Medicine and Health Sciences Commons^™

Guidance For Research On Social Isolation, Loneliness, And Participation Among Older People: Lessons From A Mixed Methods Study, Julie Dare, Celia Wilkinson, Robert Donovan, Johnny Lo, Marie-Louise Mcdermott, Helen O'Sullivan, Ruth Marquis

Research outputs 2014 to 2021

This article provides methodological guidance to researchers wishing to develop collaborative research projects with local governments and other agencies, by describing the process adopted in a mixed methods study conducted in the City of Wanneroo (the City), a local government area in Perth, Western Australia. The study explored factors related to older people’s (60+ years) participation in community-based activities and links between their participation and levels of social isolation, loneliness, and social connectedness. The research incorporated four interrelated stages: (1) an audit of existing programs in the City and program participant characteristics; (2) focus groups with program participants and interviews …

Midwives' Use Of Best Available Evidence In Practice: An Integrative Review, Annemarie De Leo, Sara Bayes, Sadie Geraghty, Janice Butt

Research outputs 2014 to 2021

Aims and objectives: To synthesise international research that relates to midwives' use of best available evidence in practice settings and identify key issues relating to the translation of latest evidence into everyday maternity care.

Background: Midwifery is a research‐informed profession. However, a gap persists in the translation of best available evidence into practice settings, compromising gold standard maternity care and delaying the translation of new knowledge into everyday practice.

Design: A five‐step integrative review approach, based on a series of articles published by the Joanna Briggs Institute (JBI) for conducting systematic reviews, was used to facilitate development of a search …

The Effect Of Volunteers’ Care And Support On The Health Outcomes Of Older Adults In Acute Care: A Systematic Scoping Review, Rosemary Saunders, Karla Seaman, Renée Graham, Angela Christiansen

Research outputs 2014 to 2021

Aim: To examine the available evidence on the effects of care and support provided by volunteers on the health outcomes of older adults in acute care services.

Background: Acute hospital inpatient populations are becoming older, and this presents the potential for poorer health outcomes. Factors such as chronic health conditions, polypharmacy and cognitive and functional decline are associated with increased risk of health care‐related harm, such as falls, delirium and poor nutrition. To minimise the risk of health care‐related harm, volunteer programmes to support patient care have been established in many hospitals worldwide.

Design: A systematic scoping review.

Methods: The …

Associations Between Habitual Flavonoid Intake And Hospital Admissions For Atherosclerotic Cardiovascular Disease: A Prospective Cohort Study, Frederik Dalgaard, Nicola P. Bondonno, Kevin Murray, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Aedin Cassidy, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson

Research outputs 2014 to 2021

Background: Flavonoids, compounds found in plant-based foods and beverages, might ameliorate vascular damage and atherosclerosis. Therefore, our aim was to assess the association between flavonoid intake and hospital admissions due to atherosclerotic cardiovascular disease. Methods: In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study were cross-linked with Danish nationwide registries. Eligible participants were aged 50–65 years, had no previous history of atherosclerotic cardiovascular disease, and had completed a food-frequency questionnaire at baseline. We examined associations between flavonoid intake (calculated from food-frequency questionnaires with use of the Phenol-Explorer database) and hospital admissions for atherosclerotic cardiovascular disease, …

Controlled Ecological Evaluation Of An Implemented Exercise Training Programme To Prevent Lower Limb Injuries In Sport: Differences In Implementation Activity, Alex Donaldson, Belinda J. Gabbe, David G. Lloyd, Jill Cook, Caroline F. Finch

Research outputs 2014 to 2021

OBJECTIVE: The public health benefits of injury prevention programmes are maximised when programmes are widely adopted and adhered to. Therefore, these programmes require appropriate implementation support. This study evaluated implementation activity outcomes associated with the implementation of FootyFirst, an exercise training injury prevention programme for community Australian football, both with (FootyFirst+S) and without (FootyFirst+NS) implementation support. METHOD: An evaluation plan based on the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) Sports Setting Matrix was applied in a controlled ecological evaluation of the implementation of FootyFirst. RE-AIM dimension-specific (range: 0-2) and total RE-AIM scores (range: 0-10) were derived by triangulating data from …

Knowledge Of Hiv/Aids Among Older Adults (50 Years And Above) In A Peri-Urban Setting: A Descriptive Cross-Sectional Study, Reindolf Anokye, Enoch Acheampong, Amy Budu-Ainooson, Edmund Isaac Obeng, Emmanuel Tetteh, Yvonne Sabby Acheampong, Curtis Edward Nettey-Marbell

Research outputs 2014 to 2021

Background: In the absence of vaccine or cure, public knowledge about Human Immune Virus (HIV) is a central tool for curbing HIV epidemic. This study sought to assess the knowledge of HIV among older adults (50 years and above) at the Methodist Faith Healing hospital, Ankaase, Ghana. Methods: Using a descriptive study design, older adults (50 years and above) who visited the Ankaase Methodist Faith Healing hospital were randomly sampled for the study. A structured questionnaire was administered to collect data which was analyzed quantitatively using Statistical Package for Social Sciences (SPSS version 16.0). Results: A total of 100 respondents …

Role Of Lactic Acidosis As A Mediator Of Sprint-Mediated Nausea, Robert J. Merrells, Ashely J. Cripps, Paola T. Chivers, Paul A. Fournier

Research outputs 2014 to 2021

This study aims to determine whether there is a relationship between nausea level and lactic acidosis during recovery from sprinting. In all, 13 recreationally active males completed a 60 s bout of maximal intensity cycling. Prior to and for 45 min following exercise, blood pH, pCO₂, and lactate levels were measured together with nausea. In response to sprinting, nausea, lactate, and H⁺ concentrations increased and remained elevated for at least 10 min (p < .001), whereas pCO₂ increased only transiently (p < .001) before falling below pre‐exercise levels (p < .001), with all these variables returning toward pre‐exercise levels during recovery. Both measures of nausea adopted for analyses (nausea profile, NP; visual analogue scale, VAS), demonstrated significant repeated measures correlation (rmcorr) post‐exercise between nausea and plasma lactate (VAS and NPr_rm> 0.595, p < .0001) and H⁺ concentrations (VAS and NPr_rm> 0.689, p < .0001), but an inconsistent relationship with pCO₂ (VAS r_rm = …

The Association Between Normal Bmi With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation, Di Liu, Qihuan Li, Jing Dong, Dong Li, Xizhu Xu, Weijia Xing, Xiaoyu Zhang, Weijie Cao, Haifeng Hou, Hao Wang, Manshu Song, Lixin Tao, Xiaoping Kang, Qun Meng, Wei Wang, Xiuhua Guo, Youxin Wang

Research outputs 2014 to 2021

Background: The mechanism by which normal body mass index (BMI) with central adiposity (NWCA) increases the risk of the diseases has not been completely elucidated. The inflammatory role of immunoglobulin G (IgG) N-glycosylation in obesity defined by BMI or central adiposity defined by waist-to-hip ratio (WHR) was reported, respectively. We undertook this three-center cross-sectional study to determine the association between the IgG N-glycans and NWCA. Methods: The participants were categorized into four different phenotypes: normal BMI with normal WHR (NW), normal BMI with central adiposity (NWCA), obesity with normal WHR (ONCA) and obesity with central adiposity (OCA). The …

A Hardware-Deployable Neuromorphic Solution For Encoding And Classification Of Electronic Nose Data, Anup Vanarse, Alexander Rassau, Peter Van Der Made

Research outputs 2014 to 2021

In several application domains, electronic nose systems employing conventional data processing approaches incur substantial power and computational costs and limitations, such as significant latency and poor accuracy for classification. Recent developments in spike-based bio-inspired approaches have delivered solutions for the highly accurate classification of multivariate sensor data with minimized computational and power requirements. Although these methods have addressed issues related to efficient data processing and classification accuracy, other areas, such as reducing the processing latency to support real-time application and deploying spike-based solutions on supported hardware, have yet to be studied in detail. Through this investigation, we proposed a spiking …

Effects Of Complex Training Versus Heavy Resistance Training On Neuromuscular Adaptation, Running Economy And 5-Km Performance In Well-Trained Distance Runners, Fei Li, Ran Wang, Robert U, Newton, David Sutton, Yue Shi, Haiyong Ding

Research outputs 2014 to 2021

Background: Recently, much attention has been paid to the role of neuromuscular function in long-distance running performance. Complex Training (CT) is a combination training method that alternates between performing heavy resistance exercises and plyometric exercises within one single session, resulting in great improvement in neuromuscular adaptation. The purpose of this study was to compare the effect of CT vs. heavy resistance training (HRT) on strength and power indicators, running economy (RE), and 5-km performance in well-trained male distance runners. Methods: Twenty-eight well-trained male distance runners (19–23 years old, VO_2max:65.78 ± 4.99 ml.kg⁻¹.min⁻¹) performed one …

The Acute Neuromuscular Responses To Cluster Set Resistance Training: A Systematic Review And Meta-Analysis, Christopher Latella, Wei‑Peng Teo, Eric J. Drinkwater, Kristina Kendall, G. Gregory Haff

Research outputs 2014 to 2021

Background: Cluster sets (CSs) are a popular resistance training (RT) strategy categorised by short rest periods implemented between single or groups of repetitions. However, evidence supporting the effectiveness of CSs on acute intra-session neuromuscular performance is still equivocal.

Objective: The objective of this investigation was to determine the efficacy of a single session of CSs to attenuate losses in force, velocity and power compared to traditional set (TS) training.

Methods: Screening consisted of a systematic search of EMBASE, Google Scholar, PubMed, Scopus and SPORTDiscus. Inclusion criteria were (1) measured one or more of mean/peak force, velocity or power; (2) …

Post-Activation Potentiation Versus Post-Activation Performance Enhancement In Humans: Historical Perspective, Underlying Mechanisms, And Current Issues, Anthony J. Blazevich, Nicolas Babault

Research outputs 2014 to 2021

Post-activation potentiation (PAP) is a well-described phenomenon with a short half-life (~28 s) that enhances muscle force production at submaximal levels of calcium saturation (i.e., submaximal levels of muscle activation). It has been largely explained by an increased myosin light chain phosphorylation occurring in type II muscle fibers, and its effects have been quantified in humans by measuring muscle twitch force responses to a bout of muscular activity. However, enhancements in (sometimes maximal) voluntary force production detected several minutes after high-intensity muscle contractions are also observed, which are also most prominent in muscles with a high proportion of type II …

"I Love Being A Midwife; It's Who I Am": A Glaserian Grounded Theory Study Of Why Midwives Stay In Midwifery, Dianne Bloxsome, Sara Bayes, Deborah Ireson

Research outputs 2014 to 2021

Aims and objectives: To understand why Western Australian (WA) midwives choose to remain in the profession.

Background: Midwifery shortages and the inability to retain midwives in the midwifery profession is a global problem. The need for effective midwifery staff retention strategies to be implemented is therefore urgent, as is the need for evidence to inform those strategies.

Design: Glaserian grounded theory (GT) methodology was used with constant comparative analysis.

Methods: Fourteen midwives currently working clinically area were interviewed about why they remain in the profession. The GT process of constant comparative analysis resulted in an overarching core category …

Association Of Depressive Symptoms With Incident Cardiovascular Diseases In Middle-Aged And Older Chinese Adults, Haibin Li, Deqiang Zheng, Zhiwei Li, Zhiyuan Wu, Wei Feng, Xue Cao, Jiaxin Wang, Qi Gao, Xia Li, Wei Wang, Brian J. Hall, Yu-Tao Xiang, Xiuhua Guo

Research outputs 2014 to 2021

Importance: The prevalence of depressive symptoms among older adults has become an increasingly important public health priority. Elevated depressive symptoms are well documented among elderly people with cardiovascular disease (CVD), but studies conducted among Chinese adults are scarce. Objective: To estimate the association between depressive symptoms and incident CVD among middle-aged and older Chinese adults. Design, Setting, and Participants: The China Health and Retirement Longitudinal Study is an ongoing nationally representative prospective cohort study that was initiated in 2011. This cohort study included 12 417 middle-aged and older Chinese adults without heart disease and stroke at baseline. Statistical analysis was …

Genetics Of Diabetic Kidney Disease: A Follow-Up Study In The Arab Population Of The United Arab Emirates, Wael M. Osman, Herbert F. Jelinek, Guan K. Tay, Mohamed H. Hassan, Wael Almahmeed, Ahsan H. Khandoker, Kinda Khalaf, Habiba S. Alsafar

Research outputs 2014 to 2021

Background: Two genome-wide association studies in European and Japanese populations reported on new loci for diabetic kidney disease (DKD), including FTO. In this study, we have replicated these investigations on a cohort of 410 Type 2 diabetes mellitus (T2DM) patients of Arab origin from the United Arab Emirates (UAE). Methods and Results: The cohort included 145 diabetic patients diagnosed with DKD and 265 diabetics free of the disease. In general, we were able to confirm the association between the FTO locus and DKD, as reported in the Japanese population. Specifically, there were significant associations with two single nucleotide polymorphisms (SNPs), …

Prognostic Relevance Of Ccdc88c (Daple) Transcripts In The Peripheral Blood Of Patients With Cutaneous Melanoma, Ying Dunkel, Anna L. Reid, Jason Ear, Nicolas Aznar, Michael Millward, Elin Gray, Robert Pearce, Melanie Ziman, Pradipta Ghosh

Research outputs 2014 to 2021

A loss of balance between G protein activation and deactivation has been implicated in the initiation of melanomas, and non-canonical Wnt signaling via the Wnt5A/Frizzled (FZD) pathway has been shown to be critical for the switch to an invasive phenotype. Daple [CCDC88C], a cytosolic guanine nucleotide exchange modulator (GEM) which enhances non-canonical Wnt5A/FZD signaling via activation of trimeric G protein, Gαi, has been shown to serve opposing roles-as an inducer of EMT and invasiveness and a potent tumor suppressor-via two isoforms, V1 (full-length) and V2 (short spliced isoform), respectively. Here we report that the relative abundance of these isoforms in …

Health-Services Utilisation Amongst Older Persons During The Last Year Of Life: A Population-Based Study, Danielle Ní Chróinín, David E. Goldsbury, Alexander Beveridge, Patricia M. Davidson, Afaf Girgis, Nicholas Ingham, Jane L. Phillips, Anne M. Wilkinson, Jane M. Ingham, Dianne L. O'Connell

Research outputs 2014 to 2021

BACKGROUND: Accurate population-based data regarding hospital-based care utilisation by older persons during their last year of life are important in health services planning. We investigated patterns of acute hospital-based service use at the end of life, amongst older decedents in New South Wales (NSW), Australia.

METHODS: Data from all persons aged ≥70 years who died in the state of NSW Australia in 2007 were included. Several measures of hospital-based service utilisation during the last year of life were assessed from retrospectively linked data comprising data for all registered deaths, cause of death, hospital care during the last year of life …

Strategies And Challenges Associated With Recruiting Retirement Village Communities And Residents Into A Group Exercise Intervention, Rachel L. Duckham, Jamie L. Tait, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Robin M. Daly

Research outputs 2014 to 2021

BACKGROUND: Randomized controlled trials (RCTs) provide the highest level of scientific evidence, but successful participant recruitment is critical to ensure the external and internal validity of results. This study describes the strategies associated with recruiting older adults at increased falls risk residing in retirement villages into an 18-month cluster RCT designed to evaluate the effects of a dual-task exercise program on falls and physical and cognitive function.

METHODS: Recruitment of adults aged ≥65 at increased falls risk residing within retirement villages (size 60-350 residents) was initially designed to occur over 12 months using two distinct cohorts (C). Recruitment occurred via …

Mechanical Suppression Of Osteolytic Bone Metastases In Advanced Breast Cancer Patients: A Randomised Controlled Study Protocol Evaluating Safety, Feasibility And Preliminary Efficacy Of Exercise As A Targeted Medicine, Nicolas H. Hart, Daniel A. Galvão, Christobel Saunders, Dennis R. Taaffe, Kynan T. Feeney, Nigel A. Spry, Daphne Tsoi, Hilary Martin, Raphael Chee, Tim Clay, Andrew D. Redfern, Robert U. Newton

Research outputs 2014 to 2021

BACKGROUND: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80% of patients with advanced breast cancer. Preclinical models have demonstrated the ability of mechanical stimulation to suppress tumour formation and promote skeletal preservation at bone sites with osteolytic lesions, generating modulatory interference of tumour-driven bone remodelling. Preclinical studies have also demonstrated anti-cancer effects through exercise by minimising tumour hypoxia, normalising tumour vasculature and increasing tumoural blood perfusion. This study proposes to explore the promising …

The Current State Of Subjective Training Load Monitoring—A Practical Perspective And Call To Action, Joseph O. C. Coyne, G. Gregory Haff, Aaron J Coutts, Robert U. Newton, Sophia Nimphius

Research outputs 2014 to 2021

This commentary delivers a practical perspective on the current state of subjective training load (TL) monitoring, and in particular sessional ratings of perceived exertion, for performance enhancement and injury prevention. Subjective measures may be able to reflect mental fatigue, effort, stress, and motivation. These factors appear to be important moderators of the relationship TL has with performance and injury, and they also seem to differ between open and closed skill sports. As such, mental factors may affect the interaction between TL, performance, and injury in different sports. Further, modeling these interactions may be limited due to the assumption that an …

Clinical And Genetic Associations Of Renal Function And Diabetic Kidney Disease In The United Arab Emirates: A Cross-Sectional Study, Wael M. Osman, Herbert F. Jelinek, Guan K. Tay, Ahsan H. Khandoker, Kinda Khalaf, Wael Almahmeed, Mohamed H. Hassan, Habiba S. Alsafar

Research outputs 2014 to 2021

OBJECTIVES: Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.

RESEARCH DESIGN AND METHODS: Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with …

Correction To: Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction Induced Injury, Andrew N. Billin, Samuel E. Honeycutt, Alan V. Mcdougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell

Research outputs 2014 to 2021

Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.

Association Of Dietary Nitrate Intake With The 15-Year Incidence Of Age-Related Macular Degeneration, Bamini Gopinath, Gerald Liew, Annette Kifley, Joshua R. Lewis, Catherine Bondonno, Nichole Joachim, Jonathan M. Hodgson, Paul Mitchell

Research outputs 2014 to 2021

Background

Dietary nitrate, found predominantly in green leafy vegetables and beetroot, is a precursor of nitric oxide. Under- or overproduction of nitric oxide is implicated in the etiology of several eye diseases. However, the potential influence of dietary nitrate intake on age-related macular degeneration (AMD) risk has not been assessed.

Objective

To investigate the temporal association between dietary nitrate intake (from both vegetable and nonvegetable sources) and the 15-year incidence of AMD, independent of potential confounders.

Design

A longitudinal cohort study conducted from 1992-1994 to 2007-2009.

Participants/setting

The Blue Mountains Eye Study is a population-based study of adults aged 49+ …

The Effect Of Altering Body Posture And Barbell Position On The Between-Session Reliability Of Force-Time Curve Characteristics In The Isometric Mid-Thigh Pull, Stuart N. Guppy, Claire J. Brady, Yosuke Kotani, Michael H. Stone, Nikola Medic, Guy Gregory Haff

Research outputs 2014 to 2021

Seventeen strength and power athletes (n = 11 males, 6 females; height: 177.5 ± 7.0 cm, 165.8 ± 11.4 cm; body mass: 90.0 ± 14.1 kg, 66.4 ± 13.9 kg; age: 30.6 ± 10.4 years, 30.8 ± 8.7 years), who regularly performed weightlifting movements during their resistance training programs, were recruited to examine the effect of altering body posture and barbell position on the between-session reliability of force-time characteristics generated in the isometric mid-thigh pull (IMTP). After participants were familiarised with the testing protocol, they undertook two testing sessions which were separated by seven days. In each session, the participants …

Effects Of Ambient Carbon Monoxide On Daily Hospitalizations For Cardiovascular Disease: A Time-Stratified Case-Crossover Study Of 460,938 Cases In Beijing, China From 2013 To 2017, Haibin Li, Jingwei Wu, Anxin Wang, Xia Li, Songxi Chen, Tianqi Wang, Endawoke Amsalu, Qi Gao, Yanxia Luo, Xinghua Yang, Wei Wang, Jin Guo, Yuming Guo, Xiuhua Guo

Research outputs 2014 to 2021

BACKGROUND: Evidence focused on exposure to ambient carbon monoxide (CO) and the risk of hospitalizations for cardiovascular diseases (CVD) is lacking in developing countries. This study aimed to examine the effect of CO exposure on hospitalizations for CVD in Beijing, China.

METHODS: A total of 460,938 hospitalizations for cardiovascular diseases were obtained from electronic hospitalization summary reports from 2013 to 2017. A time-stratified case-crossover design was conducted to investigate the association between CO exposure and hospitalizations for total and cause-specific CVD, including coronary heart disease (CHD), atrial fibrillation (AF), and heart failure (HF). Stratified analysis was also conducted by age …

Effect Of A Repeated Sprint Ability Test On The Muscle Contractile Properties In Elite Futsal Players, Javier Sánchez-Sánchez, David Bishop, Jorge García-Unanue, Esther Ubago-Guisado, Enrique Hernando, Jorge López-Fernández, Enrique Colino, Leonor Gallardo

Research outputs 2014 to 2021

The aim of this study was to evaluate the effect of a repeated sprint ability (RSA) test on the contractile properties of the muscles in elite futsal players. A total of 20 elite players completed the RSA test (7 × 30 m), and the contractile response from the rectus femoris (RF) and biceps femoris (BF) of both legs were analysed pre and post through tensiomyography. There was a significant increment in 30-m times from the third sprint onwards (p < 0.05). The percent decrement in sprint ability (RSA) with respect to the first sprint was significantly higher in the last sprint. The players did not show evidence of lateral asymmetry in any of the muscle groups analysed after the RSA test (p > 0.05). Following the RSA test there was a significant reduction in the delay time (Td) in RF, a significant decrement …

Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction-Induced Injury, Andrew N Billin, Samuel E Honeycutt, Alan V Mcdougal, Jaclyn P Kerr, Zhe Chen, Johannes M Freudenberg, Deepak K Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S Geske, Frank Fang, Bert Yao, Richard V Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C Hinken, Alan J Russell

Research outputs 2014 to 2021

BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair. We tested the importance of HIF activation following skeletal muscle injury, in both a murine model and human volunteers, using prolyl hydroxylase inhibitors that stabilize and activate HIF.

METHODS: Using a mouse eccentric limb injury model, we characterized the protective effects …

Impact Of Biobanks On Research Outcomes In Rare Diseases: A Systematic Review, Monique Garcia, Jenny Downs, Alyce Russell, Wei Wang

Research outputs 2014 to 2021

BACKGROUND: Alleviating the burden of rare diseases requires research into new diagnostic and therapeutic strategies. We undertook a systematic review to identify and compare the impact of stand-alone registries, registries with biobanks, and rare disease biobanks on research outcomes in rare diseases.

METHODS: A systematic review and meta-aggregation was conducted using the preferred reporting items for systematic reviews and meta-analyses (the PRISMA statement). English language publications were sourced from PubMed, Medline, Scopus, and Web of Science. Original research papers that reported clinical, epidemiological, basic or translational research findings derived from data contained in stand-alone registries, registries with biobanks, …

The Validity Of The Push Band 2.0 During Vertical Jump Performance, Jason P. Lake, Simon Augustus, Kieran Austin, Peter Mundy, John J. Mcmahon, Paul Comfort, Guy G. Haff

Research outputs 2014 to 2021

The Push Band has the potential to provide a cheap and practical method of measuring velocity and power during countermovement vertical jumping (CMJ). However, very little is known about whether it conforms to laboratory-based gold standards. The aim of this study was to assess the agreement between peak and mean velocity and power obtained from the belt-worn Push Band, and derived from three-dimensional motion capture, and vertical force from an in-ground force platform. Twenty-two volunteers performed 3 CMJ on a force platform, while a belt-worn Push Band and a motion capture system (a marker affixed to the Push Band) simultaneously …

Depression And Prostate Cancer: Examining Comorbidity And Male-Specific Symptoms, Simon M Rice, John L Oliffe, Mary T Kelly, Prue Cormie, Suzanne K. Chambers, John S Ogrodniczuk, David Kealy

Research outputs 2014 to 2021

Depression in men with prostate cancer is a significant and complex issue that can challenge clinicians' diagnostic efforts. The objective of the current study was to evaluate prototypic and male-specific depression symptoms and suicidal ideation in men with a diagnosis of prostate cancer relative to those with and without comorbidity. The Patient Health Questionnaire-9 (PHQ-9) and Male Depression Risk Scale-22 (MDRS-22) were completed online along with demographic and background variables by 100 men with a diagnosis of prostate cancer ( n = 54 prostatectomy, n = 33 receiving active treatment). Hierarchical logistic regression was used to examine recent (past 2 …