Medicine and Health Sciences Commons^™

When Doctors Say "No", Charles Weijer

Charles Weijer

No abstract provided.

Canada’S First Gene Therapy Death, Charles Weijer

Charles Weijer

No abstract provided.

Ethical Challenges Of The Randomized Controlled Trial, Charles Weijer

Charles Weijer

No abstract provided.

Protecting Communities In Research: Current Guidelines And Limits Of Extrapolation, Charles Weijer, Gary Goldsand, Ezekiel Emanuel

Charles Weijer

As genetic research increasingly focuses on communities, there have been calls for extending research protections to them. We critically examine guidelines developed to protect aboriginal communities and consider their applicability to other communities. These guidelines are based on a model of researcher-community partnership and span the phases of a research project, from protocol development to publication. The complete list of 23 protections may apply to those few non-aboriginal communities, such as the Amish, that are highly cohesive. Although some protections may be applicable to less-cohesive communities, such as Ashkenazi Jews, analysis suggests substantial problems in extending these guidelines in toto …

We’Re Alright Jack, Charles Weijer

Charles Weijer

No abstract provided.

Getting Doctors To Listen: Ethics And Outcomes Data In Context, Charles Weijer

Charles Weijer

No abstract provided.

Why I Am Not A Futilitarian (Review Of When Doctors Say No: The Battleground Of Medical Futility), Charles Weijer

Charles Weijer

No abstract provided.

Consensus-Seeking Roundtable On Placebos In Clinical Research, Charles Weijer

Charles Weijer

No abstract provided.

Medical Futility: Physicians, Not Patients, Call The Shots, Charles Weijer

Charles Weijer

No abstract provided.

The Analysis Of Risks And Potential Benefits In Research, Charles Weijer

Charles Weijer

No abstract provided.

Protecting Human Research Subjects: Case-Based Learning For Canadian Research Ethics Boards And Researchers, Françoise Baylis, A. Ireland, David Kaufman, Charles Weijer

Charles Weijer

No abstract provided.

Duty And Healing: Foundations Of A Jewish Bioethic, Benjamin Freedman, Charles Weijer

Charles Weijer

No abstract provided.

Integrating Bioethics And Health Law Into The Canadian Institutes Of Health Research, Susan Sherwin, FrançOise Baylis, Alan Bernstein, Timothy Caulfield, Bernard Dickens, Jocelyn Downie, Bartha Knoppers, ThéRèSe Leroux, Neil Macdonald, Michael Mcdonald, Janet Storch, Charles Weijer

Charles Weijer

No abstract provided.

Bioethics For Clinicians: 16. Dealing With Demands For Inappropriate Treatment, Charles Weijer, Peter Singer, Bernard Dickens, Stephen Workman

Charles Weijer

Demands by Patients or their Families for treatment thought to be inappropriate by health care providers constitute an important set of moral problems in clinical practice. A variety of approaches to such cases have been described in the literature, including medical futility, standard of care and negotiation. Medical futility fails because it confounds morally distinct cases: demand for an ineffective treatment and demand for an effective treatment that supports a controversial end (e.g., permanent unconsciousness). Medical futility is not necessary in the first case and is harmful in the second. Ineffective treatment falls outside the standard of care, and thus …

Reb Review Of Research Proposals Involving Placebo Controls, Charles Weijer

Charles Weijer

No abstract provided.

Society’S Choices: Social And Ethical Decision Making In Biomedicine, Charles Weijer

Charles Weijer

No abstract provided.

Spilker's Guide To Clinical Trials On Cd-Rom, Charles Weijer

Charles Weijer

No abstract provided.

Selecting Subjects For Participation In Clinical Research: An Empirical Inquiry And Ethical Analysis, Charles Weijer

Charles Weijer

Procedures for the selection of subjects for participation in randomized clinical trials--usually formalized as eligibility criteria in the study protocol--have both scientific and ethical implications. In this thesis, I undertake an examination of eligibility criteria at three stages in the genesis and dissemination of medical knowledge: clinical trial protocol, interpretation by investigators, and reporting of study results.

In the first chapter, ethical issues in subject selection are reviewed and the main study questions are presented. In the second chapter, the results of an examination of eligibility criteria in two sets of clinical trials, one sponsored by the NSABP, the other …

The Human Radiation Experiments: Final Report Of The Advisory Committee On Human Radiation Experiments, Charles Weijer

Charles Weijer

No abstract provided.

Bioethics For Clinicians: 10. Research Ethics, Charles Weijer, Bernard Dickens, Eric Meslin

Charles Weijer

Medical research involving human subjects raises complex ethical, legal and social issues. Investigators sometimes find that their obligations with respect to a research project come into conflict with their obligations to individual patients. The ethical conduct of research rests on 3 guiding principles: respect for persons, beneficience, and justice. Respect for persons underlies the duty to obtain informed consent from study participants. Beneficence demands a favourable balance between the potential benefits and harms of participation. Justice requires that vulnerable people not be exploited and that eligible candidates who may benefit from participation not be excluded without good cause. Studies must …

Full House: The Spread Of Excellence From Plato To Darwin, Charles Weijer

Charles Weijer

No abstract provided.

Film And Narrative In Bioethics: Akira Kurosawa's Ikiru, Charles Weijer

Charles Weijer

No abstract provided.

Queer Science: The Use And Abuse Of Research Into Homosexuality, Charles Weijer

Charles Weijer

No abstract provided.

Ethical Issues In Research, Charles Weijer

Charles Weijer

No abstract provided.

Do The Right Thing, Charles Weijer

Charles Weijer

McGill ethicists help ensure that medical research conforms to the highest scientific and ethical standards.

Wrong Medicine: Doctors, Patients, And Futile Treatment, Charles Weijer

Charles Weijer

No abstract provided.

Cruel And Unusual Treatment, Carl Elliott, Charles Weijer

Charles Weijer

No abstract provided.

Characterizing The Population In Clinical Trials: Barriers, Comparability, And Implications For Review, Charles Weijer

Charles Weijer

The definition of the study population for a clinical trial via the criteria for trial eligibility has implications for the validity of the study and its applicability to clinical practice. Though issues of equity regarding the selection of subjects for research have long been a concern of ethicists, issues regarding the impact of subject selection on a trial's generalizability have only recently attracted ethical scrutiny. After a review of the history of the ethics of subject selection, I focus on three empirical questions regarding the generalizability of clinical trials. (1) What proportion of diseased populations are studied in clinical trials? …

The Ethics And Politics Of Human Experimentation, Charles Weijer

Charles Weijer

No abstract provided.

Our Bodies, Our Science, Charles Weijer

Charles Weijer

No abstract provided.