Medicine and Health Sciences Commons^™

Genotype And Cardiovascular Phenotype Correlations With Tbx1 In 1,022 Velo-Cardio-Facial/Digeorge/22q11.2 Deletion Syndrome Patients, Tingwei Guo, Donna Mcdonald-Mcginn, Anna Blonska, Alan L. Shanske, Anne S. Bassett, Eva Chow, Mark Bowser, Molly Sheridan, Frits Beemer, Koen Devriendt, Ann Swillen, Jeroen Breckpot, Maria C. Digilio, Bruno Marino, Bruno Dallapiccola, Courtney Carpenter, Xin Zheng, Jacob Johnson, Jonathan Chung, Anne Marie Higgins, Nicole Philip, Tony J. Simon, Karlene Coleman, Damian Heine-Suner, Jordi Rosell, Wendy R. Kates, Marcella Devoto, Elizabeth Goldmuntz, Elaine Zackai, Tao Wang, Robert J. Shprintzen, Beverly Emanuel, Bernice Morrow, The International Chromosome 22q11.2 Consortium

Communication Disorders Faculty Publications

Haploinsufficiency of TBX1, encoding a T-box transcription factor, is largely responsible for the physical malformations in velo-cardio-facial /DiGeorge/22q11.2 deletion syndrome (22q11DS) patients. Cardiovascular malformations in these patients are highly variable, raising the question as to whether DNA variations in the TBX1 locus on the remaining allele of 22q11.2 could be responsible. To test this, a large sample size is needed. The TBX1 gene was sequenced in 360 consecutive 22q11DS patients. Rare and common variations were identified. We did not detect enrichment in rare SNP (single nucleotide polymorphism) number in those with or without a congenital heart defect. One exception …

Shu Nursing Faculty Awarded Diamond Jubilee Awards For The Second Consecutive Year, Shery Watson

Shery Watson

No abstract provided.

Physical Therapy News, Volume 1, Issue 1, College Of Health Professions

Physical Therapy News

No abstract provided.

Use Of The Term "Elderly", Dale Avers, Marybeth Brown, Kevin Chui, Rita A. Wong, Michelle M. Lusardi

All PTHMS Faculty Publications

Using the term elderly for a person who is robust and independent as well as for a person who is frail and dependent says little about the individual.

Cleft Palate, Retrognathia And Congenital Heart Disease In Velo-Cardio-Facial Syndrome: A Phenotype Correlation Study, Marcia A. Friedman, Nathanial Miletta, Cheryl Roe, Dongliang Wang, Bernice Morrow, Wendy R. Kates, Anne Marie Higgins, Robert J. Shprintzen

Communication Disorders Faculty Publications

Objective: Velo-cardio-facial syndrome (VCFS) is caused by a microdeletion of approximately 40 genes from one copy of chromosome 22. Expression of the syndrome is a variable combination of over 190 phenotypic characteristics. As of yet, little is known about how these phenotypes correlate with one another or whether there are predictable patterns of expression. Two of the most common phenotypic categories, congenital heart disease and cleft palate, have been proposed to have a common genetic relationship to the deleted T-box 1 gene (TBX1). The purpose of this study is to determine if congenital heart disease and cleft palate are correlated …

Identifying And Co-Managing The Hiv-Infected Adult: A Guidebook For Primary Care Clinicians, Jason Leider, Susan F. Lelacheur, Julie G. Stewart Dnp, Mph

Nursing Faculty Publications

This guidebook was designed to help primary care clinicians improve their performance in terms of HIV identification and co-management. Surmounting barriers to opt-out screening, making an HIV diagnosis, and preventing transmission and opportunistic infections will be discussed, as will selection of initial therapy and considerations for patients receiving antiretroviral therapy (ART).

Characterizing And Predicting Outcomes Of Communication Delays In Infants And Toddlers: Implications For Clinical Practice, Rhea Paul, Forma P. Roth

Communication Disorders Faculty Publications

Purpose: This article focuses on using currently available data to assist speech-language pathologists (SLPs) in making decisions regarding a child's eligibility and considerations for recommended "dosage" of early intervention (El) services. Method: Literature describing the characteristics of infants and toddlers who are likely recipients of El services was reviewed. Results: Current literature provides information that can be used to inform clinical decisions for infants and toddlers with established medical conditions, as well as those with risk factors, for oral language, communication, and subsequent literacy disabilities. This information is summarized. Conclusion: Extant literature suggests that El makes a critical difference in …

Sally J. Rogers And Geraldine Dawson: Review Of Early Start Denver Model For Young Children With Autism: Promoting Language, Learning And Engagement (Book Review), Rhea Paul

Communication Disorders Faculty Publications

Book review by Rhea Paul:

Rogers, Sally R. and Geraldine Dawson. Early Start Denver Model for Young Children with Autism: Promoting Language, Learning and Engagement. New York: Guilford Press, 2010. 9781606236321; 9781606234914 (pbk.)

Acute Arginine Supplementation Fails To Improve Muscle Endurance Or Affect Blood Pressure Responses To Resistance Training, Beau K. Greer, Brett T. Jones

All PTHMS Faculty Publications

Dietary supplement companies claim that arginine supplements acutely enhance skeletal muscular endurance. The purpose of this study was to determine whether acute arginine a-ketoglutarate supplementation (AAKG) will affect local muscle endurance of the arm and shoulder girdle or the blood pressure (BP) response to anaerobic exercise. Twelve trained college-aged men (22.6 +/- 3.8 years) performed 2 trials of exercise separated by at least 1 week. At 4 hours before, and 30 minutes before exercise, a serving of an AAKG supplement (3,700 mg arginine alpha-ketoglutarate per serving) or placebo was administered. Resting BP was assessed pre-exercise after 16 minutes of seated …

Neuroanatomic Predictors To Prodromal Psychosis In Velocardiofacial Syndrome (22q11.2 Deletion Syndrome): A Longitudinal Study, Wendy R. Kates, Kevin M. Antshel, Stephen V. Faraone, Wanda Fremont, Anne Marie Higgins, Robert J. Shprintzen, Jo-Anna Botti, Lauren Kelchner, Christopher Mccarthy

Communication Disorders Faculty Publications

Background: Up to 30% of young adults with velocardiofacial syndrome (VCFS; 22q11.2 deletion syndrome) develop schizophrenia or psychosis. Identifying the neuroanatomic trajectories that increase risk for psychosis in youth with this genetic disorder is of great interest. Methods: We acquired high-resolution anatomic MR images and measures of psychiatric function on 72 youth with VCFS, 26 unaffected siblings and 24 age-matched community controls at two timepoints, between late childhood (mean age, 11.9 years) and mid-adolescence (mean age, 15.1 years). Results: With the exception of cranial gray matter and orbitofrontal prefrontal cortex, neuroanatomic trajectories in youth with VCFS were comparable to unaffected …

Out Of The Mouths Of Babes: Vocal Production In Infant Siblings Of Children With Asd, Rhea Paul, Yael Fuerst, Gordon Ramsay, Kasia Chawarska, Ami Klin

Communication Disorders Faculty Publications

Background: Younger siblings of children with autism spectrum disorders (ASD) are at higher risk for acquiring these disorders than the general population. Language development is usually delayed in children with ASD. The present study examines the development of pre-speech vocal behavior in infants at risk for ASD due to the presence of an older sibling with the disorder. Methods: Infants at high risk (HR) for ASD and those at low risk, without a diagnosed sibling (LR), were seen at 6, 9, and 12 months as part of a larger prospective study of risk for ASD in infant siblings. Standard clinical …

Infants At Risk For Asd Show Aberrant Preferences For Speech At Six To Nine Months, Rhea Paul, Gerald Mcroberts, Katyrzyna Chawarska

Communication Disorders Faculty Publications

Purpose: To examine auditory preferences for speech stimuli in infants at risk for Autism Spectrum Disorder due to the presence of a diagnosed sibling.

Exercise Science Program Co-Organizes Fit Kids Field Day In Norwalk, Wendy Bjerke Ph.D.

Wendy Bjerke Ph.D.

Wendy Bjerke, clinical assistant professor of SHU’s Department of Exercise Science as well as director of the University’s Wellness Program, said the Fit Kids program has been an excellent opportunity for the Exercise Science undergraduates who have served as program guides to gain service knowledge. “They have learned about exercise programming for children, health promotion and health education, which is all within the context of my Exercise Physiology course,” she said. Designed to teach elementary school students about nutrition, physical activity and healthy choices, the program runs each year from January to May, with an hour-long session held twice a …

Exploring The Five Phases Of Physical Therapist Professional Development Advanced By The Clinical Doctorate Degree, Salome V. Brooks

All PTHMS Faculty Publications

The American Physical Therapy Association (APTA) 2020 strategic plan mandated that the clinical doctor of physical therapy degree (DPT) will be the minimum practice standard. The APTA failed to articulate a functional practice description recognizing the varying levels of preparation. The current literature validates the existence of a stepwise pattern of professional development in similarly evolving disciplines. Applied nursing research by Benner (Benner model of professional development, 2001) identified five stages of professional development and characteristics that were useful in the discipline's advancement. The purpose of the study was to apply the structure of the Benner Model to physical therapy …

The Hypothesis Of Apraxia Of Speech In Children With Autism Spectrum Disorder, Lawrence D. Shriberg, Rhea Paul, Lois M. Black, Jan P. Van Santen

Communication Disorders Faculty Publications

In a sample of 46 children aged 4-7 years with Autism Spectrum Disorder (ASD) and intelligible speech, there was no statistical support for the hypothesis of concomitant Childhood Apraxia of Speech (CAS). Perceptual and acoustic measures of participants' speech, prosody, and voice were compared with data from 40 typically-developing children, 13 preschool children with Speech Delay, and 15 participants aged 5-49 years with CAS in neurogenetic disorders. Speech Delay and Speech Errors, respectively, were modestly and substantially more prevalent in participants with ASD than reported population estimates. Double dissociations in speech, prosody, and voice impairments in ASD were interpreted as …

A Comparison Of Muscular Activation During The Back Squat And Deadlift To The Countermovement Jump, David Robbins Cscs, Nasm-Cpt

SHU Theses and Dissertations

The purpose of this study was to determine whether the back squat (BS) or deadlift (DL) is most similar to the countermovement jump (CMJ) in terms of peak muscular activation. The muscles assessed in this study were the erector spinae (ES), gluteus maximus (GM), biceps femoris (BF), vastus medialis (VM), and gastrocnemius (GN). These five muscles were chosen do to their involvement in all of these exercises. Ten college-aged males (24±1.18yrs) with a minimum of 1 year strength training experience volunteered for this study. Participants must have been strength trained and could BS and DL 1.5 x bodyweight. Results showed …

The Acute Effect Of Self-Myofascial Release On Lower Extremity Plyometric Performance, Brian J. Fama, David R. Bueti

SHU Theses and Dissertations

The purpose of this study was to evaluate the acute effect of a Foam Roller (FR) warm up routine and a dynamic warm-up routine on strength, power, and reactive power using a squat jump (SJ) countermovement jump (CMJ) and depth jump (DJ). Nine college aged recreational males with a minimum of 1-year experience in plyometric training completed the study. Following baseline testing, subjectswere randomly assigned to a warm up protocol on the second session of the study and then completed the otherprotocol on the third day of the study. The best of three jumps were recorded. RMANOVA revealed a significant …

Are Scores On The Ppt Useful In Determination Of Risk Of Future Falls In Individuals With Dementia?, Mary K. Farrell, Richard A. Rutt, Michelle M. Lusardi, Ann K. Williams

All PTHMS Faculty Publications

Individuals with dementia or Alzheimer’s disease (AD), exhibit both a progressive decline in cognitive function and accumulating difficulty with physical function.¹ As cognitive impairment begins, individuals will initially demonstrate difficulties with short-term memory and with instrumental activities of daily living. As the dementia progresses, individuals will increasingly demonstrate difficulties with long-term memory, communication, and basic activities of daily living.

Assessment Of Functional Throwing Ability In Individuals With Low Expressive Autistic Spectrum Disorders, Marissa Defede

Undergraduate Honors Theses

Impairments in social interaction, communication and repetitive, restricted behaviors are seen in individuals with Autistic Spectrum Disorders (ASD). No study has ever determined the differences in movement patterns of individuals with Low Expressive Autistic Spectrum Disorder (LE-ASD) while throwing a ball. If differences in throwing patterns between an LE-ASD population and a typically developing population are determined, then the more thorough description of ASD movement impairments would be evident. Furthermore, these differences could demonstrate that older individuals with LE-ASD have a deficit in movement patterns rather than a delay.

Mapping Cortical Morphology In Youth With Velocardiofacial (22q11.2 Deletion) Syndrome, Wendy R. Kates, Ravi Bansal, Wanda Fremont, Xuejun Hao, Anne Marie Higgins, Jun Liu, Robert J. Shprintzen, Bradley S. Peterson

Communication Disorders Faculty Publications

Objective: Velo-cardio-facial syndrome (VCFS; 22q11.2 deletion syndrome) represents one of the highest known risk factors for schizophrenia. Insofar as up to thirty percent of individuals with this genetic disorder develop schizophrenia, VCFS constitutes a unique, etiologically homogeneous model for understanding the pathogenesis of schizophrenia.

Method: Using a longitudinal, case-control design, we acquired anatomic magnetic resonance images to investigate both cross-sectional and longitudinal alterations in surface cortical morphology in a cohort of adolescents with VCFS and age-matched typical controls. All participants were scanned at two time points.

Results: Relative to controls, youth with VCFS exhibited alterations in inferior frontal, dorsal frontal, …

Lifeskills Training Wellness Program: An Application For Young Adults In Supermarkets, Christopher Williams, Jessica Samuolis, Kenneth W. Griffin, Gilbert J. Botvin

Psychology Faculty Publications

To address the need for workplace substance use prevention programming, National Health Promotion Associates (NHPA) developed the LifeSkills Training Wellness Program (LST-WP) with funding from the Substance Abuse and Mental Health Services Administration’s (SAMHSA’s) Young Adults in the Workplace (YIW) grant program. LST-WP adapts and extends the highly effective, school-based LifeSkills Training (LST) model program (Botvin, 1998; Botvin et al., 1995) and provides comprehensive skills training for adolescent and young adult employees in communication, problem-solving, conflict resolution, drug resistance, and related life skills. Overall, the program is designed to be highly flexible to meet employee and manager needs across different …

Acute Arginine Supplementation Fails To Improve Muscle Endurance Or Affect Blood Pressure Responses To Resistance Training., Beau Kjerulf Greer, Brett T. Jones

Beau K. Greer

Dietary supplement companies claim that arginine supplements acutely enhance skeletal muscular endurance. The purpose of this study was to determine whether acute arginine α-ketoglutarate supplementation (AAKG) will affect local muscle endurance of the arm and shoulder girdle or the blood pressure (BP) response to anaerobic exercise. Twelve trained college-aged men (22.6 ± 3.8 years) performed 2 trials of exercise separated by at least 1 week. At 4 hours before, and 30 minutes before exercise, a serving of an AAKG supplement (3,700 mg arginine alpha-ketoglutarate per serving) or placebo was administered. Resting BP was assessed pre-exercise after 16 minutes of seated …

Branched-Chain Amino Acid Supplementation Lowers Perceived Exertion But Does Not Affect Performance In Untrained Males., Beau Kjerulf Greer, James P. White, Eric M. Arguello, Emily M. Haymes

Beau K. Greer

The purpose of this study was to determine whether branched-chain amino acid (BCAA) supplementation affects aerobic performance, ratings of perceived exertion (RPE), or substrate utilization as compared with an isocaloric, carbohydrate (CHO) beverage or a noncaloric placebo (PLAC) beverage. Nine untrained males performed three 90-minute cycling bouts at 55% VO₂ peak followed by 15-minute time trials. Subjects, who were blinded to beverage selection, ingested a total of 200 kcal via the CHO or BCAA beverage before and at 60 minutes of exercise or the PLAC beverage on the same time course. RPE and metabolic measurements were taken every 15 minutes …

Refereed Articles Or Books Published During 2010-2011, College Of Health Professions

SHU Faculty Publications

This is a bibliography of faculty scholarship published during the academic year 2010-2011.

The Neural Underpinnings Of Prosody In Autism, Inge-Marie Eigsti, Jillian Schuh, Einar Mencl, Robert T. Schultz, Rhea Paul

Communication Disorders Faculty Publications

This study examines the processing of prosodic cues to linguistic structure and to affect, drawing on fMRI and behavioral data from 16 high-functioning adolescents with autism spectrum disorders (ASD) and 11 typically developing controls. Stimuli were carefully matched on pitch, intensity, and duration, while varying systematically in conditions of affective prosody (angry versus neutral speech) and grammatical prosody (questions versus statement). To avoid conscious attention to prosody, which normalizes responses in young people with ASD, the implicit comprehension task directed attention to semantic aspects of the stimuli. Results showed that when perceiving prosodic cues, both affective and grammatical, activation of …

Reflections (2011 Issue), College Of Health Professions

College of Health Professions Newsletters & Magazines

"The continuous growth and diversification of programs in the College of Education and Health Professions has led the University to a decision to reconfigure the college into two distinct academic units -- the Isabelle Farrington College of Education and the College of Health Professions. The transition began with an announcement in May, and the new structure will be effective July 1, 2011"--From Dean Patricia Walker's introduction to this issue of Reflections.

Work Intensity And Substance Use Among Adolescents Employed Part-Time In Entry-Level Jobs, Jessica Samuolis

Psychology Faculty Publications

This study investigated the relationship between number of hours worked, or work intensity, and substance use in a sample of adolescent employees of a supermarket chain. Employees working half-time or more per week (high-intensity hours) were over three times as likely to smoke compared to those working an average of 10 hours or less per week (low-intensity hours). Males working a high intensity number of hours were more than twice as likely to drink compared to males working at low intensity. Utilizing participants drawn from a uniform employment setting, the research findings add to the growing body of evidence linking …

Addressing The Fertility Needs Of Hiv-Seropositive Males, Brian A. Levine, Sahadat K. Nurudeen, Jennifer T. Gosselin, Mark V. Sauer

Psychology Faculty Publications

An increasing number of serodiscordant couples are utilizing advanced reproductive technologies to address their reproductive needs. Recent literature has demonstrated that it is not only technically possible but also safe to utilize sperm-washing techniques to allow for the creation of embryos, thereby preventing both horizontal and vertical transmission of HIV. This article addresses the strengths and weakness of various reproductive techniques and discusses our experience at Columbia University (NY, USA), the location of the largest HIV-focused fertility program in the USA.

The Impact Of Infectious Disease On Chronic Disease: A Review Of Contemporary Findings, Wendy Bjerke

All PTHMS Faculty Publications

Infectious diseases are among the top causes of death in adults and children. Chronic diseases such as cardiovascular disease and cancer are among the top causes of death in adults. Associations between bacterial and viral infectious agents and subsequent development of chronic disease have been made in the past but are currently being reexamined with more rigor and specificity. This review examines infectious disease agent causes and associations with cancer, cardiovascular disease, metabolic disease, and neurodegenerative disease. These associations will impact future research, surveillance, treatment, and prevention of both infectious and chronic diseases.

Fitness And Adiposity As Predictors Of Functional Limitation In Adults, Andréa L. Maslow, Anna E. Price, Xuemei Sui, Duck-Chul Lee, Ikka Vuori, Steven N. Blair

All PTHMS Faculty Publications

This study examined the associations of body mass index (BMI), waist circumference (WC), and cardiorespiratory fitness (CRF) with incident functional limitation (IFL) in adults. Patients (n = 2400), 30+ years [mean age, 45.2 (SD, 8.3); 12% women], completed a baseline health examination during 1979 to 1995. CRF was quantified by age-and sex-specific thirds for maximal treadmill exercise test duration. Adiposity was assessed by BMI and WC (grouped for analysis according to clinical guidelines). Incident IFL was identified from mail-back surveys during 1995, 1999, and 2004. After adjusting for potential confounders and either BMI or WC, CRF was inversely related to …