Medicine and Health Sciences Commons^™

Neuromuscular Factors Affecting Stretch-Induced Torque Loss, Gabriel Siqueira Trajano

Theses: Doctorates and Masters

The mechanisms underpinning the immediate torque loss induced by acute, static muscle stretching are still not clear. The current research was designed to examine the neuromuscular factors influencing this torque loss. In Study 1, the contributions of central versus peripheral factors to the stretch-induced torque loss were investigated. Measures of central drive, including the EMG amplitude normalised to the muscle compound action potential amplitude (EMG:M), percent voluntary activation (%VA) and first volitional wave amplitude (V:M), and measures of peripheral function, including the twitch peak torque and 20:80 Hz tetanic torque ratio were made before, and immediately and 15 min after …

Identification Of Plasma Lipid Biomarkers In Alzheimer's Disease, Rhona Creegan

Theses: Doctorates and Masters

Alzheimer’s disease (AD), the commonest form of dementia, is a chronic, progressive neurodegenerative disease which manifests clinically as a slow global decline in cognitive function, including deterioration of memory, reasoning, abstraction, language and emotional stability, culminating in a patient with end-stage disease, totally dependent on custodial care. With an ageing population, there is predicted to be a marked increase in the number of people diagnosed with AD in the coming decades, making this a significant challenge to socio-economic policy and aged care. Currently there is no cure for AD and while current therapies may temporarily ameliorate symptoms, death usually occurs …

The Creation And Validation Of A Youth Fundamental Hitting Scale: The Assessment Of Youth Baseball And Softball Hitting Fundamentals And The Perceived Psychological Barriers To Hitting A Pitched Ball, Andrew Walsh

Theses: Doctorates and Masters

The primary purpose of the thesis was to create a hitting scale for youth players that assess the fundamentals of a baseball swing. Secondly, the purpose of this thesis was to determine the interactions between the changes in anxiety, perceived competence and fear variables have with actual hitting competence over a four week sport specific training program.

Space-Time Statistical Analysis Of Malaria Morbidity Incidence Cases In Ghana: A Geostatistical Modelling Approach, Simon K. Appiah

Theses: Doctorates and Masters

Malaria is one of the most prevalent and devastating health problems worldwide. It is a highly endemic disease in Ghana, which poses a major challenge to both the public health and socio-economic development of the country. Major factors accounting for this situation include variability in environmental conditions and lack of prevention services coupled with host of other socio-economic factors. Ghana’s National Malaria Control Programme (NMCP) risk assessment measures have been largely based on household surveys which provided inadequate data for accurate prediction of new incidence cases coupled with frequent incomplete monthly case reports. These raise concerns about annual estimates on …

Acute Physiological Effects And Perceived Enjoyment Of A Single Bout Of Aerobic Interval And Continuous Moderate-Intensity Cycling In Overweight And Obese Individuals, Fujie Koh

Theses: Doctorates and Masters

Aerobic interval training, a form of high intensity interval training, is commonly prescribed to both the general and clinical populations. However, the acute physiological effects from a single bout of aerobic interval session are not fully understood. In training studies, these acute physiological effects may confound actual training adaptations when they occur following the final training session [1]. Furthermore, while recreationally active men perceived aerobic interval training to be more enjoyable than continuous moderate-intensity exercise [2], the preference of overweight and obese individuals has not been extensively researched. Since overweight and obese individuals tend to have lower exercise tolerance, it …

Relative Importance And Plasticity Of Anatomical And Neuromuscular Factors Affecting Joint Torque Production, Joanne C. Trezise

Theses: Doctorates and Masters

The present research aimed to determine (i) the relative influence anatomical and neuromuscular variables on maximal isometric, concentric and eccentric knee extensor torque (Study 1); (ii) whether the change in strength following a 10-week strength training program is associated with changes in specific anatomical and neuromuscular variables (Study 2a); (iii) whether anatomical and neuromuscular adaptations are dependent on their pre-training magnitudes; and (iv) whether it is possible to ‘predict’ an individual’s adaptation to strength training based on their anatomical and neuromuscular pre-training magnitudes (Study 2b).

The variables assessed throughout the studies include muscle cross-sectional area (CSA), fascicle length and angle …

Understanding And Improving Pacing Strategies During Standard Distance Triathlons In Age Group Athletes, Sam Shi Xuan Wu

Theses: Doctorates and Masters

Pacing is an integral aspect of performance during all exercise, including multi-sport events such as triathlon. However, to date, the optimal pacing strategies to adopt over an entire triathlon, as well as during each specific discipline (i.e. swim, cycle and run), is not well understood. Therefore, the primary purpose of this thesis was to identify and understand current pacing strategies adopted by highly performing triathletes across different triathlon distances. This research aids in identifying pacing strategies that may improve overall performance during triathlon.

In the first study, the influence of sex and race distance on the age-related declines in the …

A Series Of Studies Examining The Development Of Sprint Speed And Momentum Of International Rugby Union Players, Matthew John Barr

Theses: Doctorates and Masters

Sprinting speed is a highly valued physical ability in rugby. There is little research examining sprinting biomechanics in rugby players and it is unclear the extent that sprinting speed and sprint momentum can even be improved in highly trained rugby players and how different speed and strength training methods might help improve it. This thesis consists of 6 studies that examine the sprinting biomechanics of elite rugby players, how strength and power training might improve sprinting speed and the potential for elite rugby players to make further improvement in their sprinting speed and sprint momentum.

Key biomechanical factors were that …

Factors That Influence The Decision-Making Of An Integrated Rehabilitation Team When Choosing A Post-Hospital Discharge Destination For Survivors Of Stroke, Jessie M. Johnson

Theses: Doctorates and Masters

Stroke is one of the more disabling conditions which may result in the inability for survivors to care for themselves independently. Stroke survivors benefit most when they receive early onset assessment, treatment, and rehabilitation. Increasingly, stroke care in Canadian hospitals relies on an interdisciplinary rehabilitation team approach to provide immediate rehabilitation services and to make decisions about discharge destination for stroke survivors. Currently, there is little research on how interdisciplinary rehabilitation teams decide upon rehabilitation placements for stroke survivors or how individuals on the team, stroke survivors, or their families participate in and contribute to this decision. This research studied …

Lower Limb Fatigue Asymmetry Of Preferred And Non-Preferred Legs After A Repeated-Sprint Test In Football Players With Previous Hamstring Injury, Cameron Lord

Theses: Doctorates and Masters

Football is the most widely played sport in the world and is thus associated with the highest total number of injuries of all sports. 12% of all football injuries are to the hamstrings, as this muscle group is subjected to constant stress during training and match play performance (Ekstrand, Hägglund, Waldén, 2011; Woods, Hawkins, Maltby, Hulse, Thomas & Hodson, 2004). While the influence of limb dominance has been extensively examined as a risk factor for injury in upper limb-dominant sports (e.g. badminton, tennis and baseball), little research has focussed on the dominance in the lower limbs. Since almost all footballers …

An Investigation Of Technique And Equipment Factors Associated With Clubhead Speed In Golf, Christopher Joyce

Theses: Doctorates and Masters

If golfers achieve long hitting distances whilst maintaining their accuracy they will gain a competitive advantage. To increase hitting distance, faster clubhead speed is required and this can potentially be achieved through a number of factors. Firstly, anthropometric factors such as height and physical factors such as trunk rotational power have been previously considered to be of importance. However, biomechanical factors such as; the X-factor (separation of the trunk-pelvis alignment when viewed in the transverse plane), have been a major focus of recent research. Further, the interaction of the golfer with the implement they hit with i.e. the golf club …

Plasma Insulin-Degrading Enzyme: Characterisation And Evaluation As A Potential Biomarker For Alzheimer's Disease, Michelle Tegg

Theses: Doctorates and Masters

Alzheimer’s disease (AD) is increasing in prevalence due to increasing lifespan and altered lifestyle. It is the fourth major cause of death in Western countries, resulting in significant economic and social impact (Von Strauss, et al., 1999; Goate, 1997). There are no blood biomarkers currently accepted for the diagnosis of AD, and the identification of suitable biomarkers would eventually reduce the necessity for invasive, expensive and slow diagnostic procedures, as well as facilitate prognostic studies. An AD blood test would decrease the need for delaying diagnosis due to ambivalent presentation, and allow therapeutic intervention to commence at an earlier …

Developing Effective Hospital Management Information Systems: A Technology Ecosystem Perspective, Christopher Bain

Theses: Doctorates and Masters

This thesis presents the results of the program of research performed in the completion of a Doctor of Philosophy (Business) entitled: Developing Effective Hospital Management Information Systems: A Technology Ecosystem Perspective.

The central contention of this thesis is that the current ecosystem models in the information technology (IT) and information systems (IS) literature can be extended and improved. In turn they can be better applied to the field of IS and the development and implementation of information systems. This research seeks to highlight an example of how these models can be extended, through an analysis of the specific context of …

Role Of Physical Exercise In Reducing Depression And Improving Mental Health In Cancer Survivors, Gregory Levin

Theses: Doctorates and Masters

Cancer survivors are more than twice as likely as the general population to suffer the debilitating effects of depression. This comorbid condition is associated with several negative consequences, such as reduction in compliance with cancer treatments, and hastened mortality. Recent research has examined the therapeutic effect of exercise on depression and reported excellent results of similar magnitude to those achieved with pharmacotherapy or psychological intervention. However, no research, to date, has examined the effectiveness of exercise on reducing depression in depressed cancer survivors. In order to address this important question this thesis reviewed previous literature in the area of cancer …

Impact Of Nutrition On Cognition And Its Association With Blood And Brain Alzheimer Disease Related Biomarkers, Samantha Gardener

Theses: Doctorates and Masters

Alzheimer’s disease (AD), the most common form of senile dementia, currently affects over 35 million people worldwide. While there is no cure or effective treatment, early intervention programs hold considerable promise. Following particular dietary patterns represents one potential intervention strategy accessible to all.

Results from previous studies investigating the association of diet, cognition and biomarkers of AD are inconsistent: Positive results have been reported (1-7), whilst others have shown no associations. Prior to this thesis, no study has assessed the relationship of four dietary patterns to cognition, blood-based and neuroimaging biomarkers of AD in a large highly-characterised ageing cohort. Participants …

Comparison Of The Physical, Physiological And Perceptual Demands Of Small-Sided Games And Match Play In Professional Football Players, Stephen Hissey

Theses: Doctorates and Masters

The physical and technical requirements of a range of small-sided football (soccer) games (SSGs) have previously been examined in order to compare their requirements to competitive match play. SSGs are used to combine the technical, tactical and physical components of normal match play in training in order to make the training sessions specific to football. However, most previous research has focused on youth players and it is known that the playing patterns, and thus session outcomes, are different for elite players. Consequently, research examining elite players is required in order to improve our understanding of the use of SSGs in …

The Identity Of The Heart Patient In The Context Of The Gift Economy: Heartnet And Media Framing, Lynsey Uridge

Theses: Doctorates and Masters

This health communication research examines the identity levels of the heart patient on a therapeutic website HeartNET through an empirical investigation of site interactions as manifestations of a gift economy. The thesis also explores the media’s representation of heart health in both television and print.

This research utilised a longitudinal qualitative ethnographic and netnographic approach involving twenty-six participants who completed two in-depth interviews. The first one-on-one interview occurred during the early stages of the participants’ heart journey, explored their heart story and use of interactive technology for heart health support. The second interview occurred six to twelve months later, and …

Higher Breakfast Glycaemic Load Is Associated With Increased Metabolic Syndrome Risk, Including Lower Hdl-Cholesterol Concentrations And Increased Tag Concentrations, In Adolescent Girls, Analise Nicholl, Mary Du Heaume, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Alexandra P. Bremner, Therese A. O'Sullivan

Research outputs 2014 to 2021

Almost all previous studies examining the associations between glycaemic load (GL) and metabolic syndrome risk have used a daily GL value. The daily value does not distinguish between peaks of GL intake over the day, which may be more closely associated with the risk of the metabolic syndrome. The aim of the present study was to investigate the cross-sectional associations between daily and mealtime measures of GL and metabolic syndrome risk, including metabolic syndrome components, in adolescents. Adolescents participating in the 14-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study completed 3 d food records and metabolic assessments. Breakfast …

The Reliability Of An Adolescent Dietary Pattern Identified Using Reduced-Rank Regression: Comparison Of A Ffq And 3 D Food Record, Geeta Appannah, Gerda K. Pot, Therese A. O'Sullivan, Wendy H. Oddy, Susan A. Jebb, Gina L. Ambrosini

Research outputs 2014 to 2021

Despite the increasing use of dietary patterns (DP) to study diet and health outcomes, relatively few studies have examined the reliability of DP using different dietary assessment methods. Reduced-rank regression (RRR) is an emerging statistical method that incorporates a priori information to characterise DP related to specific outcomes of interest. The aim of the present study was to compare DP identified using the RRR method in a FFQ with those in a 3 d food record (FR). Participants were 783 adolescents from the Western Australian Pregnancy (Raine) Cohort Study who completed both a FFQ and FR at 14 years of …

Young Australian Adults’ Reactions To Viewing Personalised Uv Photoaged Photographs, Lori L. Presti, Paul Chang, Myra F. Taylor

Research outputs 2014 to 2021

Background: Despite two nationwide sun-protection awareness campaigns, young Australian adults continue to sunbathe. Since their primary motivation for tanning is appearance enhancement, it may well be that campaigns that highlight the negative effects of tanning on appearance are more effective than campaigns that emphasise the health risks associated with sun exposure.Aims: This study aims to explore young adults’ reactions to viewing a photoaged photograph of the sun damage already visible in their facial image.Methods: Semi-structured interviews were conducted with seven females and three males aged 20-30 years. The interview transcripts were transcribed verbatim and were then subjected to Interpretive Phenomenological …

Altered Cytological Parameters In Buccal Cells From Individuals With Mild Cognitive Impairment And Alzheimer's Disease, Maxime François, Wayne Leifert, Jane Hecker, Jeffrey Faunt, Ralph Martins, Philip Thomas, Michael Fenech

Research outputs 2014 to 2021

Previous studies have shown that mild cognitive impairment (MCI) may be reflective of the early stages of more pronounced neurodegenerative disorders such as Alzheimer's disease (AD). There is a need for a minimally invasive and inexpensive diagnostic to identify those who exhibit cellular pathology indicative of MCI and AD risk so that they can be prioritized for primary preventative measures. The hypothesis was that a minimally invasive approach using cytological markers in isolated buccal mucosa cells can be used to identify individuals of both MCI and AD. An automated buccal cell assay was developed using laser scanning cytometry (LSC) to …

Motherless Mothers: Maternally Bereaved Women In Their Everyday Roles As Mothers, Bethwyn Rowe, Bronwyn A. Harman

Research outputs 2014 to 2021

Motherless mothers are women who lose their mothers to death prior to having their children, and therefore raise their children without the maternal support and guidance afforded to many women whose mothers are still alive (Edelman, 2006). A qualitative research design was used to gain an in-depth understanding of the everyday experiences faced by motherless mothers. Semi-structured, in-depth interviews were conducted with 10 motherless mothers. Four major themes emerged including grief, support, absence of knowledge, and changes to self following loss. Results provide insight into the ongoing influence a mother's death can have on a daughter's life and draw distinction …

A Dynamic Evaluation Of How Kick Point Location Influences Swing Parameters And Related Launch Conditions, Christopher Joyce, Angus Burnett, Alvaro Reyes, Stephen Herbert

Research outputs 2014 to 2021

In golf, many parameters of the driver can be modified to maximise hitting distance. The main objective of this study was to determine whether drivers fitted with shafts having high and low kick points would alter selected swing parameters and related launch conditions. In total, 12 elite male golfers (handicap score = 1.2 ± 1.8) had three shots analysed for two drivers fitted with 'stiff' shafts with differing kick point location. Stiffness profiles of these shafts were also measured. Five swing and related launch parameters were measured using a real-time launch monitor. The locations of the low and high kick …

The Use Of Unregulated Staff: Time For Regulation?, Christine M. Duffield, Di E. Twigg, Judith D. Pugh, Gemma Evans, S Dimitrelis, Michael A. Roche

Research outputs 2014 to 2021

Internationally, shortages in the nursing workforce, escalating patient demands, and financial constraints within the health system have led to the growth of unlicensed nursing support workers. Recently, in relation to the largest publicly funded health system (National Health Service), it was reported that extensive substitution of registered nurses with unskilled nursing support workers resulted in inadequate patient care, increased morbidity and mortality rates, and negative nurse outcomes. We argue that it is timely to consider regulation of nursing support workers with their role and scope of practice clearly defined. Further, the addition of these workers in a complementary model of …

Overexpression Of Phospholipase A2 Group Iia In Esophageal Squamous Cell Carcinoma And Association With Cyclooxygenase-2 Expression, Yan Chun Zhai, Bin Dong, Wen Qiang Wei, Yan He, Xin Qing Li, Robert T. Cormier, Wei Wang, Fen Liu

Research outputs 2014 to 2021

Background: Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Materials and Methods: Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high-risk population in China. Results: Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), …

Urinary And Breast Milk Biomarkers To Assess Exposure Ro Naphthalene In Pregnant Women: An Investigation Of Personal And Indoor Air Sources, Amanda J. Wheeler, Nina A. Dobbin, Marie-Eve Heroux, Mandy Fisher, Liu Sun, Cheryl F. Khoury, Russ Hauser, Mark Walker, Tim Ramsay, Jean-Francois Bienvenu, Alain Leblanc, Eric Daigle, Eric Gaudreau, Patrick Belanger, Mark Feeley, Pierre Ayotte, Tye E Arbuckle

Research outputs 2014 to 2021

Naphthalene exposures for most non-occupationally exposed individuals occur primarily indoors at home. Residential indoor sources include pest control products (specifically moth balls), incomplete combustion such as cigarette smoke, woodstoves and cooking, some consumer and building products, and emissions from gasoline sources found in attached garages. The study aim was to assess naphthalene exposure in pregnant women from Canada, using air measurements and biomarkers of exposure.

Prevalence And Risk Factors For Cervical Neoplasia: A Cervical Cancer Screening Program In Beijing, Lixin Tao, Lili Han, Xia Li, Qi Gao, Lei Pan, Lijuan Wu, Yanxia Luo, Wei Wang, Zihe Zheng, Xiuhua Guo

Research outputs 2014 to 2021

Cervical cancer is the second most common cancer and cause of cancer-related death for women worldwide. The aims of this study were to investigate the prevalence of cervical neoplasia and examine factors associated with high-grade cervical squamous intraepithelial lesions (HSIL) among women taking part in a cervical cancer screening program in Beijing.

Dystonia Type 6 Gene Product Thap1: Identification Of A 50 Kda Dna-Binding Species In Neuronal Nuclear Fractions, Maitane Ortiz-Virumbrales, Marta Ruiz, Eugene Hone, Georgia Dolios, Rong Wang, Andrika Morant, Jessica Kottwitz, Laurie J. Ozelius, Sam Gandy, Michelle Ehrlich

Research outputs 2014 to 2021

Mutations in THAP1 result in dystonia type 6, with partial penetrance and variable phenotype. The goal of this study was to examine the nature and expression pattern of the protein product(s) of the Thap1 transcription factor (DYT6 gene) in mouse neurons, and to study the regional and developmental distribution, and subcellular localization of Thap1 protein. The goal was accomplished via overexpression and knock-down of Thap1 in the HEK293T cell line and in mouse striatal primary cultures and western blotting of embryonic Thap1-null tissue. The endogenous and transduced Thap1 isoforms were characterized using three different commercially available anti-Thap1 antibodies and validated …

Toward An Ethics Of Reciprocity: Ethnobotanical Knowledge And Medicinal Plants As Cancer Therapies, John C. Ryan

Research outputs 2014 to 2021

This article develops a reciprocity ethics of the environment through a discussion of ethnobotanical medicines used in the treatment of cancer. The moral virtue of reciprocity, defined as the returning of good when good is received or anticipated, is central to the posthumanist rethinking of human relationships to the plant world. As herbal medicines are used progressively more around the globe and as plant diversity decreases as a result of habitat loss and climate change, an ethics of reciprocity should be a concern for environmental philosophers and conservationists. Aldo Leopold’s land ethic and J. Baird Callicott’s distinction between deontological and …

Time Course Of Central And Peripheral Alterations After Isometric Neuromuscular Electrical Stimulation-Induced Muscle Damage, Alexandre Fouré, Kazunori Nosaka, Jennifer Wegrzyk, Guillueme Duhamel, Arnaud Le Troter, Helene Boudinet, Jean-Pierre Mattei, Christophe Vilmen, Marc Jubeau, David Bendahan, Julien Gondin

Research outputs 2014 to 2021

Isometric contractions induced by neuromuscular electrostimulation (NMES) have been shown to result in a prolonged force decrease but the time course of the potential central and peripheral factors have never been investigated. This study examined the specific time course of central and peripheral factors after isometric NMES-induced muscle damage. Twenty five young healthy men were subjected to an NMES exercise consisting of 40 contractions for both legs. Changes in maximal voluntary contraction force of the knee extensors (MVC), peak evoked force during double stimulations at 10 Hz (Db10) and 100 Hz (Db100), its ratio (10:100), voluntary activation, muscle soreness and …