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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Adrenocortical Adenoma And Carcinoma: Histopathological And Molecular Comparative Analysis, A. Stojadinovic, M. F. Brennan, A. Hoos, A. Omeroglu, Denis H. Y. Leung, M. Dudas, A. Nissan, C. Cordon-Cardo, R.A. Ghossein
Adrenocortical Adenoma And Carcinoma: Histopathological And Molecular Comparative Analysis, A. Stojadinovic, M. F. Brennan, A. Hoos, A. Omeroglu, Denis H. Y. Leung, M. Dudas, A. Nissan, C. Cordon-Cardo, R.A. Ghossein
Research Collection School Of Economics
We compared histomorphological features and molecular expression profiles of adrenocortical adenomas (ACAd) and carcinomas (ACCa). A critical histopathological review (mean, 11 slides per patient) was conducted of 37 ACAd and 67 ACCa. Paraffin-embedded tissue cores of ACAd (n = 33) and ACCa (n = 38) were arrayed in triplicate on tissue microarrays. Expression profiles of p53, mdm-2, p21, Bcl-2, cyclin D1, p27, and Ki-67 were investigated by immunohistochemistry and correlated with histopathology and patient outcome using standard statistical methodology. Median follow-up period was 5 years. Tumor necrosis, atypical mitoses, and >1 mitosis per 50 high-power fields were factors that were …
Omission Bias In Vaccination Decision: Where's The "Omission"? Where's The "Bias"?, Terry Connolly, Jochen Reb
Omission Bias In Vaccination Decision: Where's The "Omission"? Where's The "Bias"?, Terry Connolly, Jochen Reb
Research Collection Lee Kong Chian School Of Business
Several studies have reported that parents are often reluctant to vaccinate their own or other people's children, even when the balance of health risks and benefits clearly favors vaccination. This reluctance has been interpreted as a manifestation of omission bias, a general tendency to prefer inactive to active options even when inaction leads to worse outcomes or greater risks. The research raises significant public health concerns as well as worries about human decision biases in general. In this paper we argue that existing research on vaccination decisions has not convincingly demonstrated any general reluctance to vaccinate nor has it made …
Factors Influencing Treatment Patterns In Breast Cancer Patients Age 75 And Over, Arti Hurria, Denis H. Y. Leung, Kathleen Trainor, Patrick Borgen, Larry Norton, Clifford Hudis
Factors Influencing Treatment Patterns In Breast Cancer Patients Age 75 And Over, Arti Hurria, Denis H. Y. Leung, Kathleen Trainor, Patrick Borgen, Larry Norton, Clifford Hudis
Research Collection School Of Economics
To retrospectively determine the factors influencing treatment decisions in older breast cancer patients at a single center. Experimental Design: 216 patients age > or = 75 seen in post-treatment follow-up between January, 1997 and June, 2000 were identified in the Memorial Sloan-Kettering breast cancer database. Eligible patients were > or = 75 years old at diagnosis, had a diagnosis of stage I, II, or III breast cancer, and received their follow-up care at Memorial Sloan Kettering Cancer Center. A retrospective chart review was performed. Patients were stratified by: (1) prognostic factors (age (75-79 or > or = 80), Charlson comorbidity score, tumor size, …
Antifibrinolytic Therapy And Perioperative Blood Loss In Cancer Patients Undergoing Major Orthopedic Surgery, David Amar, Florence M. Grant, Hao Zhang, Patrick J. Boland, Denis H. Y. Leung, John A. Healey
Antifibrinolytic Therapy And Perioperative Blood Loss In Cancer Patients Undergoing Major Orthopedic Surgery, David Amar, Florence M. Grant, Hao Zhang, Patrick J. Boland, Denis H. Y. Leung, John A. Healey
Research Collection School Of Economics
Background: Aprotinin has been reported to reduce blood loss and transfusion requirements in patients having major orthopedic operations. Data on whether epsilon amino-caproic acid (EACA) is effective in this population are sparse.
Methods: Sixty-nine adults with malignancy scheduled for either pelvic, extremity or spine surgery during general anesthesia entered this randomized, double-blind, placebo-controlled trial, and received either intravenous aprotinin (n = 23), bolus of 2 x 10(6) kallikrein inactivator units (KIU), followed by an infusion of 5 x 10(5) KIU/h, or EACA (n = 22), bolus of 150 mg/kg, followed by a 15 mg/kg/h infusion or saline placebo (n = …