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Zyflamend, A Polyherbal Mixture, Down Regulates Class I And Class Ii Histone Deacetylases And Increases P21 Levels In Castrate-Resistant Prostate Cancer Cells, E-Chu Huang, Yi Zhao, Guoxun Chen, Michael F. Mcentee, Steven C. Minkin, Seung J. Baek, John P. Biggerstaff, Jay Whelan
Zyflamend, A Polyherbal Mixture, Down Regulates Class I And Class Ii Histone Deacetylases And Increases P21 Levels In Castrate-Resistant Prostate Cancer Cells, E-Chu Huang, Yi Zhao, Guoxun Chen, Michael F. Mcentee, Steven C. Minkin, Seung J. Baek, John P. Biggerstaff, Jay Whelan
Seung J Baek
BACKGROUND: Zyflamend, a mixture containing extracts of ten herbs, has shown promise in a variety of preclinical cancer models, including prostate cancer. The current experiments were designed to investigate the effects of Zyflamend on the expression of class I and II histone deacetylases, a family of enzymes known to be over expressed in a variety of cancers. METHODS: CWR22Rv1 cells, a castrate-resistant prostate cancer cell line, were treated with Zyflamend and the expression of class I and II histone deacetylases, along with their downstream target the tumor suppressor gene p21, was investigated. Involvement of p21 was confirmed with siRNA knockdown …
Evaluation Of A Semiquantitative Snap Test For Measurement Of Bile Acids In Dogs, Rachel L. Seibert, Karen M. Tobias, Ann Reed, Karl R. Snyder
Evaluation Of A Semiquantitative Snap Test For Measurement Of Bile Acids In Dogs, Rachel L. Seibert, Karen M. Tobias, Ann Reed, Karl R. Snyder
Ann Reed
Background. Serum bile acids (SBA) are used as a routine screening tool of liver function in dogs. Serum samples are usually shipped to a referral laboratory for quantitative analysis with an enzymatic chemistry analyzer. The canine SNAP Bile Acids Test (SNAP-BAT) provides an immediate, semi-quantitative measurement of bile acid concentrations in-house. With the SNAP-BAT, bile acids concentrations of 5–30 µmol/L are quantified, and results outside of that range are classified as <5 or >30 µmol/L. Agreement of the SNAP-BAT with the enzymatic method has not been extensively investigated.
Objectives. The purposes of this prospective clinical study were to assess the precision of …
Evaluation Of A Semiquantitative Snap Test For Measurement Of Bile Acids In Dogs, Rachel L. Seibert, Karen M. Tobias, Ann Reed, Karl R. Snyder
Evaluation Of A Semiquantitative Snap Test For Measurement Of Bile Acids In Dogs, Rachel L. Seibert, Karen M. Tobias, Ann Reed, Karl R. Snyder
Karen M. Tobias DVM, DACVS, College of Veterinary Medicine
Background. Serum bile acids (SBA) are used as a routine screening tool of liver function in dogs. Serum samples are usually shipped to a referral laboratory for quantitative analysis with an enzymatic chemistry analyzer. The canine SNAP Bile Acids Test (SNAP-BAT) provides an immediate, semi-quantitative measurement of bile acid concentrations in-house. With the SNAP-BAT, bile acids concentrations of 5–30 µmol/L are quantified, and results outside of that range are classified as <5 or >30 µmol/L. Agreement of the SNAP-BAT with the enzymatic method has not been extensively investigated. Objectives. The purposes of this prospective clinical study were to assess the precision of …