Medicine and Health Sciences Commons^™

Conjugated Linoleic Acid Administration Induces Amnesia In Male Sprague Dawley Rats And Exacerbates Recovery From Functional Deficits Induced By A Controlled Cortical Impact Injury, Rastafa I. Gedde, Kentaro Hayashi, Quinn Bongers, Marlyse Wehber, Icelle M. Anderson, Alex D. Jansen, Chase Nier, Emily Fares, Gabrielle Farquhar, Amita Kapoor, Toni E. Ziegler, Sivan Vadakkadath Meethal, Ian M. Bird, Craig S. Atwood

Research outputs 2014 to 2021

Long-chain polyunsaturated fatty acids like conjugated linoleic acids (CLA) are required for normal neural development and cognitive function and have been ascribed various beneficial functions. Recently, oral CLA also has been shown to increase testosterone (T) biosynthesis, which is known to diminish traumatic brain injury (TBI)-induced neuropathology and reduce deficits induced by stroke in adult rats. To test the impact of CLA on cognitive recovery following a TBI, 5–6 month old male Sprague Dawley rats received a focal injury (craniectomy + controlled cortical impact (CCI; n = 17)) or Sham injury (craniectomy alone; n = 12) and were injected with …

Genome Analysis Of Clostridium Difficile Pcr Ribotype 014 Lineage In Australian Pigs And Humans Reveals A Diverse Genetic Repertoire And Signatures Of Long-Range Interspecies Transmission, Daniel R. Knight, Michael M. Squire, Deirdre A. Collins, Thomas V. Riley

Research outputs 2014 to 2021

Clostridium difficile PCR ribotype (RT) 014 is well-established in both human and porcine populations in Australia, raising the possibility that C. difficile infection (CDI) may have a zoonotic or foodborne etiology. Here, whole genome sequencing and high-resolution core genome phylogenetics were performed on a contemporaneous collection of 40 Australian RT014 isolates of human and porcine origin. Phylogenies based on MLST (7 loci, STs 2, 13, and 49) and core orthologous genes (1260 loci) showed clustering of human and porcine strains indicative of very recent shared ancestry. Core genome single nucleotide variant (SNV) analysis found 42 % of human strains showed …

Which Food Security Determinants Predict Adequate Vegetable Consumption Among Rural Western Australian Children?, Stephanie L. Godrich, Johnny Lo, Christina R. Davies, Jill Darby, Amanda Devine

Research outputs 2014 to 2021

Improving the suboptimal vegetable consumption among the majority of Australian children is imperative in reducing chronic disease risk. The objective of this research was to determine whether there was a relationship between food security determinants (FSD) (i.e., food availability, access, and utilisation dimensions) and adequate vegetable consumption among children living in regional and remote Western Australia (WA). Caregiver-child dyads (n = 256) living in non-metropolitan/rural WA completed cross-sectional surveys that included questions on FSD, demographics and usual vegetable intake. A total of 187 dyads were included in analyses, which included descriptive and logistic regression analyses via IBM SPSS (version 23). …

Effects And Moderators Of Exercise On Quality Of Life And Physical Function In Patients With Cancer: An Individual Patient Data Meta-Analysis Of 34 Rcts, Laurien M. Buffart, Joeri Kalter, Maike G. Sweegers, Kerry S. Courneya, Robert U. Newton, Neil K. Aaronson, Paul B. Jacobsen, Anne M. May, Daniel A. Galvao, Mai J. Chinapaw, Karen Steindorf, Melinda L. Irwin, Martjin M. Stuiver, Sandi Hayes, Kathleen A. Griffith, Alejandro Lucia, Ilse Mesters, Ellen Van Weert, Hans Knoop, Martine M. Goedendorp, Nanette Mutrie, Amanda J. Daley, Alex Mcconnachie, Martin Bohus, Lene Thorsen, Karl-Heinz Schulz, Camille E. Short, Erica L. James, Ron C. Plotnikoff, Gill Arbane, Martina E. Schmidt, Karin Potthoff, Marc Van Beurden, Hester S. Oldenburg, Gabe S. Sonke, Wim H. Van Harten, Rachel Garrod, Kathryn H. Schmitz, Kerri M. Winters-Stone, Miranda J. Velthuis, Dennis Taaffe, Willem Van Mechelen, Marie-Jose Kersten, Frans Nollet, Jennifer Wenzel, Joachim Wiskemann, Irma M. Verdonck-De Leeuw, Johannes Brug

Research outputs 2014 to 2021

This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics.

Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications. Principle investigators of all 69 eligible trials were requested to share IPD from …

Exercise Preserves Physical Function In Prostate Cancer Patients With Bone Metastases, Daniel A. Galvao, Dennis R. Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K. Chambers, Raphael Chee, Carolyn J. Peddle-Mcintyre, Nicolas H. Hart, Freerk T. Baumann, James Denham, Michael Baker, Robert U. Newton

Research outputs 2014 to 2021

The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting due to concerns of fragility fracture. We examined the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases.Between 2012 and 2015, 57 prostate cancer patients (70.0 ± 8.4 years; BMI 28.7 ± 4.0 kg/m) with bone metastases (pelvis 75.4%, femur 40.4%, rib/thoracic spine 66.7%, lumbar spine 43.9%, humerus 24.6%, other sites 70.2%) were randomised to multi-modal supervised aerobic, resistance and flexibility exercises undertaken thrice weekly (EX, n …

Impact Of Aquaporin (Aqp1 And Aqp4) Genetic Variation On The Relationship Between Sleep Quality And Alzheimer’S Disease Pathological Hallmarks, Gavin Noel Mazzucchelli

Theses : Honours

Alzheimer’s disease (AD) is widely recognised as a growing global health issue with far ranging social and economic implications. The accumulation of Amyloid-β (Aβ) in the brain is a pathological hallmark of AD. A recently discovered lymphatic–like system in the central nervous system (termed the glymphatic system) has been postulated to be both implicit in the clearance of Aβ from the brain, and most effective during sleep—making sleep an important consideration in the investigation of AD. Central nervous system expressed water channel proteins, namely Aquaporin 1 and 4, have been suggested to play a pivotal role in glymphatic function and …

Kinematic Repeatability Analyses Of Multi-Segment Foot Motion In University-Level Ballet Dancers, Sarah Carter, Nahoko Sato, Luke Hopper

ECU Posters

Background:

Dancers are susceptible to overuse foot and ankle injuries, however there is a lack biomechanical studies examining foot mechanics to explain the causality of these injuries. The purpose of this study was to determine the intra and inter-assessor repeatability of a modified Rizzoli Foot Model (RFM) for ballet dancers.

Methods: Six university-level ballet dancers performed the following trials in randomized order, natural stance, turnout plié and stance, and two dynamic trials; turnout rise and flex-point-flex movement. A twelve-camera motion capture system were used to track fourteen reflective markers and one triad on the following segments: shank, entire foot, hindfoot, …

Lower Leg And Foot Contributions To Turnout In University-Level Female Ballet Dancers: A Preliminary Investigation, Sarah Carter, Alan R. Bryant, Luke Hopper

ECU Posters

Functional turnout in ballet involves maximal external rotation through the lower limb kinetic chain. Hip external rotation, is considered the primary contributor of functional turnout. However, dancers will tend to increase their functional turnout angle through additional tibiofemoral external rotation and pronation of the foot/ankle complex. Hip external rotation measures in functional turnout has received extensive examination in dance science. However, the relationship between the ‘below the hip' assessments with functional turnout is poorly understood. We hypothesis that dancers with greater passive external tibiofemoral rotation (pTFR) and/or pronated stance will have a greater functional turnout angle.

Nineteen female university-level classical …

Response By Bondonno Et Al To Letter Regarding Article, “Association Of Vegetable Nitrate Intake With Carotid Atherosclerosis And Ischemic Cerebrovascular Disease In Older Women”, Catherine P. Bondonno, Lauren C. Blekkenhorst, Jonathan M. Hodgson

Research outputs 2014 to 2021

No abstract provided.

An Investigation Of The Mechanics And Sticking Region Of A One-Repetition Maximum Close-Grip Bench Press Versus The Traditional Bench Press, Robert G. Lockie, Samuel J. Callaghan, Matthew R. Moreno, Fabrice G. Risso, Tricia M. Liu, Alyssa A. Stage, Samantha A. Birmingham-Babauta, John J. Stokes, Dominic V. Giuliano, Adrina Lazar, Deshaun L. Davis, Ashley J. Orjajo

Research outputs 2014 to 2021

The close-grip bench press (CGBP) is a variation of the traditional bench press (TBP) that uses a narrower grip (~95% of biacromial distance (BAD)) and has potential application for athletes performing explosive arm actions from positions where the hands are held close to the torso. Limited research has investigated CGBP mechanics compared to the TBP. Twenty-seven resistance-trained individuals completed a one-repetition maximum TBP and CGBP. The TBP was performed with the preferred grip; the CGBP with a grip width of 95% BAD. A linear position transducer measured lift distance and duration; peak and mean power, velocity, and force; distance and …

Acute Exposure To Fine Particulate Matter And Cardiovascular Hospital Emergency Room Visits In Beijing, China, Qin Xu, Shuo Wang, Yuming Guo, Chao Wang, Fangfang Huang, Xian Li, Qi Gao, Lijuan Wu, Lixin Tao, Jin Guo, Wei Wang, Xiuhua Guo

Research outputs 2014 to 2021

Fine particulate matter (PM_2.5) air pollution outbreaks have recently occurred frequently in China. However, evidence of the associations between short-term exposure to PM_2.5 and cardiovascular morbidity is still limited in China. This study aimed to evaluate the associations between PM_2.5 and hospital emergency room visits (ERVs) for cardiovascular diseases in urban areas in Beijing. Daily counts of cardiovascular ERVs were collected from ten large general hospitals from Jan 1 to Dec 31, 2013. Air pollution data were obtained from the Beijing Environmental Protection Bureau including 17 monitoring stations. A generalized additive Poisson model was used to …

Altered Levels Of Blood Proteins In Alzheimer's Disease Longitudinal Study: Results From Australian Imaging Biomarkers Lifestyle Study Of Ageing Cohort, Veer B. Gupta, Eugene Hone, Steve Pedrini, James D. Doecke, Sid E. O'Bryant, Ian James, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Ralph N. Martins

Research outputs 2014 to 2021

Introduction

A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing.

Methods

We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort.

Results

Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P =.0003) and chemokine-309 (I-309) were increased in AD patients compared to mild cognitive impaired individuals over 36 months (P =.0008).

Discussion

These data suggest that apoJ may have potential in the context …

“Mental Health Day” Sickness Absence Amongst Nurses And Midwives: Workplace, Workforce, Psychosocial And Health Characteristics, Scott Lamont, Scott Brunero, Lin Perry, Christine M. Duffield, David Sibbritt, Robyn Gallagher, Rachel Nicolls

Research outputs 2014 to 2021

Aim

To examine the workforce, workplace, psychosocial and health characteristics of nurses and midwives in relation to their reported use of sickness absence described as ‘mental health days’.

Background

The occupational stress associated with the nursing profession is increasingly recognized and nurse/midwifery absenteeism is a significant global problem. Taking a ‘mental health day’ as sickness absence is a common phenomenon in Australian health care. No previous studies have empirically explored the characteristics of nurses and midwives using such sickness absence.

Design

Online cross-sectional survey.

Methods

Survey comprising validated tools and questions on workplace and health characteristics was distributed to nurses …

Workplace Violence Against Nurses: A Cross-Sectional Descriptive Study Of Ghanaian Nurses, Isaac Mensah Boafo, Peter Hancock

Research outputs 2014 to 2021

The aim of this study was to document the incidence, sources, and effects of workplace physical violence against Ghanaian nurses. Self-report questionnaires were completed by 592 nurses employed in public general hospitals in Ghana. Participants were selected using a combination of purposive and random sampling techniques. Nine percent of the participants experienced physical violence in the 12 months preceding the study. The majority of perpetrators were relatives of patients. Chi-square tests suggested significant relationships between type of hospital and workplace physical violence, and between intention to quit the nursing profession and workplace physical violence. Workplace violence had several negative effects …

Pd-L1 Expressing Circulating Tumour Cells In Head And Neck Cancers, Arutha Kulasinghe, Chris Perry, Liz Kenny, Majid E. Warkiani, Colleen Nelson, Chamindie Punyadeera

Research outputs 2014 to 2021

Background

Blockade of the PD-1/PD-L1 immune checkpoint pathway is emerging as a promising immunotherapeutic approach for the management and treatment of head and neck cancer patients who do not respond to 1st/2nd line therapy. However, as checkpoint inhibitors are cost intensive, identifying patients who would most likely benefit from anti PD-L1 therapy is required. Developing a non-invasive technique would be of major benefit to the patient and to the health care system.

Case presentation

We report the case of a 56 year old man affected by a supraglottic squamous cell carcinoma (SCC). A CT scan showed a 20 mm right …

Feasibility Of Presurgical Exercise In Men With Prostate Cancer Undergoing Prostatectomy, Favil Singh, Robert Newton, Michael Baker, Nigel Spry, Dennis Taaffe, Jeffery Thavaseelan, Daniel A. Galvao

Research outputs 2014 to 2021

Background:

Prostatectomy is associated with short- and long-term morbidity, which includes attenuation of muscle function and deterioration of lean body mass. Physical function is a known predictor of morbidity and mortality, with initial evidence indicating that presurgical exercise is associated with fewer postsurgical complications and shorter hospitalization. The aim was to determine the feasibility of a supervised presurgical exercise program for prostate cancer (PCa) patients scheduled for prostatectomy.

Methods:

Ten men (68+6.4 years old) with localized PCa undertook a 6-week resistance and aerobic exercise program prior surgery. Training was undertaken twice weekly and patients were assessed at baseline, presurgery, and …

Anaemia Of Chronic Kidney Disease: What We Know Now, Anoushka R. Krishnan, Debbie Trinder, Anita C. G. Chua, Aron Chakera, Grant A. Ramm, John K. Olynyk

Research outputs 2014 to 2021

Our understanding of the pathophysiology of the anaemia of chronic kidney disease (CKD) has improved considerably in the last decade with the discovery of the iron regulatory peptide hepcidin. Reduced clearance of hepcidin and the presence of a chronic inflammatory state contribute to elevated hepcidin levels in kidney disease. The recent discovery of the various factors and signalling pathways regulating hepcidin has opened up an exciting avenue for research into the development of newer agents that could treat anaemia of CKD. This review highlights our current understanding of iron metabolism in health, the regulators of hepcidin, issues associated with the …

‘Fighting A Losing Battle’: A Glaserian Grounded Theory Of Midwives’ Workplace Stress, Sadie Margaret Geraghty

Theses: Doctorates and Masters

The development of the midwifery profession and the culture of childbirth are inevitably entwined from an historical perspective through to current day practice. Early written accounts describe the fifteenth century midwife as dealing with high maternal and child mortality rates, the invention of forceps, the rise of male obstetric practitioners, and the complex social and cultural changes of that era. The twenty-first century midwife faces challenges in Australia and worldwide, which are not dissimilar to our midwifery predecessors.

Midwifery clinical practice has become more complex due to the medicalisation of childbirth and 21st century lifestyles, which have contributed to a …

The Performance Analysis Of Power Output In Professional Male Road Cyclists, Alan J. Metcalfe

Theses: Doctorates and Masters

Athletes regularly monitor exercise workload in an attempt to improve and maintain exercise performance. Within road cycling, workload is commonly measured using power output. Yet, it is plausible that power output during road cycling is influenced by several factors such as topography, road gradient or rider specialities. If these factors do influence power output they may influence quantification of workload demands. As such, the purpose of this thesis was to improve our understanding of external workload in professional road cycling and describe the factors which influence power output during performance analysis. Specifically, this thesis examined the power output within single …

Food Insecurity And Fruit And Vegetable Consumption Among Regional And Remote Western Australian Children: Determinants, Prevalence And Predictors, Stephanie Louise Godrich

Theses: Doctorates and Masters

Living in a community with adequate availability of nutritious food, and the capacity to access and utilise it, are key food security determinants (FSD). However, inequities relating to these determinants exist between regional and remote Western Australian (WA) communities, particularly regarding fruit and vegetables (F&V). This negatively impacts vulnerable populations, especially children. In order to understand determinants, prevalence and predictors of F&V and food security (FS), three concepts were explored in this PhD; (1) F&V consumption among regional and remote WA children (including determinants of F&V consumption, quantities, types, varieties of F&V consumed); (2) FS among regional and remote WA …

Exploring The Experience Of Separation In Australia: Perspectives From Formerly Married And Cohabiting Parents, Sarah M. Barbas

Theses: Doctorates and Masters

The increase in separation and divorce rates during the 20th century brought with it many far-reaching social implications for all involved, sparking a high level of interest among researchers. Most research in this area has been approached from stress frameworks that have conceptualised separation and divorce as a stressful life transition that individuals must adjust to. Yet, attempts to understand separation and divorce to date have been dominated by quantitative methods that have resulted in a relatively static and objective understanding of this experience; particularly in Australia. Furthermore, although international rates of divorce are declining, rates of separation following cohabiting …

Optimisation Of The Isolation And Identification Of Circulating Melanoma Cells, Anda-Gabriela Marsavela

Theses: Doctorates and Masters

Although melanoma is largely curable when detected in its earliest stages, it can metastasise to other tissues, drastically reducing survival rates. The most recent therapies used to treat metastatic melanoma are effective long-term in only 11 to 33% of patients. Our ability to monitor treatment failure is limited. New prognostic markers are urgently required to allow monitoring of treatment response and disease progression.

Circulating tumour cells (CTCs) are released into the bloodstream by the tumours within a patient, this being a key step in melanoma spread. Since CTCs can be detected in the blood of metastatic melanoma patients, these cells …

A Nested Environmental Approach To Typhoid Epidemiology In Central Division, Fiji, Aaron Jenkins

Theses: Doctorates and Masters

Many current disease threats involve interactions within and between nested subsystems of biological organisation. Typhoid fever is a serious disease threat in the South Pacific region, with Fiji reporting the highest annual number of cases, yet risk factors in this setting have been poorly studied. While localised behaviours have dominated perspectives on typhoid transmission, interactions between distal ecological conditions, conditions of the residential environment and localised behaviour deserve greater attention for their potential to influence transmission. This thesis demonstrates a nested approach to typhoid epidemiology using a fivefold methodology to explore how regional, river basin, residential, socio-cultural and behavioural subsystems …

Effect Of A Neuromuscular Electrical Stimulation Muscle Strength Training Intervention On Muscle Force And Mass, Physical Health And Quality Of Life In People With Spinal Cord Injury, Vanesa Bochkezanian

Theses: Doctorates and Masters

Spinal cord injury (SCI) leads to significant deficits in muscle strength and mass, impacting negatively on physical health and quality of life (QoL). Physical rehabilitation techniques for people with SCI rely on constant updates and the accumulation of evidence regarding the efficacy of available and/or new physical interventions. Neuromuscular electrical stimulation (NMES) is already commonly used to activate skeletal muscles and subsequently reverse muscle atrophy, however NMES as a high-intensity “strength training” intervention appears to be a particularly promising technique for increasing muscle strength and mass and to subsequently improve physical health and quality of life (QoL) in people with …

Investigating The Practice And Capacity Of Paediatric Occupational Therapists To Promote The Physical Activity Levels Of Children In Western Australia, Sally Coombs

Theses: Doctorates and Masters

Reorientation of the Australian health care system to meet the increasing burden of disease requires health workers to develop a focus on disease prevention and health promotion. In Western Australia (WA) a priority area for the promotion of health involves increasing the physical activity levels (PAL) of children in accordance with Australia’s Physical Activity and Sedentary Behaviour Guidelines. There is substantial support in the literature for paediatric occupational therapists, who assist children to participate in a range of meaningful occupations, to incorporate the promotion of children’s PAL into their service. However, there is a dearth of research world-wide regarding occupational …

From Gd2o3suspension To Nanocomposite: Synthesis, Properties And Radiation Protection, Ly B. T. La

Theses: Doctorates and Masters

This study provides details for the design, preparation of an environmentally friendly, clinically safe and lightweight radiation protective shield made ofGd2O3/epoxy nanocomposite (Gd-nanocomposite) which is proposed as an alternative to traditional toxic lead (Pb)-based aprons for diagnostic X-ray protection. In theory, this particulate nanocomposite can possess significant features of both inorganic particles and organic polymeric matrices. However, in practice, its performance does not simply depend on the sum of the individual contributions of characteristics of the constituent phases but on the interaction of their inner interfaces and the homogeneous dispersion of inorganic particles in the polymer matrix.

The miniaturization of …

The Impact Of Communication Satisfaction On Paediatric Nurses’ Job Satisfaction And Intention To Stay, Gemma Doleman

Theses: Doctorates and Masters

Effective communication is the most central process within an organisation and is essential to organisational values, norms and expectations. There is a documented connection between job satisfaction, work commitment and organisational communication. However, nurses’ and nursing middle managers’ satisfaction with organisational communication has not been extensively studied in recent years and not at all among paediatric nurses. Therefore, the purpose of this study was to develop and test a theoretical model that examined paediatric nurses’ and middle managers’ satisfaction with organisational communication and the effect this has on paediatric nurses’ job satisfaction and intention to stay in their job.

Employing …

Comparison In Muscle Activity Between The Back Squat, Romanian Deadlift And Barbell Hip Thrust During Hip Extension, Jose Delgado

Theses: Doctorates and Masters

Common resistance-training exercises such as back squat, Romanian deadlift (RDL), and hip thrust have been used by strength and conditioning specialists to target the musculature used during hip extension. Little is known about the differences in muscular activity of the hip extensors between these exercises, so it is not known which is the most effective as a hip extensor exercise. The primary purpose of this study was to compare muscle activity of several muscles during the high-bar back squat, RDL and barbell hip thrust, using men with a minimum of 1 year of lower-body resistance-training experience. Surface electromyography (EMG) was …

Chinese Nursing Students At Australian Universities: A Narrative Inquiry Into Their Motivation, Learning Experience, And Future Career Planning, Carol Chungfeng Wang

Theses: Doctorates and Masters

This study presents a narrative inquiry of Chinese nursing students at Australian universities in order to examine these students’ motivations, learning experiences and future career planning. Australia seeks to attract international nursing students from China to maintain its economic advantage and alleviate its projected nursing shortage. In contrast, China desperately needs its best and brightest citizens who have trained abroad as nurses to return to China in order to cope with its current challenges in the healthcare system and nursing education. Little is known about the underlying factors that motivate Chinese nursing students to study in Australia, these students’ learning …

Development Of The Meal Framework: A Multiliteracies Approach To Engaging Adolescents In Nutrition Education, Samantha Lee Baker

Theses: Doctorates and Masters

Establishing and maintaining a healthy diet is integral in promoting optimal health, growth and development. Moreover, the food choices we make and dietary behaviours we adopt are a reflection of the multiple personal, interpersonal and environmental factors to which we are exposed. Consequently, changing food habits and dietary behaviour is complex and requires the implementation of multifaceted public health strategies. Comprehensive nutrition education provided to adolescents during their school years is one such approach.

Adolescence is a period of rapid psychological and physiological changes. At a socioemotional level, there is a decreased level of dependence on parents and a greater …