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Synthesis And Characterization Of Novel Reformulated Bioactive Paclitaxel Complexes And Considerations For Administration Via Inhalation Method For Targeted Lung Cancer Treatment, Teighlor Nicole Livingston
Synthesis And Characterization Of Novel Reformulated Bioactive Paclitaxel Complexes And Considerations For Administration Via Inhalation Method For Targeted Lung Cancer Treatment, Teighlor Nicole Livingston
PCOM Biomedical Studies Student Scholarship
Paclitaxel is a natural plant product derived from bark of the Pacific Yew Tree. The secondary metabolite has been extensively studied and developed as an anticancer agent for the treatment of ovarian, breast, and lung cancer. A significant issue with the drug is its low water solubility⏤ requiring the utilization of drug vehicles for effective drug administration. Two novel paclitaxel-containing drugs, Cu5Fe5PAC and (CUPAC)5GLU12DALB, are synthesized and tested against the National Cancer Institute’s sixty cell line panel for anticancer activity. The drugs are also analyzed using MALDI-TOF-MS, FT-IR, and 1H-NMR. One major concern with paclitaxel is the toxicity associated with …