Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
The Role Of Bkca Channel Expression And Functional Regulation On The Development Of Pulmonary Hypertension In Type 2 Diabetic Individuals, Tahirah Nimi
PCOM Biomedical Studies Student Scholarship
Human pulmonary artery smooth muscle cells (HPASMC) maintain the vascular tone and exhibit myogenic reactivity in the pulmonary arteries. The BKCa channel, being the predominate K+ channel within the HPASMC, is important in regulating the pulmonary arterial pressure and because the BKCa channel’s activity can be modulated by various molecules, studies have evaluated the role that altered BKCa channel expression and function plays in the dysfunction of the HPASMC during type 2 diabetes (T2D). The results from those studies provided a basis for this project. In this study, cell cultures, western blot experiments, and cAMP assays …
Potential Differences In Male Versus Female Lymph Nodes, Vikas Damineni
Potential Differences In Male Versus Female Lymph Nodes, Vikas Damineni
PCOM Biomedical Studies Student Scholarship
The lymphatic system is one of the latest anatomical organ systems to have been discovered, and as a result, it can be considered the least understood. Limited research exists on the quantitative and qualitative values of lymph nodes. The pelvic and axillary region is anatomically unique for each sex. Observing if this extends to the lymph nodes themselves will create a clearer understanding of the lymphatic system for the medical community. The present study sought to establish potential differences in male and female lymph nodes. Quantitative data of male and female lymph nodes were collected through cadaver dissection. Fifty-three cadavers …
Synthesis And Characterization Of Novel Reformulated Bioactive Paclitaxel Complexes And Considerations For Administration Via Inhalation Method For Targeted Lung Cancer Treatment, Teighlor Nicole Livingston
Synthesis And Characterization Of Novel Reformulated Bioactive Paclitaxel Complexes And Considerations For Administration Via Inhalation Method For Targeted Lung Cancer Treatment, Teighlor Nicole Livingston
PCOM Biomedical Studies Student Scholarship
Paclitaxel is a natural plant product derived from bark of the Pacific Yew Tree. The secondary metabolite has been extensively studied and developed as an anticancer agent for the treatment of ovarian, breast, and lung cancer. A significant issue with the drug is its low water solubility⏤ requiring the utilization of drug vehicles for effective drug administration. Two novel paclitaxel-containing drugs, Cu5Fe5PAC and (CUPAC)5GLU12DALB, are synthesized and tested against the National Cancer Institute’s sixty cell line panel for anticancer activity. The drugs are also analyzed using MALDI-TOF-MS, FT-IR, and 1H-NMR. One major concern with paclitaxel is the toxicity associated with …
Associating Infection By Chlamydia Pneumoniae And The Presence Of Amyloid-Β Plaques In The Brains Of Alzheimer’S Disease/Dementia Patients, Paul J. G. Carango
Associating Infection By Chlamydia Pneumoniae And The Presence Of Amyloid-Β Plaques In The Brains Of Alzheimer’S Disease/Dementia Patients, Paul J. G. Carango
PCOM Biomedical Studies Student Scholarship
Sporadic late-onset AD (LOAD) is the most common form of dementia (Woods et al, 2020). In recent years, significant attention has been given to the role of infection in the pathogenesis of late-onset AD/dementia. The Cpn pathogen has been an organism of particular focus following the seminal study Balin et. al 1998 which found that Cpn DNA was present in 90% of brains from patients diagnosed with LOAD. Subsequent immunohistochemical studies demonstrated that Cpn antigens were present in the frontal and temporal cortices of LOAD brains and that Aβ amyloid plaques found in those regions of the brain co-localize with …