Medicine and Health Sciences Commons^™

Breeching The System: An Exploration Of Women’S Experiences And Breech Care Recommendations, Sara Morris

Research outputs 2014 to 2021

Aim:

This presentation reports the findings of a mixed methods study exploring women’s experiences of breech birth in Western Australia (WA) and professional recommendations for breech care.

Methods:

This pragmatic study consisted of a clinical guideline review, semi-structured interviews with women who had experienced a breech birth in WA and a multi-national e-Delphi study involving professionals with knowledge and/or experience of caring for women with a breech presenting fetus. These methods were deemed the optimal way of incorporating current clinical practice guidelines, with multi-disciplinary recommendations and consumer feedback.

Findings:

The clinical guideline review revealed similarities in antenatal care structure and …

Risk Factors For Covid-19 Infection, Disease Severity And Related Deaths In Africa: A Systematic Review, Hailay Abrha Gesesew, Digsu Negese Koye, Dagnachew Muluye Fetene, Mulu Woldegiorgis, Yohannes Kinfu, Ayele Bali Geleto, Yohannes Adama Melaku, Hassen Mohammed, Kefyalew Addis Alene, Mamaru Ayenew Awoke, Mulugeta Molla Birhanu, Amanuel Tesfay Gebremedhin, Yalemzewod Assefa Gelaw, Desalegn Markos Shifti, Muluken Dessalegn Muluneh, Teketo Kassaw Tegegne, Solomon Abrha, Atsede Fantahun Aregay, Mohammed Biset Ayalew, Abadi Kahsu Gebre, Kidane Tadesse Gebremariam, Tesfaye Gebremedhin, Lemlem Gebremichael, Cheru Tesema Leshargie, Getiye Dejenu Kibret, Maereg Wagnew Meazaw, Alemayehu Berhane Mekonnen, Dejen Y. Tekle, Azeb G. Tesema, Fisaha H. Tesfay, Wubshet Tesfaye, Befikadu L. Wubishet, Berihun A. Dachew, Akilew A. Adane

Research outputs 2014 to 2021

© BMJ Publishing Group Limited 2020. Objective The aim of this study was to provide a comprehensive evidence on risk factors for transmission, disease severity and COVID-19 related deaths in Africa. Design A systematic review has been conducted to synthesise existing evidence on risk factors affecting COVID-19 outcomes across Africa. Data sources Data were systematically searched from MEDLINE, Scopus, MedRxiv and BioRxiv. Eligibility criteria Studies for review were included if they were published in English and reported at least one risk factor and/or one health outcome. We included all relevant literature published up until 11 August 2020. Data extraction and …

Training In The Practice Of Noninvasive Brain Stimulation: Recommendations From An Ifcn Committee, Peter J. Fried, Emiliano Santarnecchi, Andrea Antal, David Bartres-Faz, Sven Bestmann, Linda L. Carpenter, Pablo Celnik, Dylan Edwards, Faranak Farzan, Shirley Fecteau, Mark S. George, Bin He, Yun-Hee Kim, Letizia Leocani, Sarah H. Lisanby, Colleen Loo, Bruce Luber, Michael A. Nitsche, Walter Paulus, Simone Rossi, Paolo M. Rossini, John Rothwell, Alexander T. Sack, Gregor Thut, Yoshikazu Ugawa, Ulf Ziemann, Mark Hallett, Alvaro Pascual-Leone

Research outputs 2014 to 2021

© 2020 As the field of noninvasive brain stimulation (NIBS) expands, there is a growing need for comprehensive guidelines on training practitioners in the safe and effective administration of NIBS techniques in their various research and clinical applications. This article provides recommendations on the structure and content of this training. Three different types of practitioners are considered (Technicians, Clinicians, and Scientists), to attempt to cover the range of education and responsibilities of practitioners in NIBS from the laboratory to the clinic. Basic or core competencies and more advanced knowledge and skills are discussed, and recommendations offered regarding didactic and practical …

Construct Validity Of The Suboptimal Health Status Questionnaire-25 In A Ghanaian Population, Eric Adua, Ebenezer Afrifa-Yamoah, Kwasi Frimpong, Esther A. Adama, Shantha P. Karthigesu, Enoch Odame Anto, Emmanuel Aboagye, Yuxiang Yan, Youxin Wang, Xuerui Tan, Wei Wang

Research outputs 2014 to 2021

Background

The Suboptimal Health Status Questionnaire-25 (SHS-Q-25) developed to measure Suboptimal Health Status has been used worldwide, but its construct validity has only been tested in the Chinese population. Applying Structural Equation Modelling, we investigate aspects of the construct validity of the SHS-Q-25 to determine the interactions between SHS subscales in a Ghanaian population.

Methods

The study involved healthy Ghanaian participants (n = 263; aged 20–80 years; 63% female), who responded to the SHSQ-25. In an exploratory factor and parallel analysis, the study extracted a new domain structure and compared to the established five-domain structure of SHSQ-25. A confirmatory factor …

Summary Of Sexual Health Links With Chronic Disease In Aboriginal And Torres Strait Islander Males, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

This Summary is based on the Review of sexual health issues linked with cardiovascular disease and type 2 diabetes mellitus in Aboriginal and Torres Strait Islander males (the ‘Review’) published by the Australian Indigenous HealthBulletin in 2021. It provides information about the male sexual health conditions of erectile dysfunction (ED) and low testosterone, and their links to chronic disease, specifically cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). It outlines:

• the causes and symptoms of ED and low testosterone
• how common ED and low testosterone are among the Australian male population (there are limited data available about Aboriginal and …

Hypogonadism Induced By Surgical Stress And Brain Trauma Is Reversed By Human Chorionic Gonadotropin In Male Rats: A Potential Therapy For Surgical And Tbi-Induced Hypogonadism?, Rastafa I. Geddes, Amita Kapoor, Kentaro Hayashi, Ryan Rauh, Marlyse Wehber, Quinn Bongers, Alex D. Jansen, Icelle M. Anderson, Gabrielle Farquhar, Sivan Vadakkadath-Meethal, Toni E. Ziegler, Craig S. Atwood

Research outputs 2014 to 2021

Introduction: Hypogonadotropic hypogonadism (HH) is an almost universal, yet underappreciated, endocrinological complication of traumatic brain injury (TBI). The goal of this study was to determine whether the developmental hormone human chorionic gonadotropin (hCG) treatment could reverse HH induced by a TBI. Methods: Plasma samples were collected at post-surgery/post-injury (PSD/PID) days -10, 1, 11, 19 and 29 from male Sprague-Dawley rats (5- to 6-month-old) that had undergone a Sham surgery (craniectomy alone) or CCI injury (craniectomy + bilateral moderate-to-severe CCI injury) and treatment with saline or hCG (400 IU/kg; i.m.) every other day. Results: Both Sham and CCI injury significantly decreased …

Cardiovascular Safety Of Antifracture Medications In Patients With Osteoporosis: A Narrative Review Of Evidence From Randomized Studies, Alexander J. Rodríguez, Bo Abrahamsen

Research outputs 2014 to 2021

Osteoporosis and cardiovascular (CV) disease share common risk factors and pathophysiology. Low bone mineral density (BMD) and fractures appear to increase the risk for multiple CV diseases. Equally, prevalent CV disease appears to predispose to bone loss and increase fracture rates. This relationship has naturally provoked the hypothesis that stopping bone loss may result in some CV benefit. Secondary analyses of safety and adverse event data from many randomized controlled trials (RCTs) have attempted to clarify this putative association. Recently, the discontinuation of odanacatib (anti-cathepsin K monoclonal antibody) over stroke concerns and the imbalance in ischemic events in romosozumab-treated (anti-sclerostin …

The Health Of Older Western Australians: The Role Of Age, Gender, Geographic Location, Psychological Distress, Perceived Health, Tobacco And Alcohol, Celia Wilkinson, Kim Clarke, Ros Sambell, Julie Dare, Stephen J. Bright

Research outputs 2014 to 2021

Purpose: Rates of drinking- and alcohol-related harms among older adults are increasing in most developed nations. The purpose of this paper was to explore the relationship among at-risk alcohol use, smoking, gender, geographical location, self-reported health and psychological well-being among Western Australians aged 65 years and older.

Design/methodology/approach: A secondary analysis was conducted of a cross-sectional survey that collected data from 7,804 West Australians aged 65 years and older between 2013 and 2015. Participants were categorised according to the following age groups: young-old (aged 65–74 years), older-old (aged 75–84 years) and oldest-old (aged 85+ years).

Findings: Results from a multinomial …

Validation Of Fatty Liver Disease Scoring Systems For Ultrasound Diagnosed Non-Alcoholic Fatty Liver Disease In Adolescents, Fuzhen Wan, Feng Pan, Oyekoya T. Ayonrinde, Leon A. Adams, Trevor A. Mori, Lawrence J. Beilin, Therese A. O'Sullivan, John K. Olynyk, Wendy H. Oddy

Research outputs 2014 to 2021

Background and Aims: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing in young populations. However, there are inadequate data regarding diagnosis of NAFLD. We aimed to validate three scoring systems against a previous standard of suprailiac skinfold thickness for diagnosing NAFLD in population-based adolescents.

Methods: Seventeen-year-old adolescents (n = 899), participating in the Raine Study, attended a cross-sectional follow-up. NAFLD was diagnosed using liver ultrasound. Scores for Fatty liver index (FLI), Hepatic Steatosis Index (HSI) and Zhejiang University index (ZJU index) were calculated. Diagnostic accuracy of these diagnostic tests was evaluated through discrimination and calibration.

Results: NAFLD …

Communication Surrounding Initiation And Withdrawal Of Non-Invasive Ventilation In Adults With Motor Neuron(E) Disease: Clinicians’ And Family Members’ Perspectives, Charlotte Chapman, Sara Bayes, Moira Sim

Research outputs 2014 to 2021

Introduction: International guidelines recommend that health care clinicians communicate with people with MND and their family members about non-invasive ventilation (NIV) and percutaneous gastrostomy tube (PEG) prior to or at the onset of respiratory symptoms. This study sought to discover the degree to which these recommendations are followed in practice.

Methods: Interpretive Description methodology was employed. Nineteen clinicians experienced in caring for people with MND, six relatives of recently deceased people with MND and one person with MND participated in semi-structured in-depth interviews. Clinicians’ accounts of NIV and PEG related communications were compared to family member participants’ recollections of their …

Estimating The Magnitude And Risk Associated With Heat Exposure Among Ghanaian Mining Workers, Victor Fannam Nunfam, Kwadwo Adusei-Asante, Eddie Van Etten, Kwasi Frimpong, Jacques Oosthuizen

Research outputs 2014 to 2021

Many occupational settings located outdoors in direct sun, such as open cut mining, pose a health, safety, and productivity risk to workers because of their increased exposure to heat. This issue is exacerbated by climate change effects, the physical nature of the work, the requirement to work extended shifts and the need to wear protective clothing which restricts evaporative cooling. Though Ghana has a rapidly expanding mining sector with a large workforce, there appears to be no study that has assessed the magnitude and risk of heat exposure on mining workers and its potential impact on this workforce. Questionnaires and …

Positive Drug Stories: Possibilities For Agency And Positive Subjectivity For Harm Reduction, Liam B. Engel, Stephen J. Bright, Monica J. Barratt, Matthew M. Allen

Research outputs 2014 to 2021

People who use drugs understand drugs and drug use in ways that are often different to the way knowledge of drug use is constructed within the dominant medico-legal discourse. Their experiences are, more often than not, represented in negative ways within dominant discourse, a disconnect that can create adverse consequences for people who use drugs, through the production of stigma and shame leading to poor health and social outcomes. A key difference in how drugs are understood by people who use drugs is the capacity of the former to recognize positive aspects of drug use and create more agentic subjectivities …

“You Felt Like A Prisoner In Your Own Self, Trapped”: The Experiences Of Aboriginal People With Acquired Communication Disorders, Elizabeth Armstrong, Juli Coffin, Deborah Hersh, Judith M. Katzenellenbogen, Sandra C. Thompson, Natalie Ciccone, Leon Flicker, Deborah Woods, Colleen Hayward, Catelyn Dowell, Meaghan Mcallister

Research outputs 2014 to 2021

Purpose:

Aboriginal Australians are under-represented in brain injury rehabilitation services despite a high incidence of both stroke and traumatic brain injury in this population. This study aimed to explore the experiences of Aboriginal Australian adults with acquired communication disorders (ACDs) after brain injury for the first time to inform the development of accessible and culturally secure service delivery models.

Methods and materials:

Semi-structured interviews were undertaken with 32 Aboriginal people who had experienced a brain injury resulting in ACDs (aged 35–79 years) and 18 family members/carers across Western Australia. Thematic analysis identified common themes across participants.

Results:

Overall themes related …

Organizational Factors Associated With Health Worker Protection During The Covid-19 Pandemic In Four Provinces Of South Africa, Muzimkhulu Zungu, Kuku Voyi, Nosimilo Mlangeni, Saiendhra Vasudevan Moodley, Jonathan Ramodike, Nico Claassen, Elizabeth Wilcox, Nkululeko Thunzi, Annalee Yassi, Jerry Spiegel, Molebogeng Malotle

Research outputs 2014 to 2021

Background: Health workers, in short supply in many low-and-middle-income countries, are at increased risk of SARS-CoV-2 infection. This study aimed to assess how South Africa, prepared to protect its health workers from SARS-CoV-2 infection. Methods: This was a cross-sectional study design applying participatory action research in four provinces of South Africa. A semi-structured questionnaire and a qualitative observational HealthWISE walkthrough risk assessment was carried out to collect data on occupational safety and health (OSH) systems in 45 hospitals across four provinces to identify factors associated with health worker protection. Adapting the International Labour Organization (ILO) and World Health Organization (WHO) …

Glucosinolates From Cruciferous Vegetables And Their Potential Role In Chronic Disease: Investigating The Preclinical And Clinical Evidence, Emma Connolly, Marc Sim, Nikolaj Travica, Wolfgang Marx, Gemma Beasy, Gordon S. Lynch, Catherine P. Bondonno, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst

Research outputs 2014 to 2021

An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including cardiometabolic, neurological, and musculoskeletal conditions, and certain cancers. A possible protective component, glucosinolates, which are phytochemicals found almost exclusively in cruciferous vegetables, have been identified from preclinical and clinical studies. Current research suggests that glucosinolates (and isothiocyanates) act via several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. This review summarizes the current knowledge surrounding cruciferous vegetables and their glucosinolates in relation to the specified health conditions. Although there is evidence that …

Heritability Enrichment Of Immunoglobulin G N-Glycosylation In Specific Tissues, Xingang Li, Hao Wang, Yahong Zhu, Weijie Cao, Song Manshu, Youxin Wang, Haifeng Hou, Minglin Lang, Xiuhua Guo, Xuerui Tan, Jingdong J. Han, Wei Wang

Research outputs 2014 to 2021

Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain. Leveraging data from GWAS summary statistics for 8,090 Europeans, and large-scale expression quantitative trait loci (eQTL) data from the genotype-tissue expression of 53 types of tissues (GTEx v7), we derived a linkage disequilibrium score for the specific expression of genes (LDSC-SEG) and conducted a transcriptome-wide association study (TWAS). We identified 55 gene associations whose predicted levels of expression were significantly associated with IgG N-glycosylation in 14 tissues. Three working scenarios, i.e., tissue-specific, …

Exercise Attenuates Bone Mineral Density Loss During Diet-Induced Weight Loss In Adults With Overweight And Obesity: A Systematic Review And Meta-Analysis, Jakub Mesinovic, Paul Jansons, Ayse Zengin, Barbora De Courten, Alexander J. Rodriguez, Robin M. Daly, Peter R. Ebeling, David Scott

Research outputs 2014 to 2021

Background: Weight-loss-induced fat loss improves cardiometabolic health in individuals with overweight and obesity; however, weight loss can also result in bone loss and increased fracture risk. Weight-loss-induced bone loss may be attenuated with exercise. Our aim was to compare changes in bone mineral density (BMD) in adults with overweight and obesity who undertook diet-induced weight loss alone or in combination with exercise. Methods: We included randomized controlled trials (RCTs) in adults with overweight or obesity (aged ≥ 18 years; body mass index ≥ 25 kg/m2) that prescribed diet-induced weight loss alone or in combination with supervised exercise, and measured any …

Communicating With Older People About Physical Activity, Simone Pettigrew, Michelle I. Jongenelis, Rajni Rai, Ben Jackson, Robert U. Newton

Research outputs 2014 to 2021

Objective: Little is known about how to effectively encourage higher levels of activity among older people. This study tested the effectiveness of a public service advertisement designed according to recommendations for communicating with older audiences and featuring five types of moderate-to-vigorous physical activity: tennis, line dancing, cycling, swimming and jogging. Methods: A survey administered to 1,200 Australians aged 50+ years assessed effects of the public service advertisement on: motivation (intrinsic and extrinsic); perceived believability, relevance, and effectiveness; and feelings elicited (e.g. interest, hope, guilt). Open-ended questions enabled respondents to describe aspects of the ad they considered to be most and …

Feasibility, Safety, And Acceptability Of A Remotely Monitored Exercise Pilot Champ: A Clinical Trial Of High-Intensity Aerobic And Resistance Exercise For Metastatic Castrate-Resistant Prostate Cancer, Stacey A. Kenfield, Erin L. Van Blarigan, Neil Panchal, Alexander Bang, Li Zhang, Rebecca E. Graff, Yea-Hung Chen, Charles J. Ryan, Anthony Luke, Robert U. Newton, Imelda Tenggara, Brooke Schultz, Elizabeth Wang, Emil Lavaki, Kyle Zuniga, Nicole Pinto, Hala Borno, Rahul Aggarwal, Terence Friedlander, Vadim S. Koshkin, Andrea Harzstark, Eric Small, June M. Chan

Research outputs 2014 to 2021

Background: Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate-resistant prostate cancer (mCRPC). Methods: We conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high- and moderate-intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based …

The Support Person's Preferences And Perspectives Of Physical Activity Programs For Older Adults With Cognitive Impairment, Terence W. H. Chong, Emily You, Kathryn A. Ellis, Kay L. Cox, Karra D. Harrington, Stephanie R. Rainey-Smith, David Ames, Nicola T. Lautenschlager, Aibl Research Group

Research outputs 2014 to 2021

Objectives: Physical activity (PA) is beneficial for older adults' cognition. There is limited research investigating perspectives of support persons (SPs) of next-of-kins (NOKs) with cognitive impairment. This exploratory study aimed to investigate perspectives of SPs of older adults with Alzheimer's Dementia (AD) or Mild Cognitive Impairment (MCI). Methods: A telephone survey of 213 SPs of NOKs from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) was undertaken to quantitatively assess SPs' beliefs and knowledge about PA benefits, current PA level of their NOK, and PA program preferences. The contribution of age, gender, diagnosis and mental health symptoms …

Associations Between Genetic Variants In The Vitamin D Metabolism Pathway And Severity Of Covid-19 Among Uae Residents, Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba Alsafar

Research outputs 2014 to 2021

Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were …

Therapeutic Potential Of Mitophagy-Inducing Microflora Metabolite, Urolithin A For Alzheimer’S Disease, Dona Pamoda W. Jayatunga, Eugene Hone, Harjot Khaira, Taciana Lunelli, Harjinder Singh, Gilles J. Guillemin, Binosha Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins

Research outputs 2014 to 2021

Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neuro-degenerative disorders including Alzheimer’s disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bi-oactive food components, known as nutraceuticals, may serve as such agents to combat AD. Uro-lithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, …

An Assessment Of The Hopping Strategy And Inter-Limb Asymmetry During The Triple Hop Test: A Test–Retest Pilot Study, Kyle Davey, Paul Read, Joseph Coyne, Paul Jarvis, Anthony Turner, Jon Brazier, Nejc Šarabon, Matthew J. Jordan, Chris Bishop

Research outputs 2014 to 2021

The aims of the present study are to: (1) determine within-and between-session reliability of multiple metrics obtained during the triple hop test; and (2) determine any systematic bias in both the test and inter-limb asymmetry scores for these metrics. Thirteen male young American football athletes performed three trials of a triple hop test on each leg on two separate occasions. In addition to the total distance hopped, manual detection of touch down and toe-off were calculated via video analysis, enabling flight time (for each hop), ground contact time (GCT), reactive strength index (RSI), and leg stiffness (between hops) to be …

Professional Fishing Industry Fatality, Incident And Injury Data Project, Greg Penney, Bill Byrne, Marcus Cattani

Research outputs 2014 to 2021

Analysis of occupational injuries and fatalities within the wild-catch Australian Commercial Fishing Industry (ACFI) is complicated by fishing crew (masters, deckhands etc) classification as workers being dependent upon the applicable occupational health and safety, and worker’s compensation legislation of the relevant State or Territory. While fishing vessels are considered a workplace consistently across all State’s and Territories Work Health and Safety (WHS) / Occupational Health and Safety (OHS) jurisdiction’s legislation, the people who work on them may not be deemed to be workers or employees as per state and territory workers compensation legislation. The exclusion of fishing crew as workers …

Principle-Based Concept Analysis Methodology Using A Phased Approach With Quality Criteria, Stephanie Smith, Evalotte Mörelius

Research outputs 2014 to 2021

The study aimed to provide a detailed description of a process to conduct a phased principle-based concept analysis and to introduce quality criteria assessment for a phased principle-based concept analysis. Concept analysis explores how a concept is described, used and measured in the literature. This conceptual understanding is important to guide translational research to direct the development of evidence-based practice. The principle-based concept analysis is one approach of concept analysis used in published work, but the literature is lacking in articles clearly describing how to conduct it in practice. This article provides a methodology utilising a phased approach and by …

Segregation Analysis Of Genotyped And Family-Phased, Long Range Mhc Classical Class I And Class Ii Haplotypes In 5 Families With Type 1 Diabetes Proband In The United Arab Emirates, Guan K. Tay, Halima Al Naqbi, Aurélie Mawart, Zahrah Baalfaqih, Anoud Almaazmi, Asma Deeb, Habiba Alsafar

Research outputs 2014 to 2021

The classical Human Leucocyte Antigen (HLA) class II haplotypes of the Major Histocompatibility Complex (MHC) that are associated with type 1 diabetes (T1D) were identified in five families from the United Arab Emirates (UAE). Segregation analyses were performed on these 5 families with the disease, 3 with one child and 2 with 2 children diagnosed with T1D. Three HLA-DR4 haplotypes were identified: HLA- DRB1∗04:01:01-DQB1∗03:02:01:01; HLA- DRB1∗04:02:01- DQB1∗03:02:01; and HLA -DRB1∗04:05:01-DQB1∗02:02:01:02. All have previously been identified to be associated with T1D in studies of the Arabian population. In the 10 parents from the 5 families, 9 had at least one HLA-DR4 …

Atrophy Expansion Rates In Stargardt Disease Using Ultra-Widefield Fundus Autofluorescence, Rachael C. Heath-Jeffery, Jennifer A. Thompson, Johnny Lo, Tina M. Lamey, Terri L. Mclaren, Ian L. Mcallister, David A. Mackey, Ian J. Constable, John N. De Roach, Fred K. Chen

Research outputs 2014 to 2021

Purpose To investigate atrophy expansion rate (ER) using ultra-widefield (UWF) fundus autofluorescence (FAF) in Stargardt disease (STGD1). Design Retrospective, longitudinal study. Participants Patients with biallelic ABCA4 mutations who were evaluated with UWF FAF and Heidelberg 30° × 30° and 55° × 55° FAF imaging. Methods Patients with atrophy secondary to STGD1 were classified into genotype groups: group A, biallelic severe or null-like variants with early-onset disease; group B, 1 intermediate variant in trans with severe or null-like variant; and group C, 1 mild variant in trans with severe or null-like variant or late-onset disease. The boundaries of definitely decreased autofluorescence …

Into The Breech: A Multi-National E-Delphi Study Exploring Breech Presentation And Birth Care, Sara Morris

Research outputs 2014 to 2021

Aim: To establish consensus regarding care of women with a breech presenting fetus through the exploration of participants’ knowledge, experiences and opinions regarding breech presentation and care.

Design: Three round Delphi e-survey

Setting: Multi-national

Participants: A panel of fifteen midwives, four obstetricians and one academic with an interest in breech care and birth.

Methods: The initial survey comprised of open-ended questions. Answers were coded and integrated to form statements presented to participants over 3 sections in the second round due to the abundance of information collected from first round responses. Consensus was deemed reached if 70% or more of participants …

Life In A Time Of Covid: A Mixed Method Study Of The Changes In Lifestyle, Mental And Psychosocial Health During And After Lockdown In Western Australians, Ranila Bhoyroo, Paola Chivers, Lynne Millar, Caroline Bulsara, Ben Piggott, Michelle Lambert, Jim Codde

Research outputs 2014 to 2021

Background: Since the beginning of the COVID-19 pandemic, the Western Australian government imposed multiple restrictions that impacted daily life activities and the social life. The aim of this study was to examine the effects of COVID-19 lockdown on the community’s physical, mental and psychosocial health. Methods: Approximately 2 months after a three-month lockdown, a cross-sectional study was opened to Western Australian adults for an 8-week period (25th August – 21 October 2020). Participants competed a 25-min questionnaire adapted from the Western Australia Health and Wellbeing Surveillance system. Participants provided information on their socio-demographic status, lifestyle behaviours, mental health, and psychosocial …

Midwives’ Strategies For Coping With Barriers To Providing Quality Maternal And Neonatal Care: A Glaserian Grounded Theory Study, Yakubu Ismaila, Sara Bayes, Sadie Geraghty

Research outputs 2014 to 2021

Background: Midwives face direct and indirect barriers in their workplaces that have negative consequences on their ability to provide quality care to women and neonates, however, they still carry on with their duties. This study aimed at investigating the coping strategies that Ghanaian midwives adopt to be able to complete their work. Methods: Glaserian Grounded theory was used in this study. Data were collected through non-participant observations and semi-structured interviews. The study participants included 29 midwives who worked in labour/birthing environments and a pharmacist, a social worker, a national Health Insurance Scheme manager and a health services manager. Findings: The …