Medicine and Health Sciences Commons^™

Reliability Of Squat Kinetics In Well-Trained Rugby Players: Implications For Monitoring Training, Brendyn B. Appleby, Stuart J. Cormack, Robert U. Newton

Research outputs 2014 to 2021

The aim of this study was to determine the within-session reliability in kinetic variables of the squat in well-trained athletes during a typical resistance training protocol. Fifteen subjects completed 2 testing sessions. Session 1 was establishment of 1 repetition maximum (1RM) squat, and session 2 involved 2 sets of 2 maximal effort repetitions of the squat at 70, 80, and 90% of 1RM with 3D motion analysis and ground reaction force (GRF) measurement using 2 in-ground triaxial force plates. Reliability was calculated using typical error ± 90% confidence limits, expressed as the coefficient of variation and intraclass correlation coefficient. The …

Bilateral And Unilateral Resistance Training And Athletic Performance, Brendyn B. Appleby

Theses: Doctorates and Masters

Specificity is a key programming principle for optimal transfer of physiological adaptation of training to improved athletic performance. In resistance training, it has long been identified that the closer the mechanical specificity between the training exercise and outcome performance, the greater the transfer of improved capacity. Bilateral resistance exercises are predominately prescribed for the development of maximum strength and are well demonstrated to enhance athletic performance. However, unilateral exercises appear to demonstrate greater specificity to movements such as running and change of direction as these movements are predominantly single leg actions. Nonetheless, the unstable nature and comparatively lower magnitude of …

The Ward-Based Nurse Clinical Educator: Impact On Student Learning Outcomes And Student And Preceptor Experiences, Karen Ann Mccarthy

Theses: Doctorates and Masters

Aim

This study aimed to determine the impact of the implementation of a ward based Nurse Clinical Educator (NCE) role on students and staff at one health service whilst students were on clinical practicum at a Western Australian regional health care facility.

Question

The research question was: “What impact does the NCE support intervention have on students and clinical staff during clinical practicum?” Background Clinical experience for undergraduate student nurses (students) undertaking their bachelor’s degree is of utmost importance for gaining both competence and registration. Students encounter difficulties in obtaining opportunities to practice their skills and develop competence when on …

Association Between Abdominal Aortic Calcification, Bone Mineral Density And Fracture In Older Women, Joshua R. Lewis, Celeste J. Eggermont, John T. Schousboe, Wai H. Lim, Germaine Wong, Ben Khoo, Marc Sim, Mingxiang Yu, Thor Ueland, Jens Bollerslev, Jonathan M. Hodgson, Kun Zhu, Kevin E. Wilson, Douglas P. Kiel, Richard L. Prince

Research outputs 2014 to 2021

Although a relationship between vascular disease and osteoporosis has been recognized, its clinical importance for fracture risk evaluation remains uncertain. Abdominal aortic calcification (AAC), a recognized measure of vascular disease detected on single‐energy images performed for vertebral fracture assessment, may also identify increased osteoporosis risk. In a prospective 10‐year study of 1,024 older predominantly Caucasian women (mean age 75.0±2.6 years) from the Perth Longitudinal Study of Aging cohort we evaluated the association between AAC, skeletal structure and fractures. AAC and spine fracture were assessed at the time of hip densitometry and heel quantitative ultrasound. AAC was scored 0 to 24 …

A Mediterranean Diet With Fresh, Lean Pork Improves Processing Speed And Mood: Cognitive Findings From The Medpork Randomised Controlled Trial, Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A. D. Keage, Karen J. Murphy

Research outputs 2014 to 2021

Background: The Mediterranean diet may be capable of improving cognitive function. However, the red meat restrictions of the diet could impact long-term adherence in Western populations. The current study therefore examined the cognitive effects of a Mediterranean diet with additional red meat. Methods: A 24-week parallel crossover design compared a Mediterranean diet with 2–3 weekly servings of fresh, lean pork (MedPork) and a low-fat (LF) control diet. Thirty-five participants aged between 45 and 80 years and at risk of cardiovascular disease followed each intervention for 8 weeks, separated by an 8-week washout period. Cognitive function was assessed using the Cambridge …

Peer Support For The Maintenance Of Physical Activity And Health In Cancer Survivors: The Peer Trial - A Study Protocol Of A Randomised Controlled Trial, Kirsten N. Adlard, David G. Jenkins, Chloe E. Salisbury, Kate A. Bolam, Sjaan R. Gomersall, Joanne F. Aitken, Suzanne K. Chambers, Jeff C. Dunn, Kerry S. Courneya, Tina L. Skinner

Research outputs 2014 to 2021

BACKGROUND: Despite an overwhelming body of evidence showing the benefits of physical activity (PA) and exercise for cancer survivors, few survivors meet the exercise oncology guidelines. Moreover, initiating, let alone maintaining exercise programs with cancer survivors continues to have limited success. The aim of this trial is to evaluate the influence of peer support on moderate-to-vigorous PA (MVPA) and various markers of health 12 months following a brief supervised exercise intervention in cancer survivors.

METHODS: Men and women previously diagnosed with histologically-confirmed breast, colorectal or prostate cancer (n = 226), who are >1-month post-treatment, will be invited to participate in …

Nivolumab Plus Ipilimumab Versus Chemotherapy As First-Line Treatment In Advanced Non-Small-Cell Lung Cancer With High Tumour Mutational Burden: Patient-Reported Outcomes Results From The Randomised, Open-Label, Phase Iii Checkmate 227 Trial, Martin Reck, Michael Schenker, Ki Hyeong Lee, Mariano Provencio, Makoto Nishio, Krzysztof Lesniewski-Kmak, Randeep Sangha, Samreen Ahmed, Judith Raimbourg, Kynan Feeney, Romain Corre, Fabio Andre Franke, Eduardo Richardet, John R. Penrod, Yong Yuan, Faith E. Nathan, Prabhu Bhagavatheeswaran, Michael Derosa, Fiona Taylor, Rachael Lawrance, Julie Brahmer

Research outputs 2014 to 2021

BACKGROUND: In the phase III CheckMate 227 study, first-line nivolumab + ipilimumab significantly prolonged progression-free survival (co-primary end-point) versus chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC) and high tumour mutational burden (TMB; ≥10 mutations/megabase).

AIM: To evaluate patient-reported outcomes (PROs) in this population.

METHODS: Disease-related symptoms and general health status were assessed using the validated PRO questionnaires Lung Cancer Symptom Scale (LCSS) and EQ-5D, respectively. LCSS average symptom burden index (ASBI) and three-item global index (3-IGI) and EQ-5D visual analogue scale (VAS) and utility index (UI) scores and changes from baseline were analysed descriptively. Longitudinal changes were assessed …

A Qualitative Analysis Of Problematic And Non-Problematic Alcohol Use After Bariatric Surgery, Danielle L. Reaves, Joanne M. Dickson, Jason C. G. Halford, Paul Christiansen, Charlotte A. Hardman

Research outputs 2014 to 2021

OBJECTIVES: Bariatric surgery is an effective weight loss tool, but an under-communicated side effect may include the increased risk for alcohol problems. Few studies have examined contributors towards alcohol problems following surgery using a qualitative approach. Therefore, the current study aimed to generate insight informed by participants with problematic alcohol use following bariatric surgery, in comparison with participants without.

METHODS: Participants (14; females, n = 9; males, n = 5) completed semi-structured interviews using questions relating to alcohol use, relationship to food, support and surgical experiences. Thematic analysis was conducted to provide insight into the factors which influenced drinking behaviours …

New Graduate Nurses' Understanding And Attitudes About Patient Safety Upon Transition To Practice, Melanie Murray, Deborah Sundin, Vicki Cope

Research outputs 2014 to 2021

AIMS: To explore the transition experiences of newly graduated registered nurses with particular attention to patient safety.

BACKGROUND: New graduate registered nurses' transition is accompanied by a degree of shock which may be in tune with the described theory-practice gap. The limited exposure to clinical settings and experiences leaves these nurses at risk of making errors and not recognising deterioration, prioritising time management and task completion over patient safety and care.

DESIGN: Qualitative descriptive approach using semi-structured interviews.

METHODS: Data were collected during 2017-18 from 11 participants consenting to face-to-face or telephone semi-structured interviews. Interviews were transcribed verbatim, and data …

Kinetics And Kinematics Of The Squat And Step-Up In Well-Trained Rugby Players, Brendyn B. Appleby, Robert U. Newton, Stuart J. Cormack

Research outputs 2014 to 2021

The purpose of this study was to compare and contrast the kinetics and kinematics of squat and step-up performance in well-trained athletes. Triaxial ground reaction force (GRF) and 3D kinematic data were collected in 4 maximal effort repetitions each at 70, 80, and 90% of 1 repetition maximum (1RM) of squat and step-up. The difference in concentric phase kinetics and kinematics between the squat and step-up was compared using effect sizes (ES ± 90% confidence limits [CLs]) classified as: less than 0.2 as trivial; 0.2-0.6 as small; 0.6-1.2 as moderate; and 1.2-2.0 as large. Where the 90% CL crossed negative …

Reducing Aerodynamic Drag By Adopting A Novel Road-Cycling Sprint Position, Paul F. J. Merkes, Paolo Menaspa, Chris R. Abbiss

Research outputs 2014 to 2021

Purpose:

To assess the influence of seated, standing, and forward-standing cycling sprint positions on aerodynamic drag (CdA) and the reproducibility of a field test of CdA calculated in these different positions.

Methods:

A total of 11 recreational male road cyclists rode 250 m in 2 directions at around 25, 32, and 40 km·h.

Results:

A main effect of position showed that the average CdA of the 2 d was lower for the forward-standing position (0.295 [0.059]) compared with both the seated (0.363 [0.071], P = .018) and standing positions (0.372 [0.077], P = .037). Seated and standing positions did …

Measuring Masculinity In Men With Chronic Disease, Stefano Occhipinti, Kirstyn Laurie, Melissa K. Hyde, Sean Martin, John Oliffe, Gary Wittert, Suzanne K. Chambers

Research outputs 2014 to 2021

The Masculinity in Chronic Disease Inventory (MCD-I) is a new measure of internalized masculine beliefs previously validated in the context of prostate cancer. The present study assessed the validity of the MCD-I in men with other chronic diseases to explore its potential for wider application. A cross-sectional survey of 633 men aged 47–93 years old (M = 68 years), of whom 68% reported ≥2 chronic conditions, was conducted. Measures included the MCD-I and Erectile Function. Exploratory and confirmatory factor analyses were performed followed by tests for discriminant validity. A five-factor structure was confirmed that explained 60% of the …

Low Vitamin D Status Is Associated With Impaired Bone Quality And Increased Risk Of Fracture-Related Hospitalization In Older Australian Women, Kun Zhu, Joshua R. Lewis, Marc Sim, Richard L. Prince

Research outputs 2014 to 2021

The vitamin D debate relates in part to ideal public health population levels of circulating 25-hydroxyvitamin D (25OHD) to maintain bone structure and reduce fracture. In a secondary analysis of 1,348 women aged 70-85 years at baseline (1998) from the Perth Longitudinal Study of Aging in Women (PLSAW, a five-year calcium supplementation trial followed by two five-year extensions), we examined the dose-response relations of baseline plasma 25OHD with hip DXA BMD at year 1, lumbar spine BMD and trabecular bone score (TBS) at year 5, and fracture-related hospitalizations over 14.5 years obtained by health record linkage. Mean baseline plasma 25OHD …

Resistant Starch Is Actively Fermented By Infant Faecal Microbiota And Increases Microbial Diversity, Geetha Gopalsamy, Elissa Mortimer, Paul Greenfield, Anthony R. Bird, Graeme P. Young, Claus T. Christophersen

Research outputs 2014 to 2021

In adults, fermentation of high amylose maize starch (HAMS), a resistant starch (RS), has a prebiotic effect. Were such a capacity to exist in infants, intake of RS might programme the gut microbiota during a critical developmental period. This study aimed to determine if infant faecal inocula possess the capacity to ferment HAMS or acetylated-HAMS (HAMSA) and characterise associated changes to microbial composition. Faecal samples were collected from 17 healthy infants at two timepoints: Preweaning and within 10 weeks of first solids. Fermentation was assessed using in vitro batch fermentation. Following 24 h incubation, pH, short-chain fatty acid (SCFA) production …

Overexpression Of Mirna-25-3p Inhibits Notch1 Signaling And Tgf-Β-Induced Collagen Expression In Hepatic Stellate Cells, Berit Genz, Miranda A. Coleman, Katharine M. Irvine, Jamie R. Kutasovic, Mariska Miranda, Francis D. Gratte, Janina E. E. Tirnitz-Parker, John K. Olynyk, Diego A. Calvopina, Anna Weis, Nicole Cloonan, Harley Robinson, Michelle M. Hill, Fares Al-Ejeh, Grant A. Ramm

Research outputs 2014 to 2021

During chronic liver injury hepatic stellate cells (HSCs), the principal source of extracellular matrix in the fibrotic liver, transdifferentiate into pro-fibrotic myofibroblast-like cells - a process potentially regulated by microRNAs (miRNAs). Recently, we found serum miRNA-25-3p (miR-25) levels were upregulated in children with Cystic Fibrosis (CF) without liver disease, compared to children with CF-associated liver disease and healthy individuals. Here we examine the role of miR-25 in HSC biology. MiR-25 was detected in the human HSC cell line LX-2 and in primary murine HSCs, and increased with culture-induced activation. Transient overexpression of miR-25 inhibited TGF-β and its type 1 receptor …

Local Challenges And Successes Associated With Transitioning To Sustainable Food System Practices For A West Australian Context: Multi-Sector Stakeholder Perceptions, Ros Sambell, Lesley Andrew, Stephanie Godrich, Justin Wolfgang, Dieter Vandenbroeck, Katie Stubley, Nick Rose, Lenore Newman, Pierre Horwitz, Amanda Devine

Research outputs 2014 to 2021

Large-scale food system practices have diminished soil and water quality and negatively impacted climate change. Yet, numerous opportunities exist to harness food system practices that will ensure better outcomes for human health and ecosystems. The objective of this study was to consider food Production, Processing, Access and Consumption domains, and for each determine the challenges and successes associated with progressing towards a sustainable food system. A workshop engaging 122 participants including producers, consultants, consumers, educators, funders, scientists, media, government and industry representatives, was conducted in Perth, Western Australia. A thematic analysis of statements (Successes (n = 170) or Challenges (n …

Dietary Nitrate Intake Is Associated With Muscle Function In Older Women, Marc Sim, Joshua R. Lewis, Lauren C. Blekkenhorst, Catherine P. Bondonno, Amanda Devine, Kun Zhu, Peter Peeling, Richard L. Prince, Jonathan M. Hodgson

Research outputs 2014 to 2021

Background

In younger individuals, dietary nitrate supplementation has been shown to improve short‐term vascular and muscle function. The role of higher habitual nitrate intake as part of a typical diet on muscle function in ageing has not been investigated. A cross‐sectional study of relationships between dietary nitrate and measures of muscle function in older community‐dwelling Australian women (n = 1420, ≥70 years) was undertaken.

Methods

Participants completed a semi‐quantitative food frequency questionnaire assessing dietary intake over the previous year. Total nitrate from vegetables and non‐vegetable sources was calculated from a validated instrument that quantified the nitrate content of food …

Comt Val158met Is Not Associated With Aβ-Amyloid And Apoe Ε4 Related Cognitive Decline In Cognitively Normal Older Adults, Tenielle Porter, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Hamid R. Sohrabi, Madeline Peretti, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Simon M. Laws

Research outputs 2014 to 2021

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer’s disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or …

Variables Associated With Successful Vascular Access Cannulation In Hemodialysis Patients: A Prospective Cohort Study, Linda L. Coventry, Jon M. Hosking, Doris T. Chan, Evelyn Coral, Wai H. Lim, Amanda Towell-Barnard, Diane E. Twigg, Claire M. Rickard

Research outputs 2014 to 2021

BACKGROUND: Successful vascular access (VA) cannulation is integral to the delivery of adequate dialysis, highlighting the importance of ensuring the viability of arteriovenous access in hemodialysis (HD) patients. Missed VA cannulation can lead to infection, infiltration, hematoma or aneurysm formation resulting in the need for access revision, central venous catheter (CVC) placement, or permanent loss of VA. Cannulation-related complications can also negatively impact on a patient's dialysis experience and quality of life. This study aimed to identify patient, VA and nurse factors associated with unsuccessful VA cannulations.

METHODS: A prospective cohort study was conducted in HD patients with a permanent …

The Current State Of Weight-Cutting In Combat Sports, Oliver R. Barley, Dale W. Chapman, Chris R. Abbiss

Research outputs 2014 to 2021

In combat sports, athletes are divided into categories based on gender and body mass. Athletes attempt to compete against a lighter opponent by losing body mass prior to being weighed (i.e., 'weight-cutting'). The purpose of this narrative review was to explore the current body of literature on weight-cutting and outline gaps for further research. Methods of weight-loss include energy intake restriction, total body fluid reduction and pseudo extreme/abusive medical practice (e.g., diuretics). The influence of weight-cutting on performance is unclear, with studies suggesting a negative or no effect. However, larger weight-cuts (~5% of body mass inh) do impair repeat-effort performance. …

Predominant Complications Of Type 2 Diabetes In Kumasi: A 4-Year Retrospective Cross-Sectional Study At A Teaching Hospital In Ghana, Max Efui Annani-Akollor, Otchere Addai-Mensah, Linda Ahenkorah Fondjo, Lorraine Sallah, Eddie-Williams Owiredu, Emmanuel Acheampong, Solomon Akamugri

Research outputs 2014 to 2021

Background and objectives: Diabetes mellitus type 2 (T2DM) has been associated with several microvascular and macrovascular complications. However, studies regarding the predominant complications of T2DM in Ghana have not been conducted. This study evaluated the prevalence and predominant complications of T2DM and assessed the sociodemographic factors associated with the development of diabetes-related complications in Kumasi, Ghana. Materials and Methods: This was a retrospective cross-sectional study conducted at Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. A total of 1600 Ghanaian T2DM adults were included in this study. Patients’ clinical data from 2012 to 2016 were retrieved from the hospital’s archive. Results: …

A Qualitative Study Into The Communication Surrounding The Initiation And Withdrawal Of Non-Invasive Ventilation (Niv) In People With Motor Neurone Disease, Charlotte Chapman

Theses: Doctorates and Masters

Introduction

Motor neurone disease (MND) is a degenerative disease that adversely affects the nervous system and muscular control. Eventually respiratory muscles weaken, causing breathing, communication and swallowing difficulties, and ultimately, respiratory failure and death. Improved quality of life and potentially a short extension of life can be provided with non-invasive ventilation (NIV), which is offered to people with MND when symptoms of respiratory distress become evident.

It is recommended that end-of-life communication, encompassing the benefits and burdens of symptom-relieving interventions (NIV and percutaneous gastrostomy tube to assist with nutrition), NIV withdrawal (proposed when continued use is considered futile) and other …

Spatial Distribution Of Tuberculosis And Its Association With Meteorological Factors In Mainland China, Yingjie Zhang, Mengyang Liu, Samuel S. Wu, Hui Jiang, Junjie Zhang, Songwang Wang, Wei Ma, Qihuan Li, Yuan Ma, Yue Liu, Wei Feng, Endawoke Amsalu, Xia Li, Wei Wang, Weimin Li, Xiuhua Guo

Research outputs 2014 to 2021

BACKGROUND: The incidence of tuberculosis (TB) remains high worldwide. Current strategies will not eradicate TB by 2035; instead, by 2182 is more likely. Therefore, it is urgent that new risk factors be identified.

METHODS: An ecological study was conducted in 340 prefectures in China from 2005 to 2015. The spatial distribution of TB incidence was shown by clustering and hotspot analysis. The relationship between the distribution patterns and six meteorological factors was evaluated by the geographically weighted regression (GWR) model.

RESULTS: During the 11 years of the study period, TB incidence was persistently low in the east and high in …

A 2-Year Prospective Study Of Injury Epidemiology In Elite Australian Rugby Sevens: Exploration Of Incidence Rates, Severity, Injury Type, And Subsequent Injury In Men And Women, Liam A. Toohey, Michael K. Drew, Caroline F. Finch, Jill L. Cook, Lauren V. Fortington

Research outputs 2014 to 2021

Background:

Injuries are common in rugby sevens, but studies to date have been limited to short, noncontinuous periods and reporting of match injuries only.

Purpose:

To report the injury incidence rate (IIR), severity, and burden of injuries sustained by men and women in the Australian rugby sevens program and to provide the first longitudinal investigation of subsequent injury occurrence in rugby sevens looking beyond tournament injuries only.

Study design:

Descriptive epidemiology study.

Methods:

Ninety international rugby sevens players (55 men and 35 women) were prospectively followed over 2 consecutive seasons (2015-2016 and 2016-2017). All medical attention injuries were reported irrespective …

Recursive Residuals For Linear Mixed Models, Ahmed Bani‑Mustafa, K. M. Matawie, Caroline F. Finch, Amjad Al‑Nasser, Enrico Ciavolino

Research outputs 2014 to 2021

This paper presents and extends the concept of recursive residuals and their estimation to an important class of statistical models, Linear Mixed Models (LMM). Recurrence formulae are developed and recursive residuals are defined. Recursive computable expressions are also developed for the model’s likelihood, together with its derivative and information matrix. The theoretical framework for developing recursive residuals and their estimation for LMM varies with the estimation method used, such as the fitting-of-constants or the Best Linear Unbiased Predictor method. These methods are illustrated through application to an LMM example drawn from a published study. Model fit is assessed through a …

Genomic Analysis Of Circulating Tumor Dna Using A Melanoma-Specific Ultraseek Oncogene Panel, Elin S. Gray, Tom Witkowski, Michelle Pereira, Leslie Calapre, Karl Herron, Darryl Irwin, Brett Chapman, Muhammad A. Khattak, Jeanette Raleigh, Athena Hatzimihalis, Jonathan Cebon, Shahneen Sandhu, Grant A. Mcarthur, Michael Millward, Melanie Ziman, Alexander Dobrovic, Stephen Q. Wong

Research outputs 2014 to 2021

The analysis of circulating tumor DNA provides a minimally invasive molecular interrogation that has the potential to guide treatment selection and disease monitoring. Here, the authors evaluated a custom UltraSEEK melanoma panel for the MassARRAY system, probing for 61 mutations over 13 genes. The analytical sensitivity and clinical accuracy of the UltraSEEK melanoma panel was compared with droplet digital PCR. The blinded analysis of 68 mutations detected in 48 plasma samples from stage IV melanoma patients revealed a concordance of 88% between the two platforms. Further comparison of both methods for the detection of BRAF V600E mutations in 77 plasma …

In Vivo Safety Profile And Biodistribution Of Gmp-Manufactured Human Skin-Derived Abcb5-Positive Mesenchymal Stromal Cells For Use In Clinical Trials, Nils Tappenbeck, Hannes M. Schröder, Elke Niebergall-Roth, Fathema Hassinger, Ulf Dehio, Kathrin Dieter, Korinna Kraft, Andreas Kerstan, Jasmina Esterlechner, Natasha Y. Frank, Karin Scharffetter-Kochanek, George F. Murphy, Dennis P. Orgill, Joachim Beck, Markus H. Frank, Christoph Ganss, Mark A. Kluth

Research outputs 2014 to 2021

Background aims

Human dermal ABCB5-expressing mesenchymal stromal cells (ABCB5⁺ MSCs) represent a promising candidate for stem cell–based therapy of various currently uncurable diseases in several fields of regenerative medicine. We have developed and validated a method to isolate, from human skin samples, and expand ABCB5⁺ MSCs that meet the guideline criteria of the International Society for Cellular Therapy. We are able to process these cells into a Good Manufacturing Practice–conforming, MSC-based advanced-therapy medicinal product.

Methods

To support the development of ABCB5⁺ MSCs for potential therapeutic topical, intramuscular and intravenous administration, we have tested our product in a …

Online Video Instruction On Hand Expression Of Colostrum In Pregnancy Is An Effective Educational Tool, Therese A. O'Sullivan, Joy Cooke, Chris Mccafferty, Roslyn Giglia

Research outputs 2014 to 2021

The use of antenatal colostrum expression in the weeks prior to birth may help improve long-term breastfeeding, but few large-scale studies exist. Typically, antenatal colostrum expression instruction relies on face-to-face education, making large interventions costly. We aimed to determine whether an expert online instructional video can improve knowledge and confidence around antenatal colostrum expressing. Pregnant women were asked to complete a questionnaire pre- and post-watching the instructional video online. Ninety five pregnant women completed both pre- and post-questionnaires. Total antenatal colostrum expression knowledge scores improved after watching the video, from a mean of 3.05 ± 1.70 correct out of a …

Evolutionary And Genomic Insights Into Clostridioides Difficile Sequence Type 11: A Diverse Zoonotic And Antimicrobial-Resistant Lineage Of Global One Health Importance, Daniel R. Knight, Brian Kullin, Grace O. Androga, Frederic Barbut, Catherine Eckert, Stuart Johnson, Patrizia Spigaglia, Kazuhiro Tateda, Pei-Jane Tsai, Thomas V. Riley

Research outputs 2014 to 2021

Clostridioides difficile (Clostridium difficile) sequence type 11 (ST11) is well established in production animal populations worldwide and contributes considerably to the global burden of C. difficile infection (CDI) in humans. Increasing evidence of shared ancestry and genetic overlap of PCR ribotype 078 (RT078), the most common ST11 sublineage, between human and animal populations suggests that CDI may be a zoonosis. We performed whole-genome sequencing (WGS) on a collection of 207 ST11 and closely related ST258 isolates of human and veterinary/environmental origin, comprising 16 RTs collected from Australia, Asia, Europe, and North America. Core genome single nucleotide variant (SNV) analysis identified …

Cross-Cultural Evidence Does Not Support Universal Acceleration Of Puberty In Father-Absent Households, Rebecca Sear, Paula Sheppard, David A. Coall

Research outputs 2014 to 2021

Father absence in early life has been shown to be associated with accelerated reproductive development in girls. Evolutionary social scientists have proposed several adaptive hypotheses for this finding. Though there is variation in the detail of these hypotheses, they all assume that family environment in early life influences the development of life-history strategy, and, broadly, that early reproductive development is an adaptive response to father absence. Empirical evidence to support these hypotheses, however, has been derived from WEIRD (Western, Educated, Industrialized, Rich and Democratic) populations. Data from a much broader range of human societies are necessary in order to properly …