Medicine and Health Sciences Commons^™

A Data Collection Program For Reducing Ipv In Lgbtq+ Communities, Alexandra Michel, Nicholas Cheke, Lourdes Gonzalez, Rachel Greim

OHSU-PSU School of Public Health Annual Conference

Sexual and gender minority populations are not currently being accurately tracked or counted in most domestic violence (DV) and intimate partner violence (IPV) surveillance programs in Oregon. However, research indicates that LGBTQ+ populations experience IPV at rates comparable or even higher than heterosexual populations. Additionally, distrust of law enforcement and services designed around heterosexual experiences of IPV further reduce the ability of LGBTQ+ populations, particularly transgender women, to access IPV services. We propose that through the use of a PRECEED-PROCEED model, a program could be developed to more accurately collect sexual orientation and gender identity data by IPV service providers …

A New Method For Assessing Smoking Behavior In Orthopaedic Patients, David Gallacher

OHSU-PSU School of Public Health Annual Conference

“A New Method for Assessing Smoking Behavior in Orthopaedic Patients”

Background:Tobacco use is associated with post-operative complications and self-reporting often introduces a bias that underestimates the true exposure. Traditional tobacco testing methods, including serum cotinine are associated with issues of specificity, as they do not differentiate active smokers from those on nicotine replacement therapies (NRTs). This study intends to evaluate the effectiveness of point-of-care carbon monoxide (CO) breathalyzer test to assess patient smoking status and to differentiate active smokers from those using NRTs.

Methods:Eligible patients will be >18 years old and indicated for joint or fracture surgery at …

Validity Of An Atopic Dermatitis Outcome Measure For Real-World Clinical Practice, Christina Topham, Dylan Haynes, Molly Brazil, Eric Simpson

OHSU-PSU School of Public Health Annual Conference

Introduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the United States. AD is associated with reduced quality of life and substantial financial costs, making it burdensome at an individual and population level. Disease severity outcome measures are validated tools to assess severity and therapeutic response. Recent consensus statements have identified gold-standard outcome measures for AD in clinical trials, but further work is needed evaluating outcome measures feasible for clinical practice.

Objective: To investigate the validity and feasibility of the product of investigator global assessment and body surface area (IGA x BSA) as an outcome measure …

Take Control: A Proposed Mental Health Treatment Program To Be Implemented In Youth Correctional Facilities Around Oregon Based On The Evidence-Based Target Program, Zoey S. Rochefort

OHSU-PSU School of Public Health Annual Conference

70% of youth in state and local juvenile justice systems exhibit symptoms of one or more mental health disorders and are not receiving adequate treatment. Currently, in Oregon, there is no mental health-screening requirement for youth admitted into detention centers or correctional facilities. Though this doesn’t mean kids never get diagnosed, it does mean there is a large delay in time before treatment begins where they could be receiving care. The Take Control program is working to mitigate wasted time and improve mental health treatment for youth inmates through a seven-step treatment program that provides youth with steps and strategies …

Improving Access To Rare Disease Clinical Trials Through Telemedicine, Dylan Haynes, Christina Topham, Teri Greiling

OHSU-PSU School of Public Health Annual Conference

Introduction: Rare diseases affect nearly 400 million individuals worldwide. The geographic density of any single disease, however, can prohibit access to care and research efforts. Telemedicine has improved access barriers in the clinical setting, though its application in rare disease trials has not been evaluated.

Objective: To assess the impact on access to care of videoconferencing in a rare disease clinical trial.

Materials and Methods: Preliminary analysis was performed on the first five participants to complete our ongoing trial (NCT03485976) evaluating the efficacy of ixekizumab for the treatment of pityriasis rubra pilaris. Participants were required to travel to Oregon Health …

A Visual Exploration Of Walking In Mild Traumatic Brain Injury (Mtbi), Bryana Popa

OHSU-PSU School of Public Health Annual Conference

Visual exploration of the environment is vital for safe and effective walking, and is influenced by cognitive load. Eye movement deficits can occur following mTBI and may impact visual exploration when walking, leading to issues with mobility. This study aims to examine visual exploration when walking under single and dual-task in mTBI and controls.

Sixteen people with mTBI (Age: 30.1±12.8 yrs, days since injury: 39.5±21.7) and 10 healthy controls (Age: 26.3±5.2 yrs) walked for 1 minute while wearing a mobile eye tracker under single and dual-task conditions. The primary outcome was visual exploration measured by saccade frequency (sacc/sec). Secondary outcomes …

Study Of Physical Literacy And Physical Fitness In School Children, Natalie T. Pexton

OHSU-PSU School of Public Health Annual Conference

Background: Currently there is no standard physical education (P.E.) assessment for tracking students’ progress across the state. As a result, there is little data on the physical literacy and physical fitness of school children which are essential to lifelong physical activity.

Physical Literacy is the confidence, knowledge, and ability to execute fundamental movement skills like hopping, throwing, and kicking.

Cardiorespiratory fitness is a measure of the stamina and capacity to perform aerobic exercise.

Objective: To test the “PlayFun” physical literacy and “Pacer” cardiorespiratory fitness tests with Portland Public School students.

Methods:

Setting: Two Portland Public School district elementary …

Preventing Infectious Hematopoietic Necrosis In Salmonid Fish Along The Columbia River Basin, Whitney L. Wright

OHSU-PSU School of Public Health Annual Conference

Infectious hematopoietic necrosis virus (IHNV) is a member of the Rhabdoviridae family and causes infectious hematopoietic necrosis (IHN) disease in many salmonid species during the juvenile or “fry” stage of life. IHNV is endemic to Western North America and occurs in the Columbia River Basin, where Steelhead and Chinook salmon are the most abundant IHNV-vulnerable species. IHNV can cause an epidemic in wild or farmed stocks, killing 90-95 percent of the fish it infects. Transmission is currently understood to occur by direct exposure through the gills, and the virus is shed typically from asymptomatic or clinically ill carrier adults at …

Utility Of Spirometry As A Measurement Tool To Evaluate Breathing And Swallowing Coordination (Bsc), Aamna Malik, Jessica Thurman, Deanna Britton, Andrew Demetrius Palmer, Donna Jensen Graville

Student Research Symposium

Breathing swallowing coordination (BSC) is commonly evaluated using nasal thermistry and respiratory inductance plethysmography. In this study, BSC will be evaluated via spirometry in healthy adults. Spirometry may yield additional useful information regarding BSC in adults with neurodegenerative diseases.

Metallodithiolate Ligands For Reversing Metal Ion Induced Aggregation Of Beta Amyloid, Eleanor K. Adams, Marilyn Rampersad Mackiewicz

Student Research Symposium

Alzheimer’s Disease (AD) is the sixth leading cause of death in the United States with no known methods to cure, reverse or halt disease progression. The “metal hypothesis” states that Fe^II, Cu^II, Zn^II, and Al^II bind to truncated Aβ peptides and form soluble oligomers which deposit as senile plaques. These plaques play a crucial role in AD pathogenesis. For example, metallated-Aβ aggregates are hypothesized to disrupt membranes or generate a reactive oxygen species (ROS) through redox cycling in the presence of Cu^I/II or Fe^III/II and a reducing agent. ROS can lead …

Effects Of Chronic Stimulation Of Nucleus Accumbens On Binge Drinking And Transcriptome, Dar'ya Pozhidayeva, Evan Firsick, Kayla G. Townsley, Dan Iancu, Angela Ozburn, A.T.D. Tran

Student Research Symposium

We previously found that stimulating activity in the nucleus accumbens (NAc) reduced binge-like alcohol drinking in mice. We manipulated the NAc using clozapine-n-oxide (CNO) and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). In a subsequent study, we tested the hypothesis that chronic administration of CNO (to stimulate excitatory DREADDs expressed in the NAc) could produce lasting reductions in binge drinking (as compared with mice receiving vehicle). We observed that 4 weeks of CNO administration resulted in reductions in binge-like drinking that lasted at least 1 week. Based on these results, we hypothesized that transcriptional changes may underlie the observed …

Inhibiting Infectivity Of The Spindle Shaped Virus Using Silver Nanoparticles, Diana S. Demchenko

Student Research Symposium

Exploring the inhibiting factors of silver nanoparticles could change the way we approach drug-resistant viruses. In previous research, silver nanoparticles have shown to physically block viruses, such as HIV-1, from infecting its host by theoretically binding to surface receptors on the virus. Since there is little research done in this area, we have decided to combine silver nanoparticles with a virus that thrives within an extreme environment: the Spindle Shaped virus. By combining these two factors, we could reveal the biological and chemical properties that block the virus from infecting its host, Sulfolobus. Currently, we have collected data that shows …

Mindfulness Meditation As A Stress Reactivity Intervention: An Event-Related Potential Study, Jessica L. Trottier, Barry S. Oken

Student Research Symposium

The biological and neural mechanisms of stress have been extensively studied and supported, but are still unclear. Event-related potentials (ERP’s) emitted by neurons in the brain are a useful tool in measuring stress because they reflect neural response in real-time, to the millisecond, versus typical biological markers, which are typically evaluated before and after a stress test. The neurobiological relationship between ERP’s and stress originates in the anterior cingulate cortex, which in turn activates the hypothalamic–pituitary–adrenal axis; the main physiological cascade fueling the stress response and its chronically harmful symptoms. Malfunctions in the stress response, as in the cases of …

Evaluating Knowledge Of Developmental Disabilities Among Wic Participants, Carolina Regalado Murillo, Katharine Zuckerman, Alison Chavez, Julie A. Reeder

Student Research Symposium

Background: Children in racial/ethnic minority and low-income families are more likely to experience low rates of early developmental disability (DD) diagnosis. Racial/ethnic and language differences in parent information about DDs could contribute to diagnostic delays, but little is known about differences in parent DD familiarity.

Objectives: To assess DD knowledge and information in a sample of low-income families.

Methods: We conducted a self-administered survey on 539 parents attending their child’s appointment at the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in six Oregon counties. Survey items assessed familiarity with early signs of DDs, self-reported knowledge about DDs, …

Mujeres Fuertes Y Corazones Saludables: Adaptation Of The Strongwomen—Healthy Hearts (Swhh) Program For Rural Latinas Using An Intervention Mapping Approach, Christie L. Jackson, Cynthia K. Perry, Jean Mccalmont, Emma Solanki, Rebecca Seguin, Judy P. Ward, Hannah-Dulya K. Menelas

Student Research Symposium

Objectives: To adapt Strong Women, Healthy Hearts (SWHH), an evidence-based physical activity and nutrition program to reflect the needs of rural Latinas.

Methods: Using a community-based participatory approach and an intervention mapping process, we partnered with a community advisory board of rural Latinas to identify and adapt a nutrition and physical activity program. A needs assessment and a logic model determined which program best aligned with community objectives and most fit for adaptation. SWHH was adapted; using feedback from the community advisory board to reflect the community’s culture, resources, and needs. We collaborated with one of developers of SWHH in …

Comparing The Effects Of Phonomotor Treatment And Semantic Feature Analysis On Discourse Production For Individuals With Aphasia, Kasey Graue

Student Research Symposium

Phonomotor treatment is a program designed to address anomic deficits in people with aphasia (PWA) by training speech sounds in isolation before progressing to sound combinations and single words (Kendall et al., 2013). Kendall et al. (2015) investigated phonomotor treatment in a sample of 26 PWA, reporting improved naming of untrained nouns and ultimate generalization of phonologic processing abilities. Despite emerging literature on the effects of the phonomotor treatment on single word production, research is limited at the discourse level. This study’s objective is to examine the extent that phonomotor treatment used for PWA increases the amount of correct information …

Nonword Reading In Children Who Do And Do Not Stutter, Bailey Broxson, Laura Qualls, Tram Nguyen

Student Research Symposium

Stuttering is a multifactorial disorder characterized by disruptions in the forward flow of speech (ASHA). Previous research has demonstrated that children and adults who stutter have phonological working memory systems that are less efficient and accurate than children and adults who do not stutter. This difference in phonological working memory plays a key role in the production of stuttered speech. Anecdotally, speech-language pathologists who work with children who stutter report that three clients also demonstrate difficulty decoding novel works during reading tasks. To date, the link between phonological working memory, stuttered speech, and reading have not been explored. The purpose …

The Rise And Fall Of Human Dissection In Hellenistic Alexandria, Ellie H. Barany

Young Historians Conference

Classical and Hellenistic Greece were known to be a hub of scientific research. However, the potential for scientific discovery was limited by dominating religious beliefs. Advancements in the study of human anatomy were inhibited by religious taboos that prevented the practice of human dissection. These taboos took hold of Greek society, with a consequence of exile to anyone who violated them. The exception however, is in Hellenistic Alexandria under the rule of the Ptolemaic Kings, Soter and Philadelphus. This paper examines the factors under which the Greek scientist Herophilus was allowed to practice systematic human dissection, as well as the …

To What Extent Did Blood Transfusion Systems And Technologies Modernize During World War Ii?, Hannah J. Leblanc

Young Historians Conference

This investigation will explore changes in blood transfusion during World War II (1939-1945). Medical technology and collection systems for whole blood and blood plasma in particular will be examined. The focus of this investigation will be the United States, but Great Britain will also be mentioned due to its close blood transfusion-related interactions with the United States during this period. Additionally, blood transfusion prior to World War II and in modern times will also be considered in this investigation to provide context and to allow assessment of modernization during the war. However, artificial blood substitutes will not be considered, nor …

A Study To Evaluate The Maximal Dose Administration At Two Different Locations In Two Different Vdr4 High Frequency Percussive Ventilator (Hpfv) Circuits, Jeff L. Heltborg, Bethany S. Kobza, Ace Nilson

Student Research Symposium

The purpose of this study was to determine if the positioning of a nebulizer at two different locations in the VDR4, a specialty ventilator, would result in differing dose administrations of a bronchodilator, Albuterol Sulfate. We hypothesized that placement near the endotracheal tube will provide greater dose deposition. The ventilator was set up to mimic the normal adult patient. Administration was done through the nebulizer placed in the ventilator circuit either before the humidifier or between the endotracheal tube and the VDR 4’s Phasitron. Three trials were performed using a standard dose of Albuterol for each trial. The mass of …

A Program Evaluation Of A Housing With Services Project For Low-Income Adults In Portland, Oregon, Jack A. Phillips, Paula C. Carder, Diana White

Student Research Symposium

Reducing hospital use and connecting individuals to local available services and supports are key features of the Affordable Care Act. Adult residents of public housing tend to experience worse health outcomes than other adults. Poor self-rated health and high rates of emergency department use and hospitalization among these residents have prompted efforts to improve health outcomes. Even among residents living independently, prior research indicates that health and social disparities can be effectively addressed through coordinated care and improved access to health and social services.

Cedar Sinai Park—a nonprofit residential care organization located in Portland, Oregon—will implement a demonstration project attempting …

Using Radiation Therapy For Mesothelioma, Samira Rezaei

Student Research Symposium

This poster details research that shows that patients who suffer from mesothelioma cancer and choose Immune Therapy treatment have a longer survival rate in comparison with other methods of treatment.

Polyethylenimine-Enhanced Alumina Nanoscale Adjuvant For Cancer Vaccine, Naoko Uno, Haiyan Li, Hong-Ming Hu, Jun Jiao

Student Research Symposium

Aluminum oxide nanoparticles (Al2O3 NPs) have been shown to increase the efficiency of cell-mediated immune response. Specifically, CD8 and CD4 immune response is required for T cell activation by dendritic cells. These nanoparticles, when functionalized with peptides and other molecules, can be used as vaccine in cancer treatment. In this study, Al2O3 NPs were attached to E6/E7 proteins. HPV-induced cervical cancer expresses E6/E7 antigens. E6/E7 proteins were attached using surface modification of the Al2O3 NPs; different types of molecules were tested to see which adhered the highest amount of protein and produced the strongest cell response. Protein measurements were done …