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Full-Text Articles in Medicine and Health Sciences
Title, Fergus Ryan, D Devaney, Caroline Joyce, A Nestorowicz, M Permutt, Benjamin Glaser, Paul Thornton, David E. Barton
Title, Fergus Ryan, D Devaney, Caroline Joyce, A Nestorowicz, M Permutt, Benjamin Glaser, Paul Thornton, David E. Barton
Articles
Persistent hypoglycaemia in infancy is most commonly caused by hyperinsulinism. A case is reported of the somatic loss of the maternal 11p in an insulin secreting focal adenoma in association with a germline SUR-1mutation on the paternal allele in a baby boy with hyperinsulinism diagnosed at 49 days old. A reduction to homozygosity of an SUR-1 mutation is proposed as a critical part of the cause of focal hyperinsulinism.
Phenmedipham Process Development, Maura Byrne
Phenmedipham Process Development, Maura Byrne
Masters
The objective of this work was to investigate the process for the production of an organic herbicide, phenmedipham, utilising isobutylacetate as solvent and to scale up the reaction to one litre. This was carried out according to a technical bulletin received from Barclay Plant Protection Ltd. Difficulties were encountered in isolating the product, methyl N-(3-hydroxyphenyl) carbamate, from stage 1 with isobutylacetate as solvent. An investigation of the use of other solvents for the reaction process led to the use of ethyl acetate, in a modified version of the method used by Schering A-G, and resulted in a 93% yield of …