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Articles 361 - 390 of 4977
Full-Text Articles in Medicine and Health Sciences
Optimising Vaginal Microbiome Profiling For Clinical Translation: A Comparative Assessment Of Sample Storage Methods And A Vagina-Specific 16s Rrna Gene Database, Alishum Ali, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Morten E. Allentoft, Michael Bunce, Claus T. Christophersen
Optimising Vaginal Microbiome Profiling For Clinical Translation: A Comparative Assessment Of Sample Storage Methods And A Vagina-Specific 16s Rrna Gene Database, Alishum Ali, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Morten E. Allentoft, Michael Bunce, Claus T. Christophersen
Research outputs 2022 to 2026
Vaginal microbiome composition has been linked to risk of preterm birth (PTB), a persistent global health challenge. 16S rRNA microbial profiling has identified specific vaginal community state types (CSTs) that have been associated with PTB risk. Diagnostic profiling requires standardised pre-analytical protocols. We evaluated two storage methods and validated a curated, vagina-specific 16S rRNA gene database (VagDB) to enhance annotation. Paired Copan FLOQ swabs from 22 women at high PTB risk were processed for either (a) dry/immediate freezing or (b) Amies-stabilisation/refrigeration. Amplicon sequence variants were generated via 16S rRNA gene (V4) PCR and Illumina sequencing. We assessed diversity, composition, and …
The Effectiveness Of Virtual Reality Aggression And Violence De-Escalation Training For Nursing And Midwifery Students: A Quasi-Experimental Study, Joshua Johnson, Brennen Mills, Luke Hopper, Sara Hansen, Kelley Mumford, Renju Joseph, Susan Philip, Gina Kruger, Abdi D. Osman
The Effectiveness Of Virtual Reality Aggression And Violence De-Escalation Training For Nursing And Midwifery Students: A Quasi-Experimental Study, Joshua Johnson, Brennen Mills, Luke Hopper, Sara Hansen, Kelley Mumford, Renju Joseph, Susan Philip, Gina Kruger, Abdi D. Osman
Research outputs 2022 to 2026
Background: Nursing students experience substantial exposure to aggression and violence while attending clinical placement. De-escalation training can effectively prepare students for aggressive encounters, yet is resource-intensive to deliver. Immersive virtual reality (VR) may improve training accessibility for nursing students. Aim: To evaluate the effectiveness of a VR de-escalation training program to improve nursing students’ confidence in managing patient aggression and its perceived usability. Methods: This study utilized a single-group quasi-experimental pre-/post-test design. Undergraduate Australian nursing students (n = 221) completed a VR de-escalation training program, providing pre-/postintervention self-reported confidence in coping with patient aggression, system usability, and motion sickness data. …
Barriers And Facilitators To Recruiting Older Adult Care Homeresidents Into Clinical Trials Of Medicines And Vaccines: A Scoping Review, Selvarani Subbarayan, Imogen A. Smith-Dodd, Gabriel Nicolson, Jennifer K. Burton, Janet T. Scott, Seshadri S. Vasan, Susan D. Shenkin, Roy L. Soiza, The Watch Consortium
Barriers And Facilitators To Recruiting Older Adult Care Homeresidents Into Clinical Trials Of Medicines And Vaccines: A Scoping Review, Selvarani Subbarayan, Imogen A. Smith-Dodd, Gabriel Nicolson, Jennifer K. Burton, Janet T. Scott, Seshadri S. Vasan, Susan D. Shenkin, Roy L. Soiza, The Watch Consortium
Research outputs 2022 to 2026
Introduction: Excluding Care Home (CH) residents from clinical trials of medicines and vaccines has led to an evidence gap. Findings from younger adults may not be generalisable to CH residents with frailty and dementia. Therefore, it is essential to evaluate pharmacological treatments directly in CH residents to assess their safety and efficacy.
Methods: As part of the Widening Access to Trials in Care Homes project, we conducted a scoping review using Joanna Briggs Institute methodology to identify barriers and facilitators to recruiting CH residents into clinical trials of medicinal products. We searched EMBASE, MEDLINE, PsycINFO, CINAHL, and the Cochrane Library …
A Mass Cytometry-Based Blood Cell Phenotyping Workflow Enabling Inclusion Of Resource-Limited And Rural Sites In Immune System Studies, Natalie J. Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas De St Groth, Helen M. Mcguire
A Mass Cytometry-Based Blood Cell Phenotyping Workflow Enabling Inclusion Of Resource-Limited And Rural Sites In Immune System Studies, Natalie J. Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas De St Groth, Helen M. Mcguire
Research outputs 2022 to 2026
Insight into disease detection and treatment through comprehensive immune phenotyping relies on the generation of high-quality data. However, the execution of robust immune monitoring in clinical trials by flow cytometry is complex due to logistical challenges in sample preparation and reagent stability. These challenges are exacerbated when considering remote and rural communities in Australia, which are burdened by both an increased prevalence and a worse prognosis of many chronic and infectious pathologies. This is not unique to the Australian context as globally remote and rural communities are underrepresented in biomedical research studies, contributing to persistent health inequities. To address these …
Efficacy And Safety Of Tai Chi For Chronic Musculoskeletal Pain: A Systematic Review And Meta-Analysis, Shun Chen, Weiting Liu, Qinwei Fu, Mingyu Huang, Weilan Lin, Yanting Ding, Ming Li
Efficacy And Safety Of Tai Chi For Chronic Musculoskeletal Pain: A Systematic Review And Meta-Analysis, Shun Chen, Weiting Liu, Qinwei Fu, Mingyu Huang, Weilan Lin, Yanting Ding, Ming Li
Research outputs 2022 to 2026
Objectives: Tai Chi, a form of complementary intervention emphasizing breathing and mind-body connection, is increasingly recognized for its potential in pain management. This review aims to synthesize current evidence on the efficacy and safety of Tai Chi for chronic musculoskeletal pain management in adults. Design: Systematic review and meta-analysis. Data sources: AMED, EMBASE, MEDLINE, WoS, CBM, CNKI, VIP, Wanfang Databases, CENTRAL, and WHO ICTRP were searched from database inception through May 2025, with an additional supplementary search conducted in January 2026. Eligibility criteria for selecting studies: We included randomized controlled trials (RCTs) comparing Tai Chi with other interventions for chronic …
Scope Of Nursing Work And Models Of Service Delivery In Australian Primary And Secondary Schools: A Scoping Review, Anita Moyes, Chelsey Williams, Elizabeth Rankin, Imelda Hoodcamp, Eliza Jane Potter, Brent A. Hayward
Scope Of Nursing Work And Models Of Service Delivery In Australian Primary And Secondary Schools: A Scoping Review, Anita Moyes, Chelsey Williams, Elizabeth Rankin, Imelda Hoodcamp, Eliza Jane Potter, Brent A. Hayward
Research outputs 2022 to 2026
Aim: To map the scope of nursing work and models of service delivery in Australian primary and secondary schools for children aged 3–18 years. Design: Scoping Review. Data Sources: A search of CINAHL, Medline, PsycINFO, ERIC, Informit and Google was conducted in August 2024 for peer reviewed, non-peer reviewed and grey literature giving insight into nursing work in primary and secondary Australian schools in urban, regional and remote areas of all Australian states and territories. Methods: The review employed Johanna Briggs Institute methodology for scoping reviews and reported the findings in line with the Preferred Reporting Items for Systematic Reviews …
Thorium Lung Burdens Of Norm Workers Revisited, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani
Thorium Lung Burdens Of Norm Workers Revisited, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani
Research outputs 2022 to 2026
Historical thorium bioassay data collected from Australian mine workers in the 1990s, including in vivo lung counting and thoron-in-breath (TIB) measurements, were re-evaluated using current dosimetric and biokinetic models. Revised daily thorium intakes from bioassay were compared with previous estimates to assess changes in the dose profile and potential implications for contemporary operations. Reanalysis revealed lower estimates of annual dose, including the number of workers assessed as exceeding 20 mSv. However, it was found that intakes derived from industry personal air sampling (PAS) underestimated intake by up to three-fold. This study determined that sensitive bioassay techniques, such as TIB using …
Becoming A Nurse: A Lifelong Journey Beyond The Transition To Professional Practice-An Analytical Discursive Paper, Seung A. Park, Eckert, Rebecca Sharp, Judy Duchscher, Micah D.J. Peters
Becoming A Nurse: A Lifelong Journey Beyond The Transition To Professional Practice-An Analytical Discursive Paper, Seung A. Park, Eckert, Rebecca Sharp, Judy Duchscher, Micah D.J. Peters
Research outputs 2022 to 2026
Aim: To reconceptualise becoming a nurse as a lifelong developmental journey that extends beyond the traditional focus on new graduate transition, and to inform policies and practices supporting recruitment, retention and career sustainability. Background: The global nursing shortage persists, exacerbated by high attrition rates among new graduates and an aging workforce. While existing literature predominantly examines the transition from student to professional practice, we propose that ‘becoming a nurse’ begins earlier and extends beyond clinical roles into retirement. Design: An analytical discursive paper. Data Sources: Key theoretical frameworks (Schlossberg's Transition Model, Kennedy's Integrated Transition Model, Benner's Novice-to-Expert framework and Duchscher's …
Higher Legume And Cruciferous Vegetable Intakes Are Associated With Lower Cardiometabolic Risk In Young Adults: A Cross-Sectional Study, Neal Mcnamara, C. Blekkenhorst, Trevor Mori, Lawrence J. Beilin, Therese A. O'Sullivan
Higher Legume And Cruciferous Vegetable Intakes Are Associated With Lower Cardiometabolic Risk In Young Adults: A Cross-Sectional Study, Neal Mcnamara, C. Blekkenhorst, Trevor Mori, Lawrence J. Beilin, Therese A. O'Sullivan
Research outputs 2022 to 2026
Background and aims: Evidence suggests not all vegetables are the same for cardiometabolic health. Intake of specific vegetable groups exhibit significantly stronger associations with improved cardiometabolic health outcomes in adult populations. Few studies have investigated these relationships in young adults. This study aimed to investigate the relative contributions of specific vegetable groups to cardiometabolic risk in a cohort of young adults. Methods and results: A cross-sectional analysis was conducted in participants from the Western Australia-based Raine Study (n = 638) at the 22-year follow-up. Using a food frequency questionnaire, vegetables were grouped into allium, cruciferous, green leafy, legumes, and yellow-orange-red. …
Lived Experience Of Secondary Vicarious Trauma Among The Tegaru Australian Diaspora In The Postwar Context Of Tigray, Hailay Abrha Gesesew, Fauk, Kiflu Gebremicael Tesfamicael, Gebremeskel Mamu Werid, Lillian Mwanri, Amanuel Gebremedhin, Kidane Gebremariam, Semira Hailu, Kalayu Brhane Mruts, Michael Musker, Fisaha Haile Tesfay, Azeb Gebresilassie Tesema, Paul Ward
Lived Experience Of Secondary Vicarious Trauma Among The Tegaru Australian Diaspora In The Postwar Context Of Tigray, Hailay Abrha Gesesew, Fauk, Kiflu Gebremicael Tesfamicael, Gebremeskel Mamu Werid, Lillian Mwanri, Amanuel Gebremedhin, Kidane Gebremariam, Semira Hailu, Kalayu Brhane Mruts, Michael Musker, Fisaha Haile Tesfay, Azeb Gebresilassie Tesema, Paul Ward
Research outputs 2022 to 2026
Background: The war in Tigray has caused humanitarian and public health crises in North Ethiopia in addition to a high prevalence of mental health symptoms among the Tegaru (people from Tigray) diaspora in Australia. To date, there have been no studies that have explored mechanisms of vicarious mental health and resilience among Tegaru diasporas in Australia. Methods: We conducted 14 in-depth interviews with Tegaru people living in South Australia from September 2023 to June 2024. Data analysis involved an initial stage of open coding, followed by conceptual coding. We also applied “interanalyst validity” to validate the code of framework. Results: …
Non-Pharmacological Sleep Interventions For Dementia Caregivers: A Systematic Review Of Randomized Controlled Trials, Aisling Smyth, Lambert, Mark Jenkins, Adugnaw Zeleke Alem, Misganaw Gebrie Worku, Sujatha Shanmugasundaram
Non-Pharmacological Sleep Interventions For Dementia Caregivers: A Systematic Review Of Randomized Controlled Trials, Aisling Smyth, Lambert, Mark Jenkins, Adugnaw Zeleke Alem, Misganaw Gebrie Worku, Sujatha Shanmugasundaram
Research outputs 2022 to 2026
Background: Caregivers of people living with dementia frequently report poor sleep. This systematic review describes evidence from randomised controlled trials of non-pharmacological sleep interventions for dementia carers. Methods: A systematic search of major databases was undertaken. Risk of bias was assessed using the Cochrane ROB 2.0 tool. Narrative synthesis followed Synthesis Without Meta-analysis (SWiM) guidelines due to substantial heterogeneity. Findings: Eighteen articles were included. Risk of Bias analyses revealed most studies had high overall risk of bias, primarily from selection of reported result bias. Interventions comprised of five categories: sleep-promoting, carer well-being, exercise, technology-based and complementary therapy. High variability between …
S-Methyl Cysteine Sulfoxide: Its Effects On Cardiometabolic Outcomes In High-Fat Fed C57bl/6 Mice And Relevance To Human Health, Caroline R. Hill, Balmer, Hayley Abbiss, Jonathan M. Hodgson, Joshua R. Lewis, Armaghan Shafaei, Lauren C. Blekkenhorst
S-Methyl Cysteine Sulfoxide: Its Effects On Cardiometabolic Outcomes In High-Fat Fed C57bl/6 Mice And Relevance To Human Health, Caroline R. Hill, Balmer, Hayley Abbiss, Jonathan M. Hodgson, Joshua R. Lewis, Armaghan Shafaei, Lauren C. Blekkenhorst
Research outputs 2022 to 2026
S-Methyl cysteine sulfoxide (SMCSO) is an organosulfur compound with demonstrated hypocholesterolemic, anti-diabetic, and antioxidant benefits in rodents. However, the doses used have limited translatability for humans. We explored whether SMCSO could blunt development of diet-induced metabolic syndrome features in mice using doses that are potentially more translatable and achievable in humans. Male mice (C57BL/6; n = 54) were randomly assigned into one of five groups: [1] normal-diet; [2] high-fat-diet; or high-fat-diet with [3] 60 mg kg−1, [4] 170 mg kg−1, or [5] 350 mg per kg per body weight (BW) of SMCSO, respectively. Doses were administered …
Overview Of Aboriginal And Torres Strait Islander Health Status 2025, Australian Indigenous Healthinfonet
Overview Of Aboriginal And Torres Strait Islander Health Status 2025, Australian Indigenous Healthinfonet
Research outputs 2022 to 2026
This Overview provides a summary of the most recent indicators of the health and wellbeing of Aboriginal and Torres Strait Islander people (of all ages, where data are available). The topics included in the Overview cover chronic health conditions which are featured on the HealthInfoNet website. Over the years as additional funding has been obtained and in consultation with HealthInfoNet networks, more topics have been covered on the website and are now included in the Overview. The topics aim to reflect the status of Aboriginal and Torres Strait Islander health over this period and going forward.
The Prevalence Of Varus Thrust: A Systematic Review And Meta-Analysis, Haonan Shen, Nicole D'Souza, Claire E. Hiller, Marnee J. Mckay, Kun Hu, Zhiyong Wang, Milena Simic
The Prevalence Of Varus Thrust: A Systematic Review And Meta-Analysis, Haonan Shen, Nicole D'Souza, Claire E. Hiller, Marnee J. Mckay, Kun Hu, Zhiyong Wang, Milena Simic
Research outputs 2022 to 2026
Objective: To determine the prevalence of varus thrust in adults with and without knee osteoarthritis (OA), including across clinically relevant subgroups. A secondary objective was to explore whether varus thrust prevalence varied according to age, body mass index (BMI), and knee pain severity, where sufficient data were available. Design: A systematic review was conducted in accordance with PRISMA guidelines. Five electronic databases and Google Scholar were searched from inception to January 21, 2025. Studies reporting varus thrust during gait in adults, assessed using clinical observation methods, were included. Two independent reviewers screened studies, extracted data, and assessed methodological quality. Results: …
Aspiring Athletes Managing Sport, Education, Social, And Family Life: A Scoping Review, Donna Howard, Ivan Jeftic, Paul Goods, Ben Jackson, Caitlin Fox-Harding, Michael Rosenberg
Aspiring Athletes Managing Sport, Education, Social, And Family Life: A Scoping Review, Donna Howard, Ivan Jeftic, Paul Goods, Ben Jackson, Caitlin Fox-Harding, Michael Rosenberg
Research outputs 2022 to 2026
Objectives: This scoping review considers the experiences of aspiring high school-aged athletes as they navigate the complexities of managing sport, education, social, and family life. The review synthesises existing literature on the decisions, barriers, facilitators, and support systems that influence aspiring athletes' pathways. Design: Systematic scoping review. Methods: Following the PRISMA-ScR framework, four databases were searched (SCOPUS, SPORTDiscus, PsycInfo, CINAHL), and studies involving aspiring high school aged athletes were uploaded to Covidence. Results: Across the four databases 1781 studies were identified through abstract screening and 61 of these studies were used for the final review. Despite the significant commitment that …
Effect Of Traditional And Cluster Set Structures On Bar Path Kinematics During High-Volume Power Clean Training, Tsuyoshi Nagatani, Shayne Vial, Kristina L. Kendall, Paul Comfort, Jiahao Yang, G. Gregory Haff
Effect Of Traditional And Cluster Set Structures On Bar Path Kinematics During High-Volume Power Clean Training, Tsuyoshi Nagatani, Shayne Vial, Kristina L. Kendall, Paul Comfort, Jiahao Yang, G. Gregory Haff
Research outputs 2022 to 2026
The aim of this study was to examine the effects of traditional (TRAD) and cluster (CLU) set structures on bar path kinematics during a series of high-volume power clean sets, and compare insights gained from discrete versus waveform analysis. Twenty participants completed TRAD or CLU protocols in a randomised, crossover design. Each protocol involved three sets of nine repetitions at 70% of one-repetition maximum. In CLU sets, a 30-second inter-repetition rest was applied. During TRAD sets, peak velocity declined, and significant (p ≤ 0.05) changes were observed in both vertical and horizontal barbell displacement across repetitions, indicating fatigue-related technical alterations. …
Emergency Clinicians’ Knowledge And Practice Of Pain Assessment For Older Adults With Cognitive Impairment: A Cross-Sectional Study, Carrie Janerka, Kaoru Nosaka, Aaron Lapuz Alejandro, Jeffery Hughes, Natasya Raja Azlan, Amineh Rashidi, Wenhong Zhao, Rosemary Saunders
Emergency Clinicians’ Knowledge And Practice Of Pain Assessment For Older Adults With Cognitive Impairment: A Cross-Sectional Study, Carrie Janerka, Kaoru Nosaka, Aaron Lapuz Alejandro, Jeffery Hughes, Natasya Raja Azlan, Amineh Rashidi, Wenhong Zhao, Rosemary Saunders
Research outputs 2022 to 2026
Background Older adults with cognitive impairment frequently present to emergency departments and often experience poor pain management. Patients’ impaired self-reporting, limited clinician training, inconsistent use of behavioural tools, and environmental pressures have been reported challenges. This study examined emergency clinicians’ knowledge and practices in assessing pain for this population. Methods A descriptive cross-sectional survey was conducted across two emergency departments in Australia. An 86-item survey collected clinicians’ pain assessment knowledge and practices. Quantitative data were analysed using descriptive statistics, and qualitative responses were thematically analysed. Results 148 clinicians (110 nurses, 21 doctors, 17 allied health staff) responded to the survey …
Influence Of Chronotype On Cycling Performance In Simulated 20-Km Time Trials—A Pilot Study, Sabrina Forster, Sascha Schwindling, Chris Abbiss, Fabienne Döringer, Andreas Klütsch, Anne Hecksteden, Tim Meyer
Influence Of Chronotype On Cycling Performance In Simulated 20-Km Time Trials—A Pilot Study, Sabrina Forster, Sascha Schwindling, Chris Abbiss, Fabienne Döringer, Andreas Klütsch, Anne Hecksteden, Tim Meyer
Research outputs 2022 to 2026
The chronotype (CT) refers to an individual's diurnal preference towards morningness (M) or eveningness (E). The aim of this study was to determine the influence of chronotype on 20-km cycling performance throughout the day. Seventy-six competitive male cyclists and triathletes completed the Morningness-Eveningness Questionnaire to determine chronotype. Only participants categorised as ‘definite’ M- (n = 10) and E-types (n = 7) were included in the study. In a randomised order and separated by 2–7 days, participants performed four self-paced 20-km cycling time trials at four different times of the day (06:00 h, 12:00 h, 18:00 h, 22:00 h). Mental readiness …
Towards A Person-Centred Holistic Consultation Framework For Paramedics Attending Non-Acute Presentations: A Multidisciplinary Commentary, Robbie King, Angela Martin, Alan M. Batt, Sonia Louise Martin, Nigel Barr, Caroline Hwang, Bill Lord, Peter O’Meara, Louise Reynolds, Staffan Hammarbäck, Shaun Hosein, Julie Kempton, Brendan Shannon
Towards A Person-Centred Holistic Consultation Framework For Paramedics Attending Non-Acute Presentations: A Multidisciplinary Commentary, Robbie King, Angela Martin, Alan M. Batt, Sonia Louise Martin, Nigel Barr, Caroline Hwang, Bill Lord, Peter O’Meara, Louise Reynolds, Staffan Hammarbäck, Shaun Hosein, Julie Kempton, Brendan Shannon
Research outputs 2022 to 2026
Introduction: Traditional rapid-assessment models may not be fully suited for the complex non-acute presentations that paramedics commonly encounter. As paramedicine evolves to meet non-acute patient needs, extended practice community paramedic roles are emerging to deliver holistic and collaborative community-based healthcare. Purpose: This commentary outlines the need for a person-centred holistic clinical consultation framework for paramedics attending complex non-acute presentations. A framework that provides a structured and systematic process for paramedics, particularly those who are transitioning into extended practice community paramedic roles, to guide them in conducting holistic person-centred assessments. This commentary highlights the importance of understanding the biopsychosocial factors influencing …
Can Dna Be Glycosylated?, Wei Wang
Can Dna Be Glycosylated?, Wei Wang
Research outputs 2022 to 2026
No abstract provided.
Associations Between Modifiable Lifestyle Risk Factors And Abdominal Aortic Calcification In The Uk Biobank Imaging Study, Nicola P. Bondonno, Abadi K. Gebre, Benjamin H. Parmenter, Jonathan Hodgson, Lauren C. Blekkenhorst, Catherine P. Bondonno, Richard Woodman, John P. Kemp, James Webster, Carl Schultz, Cassandra Smith, Afsah Saleem, Syed Zulqarnain Gilani, Emma L. Duncan, Joseph Hung, Wai H. Lim, Parminder Raina, John T. Schousboe, Nicholas C. Harvey, Marc Sim, Joshua R. Lewis
Associations Between Modifiable Lifestyle Risk Factors And Abdominal Aortic Calcification In The Uk Biobank Imaging Study, Nicola P. Bondonno, Abadi K. Gebre, Benjamin H. Parmenter, Jonathan Hodgson, Lauren C. Blekkenhorst, Catherine P. Bondonno, Richard Woodman, John P. Kemp, James Webster, Carl Schultz, Cassandra Smith, Afsah Saleem, Syed Zulqarnain Gilani, Emma L. Duncan, Joseph Hung, Wai H. Lim, Parminder Raina, John T. Schousboe, Nicholas C. Harvey, Marc Sim, Joshua R. Lewis
Research outputs 2022 to 2026
Background and aims: Abdominal aortic calcification (AAC) reflects subclinical atherosclerotic cardiovascular disease (ASCVD), but its lifestyle determinants remain uncertain. We investigated how a Healthy Lifestyle Score (HLS) relates to AAC and whether AAC mediates the HLS-ASCVD association. Methods and results: Participants from the UK Biobank Imaging study were assessed for AAC from DXA images. A Healthy Lifestyle Score (HLS), based on smoking, physical activity, diet quality, alcohol consumption, sleep, and BMI was developed, and categorised as low, moderate and high. Cross-sectional associations with (i) any AAC (AAC≥1) and (ii) high AAC (AAC≥6) were analysed using multivariable-adjusted logistic regression models. The …
Attitudes And Expectations Towards Acupuncture For Primary Dysmenorrhoea: Findings From A Cross-Sectional Survey In Australia, Weiting Liu, Amanda Towell-Barnard, Khui Hung Lee, Timothy Leen Kang
Attitudes And Expectations Towards Acupuncture For Primary Dysmenorrhoea: Findings From A Cross-Sectional Survey In Australia, Weiting Liu, Amanda Towell-Barnard, Khui Hung Lee, Timothy Leen Kang
Research outputs 2022 to 2026
Objective: To describe attitudes towards acupuncture and expectations regarding potential treatment outcomes among women with self-reported primary dysmenorrhoea (PD) residing in Australia. Methods: A cross-sectional, descriptive online survey was conducted to assess attitudes and treatment expectancy using an adapted version of previously published complementary and alternative medicine (CAM) attitude scale and a validated acupuncture expectancy scale (AES). Data were analysed descriptively, with exploratory analysis conducted to support the interpretation of response patterns. Ethical approval was obtained from the Edith Cowan University Human Research Ethics Committee (2023-04471-LIU) and participants provided electronic informed consent. Results: A total of 247 responses were received. …
Barriers And Facilitators To Providing Women Postpartum Care By Health Care Providers In The First 12 Months After Childbirth: A Systematic Qualitative Meta-Aggregation Review, Maryam Rouhi, Silvana Bettiol, Sarah Prior, Narges Rouhi, Theodora Dedo Azu, Christine Stirling, Lynne Staff, Linda Jones, Antigoni Leftherioti, Patricia Nicholson
Barriers And Facilitators To Providing Women Postpartum Care By Health Care Providers In The First 12 Months After Childbirth: A Systematic Qualitative Meta-Aggregation Review, Maryam Rouhi, Silvana Bettiol, Sarah Prior, Narges Rouhi, Theodora Dedo Azu, Christine Stirling, Lynne Staff, Linda Jones, Antigoni Leftherioti, Patricia Nicholson
Research outputs 2022 to 2026
Introduction: Postpartum care is crucial for maternal and infant health but remains inconsistently administered. This systematic qualitative review aimed to synthesize health care providers’ perspectives by exploring the barriers and facilitators experienced by health care providers in administering optimal maternal care during the first 12 months after childbirth. Methods: A systematic qualitative meta-aggregation review was conducted using the Joanna Briggs Institute methodology. Peer-reviewed qualitative studies from January 2010 to April 2024 were retrieved from MEDLINE, CINAHL, Embase, and Web of Science. Findings were mapped onto the Behavioral Model of Health Services Use. Results: Twenty-three studies were included. Four key themes …
Cardiovascular–Kidney–Metabolic Syndrome Through The Lens Of Gut‑Derived Uremic Toxins, Chudan Xu, Matthew Snelson, Francine Z. Marques
Cardiovascular–Kidney–Metabolic Syndrome Through The Lens Of Gut‑Derived Uremic Toxins, Chudan Xu, Matthew Snelson, Francine Z. Marques
Research outputs 2022 to 2026
Cardiovascular–Kidney–Metabolic (CKM) syndrome represents a complex, interconnected cluster of cardiovascular disease, chronic kidney disease, and metabolic disorders such as obesity and type 2 diabetes. These conditions share overlapping metabolic, inflammatory, and vascular pathways, with the gut microbiome increasingly recognised as a key contributor and common underlying risk factor. Uremic toxins, traditionally considered waste products of host and microbial metabolism, are now recognised as active mediators of tissue damage across the CKM spectrum, particularly in the context of impaired renal function. Their production and accumulation are amplified by disrupted intestinal barrier integrity, chronic inflammation, and reduced renal clearance, collectively driving systemic …
Emerging Blood-Based Biomarkers For The Detection Of Parenchymal Brain Metastasis: Current Progress And Future Perspectives, Désirée Sexauer, Elin S. Gray, Helen Rizos, Pauline Zaenker, Aaron B. Beasley
Emerging Blood-Based Biomarkers For The Detection Of Parenchymal Brain Metastasis: Current Progress And Future Perspectives, Désirée Sexauer, Elin S. Gray, Helen Rizos, Pauline Zaenker, Aaron B. Beasley
Research outputs 2022 to 2026
Parenchymal brain metastases of solid malignancies remain a significant clinical challenge, as they are often detected at later symptomatic stages, which are typically associated with worse prognosis. Delayed detection limits treatment options and contributes to poor outcomes, while early detection is critical for improving patient outcomes and quality of life. In this comprehensive review, we investigated the potential use and challenges of blood-based biomarkers, including circulating tumor cells, cell-free DNA, noncoding RNAs, extracellular vesicles, proteins, and other immune-related biomarkers, for the early detection of parenchymal brain metastasis. The use of blood-based liquid biopsies offers a promising avenue for early detection …
Feasibility Of A Clinical Supervision Training Program For Mental Health Nurses: A Mixed-Methods Study, Jennifer Hamilton, Lesley Barr, Marie Boulianne, Irene Ngune, Julie Sharrock, Debbie Massey
Feasibility Of A Clinical Supervision Training Program For Mental Health Nurses: A Mixed-Methods Study, Jennifer Hamilton, Lesley Barr, Marie Boulianne, Irene Ngune, Julie Sharrock, Debbie Massey
Research outputs 2022 to 2026
Background: Clinical supervision is widely recognised as a valuable method of workplace support and professional development. Effective supervision requires clinical supervisors to be trained on theory and practice. Oftentimes, training is interdisciplinary and may not address discipline-specific needs. Aim: This study evaluated the implementation of a clinical supervision training program developed specifically for mental health nurses and informed by community and consumer involvement. Methods: A convergent parallel mixed-method design was used. A purposeful sample of 18 mental health nurses who completed the training program participated. Data collection included the Acceptability, Feasibility, Appropriateness Scale and open-ended qualitative survey responses. Quantitative data …
Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon
Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon
Research outputs 2022 to 2026
Epigenetic changes, in particular DNA methylation, accumulate with age across different tissues, but whether these changes follow consistent patterns across different organs remains poorly understood. Here we show, through a meta-analysis of more than 15,000 human methylation profiles spanning 17 tissues, that aging produces both conserved and tissue-specific epigenetic signatures. We identify systemic shifts in methylation levels, increases in methylation variability, and growing molecular disorder across tissues. Network analysis revealed tightly connected gene clusters that are not modified by beneficial interventions, alongside a more modifiable cluster linked to NAD+ metabolism, supporting NAD+ as a potential therapeutic target in …
Tall Orders: A Comparison Of Resident Food Behaviours By Dwelling Type And Apartment Characteristics In Australia, Joelie Mandzufas, Siobhan Hickling, Kevin Murray, Sarah Foster, Gina S.A. Trapp
Tall Orders: A Comparison Of Resident Food Behaviours By Dwelling Type And Apartment Characteristics In Australia, Joelie Mandzufas, Siobhan Hickling, Kevin Murray, Sarah Foster, Gina S.A. Trapp
Research outputs 2022 to 2026
To accommodate population growth, Australian cities are becoming denser, with more Australians living in apartments. However, there is little understanding of whether this shift towards apartment living raises any potential short- and long-term implications for dietary health. Using an Australian nationally representative household survey, this cross-sectional study compared meal-purchasing frequency and fruit and vegetable intake by dwelling type, apartment block height, and number of bedrooms in the apartment. Adjusted mean differences were derived from linear regressions, adjusting for socio-demographic characteristics. Apartment residents purchased 0.72 more meals out each week than house residents (p < 0.001, 95% CI [0.599,0.831]) and consumed 0.10 fewer daily serves of vegetables (p = 0.002, 95% CI [0.038,0.163]). Among apartment residents, those in high-rise blocks purchased 0.80 more meals out each week than low-rise residents (p = 0.012, 95% CI [0.250,1.348]), and residents of one-bedroom or studio apartments ate 0.25 fewer serves of fruit per day than residents in apartments with at least three bedrooms (p = 0.003, 95% CI [0.038,0.163]). These findings provide important evidence to inform policy and targeted interventions that promote healthy food behaviours in apartment-living populations.
A Collaborative Communities-Of-Practice Methodology For Environmental Design Research: A Case Study Application In Palliative Care, Emil E. Jonescu, Benjamin Farrell, Chamil Erik Ramanayaka, Lori Delaney, Edward Litton, Talia J. Uylaki, Gareth Watts, Bella Brigham, Frances Bellemore, Davinia Seah
A Collaborative Communities-Of-Practice Methodology For Environmental Design Research: A Case Study Application In Palliative Care, Emil E. Jonescu, Benjamin Farrell, Chamil Erik Ramanayaka, Lori Delaney, Edward Litton, Talia J. Uylaki, Gareth Watts, Bella Brigham, Frances Bellemore, Davinia Seah
Research outputs 2022 to 2026
Environmental design in palliative care settings receives increasing attention, yet methodologies for studying such environments often lack interdisciplinary integration. Traditional research designs may overlook the lived expertise of clinicians and designers. Objectives: This article describes a collaborative, cross-disciplinary communities-of-practice model developed as a methodological framework to enable effective environmental evaluation and design processes in healthcare settings. Its application is illustrated through a case study in a palliative care unit. Methods: A co-designed, multi-methods approach was developed by a team of clinicians, facility managers, and academic researchers. The methodology included a scoping review, site-specific environmental data logging (sound, temperature, lighting), and …
Developing Consumer Consensus On Remote Assessment And Management Of Physical Function In Older Adults (Ramp): International Modified Delphi Process, Elsa Dent, Christopher Hurst, Jack Dalla Via, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Gary Skinner, Marc Sim, Mylene Aubertin-Leheudre, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Jennifer R.A. Jones, Pauline Kelly, Robert Kob, Suzanne N. Morin, Girish Nandakumar, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Vina P.S. Tan, Rosanna Tran
Developing Consumer Consensus On Remote Assessment And Management Of Physical Function In Older Adults (Ramp): International Modified Delphi Process, Elsa Dent, Christopher Hurst, Jack Dalla Via, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Gary Skinner, Marc Sim, Mylene Aubertin-Leheudre, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Jennifer R.A. Jones, Pauline Kelly, Robert Kob, Suzanne N. Morin, Girish Nandakumar, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Vina P.S. Tan, Rosanna Tran
Research outputs 2022 to 2026
Background: Remote health care delivery, including the use of digital health interventions, is emerging as a tool for assessing and managing physical function, but its design and implementation often overlook the needs and preferences of older adult end users. Objective: The primary aim of this modified Delphi process was to develop consumer consensus on preferences for remote assessment and management of physical function in older adults. Methods: Research and consumer experts of the Remote Assessment and Management of Physical Function in Older Adults (RAMP) Working Group co-developed the Round 1 Delphi survey, which was advertised to consumers (adults aged ≥60 …