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Zyflamend, A Polyherbal Mixture, Down Regulates Class I And Class Ii Histone Deacetylases And Increases P21 Levels In Castrate-Resistant Prostate Cancer Cells, E-Chu Huang, Yi Zhao, Guoxun Chen, Michael F. Mcentee, Steven C. Minkin, Seung J. Baek, John P. Biggerstaff, Jay Whelan
Zyflamend, A Polyherbal Mixture, Down Regulates Class I And Class Ii Histone Deacetylases And Increases P21 Levels In Castrate-Resistant Prostate Cancer Cells, E-Chu Huang, Yi Zhao, Guoxun Chen, Michael F. Mcentee, Steven C. Minkin, Seung J. Baek, John P. Biggerstaff, Jay Whelan
Seung J Baek
BACKGROUND: Zyflamend, a mixture containing extracts of ten herbs, has shown promise in a variety of preclinical cancer models, including prostate cancer. The current experiments were designed to investigate the effects of Zyflamend on the expression of class I and II histone deacetylases, a family of enzymes known to be over expressed in a variety of cancers. METHODS: CWR22Rv1 cells, a castrate-resistant prostate cancer cell line, were treated with Zyflamend and the expression of class I and II histone deacetylases, along with their downstream target the tumor suppressor gene p21, was investigated. Involvement of p21 was confirmed with siRNA knockdown …
Tolfenamic Acid Induces Apoptosis And Growth Inhibition In Head And Neck Cancer: Involvement Of Nag-1 Expression, S. U. Kang, Y. S. Shin, H. S. Hwang, Seung J. Baek, S. Lee, C. Kim
Tolfenamic Acid Induces Apoptosis And Growth Inhibition In Head And Neck Cancer: Involvement Of Nag-1 Expression, S. U. Kang, Y. S. Shin, H. S. Hwang, Seung J. Baek, S. Lee, C. Kim
Seung J Baek
Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) is induced by nonsteroidal anti-inflammatory drugs and possesses proapoptotic and antitumorigenic activities. Although tolfenamic acid (TA) induces apoptosis in head and neck cancer cells, the relationship between NAG-1 and TA has not been determined. This study investigated the induction of apoptosis in head and neck cancer cells treated by TA and the role of NAG-1 expression in this induction. TA reduced head and neck cancer cell viability in a dose-dependent manner and induced apoptosis. The induced apoptosis was coincident with the expression of NAG-1. Overexpression of NAG-1 enhanced the apoptotic effect of TA, whereas suppression …