Medicine and Health Sciences Commons^™

Birs Course: Rna Vaccine Manufacture And Assessment Of Regulatory Documents For Rna Vaccines, Stephen R. Byrn, Nathaniel Milton, Kari L. Clase

BIRS Technical Report Papers

This paper is in three segments: (A) Segment on Vaccine Manufacture; (B) Segment on Ready to Use (RTU) Fluid Path for Compounded Sterile Preparations, mRNA Vaccines, and Phage Therapy, (C) Segment on Competency Framework for Addressing Regulatory Review These segments can be used separately or in combination. Additionally, they can be presented in any order. The time devoted to each segment depends on the depth of the course coverage. These segments are interrelated and describe how to make vaccines, how to manufacture vaccines with a point-of-care system built from ready-to-use parts; and how to regulate vaccines. This is a timely …

The Association Between Inflammatory Diet And Infection-Related Cancers In Adults: A Systematic Review, Alfu Laily, Jason B. Reed, Madeline Q. Powers, Anna Giuliano, Monica Kasting

Libraries Faculty and Staff Supplemental Materials

Poster presented at the 2023 American Academy of Health Behavior conference. Presents preliminary results of a systematic review investigating the relationship between inflammatory dietary patterns and infection-related cancers in adults.

Disparities In Medicare Beneficiaries’ Receiving Medication Synchronization, Prajakta H. Waghmare, Chien-Yu Huang, Heather A. Jaynes, Wendy M. Green, Margie E. Snyder, Omolola A. Adeoye-Olatunde, Antoinette B. Coe, Joel F. Farley, Alan Zillich

Department of Pharmacy Practice Faculty Publications

Background

Medication synchronization (med-sync) aligns patients’ monthly or quarterly chronic medications to a predetermined single pickup date at a community pharmacy. The study objective was to examine med-sync enrollment disparities based on Medicare beneficiaries’ predisposing, enabling, and need characteristics.

Methods

This was a retrospective cohort study using a Medicare dataset of beneficiaries receiving medications from pharmacies that self-identified as providing med-sync. Medicare beneficiaries who were continuously enrolled in fee-for-service medical and pharmacy benefits during the study period (2014–2016) were included. Study cohorts (med-sync and non–med-sync patients) were defined, and bivariate and multivariable logistic regression analyses were performed. Andersen’s Health …

The Discovery Of Data-Driven Temporal Dietary Patterns And A Validation Of Their Description Using Energy And Time Cut-Offs, Luotao Lin, Jiaqi Guo, Yitao Li, Saul Gelfand, Edward Delp, Anindya Bhadra, Elizabeth Richards, Erin Hennessy, Heather A. Eicher-Miller

School of Nursing Faculty Publications

Objectives

Data-driven methods were recently applied to create temporal dietary patterns (TDPs) incorporating timing and amount of energy intake over 24-hours; their relationships to obesity were determined. However, description of the data-driven TDPs using energy and time cut-offs were not validated against obesity. Aims were to (1) create data-driven TDPs, describe pattern characteristics using energy and time cut-offs, and determine relationships to BMI and waist circumference (WC); (2) assess the concurrent validity of TDPs derived using the cut-offs by determining relationships with BMI and WC. Methods

Amount and timing of energy intake from the first day 24-hour dietary recall of …

The Impact Of Service Dogs On Objective And Perceived Sleep Quality For Veterans With Ptsd, Madhuri Vempati, Elise A. Miller, Sarah C. Leighton, Leanne O. Nieforth, Marguerite O’Haire

Discovery Undergraduate Interdisciplinary Research Internship

One in four post-9/11 veterans (Fulton et al., 2015) have been diagnosed with posttraumatic stress disorder (PTSD), facing sleep disruptions as one of their most common symptoms. Service dogs have become an increasingly popular complementary intervention and anecdotes suggest they may impact sleep for veterans with PTSD. There is a need for empirical investigation into these claims through measurement and analysis of sleep quality.

The purpose of this study was to longitudinally investigate the impact of service dogs on sleep quality through both objective and subjective measures.

Participants in the treatment group (n=92) received a service dog after baseline, while …

Candida Auris: Emergence Of A Multi-Drug Resistant Fungal Pathogen, Garrett Bryak, Brooke Tharp, Rachel Zheng

Discovery Undergraduate Interdisciplinary Research Internship

Candida auris is an emerging fungal pathogen that poses a significant public health concern due to the species’ increasing resistance to a vast array of FDA-approved antifungal drugs and high mortality rate. The pathogenic fungus has also proven difficult to identify within a conventional diagnostic laboratory and has been responsible for numerous outbreaks in healthcare settings across the globe, as noted by the Center for Disease Control and Prevention (source). This research effort aims to provide a comprehensive review detailing the history, origin, and biological characteristics of C. auris with particular emphasis on analyzing the nature of C. auris’s multidrug-resistant …

Momentary Energy Levels In Healthcare Professionals Working With Facility Dogs, Shania Sinha, Clare Jensen, Marguerite O'Haire

Discovery Undergraduate Interdisciplinary Research Internship

Past research has shown that pediatric healthcare professionals working with full-time therapy dogs (facility dogs) reported less work-related burnout and better mental health overall. However, specific in-the-moment effects of facility dogs on healthcare professionals have yet to be examined. The purpose of this study was to use Ecological Momentary Assessment (EMA) to assess the effects of facility dog presence on momentary energy levels of pediatric healthcare professionals. EMA data for the present study were collected from 122 healthcare professionals working in pediatric hospitals. Within the sample, participants working with a facility dog (handlers; n=61) were …

Deep Learning Approach To Improved Image Quality For Medical Diagnostics, Olivia Loesch, Katie Leyba, Halyley Chan, Craig Goergen

Discovery Undergraduate Interdisciplinary Research Internship

The United Nation’s health-related Sustainable Development Goals are difficult to achieve in low- and middle-income countries due to workforce shortages and inadequate health surveillance systems. However, with the growth of artificial intelligence (AI) and computer algorithms, it is possible to apply AI to healthcare technologies to improve progress towards these UN standards. This project aims at using and improving computer algorithms and deep learning to aid in the extraction of important structural and functional information from murine carotid artery ultrasound and photoacoustic images. First, we created a large database of simulated photoacoustic images to optimize the algorithms. These images were …

Teaching With Data In The Social Sciences: The Purdue Report, Jane Yatcilla, Clarence Maybee, Bethany Mcgowan, Gang Shao, D Trevor Burrows

Libraries Reports

Purdue University Libraries participated in a multi-institution study about how instructors teach with data in social sciences courses. Thirteen semi-structured interviews were conducted with social sciences faculty who teach undergraduate students to use data, addressing questions about how faculty connect students to data; how students work with data; what types of support faculty have received that informs their teaching with data. Four broad themes emerged from qualitative coding of the interview transcripts: an array of purposes and practices for teaching about data; instructors' experiences, needs, and perspectives; managing wide-ranging student confidence and ability; technical concerns when teaching with data. The …

Quantitative Proteomics And Phosphoproteomics Reveal Tnf-Α-Mediated Protein Functions In Hepatocytes, Rodrigo Mohallem, Uma K. Aryal

Department of Veterinary Clinical Sciences Faculty Publications

Increased secretion of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNFα), is often associated with adipose tissue dysregulation, which often accompanies obesity. High levels of TNFα have been linked to the development of insulin resistance in several tissues and organs, including skeletal muscle and the liver. In this study, we examined the complex regulatory roles of TNFα in murine hepatocytes utilizing a combination of global proteomic and phosphoproteomic analyses. Our results show that TNFα promotes extensive changes not only of protein levels, but also the dynamics of their downstream phosphorylation signaling. We provide evidence that TNFα induces DNA replication and …

Systemic Copper Disorders Influence The Olfactory Function In Adult Rats: Roles Of Altered Adult Neurogenesis And Neurochemical Imbalance, Sherleen Xue-Fu Adamson, Wei Zheng, Zeynep Sena Agim, Sarah Du, Sheila Fleming, Jason Cannon

School of Health Sciences Faculty Publications

Disrupted systemic copper (Cu) homeostasis underlies neurodegenerative diseases with early symptoms including olfactory dysfunction. This study investigated the impact of Cu dyshomeostasis on olfactory function, adult neurogenesis, and neurochemical balance. Models of Cu deficiency (CuD) and Cu overload (CuO) were established by feeding adult rats with Cu-restricted diets plus ip. injection of a Cu chelator (ammonium tetrathiomolybdate) and excess Cu, respectively. CuD reduced Cu levels in the olfactory bulb (OB), subventricular zone (SVZ), rostral migratory stream (RMS), and striatum, while CuO increased Cu levels in these areas. The buried pellet test revealed both CuD and CuO prolonged the latency to …

Mechanisms Of Neurotoxicity Associated With Exposure To The Herbicide Atrazine, Sydney C. Stradtman, Jennifer L. Freeman

School of Health Sciences Faculty Publications

Atrazine is an herbicide commonly used on crops to prevent broadleaf weeds. Atrazine is an endocrine-disrupting chemical mainly targeting the neuroendocrine system and associated axes, especially as a reproductive toxicant through attenuation of the luteinizing hormone (LH). Current regulatory levels for chronic exposure are based on no observed adverse effect levels (NOAELs) of these LH alterations in rodent studies. Atrazine has also been studied for its effects on the central nervous system and neurotransmission. The European Union (EU) recognized the health risks of atrazine exposure as a public health concern with no way to contain contamination of drinking water. As …

Development Of Continuous Flow Sonogashira Coupling Of Lead Anti-Cancer Small Molecule Inhibitors For Potential Treatment Of Acute Myeloid Leukemia, Yuta W. Moriuchi, Shruti A. Biyani, David H. Thompson

Discovery Undergraduate Interdisciplinary Research Internship

As the technology for science develops, the research strategy in medicines and therapeutics also improves. In this paper, I will cover the process of Sonogashira cross-coupling and Amide Coupling reaction for an anticancer agent in both batch and flow chemistry. Continuous Flow Chemistry has advantages such as being more efficient, safer, and faster. This paper studies the synthesis of HSNO608, an anticancer lead compound for Acute Myeloid Leukemia (AML), which has a specific potent activity to FTL3 Kinase. Inhibition of FLT3 Kinase leads to inhibition of downstream pathways such as MPK and P13K pathways. In this two-step experiment, the Sonogashira …

Photocatalytic Inactivation Efficacy Of Sars-Cov-2 In Hvac Systems, Andrew J. Freeman, Sudharshan Anandan, Ernest R. Blatchley Iii, W. Travis Horton, David M. Warsinger

Discovery Undergraduate Interdisciplinary Research Internship

The coronavirus pandemic has emphasized a need for robust and reliable air purification systems in buildings; with that comes a need for a standardized testing methodology for air purification technologies in HVAC air circulation systems. One such method of air purification is photocatalytic oxidation (PCO), a mechanism in which a catalyst irradiated by light produces reactive molecules that degrade a wide range of pollutants, including the aerosols that carry COVID. This technology has primarily been used in aqueous applications, but there have recently been developments in air purification that have made it a promising contender to existing technologies. One of …

Research And Scholarly Methods: Semi-Structured Interviews, Omolola A. Adeoye-Olatunde, Nicole Olenik

Department of Pharmacy Practice Faculty Publications

The popularity and value of qualitative research has increasingly been recognized in health and pharmacy services research. Although there is certainly an appropriate place in qualitative research for other data collection methods, a primary benefit of the semi-structured interview is that it permits interviews to be focused while still giving the investigator the autonomy to explore pertinent ideas that may come up in the course of the interview, which can further enhance understanding of the pharmacy service being assessed. The purpose of this narrative review is to summarize methodological considerations and procedures for conducting semi-structured interviews in pharmacy services research. …

A Mixed-Methods Study Of Pharmacy Instructors' Early Experiences With A Teaching Electronic Medical Record, Omolola A. Adeoye-Olatunde, Olga O. Vlashyn, Kimberly Plake, Jamie L. Woodyard, Zachary A. Weber, Debra K. Litzelman, Alissa L. Russ-Jara

Department of Pharmacy Practice Faculty Publications

Introduction

As use of electronic medical records (EMRs) increases in healthcare, multiple accreditation organizations recommend training future clinicians on EMRs as part of the academic curriculum. Therefore, some pharmacy programs now utilize an academic EMR. Our objective was to examine pharmacy instructors' early experiences with a commercially available teaching EMR (tEMR) in order to identify current and future priorities along with benefits and barriers to academic EMR use in pharmacy education.

Methods

We conducted semi-structured interviews and a web-based survey with pharmacy instructors. Interview and survey data analyses consisted of hybrid inductive/deductive approaches to coding data and descriptive statistics, …

Positive Deviants For Medication Therapy Management: A Mixed-Methods Comparative Case Study Of Community Pharmacy Practices, Omolola A. Adeoye-Olatunde, Leslie M. Lake, Celena Strohmier, Amanda K. Gourley, Ashli R. Ray, Alan J. Zillich, Margie E. Snyder

Department of Pharmacy Practice Faculty Publications

Background

To optimize medication use in older adults, the Centers for Medicare & Medicaid Services (CMS) launched Medication Therapy Management (MTM) services as part of Medicare Part D policy; however, strategies for achieving high quality MTM outcomes are not well understood.

Objective

The objective of this study was to generate hypotheses for strategies contributing to community pharmacies’ high performance on policy-relevant MTM quality measures.

Methods

This mixed-methods comparative case study was guided by the Positive Deviance approach and Chronic Care Model. The study population consisted of pharmacy staff employed by a Midwestern division of a national supermarket-community pharmacy chain. Data …

Public Policy Origins Of U.S. Data, Bert Chapman

Libraries Faculty and Staff Presentations

Provides detailed introduction and overview of public policy origins of U.S. data. Shows how congressional legislation and Office of Management and Budget documents influence compilation and dissemination of U.S. Government data. Stresses how Indiana General Assembly requirements influence compilation of Indiana state agency data and Indiana local government agency data. Places emphasis on roles played in data compilation and dissemination by public policy research institutions/think tanks. Concludes by stressing limitations of data collection by governmental and non-governmental entities.

Complementing The Us Food And Drug Administration Adverse Event Reporting System With Adverse Drug Reaction Reporting From Social Media: Comparative Analysis, Zeyun Zhou, Kyle Emerson Hultgren

Purdue University Libraries Open Access Publishing Fund

Background: Adverse drug reactions (ADRs) can occur any time someone uses a medication. ADRs are systematically tracked and cataloged, with varying degrees of success, in order to better understand their etiology and develop methods of prevention. The US Food and Drug Administration (FDA) has developed the FDA Adverse Event Reporting System (FAERS) for this purpose. FAERS collects information from myriad sources, but the primary reporters have traditionally been medical professionals and pharmacovigilance data from manufacturers. Recent studies suggest that information shared publicly on social media platforms related to medication use could be of benefit in complementing FAERS data in order …

Patterns And Predictors Of Older Adult Medicare Part D Beneficiaries’ Receipt Of Medication Therapy Management, Antoinette B. Coe, Omolola A. Adeoye-Olatunde, Deborah L. Pestka, Margie Snyder, Alan Zillich, Karen B. Farris, Joel F. Farley

Department of Pharmacy Practice Faculty Publications

Background

Medicare Part D medication therapy management (MTM) includes an annual comprehensive medication review (CMR) as a strategy to mitigate suboptimal medication use in older adults.

Objectives

To describe the characteristics of Medicare beneficiaries who were eligible, offered, and received a CMR in 2013 and 2014 and identify potential disparities.

Methods

This nationally representative cross-sectional study used a 20% random sample of Medicare Part A, B, and D data linked with Part D MTM files. A total of 5,487,343 and 5,822,188 continuously enrolled beneficiaries were included in 2013 and 2014, respectively. CMR use was examined among a subset of 620,164 …

Urban Warfare: Emerging Geopolitical Conundrum, Bert Chapman

Libraries Faculty and Staff Presentations

Urban warfare is as old as human history. It is becoming increasingly important in international political and military planning due to increasing global urbanization and the presence of megacities (urban areas with populations exceeding 10 million) in many global regions and being in areas of recent and potential military conflict. 2018 World Bank data notes that approximately 56% of the world's population lives in urban areas which is up from 34% in 1960. Many of these megacities, including New York City, Los Angeles, Sao Paulo, Mumbai, Shanghai, and Manila are adjacent to oceanic waters and vulnerable to trade and supply …

Process Evaluation Of An Email-Based Walking Program With Extension Educators, Elizabeth Richards

School of Nursing Faculty Publications

This study evaluated the implementation process of an email-based walking program from the perspectives of program deliverers. Twenty-four Extension Educators participated in the process evaluation. We used an online survey to examine the perceptions of the implementation process of Get WalkIN’, a twelve-week email-based walking program. Educators agreed that the provided program training and recruitment materials were sufficient for successful program delivery. Program implementation involved sending emails to program participants at least weekly. Educators also agreed that the program was easy to deliver and took twenty minutes or less to implement each week. Strengths and areas for program improvement are …

Exploring Language Use Within A Parent-Mediated Intervention For Children Exhibiting Social Communication Difficulties, Emily Garza, Ashleigh Kellerman, Christi Masters, A.J. Schwichtenberg

Discovery Undergraduate Interdisciplinary Research Internship

For infants/toddlers experiencing social communication difficulties, parent-mediated interventions (PMI) are the current field standard to promote development within a natural context. Previous research highlights the importance for parents to scaffold language learning opportunities beyond clinical settings to maximize children’s potential. However, for infants/toddlers exhibiting social communication-based difficulties currently enrolled in a family routines-based PMI, less is known about the individual contributions of communication between child and parent in order to promote optimal language development.

The present study expands our understanding of children’s communication by examining whether (1)children exhibit language impairments at enrollment; (2)whether observed mother-child communication during play increases following …

Statewide Dissemination Of An Evidenced-Based Email Walking Program Delivered Through Cooperative Extension, Elizabeth A. Richards, Stephanie Woodcox, Anna Forster

Purdue University Libraries Open Access Publishing Fund

Using the RE-AIM framework, this study evaluates the statewide dissemination of an evidenced-based, email-delivered physical activity intervention implemented through Cooperative Extension. The Get WalkIN' program is comprised of 16 email messages sent over 12 weeks. Email messages target social cognitive theory constructs of self-efficacy, goal-setting, self-monitoring, and social support. Program reach, effectiveness, adoption, implementation, and maintenance were assessed with quantitative measures in a pre-post design. Findings indicate that within the Extension system, program adoption was high and program maintenance was moderate. Program effectiveness was demonstrated with an increase of 77.1 ± 49.9 min in weekly walking post-program. This increase in …

Internet Of Things For Sustainable Human Health, Abdul Salam

Faculty Publications

The sustainable health IoT has the strong potential to bring tremendous improvements in human health and well-being through sensing, and monitoring of health impacts across the whole spectrum of climate change. The sustainable health IoT enables development of a systems approach in the area of human health and ecosystem. It allows integration of broader health sub-areas in a bigger archetype for improving sustainability in health in the realm of social, economic, and environmental sectors. This integration provides a powerful health IoT framework for sustainable health and community goals in the wake of changing climate. In this chapter, a detailed description …

Syllabus For Phrm 49000 Conversations About Death And Dying, Jason B. Reed, Chelsea M. Baker

Libraries Faculty and Staff Creative Materials

Class syllabus for Conversations on Death and Dying from spring 2020

Community Pharmacists’ And Residents’ Decision Making And Unmet Information Needs When Completing Comprehensive Medication Reviews, Kacie L. Mcpherson, Omolola A. Adeoye-Olatunde, Jayna M. Osborne, William R. Doucette, Stephanie A. Gernant, Heather Jaynes, Shobha Phansalkar, Alissa L. Russ-Jara, Margie E. Snyder

Department of Pharmacy Practice Faculty Publications

Objective

To (1) characterize community pharmacists’ and community pharmacy residents’ decision making and unmet information needs when conducting comprehensive medication reviews (CMRs) as part of medication therapy management and (2) explore any differences between community pharmacists and community pharmacy residents in CMR decision making and unmet information needs.

Design

Thirty-to 60-minute semistructured interviews framed using a clinical decision-making model (CDMM) were conducted with community pharmacists and residents.

Setting and participants

Participants were recruited from practice-based research networks and researchers’ professional networks. Eligible participants had completed or supported the completion of at least 2 CMRs in the last 30 days.

Outcome …

Appendices And Codebook For Evaluating Nursing Faculty's Use Of Frameworks And Standards In Information Literacy Instruction: A Multi-Institutional Study, Bethany S. Mcgowan, Laureen Cantwell, Jamie Conklin, Julie Planchon Wolf, Maribeth Slebodnik, Rebecca Raszewski, Sandy Mccarthy, Shannon Johnson

Libraries Faculty and Staff Supplemental Materials

In January 2018, the ACRL Health Sciences Interest Group (HSIG) convened a working group to revise the ACRL Information Literacy Competency Standards for Nursing (2013) into a Framework for Information Literacy in Higher Education for Nursing. For nearly two years, the working group has conducted research to understand how nursing faculty integrate information literacy instruction in nursing education. Results from a review of the literature and surveying of nursing faculty at nine higher education institutions suggest that a majority of nursing faculty are unaware of the ACRL Framework for Information Literacy for Higher Education but are intentional in using the …

Glioma Mimics: Magnetic Resonance Imaging Characteristics Of Granulomas In Dogs, Lauren Diangelo, Aaron A. Cohen-Gadol, Hock Gan Heng, Margaret A. Miller, Devon W. Hague, John H. Rossmeisl, Robin T. Bentley

Purdue University Libraries Open Access Publishing Fund

Granulomas can “mimic” gliomas on magnetic resonance imaging (MRI) in human patients. The goal of this retrospective study was to report canine brain granulomas that were consistent with glioma based upon MRI, report their histologic diagnosis, and identify MRI criteria that might be useful to distinguish granuloma from glioma. Ten granulomas, initially suspected to be glioma based on MRI, were ultimately diagnosed as granulomatous meningoencephalomyelitis (n = 5), infectious granulomas (n = 3) or other meningoencephalitis (n = 2). Age was 1.6–15.0 years and two dogs were brachycephalic breeds. MRI characteristics overlapping with glioma included intra-axial, heterogeneous, …

Amorphous Solid Dispersion Formation Via Solvent Granulation – A Case Study With Ritonavir And Lopinavir, Niraj S. Tirasi, Sonal Bhujbal, Qi Tony Zhou, Lynne Taylor

Department of Industrial and Physical Pharmacy Faculty Publications

Herein, we evaluate the potential of using a simple solvent granulation process to prepare a binary drug amorphous solid dispersion (ASD) containing two anti-HIV drugs, ritonavir and lopinavir. The drugs were granulated onto a mixture of lactose and microcrystalline cellulose, followed by drying to remove the solvent. The resultant granules were characterized and each drug was found to be X-ray amorphous. No crystallization was observed following storage for 1 month under accelerated stability conditions (40 °C and 75% relative humidity). The dissolution behavior of the compacted granules was compared with the marketed formulation. The dissolution rate of ritonavir was found …