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- Keyword
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- Oral squamous cell carcinoma (2)
- Aged; article; case report; case study; computer assisted tomography; diabetes mellitus; differential diagnosis; female; follicular thyroid carcinoma; histopathology; human; hypertension; mandible; metastasis; nausea and vomiting; physical examination; thorax radiography; thyroid carcinoma (1)
- Animals; Calcium Hydroxide; Dental Cementum; Dental Plaque; Dentin; Diphosphonates; Etidronic Acid; Female; Incisor; Macaca fascicularis; Male; Methylmethacrylates; Periodontal Ligament; Root Canal Filling Materials; Root Canal Obturation; Root Canal Preparation; Root Resorption; Time Factors; Tooth Ankylosis; Tooth Avulsion; Tooth Replantation; Tooth Root; Treatment Outcome; Zinc Oxide-Eugenol Cement (1)
- Betel quid (1)
- CYP1A1 (1)
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Gene Expression In Human Oral Squamous Cell Carcinoma Is Influenced By Risk Factor Exposure, Cheong S. C., Chandramouli G. V. R., Saleh A., Rosnah Binti Zain, Lau S. H., Sivakumaren S., Pathmanathan R., Prime S. S., Teo S. H., Patel V., Gutkind J. S.
Gene Expression In Human Oral Squamous Cell Carcinoma Is Influenced By Risk Factor Exposure, Cheong S. C., Chandramouli G. V. R., Saleh A., Rosnah Binti Zain, Lau S. H., Sivakumaren S., Pathmanathan R., Prime S. S., Teo S. H., Patel V., Gutkind J. S.
Prof. Dr. Rosnah Binti Zain
Oral squamous cell carcinoma (OSCC) is a world health problem and is associated with exposure to different risk factors. In the west, smoking and alcohol consumption are considered to be the main risk factors whilst in India and southeast Asia, betel quid (BQ) chewing is predominant. In this study, we compared the gene expression patterns of oral cancers associated with BQ chewing to those caused by smoking using Affymetrix microarrays. We found that 281 genes were differentially expressed between OSCC and normal oral mucosa regardless of aetiological factors including MMP1, PLAU, MAGE-D4, GNA12, IFITM3 and NMU. Further, we identified 168 …
Cyp1a1, Gstm1 And Gstt1 Polymorphisms And Oral Cancer - Correlation With Patients' Status At 2-Year, Age Of Onset, Nodal Status, Tumor Size And Stage, Abraham M. T., Karen-Ng L. P., Ghani W. M. N., Rosnah Binti Zain, Raja-Latifah R. J., Cheong S. C.
Cyp1a1, Gstm1 And Gstt1 Polymorphisms And Oral Cancer - Correlation With Patients' Status At 2-Year, Age Of Onset, Nodal Status, Tumor Size And Stage, Abraham M. T., Karen-Ng L. P., Ghani W. M. N., Rosnah Binti Zain, Raja-Latifah R. J., Cheong S. C.
Prof. Dr. Rosnah Binti Zain
Altered expression of xenobiotic enzymes such as CYP1A1, GSTM1 and GSTT1 has been reported in some malignant tumors including oral cancer. However, the correlation between these enzymes and clinicopathologic parameters has not been well documented. The aim of this study was to investigate the associations between CYP1A1, GSTM1 and GSTT1 polymorphisms with patients’ status at 2-year, age of onset, nodal status, tumor size and disease stage. A total of 195 oral cancer patients were included in this study. Peripheral blood was obtained from consented individuals and CYP1A1, GSTM1 and GSTT1 genotypes were determined using PCR and restriction enzyme digestion. Chi-square …
Metastatic Follicular Thyroid Carcinoma To The Mandible: A Case Report, Ismail , S. B., Abraham T. , M., Zaini , Z. B., Yaacob , H. B., Rosnah Binti Zain
Metastatic Follicular Thyroid Carcinoma To The Mandible: A Case Report, Ismail , S. B., Abraham T. , M., Zaini , Z. B., Yaacob , H. B., Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Introduction: Metastatic lesions to the oro-facial region may be the first evidence of dissemination of an unknown tumour from its primary site. Case presentation: We described a case of metastatic follicular thyroid carcinoma to the mandible presenting with pain and loosening of teeth in a 70 years old female patient leading to extraction of the loose teeth. Conclusion: The present case emphasizes the importance of considering metastasis in the differential diagnosis of swelling related to loosening of teeth, even though the patient had no history of any malignant disease.
Mdm2 Snp309 Does Not Confer An Increased Risk To Oral Squamous Cell Carcinoma But May Modulate The Age Of Disease Onset, Hamid S., Yang Y. H., Peng K. N. L., Ismail S. M., Rosnah Binti Zain, Lim K. P., Wan Mustafa W. M., Abraham M. T., Teo S. H., Cheong S. C.
Mdm2 Snp309 Does Not Confer An Increased Risk To Oral Squamous Cell Carcinoma But May Modulate The Age Of Disease Onset, Hamid S., Yang Y. H., Peng K. N. L., Ismail S. M., Rosnah Binti Zain, Lim K. P., Wan Mustafa W. M., Abraham M. T., Teo S. H., Cheong S. C.
Prof. Dr. Rosnah Binti Zain
The MDM2 SNP309 has been associated with increased expression of the protein which could suppress p53 function, and has been shown to modulate risk to cancer. We have previously shown that overexpression of MDM2 is a common event in oral cancers. In the present study, we determined the association between the MDM2 SNP309 polymorphism and oral cancer in 207 oral cancer patients and 116 normal subjects. We genotyped the MDM2 SNP309 by PCR-RFLP. Logistic regression was adapted to calculate odds ratios for MDM2 SNP309 polymorphism from univariate and multivariable adjusted models. Our results suggest that MDM2 SNP309 does not confer …
Intracanal Bisphosphonate Does Not Inhibit Replacement Resorption Associated With Delayed Replantation Of Monkey Incisors, Thong Y. L., Messer H. H., Rosnah Binti Zain, Saw L. H., Yoong L. T.
Intracanal Bisphosphonate Does Not Inhibit Replacement Resorption Associated With Delayed Replantation Of Monkey Incisors, Thong Y. L., Messer H. H., Rosnah Binti Zain, Saw L. H., Yoong L. T.
Prof. Dr. Rosnah Binti Zain
Progressive replacement resorption following delayed replantation of avulsed teeth has proved to be an intractable clinical problem. A wide variety of therapeutic approaches have failed to result in the predictable arrest of resorption, with a good long-term prognosis for tooth survival. Bisphosphonates are used in the medical management of a range of bone disorders and topically applied bisphosphonate has been reported to inhibit root resorption in dogs. This study evaluated the effectiveness of a bisphosphonate (etidronate disodium) as an intracanal medicament in the root canals of avulsed monkey teeth, placed before replantation after 1 h of extraoral dry storage. Incisors …
Gstm1, Gstt1 And Cyp1a1 Polymorphisms And Risk Of Oral Cancer: A Case-Control Study In Jakarta, Indonesia, Amtha R., Ching C. S., Rosnah Binti Zain, Razak I. A., Basuki B., Roeslan B. O., Gautama W., Purwanto D.
Gstm1, Gstt1 And Cyp1a1 Polymorphisms And Risk Of Oral Cancer: A Case-Control Study In Jakarta, Indonesia, Amtha R., Ching C. S., Rosnah Binti Zain, Razak I. A., Basuki B., Roeslan B. O., Gautama W., Purwanto D.
Prof. Dr. Rosnah Binti Zain
Purpose: to investigate genetic polymorphisms in GSTM1, GSTT1 and CYP1A1 and the association with the risk of oral cancer in the Jakarta population. Method: A total of 81 cases and 162 controls matched for age and sex were selected from 5 hospitals in Jakarta. Sociodemographic data using questionnaires were obtained and peripheral blood samples were collected with informed consent for PCR-RFLP assay. Conditional logistic regression analysis was performed to obtain the association between the risk of oral cancer and GSTM1, GSTT1 and CYP1A1 polymorphisms. Results: GSTM1 and GSTT1 null were slightly overrepresented among cases (60.5% and 45.7% respectively) compared to …