Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- COVID-19 (18)
- Oxidative stress (8)
- Prognosis (7)
- Children (6)
- Mortality (6)
-
- Vitamin D (6)
- Magnetic resonance imaging (5)
- Turkey (5)
- Atrial fibrillation (4)
- Breast cancer (4)
- Growth performance (4)
- Inflammation (4)
- Liver (4)
- Treatment (4)
- Type 2 diabetes mellitus (4)
- Biomarker (3)
- Blood (3)
- COPD (3)
- Chronic obstructive pulmonary disease (3)
- Diagnosis (3)
- Egg quality (3)
- Familial Mediterranean fever (3)
- Ferritin (3)
- Frailty (3)
- Goat (3)
- Histology (3)
- Interstitial lung disease (3)
- Metastasis (3)
- Milk (3)
- Morphology (3)
Articles 271 - 300 of 329
Full-Text Articles in Medicine and Health Sciences
Pleuroparenchymal Fibroelastosis In Systemic Sclerosis-Associated Interstitial Lung Disease, Alper Sari, Ömer Önder, Berkan Armağan, Ertuğrul Çağri Bölek, Bayram Fari̇soğullari, Emre Bi̇lgi̇n, Gözde Kübra Yardimci, Orhan Maci̇t Ariyürek, Ali̇ Akdoğan
Pleuroparenchymal Fibroelastosis In Systemic Sclerosis-Associated Interstitial Lung Disease, Alper Sari, Ömer Önder, Berkan Armağan, Ertuğrul Çağri Bölek, Bayram Fari̇soğullari, Emre Bi̇lgi̇n, Gözde Kübra Yardimci, Orhan Maci̇t Ariyürek, Ali̇ Akdoğan
Turkish Journal of Medical Sciences
Background/aim: To explore the frequency and clinical associations of radiologic pleuroparenchymal fibroelastosis (PPFE) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Materials and methods: In this single-center retrospective study, high resolution computed tomography (HRCT) images of 105 patients with SSc-ILD were examined for the presence of PPFE. Demographic, clinical, laboratory, and pulmonary function test (PFT) data of patients with and without PPFE were compared. Results: PPFE was detected in 19 (18.1%) patients (`definite PPFE' in 13 and `consistent with PPFE' in 6 patients). Patients with PPFE had higher age and longer disease duration than PPFE (-) patients (p < 0.05 for both). Radiologic usual interstitial pneumoniae (UIP) pattern was more frequent (26.3% vs. 4.7%, p = 0.01) and median force vital capacity (FVC) was lower in patients with PPFE (64% vs. 82%, p = 0.005). Spontaneous pneumothorax developed in one patient with PPFE. More deaths occured in PPFE (+) group during follow-up (31% vs. 11%, p = 0.04). Conclusion: PPFE on HRCT is not uncommon in SSc-ILD and is associated with radiologic UIP pattern and worse lung functions. Further studies are needed to elucidate the prognostic value of PPFE in SSc-ILD.
Effects Of Pulmonary Rehabilitation On Diaphragm Thickness And Contractility In Patients With Chronic Obstructive Pulmonary Disease, Seçi̇lay Güneş, Aysun Genç, Yeşi̇m Kurtai̇ş, Fatma Çi̇ftci̇, Serhat Hayme, Akin Kaya
Effects Of Pulmonary Rehabilitation On Diaphragm Thickness And Contractility In Patients With Chronic Obstructive Pulmonary Disease, Seçi̇lay Güneş, Aysun Genç, Yeşi̇m Kurtai̇ş, Fatma Çi̇ftci̇, Serhat Hayme, Akin Kaya
Turkish Journal of Medical Sciences
Background/aim: Studies are showing that pulmonary rehabilitation (PR) increases diaphragmatic excursion by decreasing hyperinflation in patients with chronic obstructive pulmonary disease (COPD). However, there is a lack of knowledge about its effects on the diaphragm thickness (dt) and contractility. This study aims to evaluate the dt and contractility before and after PR in patients with COPD. Materials and methods: All subjects participated in an out-patient PR of 6 weeks and 3 sessions per week prospectively. Dyspnea severity, the disease-specific quality of life (St. Georges Respiratory Questionnaire-SGRQ), pulmonary function tests (PFT), exercise capacity, the dt at the end of the expiration …
The Relationship Between Hidradenitis Suppurativa And Irritable Bowel Syndrome: A Cross-Sectional Study, Abdullah Demi̇rbaş, Ömer Faruk Elmas, Hedi̇ye Eker, Gözde Ulutaş Demi̇rbaş, Recep Dursun, Mustafa Atasoy, Ümi̇t Türsen, Torello Lotti̇
The Relationship Between Hidradenitis Suppurativa And Irritable Bowel Syndrome: A Cross-Sectional Study, Abdullah Demi̇rbaş, Ömer Faruk Elmas, Hedi̇ye Eker, Gözde Ulutaş Demi̇rbaş, Recep Dursun, Mustafa Atasoy, Ümi̇t Türsen, Torello Lotti̇
Turkish Journal of Medical Sciences
Background/aim: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which one experiences abdominal pain, tension, cramping, bloating, and changes in the form and frequency of defecation, without an underlying organic disease. Many skin diseases have been reported to be more common in people with functional bowel disease. To our knowledge, however, no previous study investigated the potential relationship between hidradenitis suppurativa (HS) and IBS. In this study, we aimed to examine the potential association between IBS and HS. Materials and methods: Patients with HS and healthy subjects were enrolled in this cross-sectional study. All participants were assessed for …
Investigation Of The Expression Levels Of Cdh1, Fhit, Pten, And Ttpal Genes In Colorectal Tumors, Evri̇m Suna Arikan Söylemez, Zafer Söylemez, Murat Çi̇lekar, Yüksel Arikan, Çi̇ğdem Tokyol, İbrahi̇m Hali̇l Kenger, Mustafa Solak
Investigation Of The Expression Levels Of Cdh1, Fhit, Pten, And Ttpal Genes In Colorectal Tumors, Evri̇m Suna Arikan Söylemez, Zafer Söylemez, Murat Çi̇lekar, Yüksel Arikan, Çi̇ğdem Tokyol, İbrahi̇m Hali̇l Kenger, Mustafa Solak
Turkish Journal of Medical Sciences
Background/aim: The main aim of the study is to assess expression levels of CDH1, FHIT, PTEN, and TTPAL genes in tumors and peripheral bloods of colorectal cancer patients in staged I-IV. Materials and methods: Gene expression analysis of related genes were performed for tumor tissues and peripheral blood samples of 51 colorectal cancer patients and colon tissues and blood samples of 5 healthy individuals. The real-time-PCR reaction method was used for the analysis. Results: Alteration of mRNA levels of related genes in tumor tissues of colorectal cancer cases was determined compared to control tissues. GAPDH and TBP were used for …
The Impact Of Jak2v617f Mutation On Philadelphia-Negative Myeloproliferative Neoplasms, Ezgi̇ Şahi̇n, İpek Yönal Hi̇ndi̇lerden, Fehmi̇ Hi̇ndi̇lerden, Aynur Aday, Meli̇ha Nalçaci
The Impact Of Jak2v617f Mutation On Philadelphia-Negative Myeloproliferative Neoplasms, Ezgi̇ Şahi̇n, İpek Yönal Hi̇ndi̇lerden, Fehmi̇ Hi̇ndi̇lerden, Aynur Aday, Meli̇ha Nalçaci
Turkish Journal of Medical Sciences
Background/aim: JAK2V617F mutation is expressed in almost all polycthemia vera (PV), 55% of essential thrombocythemia (ET), and 65% of primary myelofibrosis (PMF) patients. Studies investigating phenotypic effects of JAK2V617F mutation on Philadelphia- negative myeloproliferative neoplasms (Ph-negative MPNs) have reported controversial results. This study aims to determine the impact of JAK2V617F mutation on clinical phenotype and outcome in Ph-negative MPNs. Materials and methods: Clinical correlates and long-term prognostic relevance of the JAK2V617F mutation were analyzed in 410 Ph- negative MPNs-170 ET, 135 PV, 105 PMF- from two institutions and followed for a mean of 76.7 months (SD 62.1) (mean 87 months …
Developing The Nausea And Vomiting Thermometer Scale In Children With Cancer, Asli Akdeni̇z Kudubeş, Murat Bektaş
Developing The Nausea And Vomiting Thermometer Scale In Children With Cancer, Asli Akdeni̇z Kudubeş, Murat Bektaş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to develop the Nausea and Vomiting Thermometer Scale (NVTS) in children with cancer. Materials and methods: This methodological study was conducted on 250 children with cancer at the research and training university hospital in Turkey between September 2019 and January 2020. The t-test, the ROC analysis, the Diagnostic index, and the Youden index were used for determining the scale of the cutting point. The regression analysis, the intra-class correlation coefficient, and the Bland- Altman analysis were used for the data analysis. Results: The scale-level content validity index was .94, which was coherent. As a result of …
A Comparison Of Angled (D-Blade) And Macintosh (C-Mac) Videolaryngoscopes For Simulated Pediatric Difficult Airway: A Randomized Single-Blind Study, Alparslan Kuş, Can Aksu, Hadi̇ Ufuk Yörükoğlu, Volkan Alparslan, Kami̇l Toker
A Comparison Of Angled (D-Blade) And Macintosh (C-Mac) Videolaryngoscopes For Simulated Pediatric Difficult Airway: A Randomized Single-Blind Study, Alparslan Kuş, Can Aksu, Hadi̇ Ufuk Yörükoğlu, Volkan Alparslan, Kami̇l Toker
Turkish Journal of Medical Sciences
Background/aim: Being prepared for difficult airway (DA) is nevertheless of great importance. Failed or delayed tracheal intubation (TI) can increase morbidity and mortality, and the pediatric population is more prone to hypoxia. With the development of different types of videolaryngoscope (VL), these have become the device of choice in patients with DA. Our primary aim was to compare intubation times with D-blade and Macintosh blade of Storz C-MAC® in a simulated pediatric DA scenario with this randomized controlled trial. Materials and methods: Children aged 1-5 years scheduled for elective surgery were included in the study. Patients were randomized into two …
The Lumbar Erector Spinae Plane Block: A Cadaveric Study, Serdar Kokar, Ahmet Ertaş, Özlem Mercan, Fatma Güler Yildirim, Ömer Alp Taştan, Kenan Akgün
The Lumbar Erector Spinae Plane Block: A Cadaveric Study, Serdar Kokar, Ahmet Ertaş, Özlem Mercan, Fatma Güler Yildirim, Ömer Alp Taştan, Kenan Akgün
Turkish Journal of Medical Sciences
Background/aim: The aim of this cadaveric study was to investigate the erector spinae plane block (ESPB) in lumbar region and to elucidate the possible mechanisms of action of these injections in lumbar radicular pain by means of detecting expected dye dispersion to the neural structures. Materials and methods: Ultrasound-guided lumbar ESPB was performed in three formaldehyde-embalmed human cadavers. For this purpose, a 10 mL of methylene blue was injected into the fascial space between the L4 transverse process and the erector spinae muscles. Then, the cadavers were dissected, the cephalocaudal and lateral spread of the dye was examined, and the …
The Effects Of A Combination Treatment With Mesenchymal Stem Cell And Platelet-Rich Plasma On Tendon Healing: An Experimental Study, İlker Uyar, Zeynep Altuntaş, Siddika Findik, Mehmet Emi̇n Cem Yildirim, Serhat Yarar, Murat Aktan, Ahmet Avci
The Effects Of A Combination Treatment With Mesenchymal Stem Cell And Platelet-Rich Plasma On Tendon Healing: An Experimental Study, İlker Uyar, Zeynep Altuntaş, Siddika Findik, Mehmet Emi̇n Cem Yildirim, Serhat Yarar, Murat Aktan, Ahmet Avci
Turkish Journal of Medical Sciences
Background/Aim: The objective of this study was to investigate the effects that the application of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) following tendon repair have on the strength and healing of the tendon and also to examine the possible mechanisms of action that take place. Materials and methods: The Achilles tendons of 80 rats were repaired and divided into eight groups. Following the repairs, MSCs obtained from humans were injected into the rat tendons in groups 1 and 2, a combination of MSCs from humans and PRP from rats was injected into the tendons in groups 3 and …
Modulatory Effect Of Resveratrol And Melatonin On Natural Killer Cell Activity And Adrenomedullin In Diabetic Rats, Fati̇h Özçeli̇k, Fati̇h Hacimustafaoğlu, Alpaslan Tanoğlu
Modulatory Effect Of Resveratrol And Melatonin On Natural Killer Cell Activity And Adrenomedullin In Diabetic Rats, Fati̇h Özçeli̇k, Fati̇h Hacimustafaoğlu, Alpaslan Tanoğlu
Turkish Journal of Medical Sciences
Background/aim: Epidemiological evidence suggests that diabetes poses a high risk for many chronic diseases, especially cardiovascular diseases, and cancer by stimulating many inflammatory and immunological pathogenic mediators and affecting natural killer (NK)-cell activity. In this study, the effects of melatonin and resveratrol on IL-6, TNF-alpha, oxidant/antioxidant capacity, NK-cell activity, and mid-regional proadrenomedullin (MR-proADM) levels of diabetic rats were investigated. Materials and methods: In the study, 28 Sprague Dawley rats were randomly divided into the control group (group I) and 3 streptozotocin- induced diabetes mellitus (DM) groups (group II, III, and IV), each group consisting of 7 rats. Five mg/kg/day melatonin …
A High-Fat And High-Fructose Diet Lowers The Cecal Digesta's Weight And Short-Chain Fatty Acid Level Of A Sprague-Dawley Rat Model, Etik Sulistyowati, Dian Handayani, Setyawati Soeharto, Achmad Rudijanto
A High-Fat And High-Fructose Diet Lowers The Cecal Digesta's Weight And Short-Chain Fatty Acid Level Of A Sprague-Dawley Rat Model, Etik Sulistyowati, Dian Handayani, Setyawati Soeharto, Achmad Rudijanto
Turkish Journal of Medical Sciences
Background/aim: This study aimed to analyze the effect of a high-fat and high-fructose diet (HFFD) on the digesta weight and short- chain fatty acid (SCFA) levels of cecal digesta in rats. Materials and methods: This study was an experimental study with a posttest-only control group design with male Sprague-Dawley strain rats as the samples. A total of 36 rats were divided into two groups with normal diet (N) and modified HFFD. The data of energy intake, nutrients and fiber, body weight, Lee index, abdominal circumference, digesta weight, and SCFA levels of cecal digesta were collected. Results: The results showed an …
Antimicrobial Activities Of Ankaferd Bloodstopper, Hypochlorous Acid, And Chlorhexidine Against Specific Organisms, Ahmet Koluman, Alper Aktaş, Selen Adi̇loğlu
Antimicrobial Activities Of Ankaferd Bloodstopper, Hypochlorous Acid, And Chlorhexidine Against Specific Organisms, Ahmet Koluman, Alper Aktaş, Selen Adi̇loğlu
Turkish Journal of Medical Sciences
No abstract provided.
Ultrasound-Guided Rhomboid Intercostal Block For Myofascial Pain Syndrome: A Prospective Clinical Study, Seli̇n Güven Köse, Hali̇l Ci̇han Köse, Serkan Tulgar, Ömer Taylan Akkaya
Ultrasound-Guided Rhomboid Intercostal Block For Myofascial Pain Syndrome: A Prospective Clinical Study, Seli̇n Güven Köse, Hali̇l Ci̇han Köse, Serkan Tulgar, Ömer Taylan Akkaya
Turkish Journal of Medical Sciences
Background/aim: Myofascial pain syndrome (MPS) is a common chronic pain syndrome that may affect quality of life, daily living activities, and psychological status. Ultrasound (US)-guided rhomboid intercostal block (RIB) is a recently defined plane block and used for chronic pain such as postmastectomy syndrome and MPS. Our aim was to evaluate the efficacy of US-guided RIB for the management of pain, quality of life, physical disability, and patient satisfaction in MPS. Materials and methods: In this prospective study, between February and March 2021, a total of 30 patients who applied with the diagnosis of MPS, were included. The patients received …
Evaluation Of Metabolic Changes In Fdg Pet/Ct Imaging After Mrna-Based Covid-19 Vaccination, Serkan İşgören, Gi̇zem Köroğlu, Gözde Dağliöz Görür, Hakan Demi̇r
Evaluation Of Metabolic Changes In Fdg Pet/Ct Imaging After Mrna-Based Covid-19 Vaccination, Serkan İşgören, Gi̇zem Köroğlu, Gözde Dağliöz Görür, Hakan Demi̇r
Turkish Journal of Medical Sciences
Background/aim: It isimportant to evaluate the vaccine-related metabolic changes on FDG PET/CT to avoid confusing results. We here aimed to assess the frequency and intensity of regional and systemic metabolic PET/CT changes of patients who received the mRNAbased COVID-19 vaccine (BNT162b2-Pfizer/BioNTech) and to analyze possible factors affecting these changes. Materials and methods: Among the patients who underwent FDG PET/CT for any indication in our department between July 2021 and December 2021, 129 volunteer patients with a history of COVID-19 vaccination were included in this prospective observational study. Bilateral axillary lymph nodes, ipsilateral deltoid muscle, bone marrow, spleen, thyroid, and liver …
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Turkish Journal of Medical Sciences
Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement …
Could Lactate Clearance Be A Marker Of Mortality In Pediatric Intensive Care Unit?, Özlem Saraç Sandal, Gökhan Ceylan, Ferhat Sari, Gülhan Atakul, Mustafa Çolak, Sevgi̇ Topal, Eki̇n Soydan, Ünal Utku Karaarslan, Hasan Ağin
Could Lactate Clearance Be A Marker Of Mortality In Pediatric Intensive Care Unit?, Özlem Saraç Sandal, Gökhan Ceylan, Ferhat Sari, Gülhan Atakul, Mustafa Çolak, Sevgi̇ Topal, Eki̇n Soydan, Ünal Utku Karaarslan, Hasan Ağin
Turkish Journal of Medical Sciences
Background/aim: Hyperlactatemia is a common finding in critically ill patients and has significant prognostic implications. However, a single lactate measurement has not been correlated to mortality consistently. In this study, we aimed to correlate the clinical efficacy of lactate clearance for the prediction of mortality in pediatric intensive care unit patients. Materials and methods: This retrospective observational study was performed in the pediatric intensive care unit in patients with lactate level >3 mmol/lt. Initial, 6th h, and 24th h lactate levels were recorded and lactate clearance was calculated using these values (lactate level at admission - level 6 h later …
The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün
The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün
Turkish Journal of Medical Sciences
Background/aim: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common causes of death worldwide. Therefore, optimizing medical therapy in the comprehensive management of the disease, as well as including pulmonary rehabilitation (PR) in the treatment, is essential. The goal of our study was to determine the impact of PR on the survival of COPD patients. Materials and methods: Between 2007-2015, 509 COPD patients who completed the PR constituted the PR group, while 167 patients who applied but could not complete it after the initial evaluations formed the control group. In the PR group, dyspnea perception, exercise capacity, muscle …
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Turkish Journal of Medical Sciences
Background/aim: Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor (AR) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects. Materials and methods: This was a cross-sectional study conducted at Aga Khan University, Karachi, Pakistan. A total of 376 males were recruited, out of which group A (N = 208) and group B (N = 168) were comprised of …
Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci
Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci
Turkish Journal of Medical Sciences
Background/aim: Intravesical BCG treatment fails inexplicably in 30%-45% of patients for high-grade nonmuscle-invasive bladder cancer (NMIBC). We aimed to investigate the role of PD-1/PD-L1 interaction on BCG failure of high-grade NMIBC and to identify biomarkers for predicting BCG responsive cases. Materials and methods: Thirty BCG responsive and 29 nonresponsive NMIBCs were included in the study. Expressions of PDL1(SP-263), MSH2, MSH6, PMS2, and MLH1 were evaluated on pre- and post-BCG transurethral resection (TUR-B) specimens by immunohistochemistry. PD-L1(SP-263) expression was categorised as negative/low, high. DNA mismatch repair protein (MMR) expressions were classified as 'reduced' if ≤30% of nuclei stained, 'preserved' if >30% …
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Nicotine acts as an agonist of nicotinic acetylcholine receptors (nAChR). These receptors belong to a superfamily of ligand-gated ion channels. We previously demonstrated that nicotine increased electrical field stimulation (EFS)-induced contractile or relaxation responses, possibly by facilitating neurotransmitter release from nerve terminals in various rabbit tissues. Studies have shown that there is an interaction between the endocannabinoid and nicotinic systems. This study aimed to investigate the interaction between nicotine and the endocannabinoid system in the rabbit urine bladder and also investigate the enhancing effect of nicotine on EFS-induced contractile responses in rabbit isolated bladder smooth muscle and its interaction …
Favorable Efficacy Of Adalimumab Treatment In Experimental Acute Pancreatitis Model, Başak Çakir Güney, Alpaslan Tanoğlu, Murat Yeni̇çeri̇, Zafer Çirak, Ayşe Gökçen Sade, Yeşi̇m Önal Taştan, Zeli̇ha Seri̇ndağ, Mustafa Kaplan
Favorable Efficacy Of Adalimumab Treatment In Experimental Acute Pancreatitis Model, Başak Çakir Güney, Alpaslan Tanoğlu, Murat Yeni̇çeri̇, Zafer Çirak, Ayşe Gökçen Sade, Yeşi̇m Önal Taştan, Zeli̇ha Seri̇ndağ, Mustafa Kaplan
Turkish Journal of Medical Sciences
Background/aim: Acute pancreatitis is a clinical picture with a wide range of symptoms from mild inflammation to multiorgan failure and death. The aim of this study is to investigate the effects of Adalimumab (ADA) on inflammation and apoptosis in a cerulein-induced acute pancreatitis model in rats. Material and methods: Experimental cerulein-induced acute pancreatitis model was created by applying 4 intraperitoneal cerulein injections at 1-h intervals. A total of 40 rats, 8 in each group, were randomly distributed into five groups. In the groups that ADA treatment was given, two different doses of ADA were administered 5 mg/kg and 20 mg/kg …
The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut
The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut
Turkish Journal of Medical Sciences
Background/aim: Needle phobia occurs in more than half of diabetic patients due to the pain caused by frequent insulin injections. Therefore, this study evaluated the effect of topically administered lavender aromatherapy on the pain of insulin injections in diabetic patients. Materials and methods: In this double-blind randomized controlled and experimental study, patients who met the study criteria were divided into three groups; topical lavender oil (n = 60), placebo (n = 60), and control (n = 60) groups. The data were collected using the "Patient Information Form", the "Follow-up Form", the "Verbal Category Scale (VCS)", and the "Visual Analogue Scale …
Etiological, Clinical, And Laboratory Evaluation Of Congenital Hypothyroidism And Determination Of Levothyroxine (Lt4) Dose At Treatment Interruption In Differentiating Permanent Vs. Transient Patients, İsmai̇l Dündar, Mehmet Aki̇f Büyükavci, Nurdan Çi̇ftci̇
Etiological, Clinical, And Laboratory Evaluation Of Congenital Hypothyroidism And Determination Of Levothyroxine (Lt4) Dose At Treatment Interruption In Differentiating Permanent Vs. Transient Patients, İsmai̇l Dündar, Mehmet Aki̇f Büyükavci, Nurdan Çi̇ftci̇
Turkish Journal of Medical Sciences
Background/aim: Congenital hypothyroidism (CH) is the most common cause of preventable but irreversible mental retardation in children, although the risk has been widely abolished by national neonatal screening programs. The aim of this study was to determine, (a) the cause of CH, (b) the etiological cause of persistent CH and (c) to investigate the role of laboratory and clinical data in predicting persistent and transient CH. Materials and methods: Patients diagnosed with CH, who started L-thyroxine treatment and were followed up for at least three years were included. Patient data were reviewed retrospectively. Serum thyroid hormones were measured four weeks …
Management Of Recurrent Hemoptysis: A Single-Center Experience, Seda Tural Önür, Sedat Altin, Fatma Tokgöz Akyil, Kaan Kara, Si̇nem Nedi̇me Sökücü, Cengi̇z Özdemi̇r, Mehmet Aki̇f Özgül, Muzaffer Meti̇n, Levent Cansever, Aysun Ölçmen, Nuri̇ Özgür Kiliçkesmez
Management Of Recurrent Hemoptysis: A Single-Center Experience, Seda Tural Önür, Sedat Altin, Fatma Tokgöz Akyil, Kaan Kara, Si̇nem Nedi̇me Sökücü, Cengi̇z Özdemi̇r, Mehmet Aki̇f Özgül, Muzaffer Meti̇n, Levent Cansever, Aysun Ölçmen, Nuri̇ Özgür Kiliçkesmez
Turkish Journal of Medical Sciences
Background/aim: A successful planning methodology for patients with hemoptysis promises overall improvement in patient care. Conducted in a reference center for chest diseases, the present study aims to analyze characteristics and predictors of interventional methods in patients with recurrent hemoptysis. Materials and methods: The present study is a single-center, retrospective observational study. Between 2015 and 2018, 5973 patients with follow-up data until 2021 requiring more than one hospitalization due to recurrent hemoptysis were investigated. Patient characteristics, the amount of hemoptysis, baseline admission parameters, interventional procedures of bronchial artery embolization (BAE), fiberoptic bronchoscopy, rigid bronchoscopy, and surgical resections applied were analyzed …
Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli
Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli
Turkish Journal of Medical Sciences
Background/aim: Systemic sclerosis (SSc) is a chronic systemic disease characterized by vascular damage, autoimmunity, and fibrosis in the skin and internal organs. In this study, we tried to determine the causes of severe infection in patients with SSc and to reveal the factors associated with severe infection. Materials and methods: We retrospectively examined 214 SSc patients between January 2010 and August 2020. Forty-seven patients with at least one severe infection and 167 patients without severe infection were compared. Results: A total of 76 episodes of severe infections were detected in 47 (22%) patients. Common infections included pneumonia, infected digital ulcer, …
Extremely High Erythrocyte Sedimentation Rate Revisited In Rheumatic Diseases: A Singlecenter Experience, Zehra Özsoy, Emre Bi̇lgi̇n, Melek Seren Aksun, İmdat Eroğlu, Umut Kalyoncu
Extremely High Erythrocyte Sedimentation Rate Revisited In Rheumatic Diseases: A Singlecenter Experience, Zehra Özsoy, Emre Bi̇lgi̇n, Melek Seren Aksun, İmdat Eroğlu, Umut Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: The objectives were to define the distribution of rheumatic diseases in patients with erythrocyte sedimentation rate (ESR) ≥ 100 mm/h and to find variables that can differentiate main study groups from others. Materials and methods: Charts of patients admitted with ESR ≥ 100 mm/h between 2015 and 2020 were reviewed. Patients were divided into four diagnostic groups based on etiology: infection (without a rheumatic diagnosis), oncologic (without a rheumatic diagnosis), rheumatic, and no definitive diagnosis. Patients with the rheumatic diagnosis were divided into three main study groups: those who had been recently diagnosed with a rheumatic disease, those who …
Effect Of Vitamin D On Myocardial Remodeling And Inflammatory Status In Children With Congenital Heart Disease, Sabi̇re Gökalp, Fatma Sedef Tunaoğlu, Fatma Canbeyli̇, Semi̇ha Terlemez, Vi̇ldan Atasayan, Lati̇fe Arzu Aral, Serdar Kula, Ayşe Deni̇z Oğuz
Effect Of Vitamin D On Myocardial Remodeling And Inflammatory Status In Children With Congenital Heart Disease, Sabi̇re Gökalp, Fatma Sedef Tunaoğlu, Fatma Canbeyli̇, Semi̇ha Terlemez, Vi̇ldan Atasayan, Lati̇fe Arzu Aral, Serdar Kula, Ayşe Deni̇z Oğuz
Turkish Journal of Medical Sciences
Background/aim: Vitamin D insufficiency is a common public health problem that is often unrecognized in children with congenital heart disease, and is not generally evaluated at congenital heart disease (CHD) follow-up. Recent studies have suggested that inadequate vitamin D status may have an adverse effect on cardiovascular health. This study investigates the relationship between vitamin D levels and hemodynamic parameters in children with CHD. Methods: Included in the study 40 patients (25 females, 15 males) with CHD, who were evaluated for Ross heart failure score, vitamin D, parathyroid hormone (PTH), calcium, phosphorus, alkaline phosphatase (ALP), whole blood count (WBC) and …
The Relationship Between Morning Blood Pressure Surge And Asymptomatic Episodes Of Paroxysmal Atrial Fibrillation In Patients With Systemic Arterial Hypertension, Ümmü Taş, Sedat Taş, İdi̇l Yavuz
The Relationship Between Morning Blood Pressure Surge And Asymptomatic Episodes Of Paroxysmal Atrial Fibrillation In Patients With Systemic Arterial Hypertension, Ümmü Taş, Sedat Taş, İdi̇l Yavuz
Turkish Journal of Medical Sciences
Background/aim: Hypertension is a known risk factor for developing atrial fibrillation. However, there is limited data to investigate the association between morning blood pressure surge (MBPS) and paroxysmal atrial fibrillation (PAF). We conducted the present study to determine whether there is a relationship between asymptomatic PAF and MBPS and whether MBPS may be a predictor of asymptomatic PAF episodes. Materials and methods: This prospective study comprised 264 adult patients who were newly diagnosed with essential hypertension or were previously diagnosed but not receiving regular antihypertensive therapy. We evaluated the patients in 2 groups according to their 24-h electrocardiography monitoring results: …
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Acute cerebral infarction (ACI) occurs as a result of instant disruption of vascular flow that causes disbalance between oxidative/antioxidative activity. We examined the relationship of serum neuro-oxidative stress parameters with stroke severity and infarct volume in ACI and emphasized the qualitative importance of high-density lipoprotein (HDL) on its relationship with myeloperoxidase (MPO) and paraoxonase-1 (PON1) in the acute period of stroke. Materials and methods: One hundred ACI patients applied within the first 24 h and 50 healthy volunteers were included. The patient group was evaluated with demographic data (including arrival serum biochemical assessment), clinical disability scores, infarct volume, serum …
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Turkish Journal of Medical Sciences
Background/aim: Sarcopenia and dementia are growing concerns among older adults that muscle and brain atrophy may cooccur. We aimed to compare the age-related loss of muscle mass by using ultrasound (US), and skeletal muscle mass index (SMI) by bioelectrical impedance analysis in older adults with and without dementia. Materials and methods: A total of 221 older adults aged ≥65 years were included in the study. The diagnosis of sarcopenia was established if low muscle mass according to either SMI or sonographic gastrocnemius (GC) muscle thickness was combined with low grip strength. The diagnosis of dementia was based on the National …