Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Cancer (2)
- Interleukin 12 (2)
- Acquisition (1)
- Activated caspase 3 (1)
- African American English (1)
-
- African American shared book reading behaviors (1)
- Alpha-cells (1)
- Angiotensin II (1)
- Auxiliary system (1)
- Brucella (1)
- Ca2+ signaling (1)
- Cardiac hypertrophy (1)
- Caregiver training (1)
- Carprofen (1)
- Child language (1)
- Children with speech and language impairments (1)
- Classroom-based (1)
- Colon (1)
- Communicative effectiveness (1)
- Cytokine (1)
- Cytokines (1)
- DNP (1)
- Decoding (1)
- Dinitrophenol (1)
- Dizziness (1)
- Dysarthria treatment (1)
- Early literacy (1)
- Equine bone (1)
- Flow cytometry (1)
- Francisella (1)
Articles 1 - 25 of 25
Full-Text Articles in Medicine and Health Sciences
Item Analysis Of The Grammar Subtests Of The Cdi: Words & Sentences For African American Children, Zainab Maqsood
Item Analysis Of The Grammar Subtests Of The Cdi: Words & Sentences For African American Children, Zainab Maqsood
Honors Theses
No abstract provided.
Mothers’ Speech To Infants With And Without Down Syndrome, Christina M. Gary
Mothers’ Speech To Infants With And Without Down Syndrome, Christina M. Gary
Honors Theses
No abstract provided.
The Relation Between Two Caregiver Questionnaires About Children’S Early Literacy Experiences, Amy L. Sewell
The Relation Between Two Caregiver Questionnaires About Children’S Early Literacy Experiences, Amy L. Sewell
Honors Theses
No abstract provided.
Fleshing Out The Spirit Of Contention: Conflicting Preventative Approaches To The Aids Pandemic In Africa And The Promise Of A Scientific Narrative, Rachel Zimmerman
Fleshing Out The Spirit Of Contention: Conflicting Preventative Approaches To The Aids Pandemic In Africa And The Promise Of A Scientific Narrative, Rachel Zimmerman
Honors Theses
No abstract provided.
Role Of Gastrointestinal Multidrug Resistance (Mdr1) Gene And P-Glycoprotein (P-Gp) In The Oral Absorption Of Methadone In Horses, Renata Lehn Linardi
Role Of Gastrointestinal Multidrug Resistance (Mdr1) Gene And P-Glycoprotein (P-Gp) In The Oral Absorption Of Methadone In Horses, Renata Lehn Linardi
LSU Doctoral Dissertations
Methadone is a mu-opioid receptor agonist which is a very effective analgesic used to treat moderate to severe acute and chronic pain in humans. Due to methadone’s minimal undesirable side-effects in people, we believed it could be of use in horses as an analgesic agent. As found with the majority of lipophilic drugs, absorption of methadone occurs primarily in the small intestine via transcellular transport and its absorption is regulated by P-glycoprotein. P-glycoprotein is a transmembrane transporter protein encoded by the multidrug resistance gene, which is constitutively expressed in the apical membrane of enterocytes of various species. This protein may …
Optimization And Toxocologic Effects Of Cancer Immuno-Electrogene Therapy Using A Tumor-Targeted Interleukin-12 Gene Construct, Scott Douglas Reed
Optimization And Toxocologic Effects Of Cancer Immuno-Electrogene Therapy Using A Tumor-Targeted Interleukin-12 Gene Construct, Scott Douglas Reed
LSU Doctoral Dissertations
This dissertation includes a comprehensive current review of reversible electroporation (EP) and other related physical gene transfection techniques; an overview of results of electrochemogene therapy (ECGT) used to treat naturally occurring spontaneous neoplasms in dogs; and the results of comprehensive, pre-clinical toxicology testing of electrogene therapy (EGT) of a tumor-targeted version of interleukin-12 (IL-12) in mice. Intralesional bleomycin (BLM) and feline interleukin-12 (fIL-12) DNA injection combined with trans-lesional EP resulted in complete cure of two recurrent oral squamous cell carcinomas and an acanthomatous ameloblastoma in a series of six cases of spontaneous neoplasia in pet dogs. The three remaining dogs, …
In Vitro And In Vivo Evaluation Of A Brucella Putative Hemagglutinin, Lauren E. Duhon
In Vitro And In Vivo Evaluation Of A Brucella Putative Hemagglutinin, Lauren E. Duhon
LSU Doctoral Dissertations
Brucellosis, a zoonotic disease caused by Brucella spp., presents both health and economic difficulties for livestock, wildlife, and humans. While brucellosis is nearly eradicated in the United States, the disease remains detrimental in many countries worldwide. Attempts to produce a safe and effective small ruminant vaccine have been met with limited success. The current vaccine for bovine brucellosis in the United States is B. abortus RB51. This strain transiently colonizes the host and induces a cell-mediated immune response. Levels of protection have not been demonstrated in goats and thus it is considered a relatively poor caprine vaccine that probably does …
Vocal Warm-Up Practices And Perceptions In Vocalists: A Pilot Survey, Allison Kimberly Gish
Vocal Warm-Up Practices And Perceptions In Vocalists: A Pilot Survey, Allison Kimberly Gish
LSU Master's Theses
Vocal warm-up exercises are believed to contribute to the prevention of vocal fold injury in professional voice users. Professional singers and students of singing consider a regular vocal warm-up regimen essential. There is conflicting information in the vocal pedagogy literature about the most effective and widely used vocal warm-up exercises and the optimal frequency and duration of vocal warm-up sessions. The goal of this current study was to investigate the characteristics of vocal warm-up regimens in the singing community using a survey. One hundred seventeen participants completed the survey. Participants included voice students from undergraduate, masters, and doctoral music programs …
Depolarization By Transient Receptor Potential Melastatin 4 In Pancreatic Alpha-Cells Regulates Glucagon Secretion, Piper Lynn Nelson
Depolarization By Transient Receptor Potential Melastatin 4 In Pancreatic Alpha-Cells Regulates Glucagon Secretion, Piper Lynn Nelson
LSU Master's Theses
The Transient Receptor Potential Melastatin 4 protein (TRPM4) is a member of the TRP family of ion channels that is expressed in both electrically excitable and non-excitable cells. Functional studies revealed that TRPM4 significantly impacts Ca2+ signals in both immune and pancreatic β-cells, which is important for cellular processes such as hormone secretion. However, its role in glucagon secreting α-cells has not been reported. Type 2 Diabetes Mellitus is often associated with increased glucagon levels; yet, the exact mechanism controlling its secretion is not known. In pancreatic α-cells, an increase in intracellular Ca2+ concentration causes glucagon secretion. We hypothesize that …
The Role Of Bone Marrow In Siv Pathogenesis Using The Rhesus Macaque Model, Amy F. Gill
The Role Of Bone Marrow In Siv Pathogenesis Using The Rhesus Macaque Model, Amy F. Gill
LSU Doctoral Dissertations
CD4+ memory T cells are depleted in mucosal tissues post human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection without restoration to pre-infection levels during progressive course of disease. Bone marrow (BM) as a hematopoietic organ has been investigated for hematologic and morphologic changes during HIV infection. However, BM as a primary lymphoid tissue during HIV infection has been poorly characterized. We proposed BM was also a site of CD4+ T cell depletion driven by increased apoptosis during progressive HIV disease. We chose to investigate bone marrow changes using the premier non-human primate Rhesus macaque SIV model for the …
The Auxiliary System Of Typically Developing Children Acquiring African American English, Brandi Lynette Newkirk
The Auxiliary System Of Typically Developing Children Acquiring African American English, Brandi Lynette Newkirk
LSU Doctoral Dissertations
This study’s purpose was to examine the acquisition and use of BE, DO, and modal auxiliaries by African American English (AAE)-speaking children. The impetus for this work was the lack of information regarding the developmental trajectory of these auxiliary types and their use, in AAE relative to what is known about auxiliary acquisition and use in Mainstream American English (MAE). The study used two datasets of language samples: one that contained 48 language samples from 3 ½-year-old children and one that contained 36 longitudinal language samples of five children who were between 18 and 51 months of age. Results from …
Investigation Of A Classroom-Based Reading Intervention Strategy For Older Elementary Students With Poor Decoding Skills, Shara Brinkley
Investigation Of A Classroom-Based Reading Intervention Strategy For Older Elementary Students With Poor Decoding Skills, Shara Brinkley
LSU Doctoral Dissertations
Using a response to intervention framework, this study investigates the efficacy of a classroom-based intervention for struggling readers with decoding deficits in the upper elementary grades. Twenty two students in the fourth and sixth grades from four classrooms in low-performing schools received either a short 20-minute intervention delivered by their teacher or access to the lessons for an equivalent amount of time but no teacher instruction. Using three orthographic patterns, the 24 lessons consisted of a series of ten minimally contrasted words differing by one letter. The students in the experimental group decoded the words using a visual alphabet (Phonic …
Treatment Effect Of Maximum Performance Speech Therapy For Individuals With Parkinson's Disease And Dysarthria, Heidi Huckabee Michiels
Treatment Effect Of Maximum Performance Speech Therapy For Individuals With Parkinson's Disease And Dysarthria, Heidi Huckabee Michiels
LSU Master's Theses
The Lee Silverman Voice Treatment (LSVT™) has received much attention in the past decade for its use in the treatment of individuals with Parkinson’s disease (Jones, 2005; Ramig, Countryman, O'Brien, Hoehn, & Thompson, 1996; Ramig, Sapir, Countryman et al., 2001; Wohlert, 2004). This intensive program requires therapy four times a week for four weeks in order to improve perceptual characteristics of the voice, such as loudness. However, since LSVT™ was introduced, the rehabilitation industry has experienced systematic reductions in allowable frequency and duration of covered services. The result has been that individuals often cannot qualify for the rigorous LSVT™ protocol …
In Vivo And In Vitro Pathogenesis Of Francisella Asiatica In Tilapia Nilotica (Oreochromis Niloticus), Esteban Soto
In Vivo And In Vitro Pathogenesis Of Francisella Asiatica In Tilapia Nilotica (Oreochromis Niloticus), Esteban Soto
LSU Doctoral Dissertations
Francisella asiatica is a Gram negative, facultative intracellular pathogen that causes fish francisellosis. In this project, homologues to the F. tularensis iglABCD genes were found present in F. asiatica. As few as 23 F. asiatica bacteria injected in the peritoneum were found capable of causing mortalities in tilapia nilotica (Oreochromis niloticus), and even fewer were enough to cause pathological changes. We examined the in vivo and in vitro interaction of F. asiatica wild type (WT) and a ÄiglC strain with tilapia and tilapia head kidney derived macrophages (HKDM). The ÄiglC was found to be attenuated following intraperitoneal and immersion challenges …
Revealing The Role Of Receptor Wsx1: A Double-Edged Sword In Tumor Progession, Denada Dibra
Revealing The Role Of Receptor Wsx1: A Double-Edged Sword In Tumor Progession, Denada Dibra
LSU Doctoral Dissertations
Tumor initiation and progression are dependent on both aberrant gene expression in tumor cells and the communication between tumor cells and its micro- and systemic microenvironment. Many tumor suppressor genes and oncogenes have been characterized to suppress or promote tumor growth, but fewer genes in tumors are well-characterized as interacting with immune cells in the host to promote or inhibit tumor growth. The interleukin (IL) 27 receptor WSX1 is expressed in immune cells and induces an IL27-dependent immune response. Opposing this conventional dogma, our initial results reveal a much higher level of WSX1 expression in multiple types of epithelial tumor …
The Roles Of Transcription Factors In Nucleotide Excision Repair In Yeast, Baojin Ding
The Roles Of Transcription Factors In Nucleotide Excision Repair In Yeast, Baojin Ding
LSU Doctoral Dissertations
Nucleotide excision repair (NER) is a conserved DNA repair mechanism capable of removing a variety of helix-distorting lesions, such as UV-induced cyclobutane pyrimidine dimers (CPDs). NER can be grouped into two pathways: global genomic NER (GGR), which refers to repair throughout the genome, and transcription coupled NER (TCR), which refers to a repair mechanism that is dedicated to the transcribed strand (TS) of actively transcribed genes. In yeast S. cerevisiae, Rad7, Rad16, and Elc1 are specifically required for GGR. TCR is believed to be initiated by RNA polymerase II (Pol II) stalled at a lesion in the TS of a …
Parent Report Of Home Literacy Experiences In Children With And Without Speech And Language Impairments, Amanda Blair Grace
Parent Report Of Home Literacy Experiences In Children With And Without Speech And Language Impairments, Amanda Blair Grace
LSU Master's Theses
The purpose of this study was to evaluate caregivers’ perceptions of their children’s literacy experiences and determine if their perceptions differed as a function of whether their children presented with speech and language impairment or with typical language development. Participants were caregivers of children, between the ages of 24 and 54 months. Eleven children presented with speech and language impairments (S/LI) and 14 children presented with typically developing (TD) language. Caregivers’ perceptions about early home literacy experiences were collected through a questionnaire. Results showed that there were no statistically significant differences between the two groups of caregivers’ responses to the …
Interaction Of Tumor Necrosis Factor-Alpha And The Renin Angiotensin System In The Pathogenesis Of Hypertension, Srinivas Sriramula
Interaction Of Tumor Necrosis Factor-Alpha And The Renin Angiotensin System In The Pathogenesis Of Hypertension, Srinivas Sriramula
LSU Doctoral Dissertations
Hypertension is a major predisposing factor for the development of cardiovascular and renal diseases. The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases such as hypertension, myocardial infarction, heart failure, and stroke. Angiotensin II (Ang II), the effector peptide of the RAS, activates a wide spectrum of signaling responses via the Ang II type-I receptor that mediate its physiological control of blood pressure, thirst and sodium balance. For the past two decades, increasing evidence has demonstrated that the circulatory RAS and local/tissue RAS components (heart and brain) may contribute to the development of hypertensive response. …
Identification Of A Tumor-Targeting-Peptide And Development Of A Tumor-Targeted-Cytokine Vector For Systemic Treatment Of Primary And Metastatic Malignancies, Jeffry Cutrera
LSU Doctoral Dissertations
Advances in cancer therapies continue to be improved, yet cancer continues to be one of the deadliest diseases in the world. Harnessing the power of the body’s immune system to attack cancer is a promising strategy that can further improve therapies for neoplastic diseases. As part of this strategy, cytokines such as interleukin (IL) 2 and interferon á are currently accepted cancer treatments, and other cytokines such as IL12 and GM-CSF also show potential as new treatments. Clinical trials with these cytokines have shown less than acceptable therapeutic efficacy and toxicities, but tumor-targeting motifs can improve these effects. Both antibodies …
Applicability And Integration Of Plasma Sprayed Hydroxyapatite Coated Ao Cortical Bone Screws In Equine Bone, Timm Gudehus
Applicability And Integration Of Plasma Sprayed Hydroxyapatite Coated Ao Cortical Bone Screws In Equine Bone, Timm Gudehus
LSU Master's Theses
To compare insertion temperatures and torques of Hydroxyapatite (HA) coated and uncoated 5.5 mm AO cortical screws in equine third metatarsal bones (MTIII) in vitro, and to compare insertion and extraction torques of HA coated and uncoated screws after 4, 8, 12 and 16 weeks of healing in equine third metacarpal bones (MCIII) in vivo. No significant temperature differences were recorded in cadaveric bones for AO and HA coated screws. Insertion torques were significantly higher for HA coated implants compared to uncoated screws. In vivo, the AO screws lost 50% of their initial stability within 4 weeks of healing and …
Child Acquisition Of Referring Expressions, Carlton M. Downey
Child Acquisition Of Referring Expressions, Carlton M. Downey
LSU Doctoral Dissertations
Children, like adults, use referring expressions to refer to specific objects, events, or people. Research has provided insights into how children use referring expressions and the appearance of forms developmentally (Radford, 1990; Abu-Akel, et al., 2004; Pine & Lieven, 1997). This study examined how three, four, and five year-old children use referring expressions across increasingly more decontextualized tasks as defined by the Situational-Discourse-Semantic (SDS) Model (Norris & Hoffman, 1993, 2002) . The participants included 4 three-year-old, 12 four-year-old, and 20 five-year-old children. Language samples were elicited using seven tasks of increasing difficulty. The referring expressions produced for each task were …
Behaviors And Beliefs Of African American Caregivers As Related To Their Children's Language-Literacy Development, Lekeitha Renee' Morris
Behaviors And Beliefs Of African American Caregivers As Related To Their Children's Language-Literacy Development, Lekeitha Renee' Morris
LSU Doctoral Dissertations
This study examined African American (AA) caregivers’ beliefs about their children’s language-literacy development and their book reading behaviors with their children as a function of socioeconomic status (SES). Caregivers’ behaviors were examined before, during, and after a three-day caregiver training program that targeted four behaviors (i.e., tracking print, reference to print, text to life, and interpretations). Participants were 20 caregiver-child dyads classified as Low-SES (LSES) or Middle-SES (MSES) based on the caregivers’ level of education. Children were typically developing girls between the ages of four and five years. At pre-test, the two groups of caregivers differed in some of their …
The Effects Of Aging And Unilateral Vestibular Disorders On The Kinematic Performance Of Vestibular Rehabilitation Exercises And Physical Function, Micah Leslie Bradshaw Klumpp
The Effects Of Aging And Unilateral Vestibular Disorders On The Kinematic Performance Of Vestibular Rehabilitation Exercises And Physical Function, Micah Leslie Bradshaw Klumpp
LSU Doctoral Dissertations
The overall purpose of this study was to evaluate the effects of unilateral vestibular disorders and aging on functional performances of activities of daily living and vestibular rehabilitation exercises by examining the correlations among actual and perceived functional measures, the kinematic measurement differences among young healthy adults, older healthy adults, and older adults with unilateral vestibular deficits, and the correlations between kinematic and functional measures. Perceived and actual functional abilities and kinematic variables were compared for young controls, older healthy controls, and patients with unilateral vestibular hypofunction with no previous vestibular rehabilitation. In older adults, better strength, balance, coordination, and …
Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli
Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli
LSU Doctoral Dissertations
Lyme disease is a multisystem disorder caused by the tick vector Borrelia burgdorferi. During its life cycle between the tick vector and the mammalian host, Borrelia up- and down-regulates the expression of its surface lipoproteins. Of its many surface lipoproteins, the Outer surface protein C (OspC) is crucial for initial mammalian infection. OspC has a common role shared with other lipoproteins of protection against host innate defences and a unique function in facilitating the dissemination of B. burgdorferi in the murine host. The structure of OspC was solved in 2001 and the lipoprotein was found to be predominantly alpha-helical with …
Carprofen-Induced Oxidative Stress In Mitochondria Of The Colonic Mucosa Of The Dog, Lynne A. Snow
Carprofen-Induced Oxidative Stress In Mitochondria Of The Colonic Mucosa Of The Dog, Lynne A. Snow
LSU Master's Theses
Objectives 1) To measure conductance and permeability of canine colonic mucosa exposed to increasing concentrations of carprofen. 2) To compare conductance and permeability of canine colonic mucosa exposed to carprofen or 2,4-dinitrophenol (DNP) and tempol blockade. Design In vitro randomized block design Animal 20 mixed breed dogs Methods Conductance, mannitol flux, and histology were evaluated in colonic mucosa mounted in Ussing chambers. Mucosa was first exposed to increasing concentrations of carprofen. Mucosa was then exposed to either carprofen (200 μg/ml) or DNP (0.25mM) +/- tempol (1mM) pretreatment. Conductance over time, mannitol fluxes, and frequency of histologic categories were analyzed for …