack, page 18

Croce wins Mott Prize, page 19

Westermark given …

Department Of Radiology-Annual Report-July 1, 1992 To June 30, 1993, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1992 to June 30, 1993. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 85 pages.

Sequencing Of Cdna From 50 Unrelated Patients Reveals That Mutations In The Triple-Helical Domain Of Type Iii Procollagen Are An Infrequent Cause Of Aortic Aneurysms., Gerard Tromp, Yuli Wu, Darwin J. Prockop, Swarna L. Madhatheri, Caren Kleinert, James J. Earley, Jiapiao Zhuang, Orjan Norrgård, R. Clement Darling, William M. Abbott, C. William Cole, Pekka Jaakkola, Markku Ryynanen, William H. Pearce, James S.T. Yao, Kari Majamaa, Stanton N. Smullens, Zoran Gatalica, Robert E. Ferrell, Sergio A. Jimenez, Charles E. Jackson, Virginia V. Michels, Michael Kaye, Helena Kuivaniemi

Department of Biochemistry and Molecular Biology Faculty Papers

Detailed DNA sequencing of the triple-helical domain of type III procollagen was carried out on cDNA prepared from 54 patients with aortic aneurysms. The 43 male and 11 female patients originated from 50 different families and five different nationalities. 43 patients had at least one additional blood relative who had aneurysms. Five overlapping asymmetric PCR products, covering all the coding sequences of the triple-helical domain of type III procollagen, were sequenced with 28 specific sequencing primers. Analysis of the sequencing gels revealed only two nucleotide changes that altered the structure of the protein. One was a substitution of threonine for …

Regulation Of Human Lung Fibroblast Alpha 1(I) Procollagen Gene Expression By Tumor Necrosis Factor Alpha, Interleukin-1 Beta, And Prostaglandin E2., Arturo Diaz, Elena Munoz, Rosemary Johnston, Joseph H. Korn, Sergio A. Jimenez

Department of Medicine Faculty Papers

We investigated the participation of prostaglandin (PG) E2 in the regulation of the alpha 1(I) procollagen gene expression by tumor necrosis factor alpha (TNF alpha), and interleukin-1 beta (IL-1 beta) in normal adult human lung fibroblasts. TNF alpha (100 units/ml) and IL-1 beta (100 units/ml) stimulated the production of PGE2 and caused a dose-dependent inhibition of up to 54 and 66%, respectively, of the production of type I procollagen. Preincubation of cultures with indomethacin partially reversed the inhibition of procollagen production induced by the cytokines. Cytokine-stimulated endogenous fibroblast PG accounted for 35 and 68% of the inhibition induced by TNF …

Jefferson Alumni Bulletin – Volume Xlii, Number 3, Spring 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLII, Number 3, Spring 1993

Genetic factors behind behavioral disorder are at the center of department research, page 2

Baldwin L. Keyes, ’17: A career through many countries, battles, and specialties, page 5

Baldwin L. Keyes, ’17: A chairman who taught by personal example, page 7

Committee provides guidance on ethical issues that underlie clinical cases, page 9

John E. Deitrick, M.D.: Early appraiser of medical education, page 12

Scientists link nitric oxide to brain damage in neurologic viral diseases, page 14

Study shows Jefferson succeeds in training rural physicians, page 15

Students help organize …

The Tight Skin Mouse: Demonstration Of Mutant Fibrillin-1 Production And Assembly Into Abnormal Microfibrils, Cay M. Kielty, Michael Raghunath, Linda D. Siracusa, Michael J. Sherratt, Reiner Peters, C. Adrian Shuttleworth, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

Mice carrying the Tight skin (Tsk) mutation harbor a genomic duplication within the fibrillin-1 (Fbn 1) gene that results in a larger than normal in-frame Fbn 1 transcript. In this study, the consequences of the Tsk mutation for fibrillin-containing microfibrils have been examined. Dermal fibroblasts from Tsk/+ mice synthesized and secreted both normal fibrillin (approximately 330 kD) and the mutant oversized Tsk fibrillin-1 (approximately 450 kD) in comparable amounts, and Tsk fibrillin-1 was stably incorporated into cell layers. Immunohistochemical and ultrastructural analyses of normal and Tsk/+ mouse skin highlighted differences in the gross organization and distribution of microfibrillar arrays. Rotary …

A Model To Promote Activity Competence In Elders., Ruth E. Levine, Laura N. Gitlin

Department of Occupational Therapy Faculty Papers

This paper describes an occupational therapy home-based intervention in which purposeful activities were used to promote adaptation and competence in older adults with chronic disabilities. Seven home care therapists visited 17 randomly selected, community-living elders who were chronically disabled and who volunteered to participate in the program. The number of visits ranged from 3 to 10 and occurred over a 3-month period according to clients' needs and wishes. Therapists enhanced their ability to enter the client's social and cultural system by using participant-observation techniques and collaboratively identified activities. Therapists documented each home visit with a structured fieldnote form. An analysis …

Jefferson Alumni Bulletin – Volume Xlil, Number 2, Winter 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIL, Number 2, Winter 1993 New technology, new faculty, and new productivity Mark Jefferson Radiology, page 2 An early contract for medical care, page 10 Jefferson meets the challenges of geriatric medicine, page 11 Students establish a community outreach initiative, page 14 What does a Jefferson medical college diploma mean to me? Page 16 Jefferson discoveries May help show how to keep AIDS dormant, page 18 Genetic cause of common leukemia is found here, page 19 Alcohol research center receives $8 million grant to continue basic investigations, page 20 Use of decoy peptides to block …