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Full-Text Articles in Medicine and Health Sciences

Identifying Gait Pathology After Acl Reconstruction Using Temporal Characteristics Of Kinetics And Electromyography, Naoaki Ito, Jacob J. Capin, Ashutosh Khandha, Thomas S. Buchanan, Lynn Snyder-Mackler Jun 2022

Identifying Gait Pathology After Acl Reconstruction Using Temporal Characteristics Of Kinetics And Electromyography, Naoaki Ito, Jacob J. Capin, Ashutosh Khandha, Thomas S. Buchanan, Lynn Snyder-Mackler

Physical Therapy Faculty Research and Publications

Purpose

Asymmetrical gait mechanics after anterior cruciate ligament reconstruction (ACLR) are associated with the development of posttraumatic knee osteoarthritis. Current measures of gait mechanics have focused heavily on peak magnitudes of knee kinematics, kinetics, and joint contact forces but have seldom considered the rate of knee loading, cumulative knee load, or the timing of motor input surrounding peaks. The purpose of this study was to introduce and describe novel metrics of gait using temporal characteristics of kinetics and EMG to identify neuromuscular deficits of the quadriceps in patients after ACLR.

Methods

Gait mechanics were assessed 6 months (n = …


Total Knee Arthroplasty Assessments Should Include Strength And Performance-Based Functional Tests To Complement Range-Of-Motion And Patient-Reported Outcome Measures, Jacob J. Capin, Michael J. Bade, Jason M. Jennings, Lynn Snyder-Mackler, Jennifer E. Stevens-Lapsley Jun 2022

Total Knee Arthroplasty Assessments Should Include Strength And Performance-Based Functional Tests To Complement Range-Of-Motion And Patient-Reported Outcome Measures, Jacob J. Capin, Michael J. Bade, Jason M. Jennings, Lynn Snyder-Mackler, Jennifer E. Stevens-Lapsley

Physical Therapy Faculty Research and Publications

Range of motion (ROM) and pain often define successful recovery after total knee arthroplasty (TKA), but these routine clinical outcomes correlate poorly or not at all to functional capacity after TKA. The purpose of this Perspective is to underscore the importance of muscle strength and performance-based functional tests in addition to knee ROM and patient-reported outcome (PRO) measures to evaluate outcomes after TKA. Specifically: (1) muscle strength is the rate-limiting step for recovery of function after TKA; (2) progressive rehabilitation targeting early quadriceps muscle strengthening improves outcomes and does not compromise ROM after TKA; (3) ROM and PROs fail to …


Parent Health-Related Quality Of Life For Infants With Congenital Anomalies Receiving Neonatal Intensive Care, Krishna Acharya, Erin Rholl, Kathryn J. Malin, Margaret Malnory, Jonathan Leuthner, Steven R. Leuthner, Joanne Lagatta Jun 2022

Parent Health-Related Quality Of Life For Infants With Congenital Anomalies Receiving Neonatal Intensive Care, Krishna Acharya, Erin Rholl, Kathryn J. Malin, Margaret Malnory, Jonathan Leuthner, Steven R. Leuthner, Joanne Lagatta

College of Nursing Faculty Research and Publications

Objective

To examine factors associated with parent quality of life during and after neonatal intensive care unit (NICU) discharge among parents of infants with congenital anomalies admitted to the NICU.

Study design

This secondary analysis of 2 prospective cohort studies between 2016 and 2020 at a level IV NICU included parents of infants with major congenital anomalies receiving NICU care. The primary outcomes were parent health-related quality of life (HRQL) during the NICU stay and at 3 months post-NICU discharge.

Results

A total of 166 parent–infant dyads were enrolled in the study, 124 of which completed the 3-month follow-up interview. …


Neoadjuvant Chemotherapy Is Associated With Improved Outcomes In Patients With Stage 1a And 1b Pancreatic Cancer Undergoing Surgery: An Ncdb Study, Noah Rozich, Maharaj Singh, Isaac Kriley, James L. Weese, Aaron Chevinsky, Wesley A. Papenfuss, Geoffrey Bellini Jun 2022

Neoadjuvant Chemotherapy Is Associated With Improved Outcomes In Patients With Stage 1a And 1b Pancreatic Cancer Undergoing Surgery: An Ncdb Study, Noah Rozich, Maharaj Singh, Isaac Kriley, James L. Weese, Aaron Chevinsky, Wesley A. Papenfuss, Geoffrey Bellini

College of Nursing Faculty Research and Publications

Background: The use of neoadjuvant chemotherapy (NAC) for pancreatic ductal adenocarcinoma (PDAC) has shown clear advantages in locally advanced and borderline resectable disease. The benefit in upfront resectable PDAC is debated. Moreover, in early clinical stages IA/IB, potential benefits including improved R0 resection rate, decreased tumor upstaging, and survival, are not clear. We hypothesize that NAC will be associated with improved outcomes and survival compared to adjuvant therapy in patients with clinical stage IA/IB PDAC. Methods: The National Cancer Database (NCDB) PUFs (2004-2017) were used to perform a retrospective review of patients with clinical stage IA or IB PDAC undergoing …


Edge Chipping Of Translucent Zirconia, Joseph D. Flask, Geoffrey A. Thompson, Maharaj Singh, David W. Berzins May 2022

Edge Chipping Of Translucent Zirconia, Joseph D. Flask, Geoffrey A. Thompson, Maharaj Singh, David W. Berzins

School of Dentistry Faculty Research and Publications

Statement of problem

More translucent dental zirconias have been developed by incorporating the cubic phase and reducing the tetragonal phase content that undergoes transformation toughening, leading to reduced mechanical properties. Whether the clinically relevant mechanical property of the edge chipping toughness of the material is also reduced is unclear.

Purpose

The purpose of this in vitro study was to evaluate the edge chipping toughness and translucency of translucent zirconia, 3mol% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP), and lithium disilicate.

Material and methods

Two translucent zirconia products, Katana and Lava Esthetic; one 3Y-TZP, Lava Plus; and one lithium disilicate, IPS e.max Press …


Emollients To Prevent Eczema In High-Risk Infants: An Integrative Review, Julie Armstrong, Nicole K. Rosinski, Alissa V. Fial, Selorm Ansah, Kristin Haglund May 2022

Emollients To Prevent Eczema In High-Risk Infants: An Integrative Review, Julie Armstrong, Nicole K. Rosinski, Alissa V. Fial, Selorm Ansah, Kristin Haglund

Library Faculty Research and Publications

The purpose of this integrative review was to assess the research on topical emollients to prevent atopic dermatitis (AD) also known as eczema, in infants at high risk for this condition. Atopic dermatitis is a common chronic inflammatory skin disorder. Skin barrier dysfunction plays a prominent role in its development. Topical emollients have been hypothesized to enhance the skin barrier and prevent AD.

Methods:

Searches were conducted in September 2021 in PubMed, CINAHL, Cochrane Library, and Web of Science using key word search terms dermatitis, atopic, emollients, petrolatum, and infant, newborn. Inclusion criteria were articles written in English …


More Than A Meme: The Dunning-Kruger Effect As An Opportunity For Positive Change In Nursing Education, Cynthia Sherraden Bradley, Kristina Dreifuerst, Brandon Kyle Johnson, Ann Loomis May 2022

More Than A Meme: The Dunning-Kruger Effect As An Opportunity For Positive Change In Nursing Education, Cynthia Sherraden Bradley, Kristina Dreifuerst, Brandon Kyle Johnson, Ann Loomis

College of Nursing Faculty Research and Publications

The Dunning–Kruger Effect (DKE) describes the cognitive bias in which novices tend to overestimate performance or competence while experts tend to underestimate. Those who are lacking in competence do not have the skills to accurately recognize deficient performance. Subjective assessment is used widely in simulation learning and in nursing curricula, yet often without expert feedback and reflective discussions, which can result in mistakes being overlooked and encoded, which could subsequently result in clinical errors. The prevalence of DKE should not be interpreted solely as a deprecation of the use of subjective measures, but rather as an indicator of the need …


Helping Nurses Identify And Report Sentinel Injuries Of Child Abuse In Infants, Elizabeth Cleek, Joan P. Totka, Lynn K. Sheets, Joshua P. Mersky, Kristin Haglund May 2022

Helping Nurses Identify And Report Sentinel Injuries Of Child Abuse In Infants, Elizabeth Cleek, Joan P. Totka, Lynn K. Sheets, Joshua P. Mersky, Kristin Haglund

College of Nursing Faculty Research and Publications

Sentinel injuries (SIs) are some of the earliest and most readily identifiable red flags of child abuse. SIs are unexpected bruising or intra-oral injuries in pre-mobile infants and highly correlated with child abuse. However, SIs are not always recognized and reported as red flags of child abuse. Infants are left at risk for continued harm when SIs are not identified and reported. Although increasing nurses' knowledge of SIs is important, child abuse researchers and behavioral theorists have identified that knowledge alone does not predict nurses' behaviors when identifying and reporting suspected child abuse. Other predictors may include implicit biases, interpersonal …


Economic Impression Of On-Farm Research For Sustainable Crop Production, Milk Yield, And Livelihood Options In Semi-Arid Regions Of Central India, Sunil Kumar, Purushottam Sharma, Prabhu Govindasamy, Maharaj Singh, Sant Kumar, Hanamant M. Halli, Bishwa Bhaskar Choudhary, Muthukumar Bagavathiannan May 2022

Economic Impression Of On-Farm Research For Sustainable Crop Production, Milk Yield, And Livelihood Options In Semi-Arid Regions Of Central India, Sunil Kumar, Purushottam Sharma, Prabhu Govindasamy, Maharaj Singh, Sant Kumar, Hanamant M. Halli, Bishwa Bhaskar Choudhary, Muthukumar Bagavathiannan

College of Nursing Faculty Research and Publications

Farming system research (FSR) is on-farm research that brings cutting-edge agricultural technologies to growers to enhance farm production, family income, and livelihood status. In 2007, an on-farm study was started on FSR in central India, and the effect was assessed after 5 yr (2012–2013) of implementation by comparing adopters and nonadopters of FSR-based promoted technologies. Further, in 2018–2019, the status of adoption of introduced technologies was also assessed. The study revealed that improved practices such as pre-sowing irrigation, high-yielding varieties, and crop protection measures collectively improved the system productivity of the adopters by 28%; the improved productivity was mainly due …


Engagement Of Families In The Care Of Hospitalized Pediatric Patients: A Scoping Review, Teresa Jerofke-Owen, Natalie S. Mcandrew, Karen Gralton, Joan P. Totka, Marianne E. Weiss, Alissa V. Fial, Kathleen J. Sawin May 2022

Engagement Of Families In The Care Of Hospitalized Pediatric Patients: A Scoping Review, Teresa Jerofke-Owen, Natalie S. Mcandrew, Karen Gralton, Joan P. Totka, Marianne E. Weiss, Alissa V. Fial, Kathleen J. Sawin

College of Nursing Faculty Research and Publications

This scoping review was conducted to examine the range, nature, and extent of the published family engagement literature specific to the pediatric acute care setting to highlight future research and practice development opportunities. Included studies (N = 247) revealed global relevance. Engagement strategies ranged from more passive such as allowing/encouraging families to be present at the bedside to more active strategies aimed at promoting mutual and reciprocal nurse–patient interactions. Family engagement is distinguished by a mutually beneficial partnership of families with health care team members and care organizations. Future research in the area of family engagement in pediatric nursing …


Beliefs About Safe Traffic Behaviors Among Male High School Students In Hamadan, Iran: A Qualitative Study Based On The Theory Of Planned Behavior, Vahid Ranaei, Alireza Sahab Jahanlu, Laleh Hassani, Ghodratollah Roshanaei, Kristin Haglund, Jagnoor Jagnoor, Forouzan Rezapur Shahkolaei May 2022

Beliefs About Safe Traffic Behaviors Among Male High School Students In Hamadan, Iran: A Qualitative Study Based On The Theory Of Planned Behavior, Vahid Ranaei, Alireza Sahab Jahanlu, Laleh Hassani, Ghodratollah Roshanaei, Kristin Haglund, Jagnoor Jagnoor, Forouzan Rezapur Shahkolaei

College of Nursing Faculty Research and Publications

Road traffic injuries are public health challenges with heavy economic and social burdens. Road traffic injuries are common in developing countries and occur disproportionately with adolescents. This study aimed to elicit beliefs about traffic behaviors based on the theory of planned behavior among male high school students in Hamadan, Iran. We used a constructivist-interpretive qualitative design with directional content analysis. Interviews were conducted with 19 adolescent males in Hamadan, Iran. Analysis revealed that theory of planned behavior fit well to explain how perceptions, attitudes, and beliefs influenced traffic behaviors. Perceived subjective norms in the forms of parental encouragement, traffic rules …


Developing Situation Awareness In Simulation Prebriefing, Amanda L. Potter, Kristina Dreifuerst, Aimee A. Woda May 2022

Developing Situation Awareness In Simulation Prebriefing, Amanda L. Potter, Kristina Dreifuerst, Aimee A. Woda

College of Nursing Faculty Research and Publications

BACKGROUND:

Prebriefing before simulation is a recommended practice that increases learner satisfaction and improves performance. Promoting situation awareness through prebriefing facilitates optimal learning outcomes.

METHOD:

Endsley's Model of Situation Awareness is applied to the cognitive work of nursing practice that occurs during the prebriefing phase of simulation. Perceiving, comprehending, and projecting about elements of a situation lead to clinical judgement, reasoning, decision making, and ultimately nursing actions.

RESULTS:

Developing situation awareness in prebriefing is a supported process that connects learners' prior knowledge and experience with the needed knowledge, skills, and abilities in the simulation environment. These mental models become the …


Symmetry Is Associated With Interlimb Coordination During Walking And Pedaling After Stroke, Brice T. Cleland, Sheila M. Schindler-Ivens Apr 2022

Symmetry Is Associated With Interlimb Coordination During Walking And Pedaling After Stroke, Brice T. Cleland, Sheila M. Schindler-Ivens

Physical Therapy Faculty Research and Publications

Background and Purpose:

Asymmetry during walking may be explained by impaired interlimb coordination. We examined these associations: (1) propulsive symmetry with interlimb coordination during walking, (2) work symmetry with interlimb coordination during pedaling, and (3) work symmetry and interlimb coordination with clinical impairment.

Methods:

Nineteen individuals with chronic stroke and 15 controls performed bilateral, lower limb pedaling with a conventional device and a device with a bisected crank and upstroke assistance. Individuals with stroke walked on a split-belt treadmill. Measures of symmetry (%Propulsionwalk, %Workped) and interlimb phase coordination index (PCIwalk, PCIped) were …


Predicting Duration Of Outpatient Physical Therapy Episodes For Individuals With Spinal Cord Injury Based On Locomotor Training Strategy, Mauricio Garnier-Villarreal, Daniel Pinto, Chaithanya K. Mummidisetty, Arun Jayaraman, Candy Tefertiller, Susan Charlifue, Heather B. Tayler, Shuo-Hsiu Chang, Nicholas Mccombs, Catherine L. Furbish, Edelle C. Field-Fote, Allen W. Heinemann Apr 2022

Predicting Duration Of Outpatient Physical Therapy Episodes For Individuals With Spinal Cord Injury Based On Locomotor Training Strategy, Mauricio Garnier-Villarreal, Daniel Pinto, Chaithanya K. Mummidisetty, Arun Jayaraman, Candy Tefertiller, Susan Charlifue, Heather B. Tayler, Shuo-Hsiu Chang, Nicholas Mccombs, Catherine L. Furbish, Edelle C. Field-Fote, Allen W. Heinemann

Physical Therapy Faculty Research and Publications

Objective

To characterize individuals with spinal cord injuries (SCI) who use outpatient physical therapy or community wellness services for locomotor training and predict the duration of services, controlling for demographic, injury, quality of life, and service and financial characteristics. We explore how the duration of services is related to locomotor strategy.

Design

Observational study of participants at 4 SCI Model Systems centers with survival. Weibull regression model to predict the duration of services.

Setting

Rehabilitation and community wellness facilities at 4 SCI Model Systems centers.

Participants

Eligibility criteria were SCI or dysfunction resulting in motor impairment and the use of …


Nonlinear Association Of Nurse Staffing And Readmissions Uncovered In Machine Learning Analysis, Olga Yakusheva, James Bang, Ronda G. Hughes, Kathleen L. Bobay, Linda L. Costa, Marianne Weiss Apr 2022

Nonlinear Association Of Nurse Staffing And Readmissions Uncovered In Machine Learning Analysis, Olga Yakusheva, James Bang, Ronda G. Hughes, Kathleen L. Bobay, Linda L. Costa, Marianne Weiss

College of Nursing Faculty Research and Publications

Objective: Several studies of nurse staffing and patient outcomes found a curvilinear or U-shaped relationship, with benefits from additional nurse staffing diminishing or reversing at high staffing levels. This study examined potential diminishing returns to nurse staffing and the existence of a "tipping point" or the level of staffing after which higher nurse staffing no longer improves and may worsen readmissions.

Data Sources/Study Setting: The Readiness Evaluation And Discharge Interventions (READI) study database of over 130,000 adult (18+) inpatient discharges from 62 medical, surgical, and medical-surgical (noncritical care) units from 31 United States (US) hospitals during October 2014-March 2017.

Study …


Pituitary Adenylate Cyclase-Activating Polypeptide Receptor Activation In The Hypothalamus Recruits Unique Signaling Pathways Involved In Energy Homeostasis, Brian Maunze, Katherine Wood Bruckner, Nikhil Nilesh Desai, Christopher Chen, Fanghong Chen, David Baker, Sujean Choi Mar 2022

Pituitary Adenylate Cyclase-Activating Polypeptide Receptor Activation In The Hypothalamus Recruits Unique Signaling Pathways Involved In Energy Homeostasis, Brian Maunze, Katherine Wood Bruckner, Nikhil Nilesh Desai, Christopher Chen, Fanghong Chen, David Baker, Sujean Choi

Biomedical Sciences Faculty Research and Publications

Pituitary adenylate cyclase activating polypeptide (PACAP) exerts pleiotropic effects on ventromedial nuclei (VMN) of the hypothalamus and its control of feeding and energy expenditure through the type I PAC1 receptor (PAC1R). However, the endogenous role of PAC1Rs in the VMN and the downstream signaling responsible for PACAP’s effects on energy balance are unknown. Numerous studies have revealed that PAC1Rs are coupled to both Gαs/adenylyl cyclase/protein kinase A (Gαs/AC/PKA) and Gαq/phospholipase C/protein kinase C (Gαq/PLC/PKC), while also undergoing trafficking following stimulation. To determine the endogenous role of PAC1Rs and downstream signaling that may explain PACAP’s pleiotropic effects, we used RNA interference …


Degenerative Cervical Myelopathy Delays Responses To Lateral Balance Perturbations Regardless Of Predictability, T. F. Boerger, L. Mcginn, M. C. Wang, Brian Schmit, Allison S. Hyngstrom Mar 2022

Degenerative Cervical Myelopathy Delays Responses To Lateral Balance Perturbations Regardless Of Predictability, T. F. Boerger, L. Mcginn, M. C. Wang, Brian Schmit, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

The aim of this study was to quantify balance impairments in standing in people with degenerative cervical myelopathy (PwDCM) in response to external perturbations. PwDCM have damage to their spinal cord due to degeneration of the cervical vertebral column, but little is known about balance. Balance was quantified by capturing kinetics, kinematic, and electromyographic data during standing in response to lateral waist pulls. Participants received pulls during predictable and unpredictable contexts in three stance widths at two magnitudes. In response to lateral waist pulls, PwDCM had larger center of mass excursion (P < 0.001) and delayed gluteus medius electromyography onset (P < 0.001) and peak (P < 0.001) timing. These main effects of history of myelopathy were consistent across predictability, stance width, and magnitude. A multilinear regression determined that gluteus medius peak timing + tibialis anterior peak timing most strongly predicted center of mass excursion (R2 = 0.50, P < 0.001). These data suggest that PwDCM have delays in generating voluntary and reactive motor commands, contributing to balance impairments. Future rehabilitation strategies should focus on generating rapid muscular contractions. Additionally, frontal plane postural control is regulated by the gluteus medius and the tibialis anterior, whereas other muscles (e.g. gluteus minimus, ankle invertors/evertors) not studied here may also contribute.


Prospective Telehealth Analysis Of Functional Performance, Frailty, Quality Of Life, And Mental Health After Covid-19 Hospitalization, Jacob J. Capin, Melissa P. Wilson, Kristine Hare, Swati Vempati, Carley E. Little, Donna Mcgregor, Jose Castillo-Mancilla, Jennifer E. Stevens-Lapsley, Sarah Jolley, Kristine M. Erlandson Mar 2022

Prospective Telehealth Analysis Of Functional Performance, Frailty, Quality Of Life, And Mental Health After Covid-19 Hospitalization, Jacob J. Capin, Melissa P. Wilson, Kristine Hare, Swati Vempati, Carley E. Little, Donna Mcgregor, Jose Castillo-Mancilla, Jennifer E. Stevens-Lapsley, Sarah Jolley, Kristine M. Erlandson

Physical Therapy Faculty Research and Publications

Background

COVID-19 is a global pandemic with poorly understood long-term consequences. Determining the trajectory of recovery following COVID-19 hospitalization is critical for prioritizing care, allocating resources, facilitating prognosis, and informing rehabilitation. The purpose of this study was to prospectively evaluate recovery following COVID-19 hospitalization.

Methods

Participants age 18 years or older who were hospitalized for ≥24 h due to COVID-19 completed phone/video call virtual assessments (including the 10-time chair rise test) and survey forms at three time points (2–6, 12, and 18 weeks) after hospital discharge. Univariate logistic and linear regression models assessed the associations of the outcomes with primary …


A Scoping Review Of The Experiences Of Adolescents And Young Adults In The Icu, Their Family Members, And Their Health Care Team, Natalie S. Mcandrew, Jeanne Erickson, Jill L. Guttormson, Alexandrea Bear, Sean Marks, Jayshil Patel, Eric Harding Mar 2022

A Scoping Review Of The Experiences Of Adolescents And Young Adults In The Icu, Their Family Members, And Their Health Care Team, Natalie S. Mcandrew, Jeanne Erickson, Jill L. Guttormson, Alexandrea Bear, Sean Marks, Jayshil Patel, Eric Harding

College of Nursing Faculty Research and Publications

No abstract provided.


Pandemic Visitor Policies: Parent Reactions And Policy Implications, Ashlee J. Vance, Kathryn J. Malin, Annella Benjamin, Clayton J. Shuman, Tiffany A. Moore, Deena K. Costa Mar 2022

Pandemic Visitor Policies: Parent Reactions And Policy Implications, Ashlee J. Vance, Kathryn J. Malin, Annella Benjamin, Clayton J. Shuman, Tiffany A. Moore, Deena K. Costa

College of Nursing Faculty Research and Publications

No abstract provided.


Association Of Geriatric Emergency Department Post-Discharge Referral Order And Follow-Up With Healthcare Utilization, Michelle Simpson, Clinton Sergi, Aaron Malsch, Suzanne Ryer, Christopher Rubach, Maharaj Singh Mar 2022

Association Of Geriatric Emergency Department Post-Discharge Referral Order And Follow-Up With Healthcare Utilization, Michelle Simpson, Clinton Sergi, Aaron Malsch, Suzanne Ryer, Christopher Rubach, Maharaj Singh

College of Nursing Faculty Research and Publications

Background

Compared with younger adults who receive care in the emergency department (ED), older patients who are discharged home have greater risk of adverse health outcomes. Connecting older adults with outpatient care following ED discharge are among the guidelines of the Geriatric Emergency Department (GED). The objective of this study was to examine the association between referral order placed during the ED visit for older adults and post-discharge follow-up to the outcomes of 72-h ED revisit, 30-day ED revisit, and 30-day all cause and unplanned hospital admission.

Methods

We conducted a retrospective cohort study. Ten accredited GEDs within one midwestern …


Complexes Of Ghrelin Ghs-R1a, Ghs-R1b, And Dopamine D1 Receptors Localized In The Ventral Tegmental Area As Main Mediators Of The Dopaminergic Effects Of Ghrelin, Gemma Navarro, William Rea, César Quiroz, Estefanía Moreno, Devan Gomez, Cody J. Wenthur, Vicent Casadó, Lorenzo Leggio, Matthew C. Hearing, Sergi Ferré Feb 2022

Complexes Of Ghrelin Ghs-R1a, Ghs-R1b, And Dopamine D1 Receptors Localized In The Ventral Tegmental Area As Main Mediators Of The Dopaminergic Effects Of Ghrelin, Gemma Navarro, William Rea, César Quiroz, Estefanía Moreno, Devan Gomez, Cody J. Wenthur, Vicent Casadó, Lorenzo Leggio, Matthew C. Hearing, Sergi Ferré

Biomedical Sciences Faculty Research and Publications

Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a complex modulatory role that depends on its relative expression. D1 dopamine receptor (D1R) and D5R constitute the two D1-like receptor subtypes. Previous studies showed that GHS-R1b also facilitates oligomerization of GHS-R1a with D1R, conferring GHS-R1a distinctive pharmacological properties. Those include a switch in the preferred coupling of GHS-R1a from Gq to Gs and the ability of D1R/D5R agonists and antagonists to counteract GHS-R1a signaling. Activation of ghrelin …


Craniofacial Fluctuating Asymmetry In Gorillas, Chimpanzees, And Macaques, Ashly N. Romero, D. Rex Mitchell, Siobhán B. Cooke, Claire A. Kirchhoff, Claire E. Terhune Feb 2022

Craniofacial Fluctuating Asymmetry In Gorillas, Chimpanzees, And Macaques, Ashly N. Romero, D. Rex Mitchell, Siobhán B. Cooke, Claire A. Kirchhoff, Claire E. Terhune

Biomedical Sciences Faculty Research and Publications

Objectives

Craniofacial fluctuating asymmetry (FA) refers to the random deviations from symmetry exhibited across the craniofacial complex and can be used as a measure of developmental instability for organisms with bilateral symmetry. This article addresses the lack of data on craniofacial FA in nonhuman primates by analyzing FA magnitude and variation in chimpanzees, gorillas, and macaques. We offer a preliminary investigation into how FA, as a proxy for developmental instability, varies within and among nonhuman primates.

Materials and Methods

We generated 3D surface models of 121 crania from Pan troglodytes troglodytes, Gorilla gorilla gorilla, and Macaca fascicularis fascicularis …


Task Effects On Functional Connectivity Measures After Stroke, Kaleb Vinehout, Sheila M. Schindler-Ivens, Jeffrey R. Binder, Brian D. Schmit Feb 2022

Task Effects On Functional Connectivity Measures After Stroke, Kaleb Vinehout, Sheila M. Schindler-Ivens, Jeffrey R. Binder, Brian D. Schmit

Physical Therapy Faculty Research and Publications

Understanding the effect of task compared to rest on detecting stroke-related network abnormalities will inform efforts to optimize detection of such abnormalities. The goal of this work was to determine whether connectivity measures obtained during an overt task are more effective than connectivity obtained during a “resting” state for detecting stroke-related changes in network function of the brain. This study examined working memory, discrete pedaling, continuous pedaling and language tasks. Functional magnetic resonance imaging was used to examine regional and inter-regional brain network function in 14 stroke and 16 control participants. Independent component analysis was used to identify 149 regions …


Disparities In The Allocation Of Inpatient Physical And Occupational Therapy Services For Patients With Covid-19, Sarah Jolley, Amy Nordon-Craft, Melissa P. Wilson, Kyle Ridgeway, Michelle R. Rauzi, Jacob J. Capin, Lauren M. Heery, Jennifer Stevens-Lapsley, Kristine M. Erlandson Feb 2022

Disparities In The Allocation Of Inpatient Physical And Occupational Therapy Services For Patients With Covid-19, Sarah Jolley, Amy Nordon-Craft, Melissa P. Wilson, Kyle Ridgeway, Michelle R. Rauzi, Jacob J. Capin, Lauren M. Heery, Jennifer Stevens-Lapsley, Kristine M. Erlandson

Physical Therapy Faculty Research and Publications

Background

Survivors of the novel coronavirus (COVID-19) experience significant morbidity with reduced physical function and impairments in activities of daily living. The use of in-hospital rehabilitation therapy may reduce long-term impairments.

Objective

To determine the frequency of therapy referral and treatment amongst hospitalized COVID-19 patients, assess for disparities in referral and receipt of therapy, and identify potentially modifiable factors contributing to disparities in therapy allocation.

Design, Setting and Participants

Retrospective cohort study using data collected from the University of Colorado Health Data Compass data warehouse assessing therapy referral rates and estimated delivery based on available administrative billing.

Measurements

Multivariable logistic …


Developing Peri-Operative Rehabilitation In Degenerative Cervical Myelopathy [Ao Spine Recode-Dcm Research Priority Number 6]: An Unexplored Opportunity?, Timothy F. Boerger, Allison S. Hyngstrom, Julio C. Furlan, Sukhvinder Klasi-Ryan, Armin Curt, Brian K. Kwon, Shekar N. Kurpad, Michael G. Fehlings, James S. Harrop, Bizhan Aarabi, Vafa Rahimi-Movaghar, James D. Guest, Jefferson R. Wilson, Benjamin M. Davies, Mark R. N. Kotter, Paul A. Koljonen Feb 2022

Developing Peri-Operative Rehabilitation In Degenerative Cervical Myelopathy [Ao Spine Recode-Dcm Research Priority Number 6]: An Unexplored Opportunity?, Timothy F. Boerger, Allison S. Hyngstrom, Julio C. Furlan, Sukhvinder Klasi-Ryan, Armin Curt, Brian K. Kwon, Shekar N. Kurpad, Michael G. Fehlings, James S. Harrop, Bizhan Aarabi, Vafa Rahimi-Movaghar, James D. Guest, Jefferson R. Wilson, Benjamin M. Davies, Mark R. N. Kotter, Paul A. Koljonen

Physical Therapy Faculty Research and Publications

Study Design

Narrative review.

Objective

Degenerative cervical myelopathy is one of the most frequent impairments of the spinal cord encountered internationally in adults. Currently, surgical decompression is the recommended treatment for people with DCM (PwCM) presenting with moderate to severe symptoms or neurological deficits. However, despite surgical intervention, not all patients make a complete recovery due to the irreversible tissue damage within the spinal cord. The objective of this review is to describe the state and gaps in the current literature on rehabilitation for PwCM and possible innovative rehabilitation strategies.

Methods

Literature search.

Results

In other neurological disorders such as …


Parent Physical Activity: A Systematic Review Of The Literature And Recommendations For Parents Of Children With Autism Spectrum Disorder, Norah L. Johnson, Abir K. Bekhet, Rachel Sawdy, Emily Zint, June Wang, Sylvia Pena, Hannah Zurcher, Nina Enea Feb 2022

Parent Physical Activity: A Systematic Review Of The Literature And Recommendations For Parents Of Children With Autism Spectrum Disorder, Norah L. Johnson, Abir K. Bekhet, Rachel Sawdy, Emily Zint, June Wang, Sylvia Pena, Hannah Zurcher, Nina Enea

College of Nursing Faculty Research and Publications

Background: The aims of this review were to describe exercise interventions, facilitators, and barriers to physical activity for parents of children with autism spectrum disorder.

Methods: A systematic review of the literature, appraising the validity of each article with Melnyk and Fineout-Overholt’s level of evidence, from different databases CINAHL, Cochrane, PsycINFO, PubMed, ProQuest, and Web of Science between 2000 and 2020 was conducted. As the initial search revealed no articles on exercise interventions and only 2 articles with children with autism spectrum disorder, the aim was widened to all parents of children.

Results: Forty-five articles were identified on barriers to …


Multisite Effectiveness Study Of The Marquette Method Of Natural Family Planning Program, Qiyan Mu, Richard J. Fehring, Thomas Bouchard Feb 2022

Multisite Effectiveness Study Of The Marquette Method Of Natural Family Planning Program, Qiyan Mu, Richard J. Fehring, Thomas Bouchard

College of Nursing Faculty Research and Publications

Women of reproductive age need reliable and effective family planning methods to manage their fertility. Natural family planning (NFP) methods or fertility awareness-based methods (FABMs) have been increasingly used by women due to their health benefits. Nevertheless, effectiveness of these natural methods remains inconsistent, and these methods are difficult for healthcare providers to implement in their clinical practice. The purpose of this study is to evaluate the effectiveness of the Marquette Model NFP system to avoid pregnancy for women at multiple teaching sites using twelve months of retrospectively collected teaching data. Survival analysis (Kaplan–Meier) was used to determine typical unintended …


Muscle-Specific Contributions To Lower Extremity Net Joint Moments While Squatting With Different External Loads, Kristof Kipp, Hoon Kim, William I. Wolf Feb 2022

Muscle-Specific Contributions To Lower Extremity Net Joint Moments While Squatting With Different External Loads, Kristof Kipp, Hoon Kim, William I. Wolf

Exercise Science Faculty Research and Publications

The purpose of this study was to determine muscle-specific contributions to lower extremity net joint moments (NJMs) during squats with different external loads. Nine healthy subjects performed sets of the back squat exercise with 0, 25, 50, and 75% of body mass as an added external load. Motion capture and force plate data were used to calculate NJMs and to estimate individual muscle forces via static optimization. Individual muscle forces were multiplied by their respective moment arms to calculate the resulting muscle-specific joint moment. Statistical parametric mapping (α = 0.05) was used to determine load-dependent changes in the time series …


Laterality Of The Activation Of The Vastus Lateralis Muscle In Females With Parkinson's Disease During The Medication State Compared With Healthy Controls, Yuichi Nishikawa, Kohei Watanabe, Tetsuya Takahashi, Noriaki Maeda, Hirofumi Maruyama, Shinobu Tanaka, Allison S. Hyngstrom Jan 2022

Laterality Of The Activation Of The Vastus Lateralis Muscle In Females With Parkinson's Disease During The Medication State Compared With Healthy Controls, Yuichi Nishikawa, Kohei Watanabe, Tetsuya Takahashi, Noriaki Maeda, Hirofumi Maruyama, Shinobu Tanaka, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

This study quantified the laterality of motor unit activation properties in females with Parkinson’s disease during force production (low to high-intensity contraction) using high-density surface electromyography. Sixteen females with Parkinson’s disease (age = ± 7.6 years, disease duration = 4.9 ± 5.1 years) and 14 healthy female subjects (age = 68.6 ± 3.6 years) performed submaximal ramp-up contractions during isometric knee extension. High-density surface electromyography signals were recorded from both vastus lateralis muscles. The level of heterogeneity was calculated in the spatial distribution patterns of the high-density surface electromyography signals to determine the modified entropy, coefficient of variation of the …