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Articles 1 - 13 of 13
Full-Text Articles in Medicine and Health Sciences
High-Resolution Physical Map For Chromosome 16q12.1-Q13, The Blau Syndrome Locus., Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams, Gerard Tromp
High-Resolution Physical Map For Chromosome 16q12.1-Q13, The Blau Syndrome Locus., Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams, Gerard Tromp
Charlene Williams
BACKGROUND: The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers, hampered us from further refining the genetic locus for the Blau syndrome. To address this problem, we constructed our own high-resolution physical map for the Blau susceptibility region. RESULTS: We generated a high-resolution physical map that provides more than 90% coverage of a refined Blau susceptibility region. The map consists of four contigs of sequence tagged site-based bacterial artificial chromosomes with a total of 124 bacterial artificial chromosomes, …
Performance Analysis Of Professional, Semiprofessional, And Junior Elite Rugby League Match-Play Using Global Positioning Systems, Chris Mclellan, Dale Lovell
Performance Analysis Of Professional, Semiprofessional, And Junior Elite Rugby League Match-Play Using Global Positioning Systems, Chris Mclellan, Dale Lovell
Chris McLellan
The aim of the present study was to examine the positional differences in physical performance measures of professional, semiprofessional, and junior elite rugby league match-play using portable Global Positioning Systems (GPSs). Twelve professional, 12 semiprofessional, and 18 junior elite male rugby league players were monitored during 5 regular-season competition matches using portable GPS software. The mean total distance traveled during professional (8,371 ± 897 m) and semiprofessional (7,277 ± 734 m) match-play was significantly (p < 0.05) greater than that traveled during elite junior (4,646 ± 978 m) match-play. Position-specific total distance traveled and distance traveled per minute of playing time were significantly (p < 0.05) less for junior elite backs (5,768 ± 765 m; 74 ± 11 m·min-1) and forwards (4,774 ± 564 m; 82 ± 5 m·min-1) in comparison to those in professional (backs: 8,158 ± 673 m; 101 ± 8 m·min-1 and forwards: 8,442 ± 812 m; 98 ± 12 m·min-1) and semiprofessional (backs: 7,505 ± 765 m; 94 ± 8 m·min-1 and forwards: 6,701 ± 678 m; 89 ± 8 m·min-1) match-play. Maximum running speed, maximum sprints, and total sprint distance traveled by professional players were all significantly (p < 0.05) greater than those traveled by junior elite players but not semiprofessional players during match-play. Professional backs and forwards performed significantly (p < 0.05) more maximum sprints and traveled greater total distance during match-play in comparison to semiprofessional and junior elite players. The present findings demonstrate minimal differences in the physical performance measures of professional and semiprofessional rugby league match-play. The position-specific performance characteristics of junior elite match-play indicate that current junior elite player-development pathways may not provide adequate preparation for players transitioning into professional competition.
Risk Of Bias In Industry-Funded Oseltamivir Trials: Comparison Of Core Reports Versus Full Clinical Study Reports, Tom Jefferson, Mark Jones, Peter Doshi, Chris B. Del Mar, Rokuro Hama, Matthew Thompson, Igho Onakpoya
Risk Of Bias In Industry-Funded Oseltamivir Trials: Comparison Of Core Reports Versus Full Clinical Study Reports, Tom Jefferson, Mark Jones, Peter Doshi, Chris B. Del Mar, Rokuro Hama, Matthew Thompson, Igho Onakpoya
Christopher Del Mar
Background: The Cochrane risk of bias tool is a prominent instrument used to evaluate potential biases in clinical trials. In three updates of our Cochrane review on neuraminidase inhibitors, we assessed risk of bias on the same trials using different levels of detail: the trials in journal publications, in core reports, and in full clinical study reports. Here we analyse whether progressively greater amounts of information and detail in full clinical study reports (including trial protocols, statistical analysis plans, certificates of analyses, individual participant data listings and randomisation lists) affected our risk of bias assessments. Methods and findings: We used …
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
Greg Haff
The relationship between isometric force-time curve characteristics and club head speed in recreational golfers. J Strength Cond Res 26(10): 2685-2697, 2012-The primary purpose of the present investigation was to examine the relationships between club head speed, isometric midthigh pull performance, and vertical jump performance in a cohort of recreational golfers. Twelve recreational golfers (age, 20.4 ± 1.0 years; weight, 77.0 ± 9.8 kg; height, 177.8 ± 6.3 cm; body fat, 17.1 ± 7.6%; handicap, 14.5 ± 7.3; experience, 8.9 ± 3.6 years) completed 3 testing sessions: (a) familiarization session and body composition measurements; (b) measurement of forcetime curves in the …
The Acute Effects Of Moderately Loaded Concentric-Only Quarter Squats On Vertical Jump Performance, Aaron Crum, Naoki Kawamori, Michael Stone, Guy Haff
The Acute Effects Of Moderately Loaded Concentric-Only Quarter Squats On Vertical Jump Performance, Aaron Crum, Naoki Kawamori, Michael Stone, Guy Haff
Greg Haff
2012-Limited research exists examining the effect of moderately loaded conditioning activities that are employed as part of a strength-power potentiating complex (SPPC). Additionally, no studies to date have explored the effects of using a concentric-only quarter back squat protocol as part of an SPPC. Therefore, the purpose of this study was to examine the effects of a moderately loaded (50-65% of 1RM) concentric-only quarter back squat protocol on the occurrence of potentiation effects at various time points. Twenty men who could quarter back squat a minimum of 2.4 times their body mass (3.7 ±: 0.7 kg-per body mass) participated in …
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
Prue Cormie
The relationship between isometric force-time curve characteristics and club head speed in recreational golfers. J Strength Cond Res 26(10): 2685-2697, 2012-The primary purpose of the present investigation was to examine the relationships between club head speed, isometric midthigh pull performance, and vertical jump performance in a cohort of recreational golfers. Twelve recreational golfers (age, 20.4 ± 1.0 years; weight, 77.0 ± 9.8 kg; height, 177.8 ± 6.3 cm; body fat, 17.1 ± 7.6%; handicap, 14.5 ± 7.3; experience, 8.9 ± 3.6 years) completed 3 testing sessions: (a) familiarization session and body composition measurements; (b) measurement of forcetime curves in the …
Can Exercise Ameliorate Treatment Toxicity During The Initial Phase Of Testosterone Deprivation In Prostate Cancer Patients? Is This More Effective Than Delayed Rehabilitation?, Robert Newton, Dennis Taaffe, Nigel Spry, Prue Cormie, Suzanne Chambers, Robert Gardiner, David Shum, David Joseph, Daniel Galvao
Can Exercise Ameliorate Treatment Toxicity During The Initial Phase Of Testosterone Deprivation In Prostate Cancer Patients? Is This More Effective Than Delayed Rehabilitation?, Robert Newton, Dennis Taaffe, Nigel Spry, Prue Cormie, Suzanne Chambers, Robert Gardiner, David Shum, David Joseph, Daniel Galvao
Prue Cormie
Background: There has been substantial increase in use of androgen deprivation therapy as adjuvant management of prostate cancer. However, this leads to a range of musculoskeletal toxicities including reduced bone mass and increased skeletal fractures compounded with rapid metabolic alterations, including increased body fat, reduced lean mass, insulin resistance and negative lipoprotein profile, increased incidence of cardiovascular and metabolic morbidity, greater distress and reduced quality of life. Numerous research studies have demonstrated certain exercise prescriptions to be effective at preventing or even reversing these treatment toxicities. However, all interventions to date have been of rehabilitative intent being implemented after a …
The Role Of Rate Of Force Development On Vertical Jump Performance, Christopher Mclellan, Dale Lovell, Gregory Gass
The Role Of Rate Of Force Development On Vertical Jump Performance, Christopher Mclellan, Dale Lovell, Gregory Gass
Chris McLellan
The purpose of this study was to examine a) the relationship between rate of force development (RFD) and vertical jump (VJ) performance during a counter movement jump (CMJ), and b) the reliability of RFD recorded during the CMJ and squat jump (SJ) forms of the VJ. Twenty-three physically active men aged 23 ± 3.9 years participated in the study. Subjects completed 3 unloaded CMJ and 3 unloaded SJ in random order on a force plate. The RFD was measured during CMJ and SJ movements with vertical jump displacement (VJD) measured simultaneously during the CMJ only. Subjects incorporated arm swing to …
A Comparison Of Asynchronous And Synchronous Arm Cranking During The Wingate Test, Dale Lovell, Dale Mason, Elias Delphinus, Christopher Mclellan
A Comparison Of Asynchronous And Synchronous Arm Cranking During The Wingate Test, Dale Lovell, Dale Mason, Elias Delphinus, Christopher Mclellan
Chris McLellan
Purpose: The aim of this study was to compare asynchronous (ASY) arm cranking (cranks at 180° relative to each other) with synchronous (SYN) arm cranking (parallel crank setting) during the 30 s Wingate anaerobic test.
Methods: Thirty-two physically active men (aged 22.1 ± 2.4 y) completed two Wingate tests (one ASY and one SYN) separated by 4 d in a randomized counterbalanced order. The Wingate tests were completed on a modified electromagnetically braked cycle ergometer. Performance measures assessed during the two tests include peak power, mean power, minimum power, time to peak power, rate to fatigue and maximum …
Review Article: Mechanisms And Management Of Hepatotoxicity In Ecstasy (Mdma) And Amphetamine Intoxications, Alison Jones, K Simpson
Review Article: Mechanisms And Management Of Hepatotoxicity In Ecstasy (Mdma) And Amphetamine Intoxications, Alison Jones, K Simpson
Alison L Jones
The social use of ecstasy (methylenedioxymethampheta-mine, MDMA) and amphetamines is widespread in the UK and Europe, and they are popularly considered as ‘safe’. However, deaths have occurred and hepatotox-icity has featured in many cases of intoxication with amphetamine or its methylenedioxy analogues such as ecstasy. Recreational use of these drugs presents an important but often concealed cause of hepatitis or acute liver failure, particularly in young people. The patterns of liver damage and multiple putative mechanisms of injury are discussed. Recognition of the aetiological agent requires a high index of suspicion. Optimum management of the resultant liver damage, including the …
How Prostate Cancer Patients Cope With The Effects Of Diagnosis And Treatment: Development Of The Effects Of Prostate Cancer Coping Strategies Scale, Christopher Sharpley, Vicki Bitsika, David Christie
How Prostate Cancer Patients Cope With The Effects Of Diagnosis And Treatment: Development Of The Effects Of Prostate Cancer Coping Strategies Scale, Christopher Sharpley, Vicki Bitsika, David Christie
Vicki Bitsika
Background: The elevated anxiety and depression experienced by prostate cancer (PCa) patients can impair their decision-making as well as decrease their psychological well-being and weaken relationships with partner and family. Although standardised assessment models exist for identifying the symptoms of anxiety or depression, relatively little attention has been given to identifying the causal antecedents that PCa patients encounter and that may lead to anxiety or depression, nor their own attempts to cope with those antecedents. This study investigated the coping strategies used by a sample of PCa patients in response to the specific stressors and lifestyle changes that arose from …
The Effects Of Laropiprant, A Selective Prostaglandin D₂ Receptor 1 Antagonist, On The Antiplatelet Activity Of Clopidogrel Or Aspirin., Aimee Dallob, Wen-Lin Luo, Julie Mabalot Luk, Lisa Ratcliffe, Amy O Johnson-Levonas, Jules I Schwartz, Victor Dishy, Walter K. Kraft, Jan N De Hoon, Anne Van Hecken, Inge De Lepeleire, Waldemar Radziszewski, John A Wagner, Eseng Lai
The Effects Of Laropiprant, A Selective Prostaglandin D₂ Receptor 1 Antagonist, On The Antiplatelet Activity Of Clopidogrel Or Aspirin., Aimee Dallob, Wen-Lin Luo, Julie Mabalot Luk, Lisa Ratcliffe, Amy O Johnson-Levonas, Jules I Schwartz, Victor Dishy, Walter K. Kraft, Jan N De Hoon, Anne Van Hecken, Inge De Lepeleire, Waldemar Radziszewski, John A Wagner, Eseng Lai
walter k Kraft
Laropiprant (LRPT) is being developed in combination with Merck's extended-release niacin (ERN) formulation for the treatment of dyslipidemia. LRPT, an antagonist of the prostaglandin PGD₂ receptor DP1, reduces flushing symptoms associated with ERN. LRPT also has affinity for the thromboxane A₂ receptor TP (approximately 190-fold less potent at TP compared with DP1). Aspirin and clopidogrel are two frequently used anti-clotting agents with different mechanisms of action. Since LRPT may potentially be co-administered with either one of these agents, these studies were conducted to assess the effects of steady-state LRPT on the antiplatelet activity of steady-state clopidogrel or aspirin. Bleeding time …
Health Alliance For Prudent Antibiotic Prescribing In Patients With Respiratory Tract Infections (Happy Audit) -Impact Of A Non-Randomised Multifaceted Intervention Programme, Lars Bjerrum, Anders Munck, Bente Gahrn-Hansen, Malene Hansen, Dorte Jarbøl, Gloria Córdoba, Carles Llor, Josep Cots, Silvia Hernández, B Lápez-Valcárcel, Antoñia Pérez, Lidia Caballero, Walter Von Der Heyde, Ruta Radzeviciene, Arnoldas Jurgutis, Anatoliy Reutskiy, Elena Egorova, Eva Strandberg, Ingvar Ovhed, Sigvard Mölstad, Robert Stichele, Ria Benkó, Vera Vlahović-Palčevski, Christos Lionis, Marit Rønning
Health Alliance For Prudent Antibiotic Prescribing In Patients With Respiratory Tract Infections (Happy Audit) -Impact Of A Non-Randomised Multifaceted Intervention Programme, Lars Bjerrum, Anders Munck, Bente Gahrn-Hansen, Malene Hansen, Dorte Jarbøl, Gloria Córdoba, Carles Llor, Josep Cots, Silvia Hernández, B Lápez-Valcárcel, Antoñia Pérez, Lidia Caballero, Walter Von Der Heyde, Ruta Radzeviciene, Arnoldas Jurgutis, Anatoliy Reutskiy, Elena Egorova, Eva Strandberg, Ingvar Ovhed, Sigvard Mölstad, Robert Stichele, Ria Benkó, Vera Vlahović-Palčevski, Christos Lionis, Marit Rønning
Malene Hansen
Background: Excessive use of antibiotics is worldwide the most important reason for development of antimicrobial resistance. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious impact on all countries. Initiatives have been taken to improve the quality of antibiotic prescribing in primary care, but only few studies have been designed to determine the effectiveness of multifaceted strategies across countries with different practice setting. The aim of this study was to evaluate the impact of …