Medicine and Health Sciences Commons^™

Resistance Training Load Effects On Muscle Hypertrophy And Strength Gain: Systematic Review And Network Meta-Analysis, Pedro Lopez, Régis Radaelli, Dennis R. Taaffe, Robert U. Newton, Daniel A. Galvão, Gabriel S. Trajano, Juliana L. Teodoro, William J. Kraemer, Keijo Häkkinen, Ronei S. Pinto

Research outputs 2014 to 2021

Purpose This study aimed to analyze the effect of resistance training (RT) performed until volitional failure with low, moderate, and high loads on muscle hypertrophy and muscle strength in healthy adults and to assess the possible participant-, design-, and training-related covariates that may affect the adaptations. Methods Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, MEDLINE, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases were searched. Including only studies that performed sets to volitional failure, the effects of low- ( > 15 repetitions maximum (RM)), moderate- (9-15 RM), and high-load ( ≤ 8 RM) RTs were examined in healthy …

Feasibility And Efficacy Of A Multicomponent Exercise Medicine Programme In Patients With Pancreatic Cancer Undergoing Neoadjuvant Therapy (The Expan Trial): Study Protocol Of A Dual-Centre, Two-Armed Phase I Randomised Controlled Trial, Hao Luo, Daniel A. Galvao, Robert U. Newton, Colin Tang, Andrew Dean, Kevin Jasas, Mikael Johansson, Ian Yusoff, Nigel Spry, Dennis R. Taaffe

Research outputs 2014 to 2021

Introduction Exercise is emerging as a therapy in oncology for its physical and psychosocial benefits and potential effects on chemotherapy tolerability and efficacy. However, evidence from randomised controlled trials (RCTs) supporting exercise in patients with borderline resectable or locally advanced pancreatic cancer (PanCa) undergoing neoadjuvant therapy (NAT) are lacking. Methods and analysis The EXPAN trial is a dual-centre, two-armed, phase I RCT. Forty patients with borderline resectable or locally advanced PanCa undergoing NAT will be randomised equally to an exercise intervention group (individualised exercise+standard NAT) or a usual care control group (standard NAT). The exercise intervention will be supervised and …

Human Ips Cells Engender Corneal Epithelial Stem Cells With Holoclone-Forming Capabilities, Shinya Watanabe, Ryuhei Hayashi, Yuzuru Sasamoto, Motokazu Tsujikawa, Bruce R. Ksander, Markus H. Frank, Andrew J. Quantock, Natasha Y. Frank, Kohji Nishida

Research outputs 2014 to 2021

Human induced pluripotent stem cells (hiPSCs) can generate a multiplicity of organoids, yet no compelling evidence currently exists as to whether or not these contain tissue-specific, holoclone-forming stem cells. Here, we show that a subpopulation of cells in a hiPSC-derived corneal epithelial cell sheet is positive for ABCB5 (ATP-binding cassette, sub-family B, member 5), a functional marker of adult corneal epithelial stem cells. These cells possess remarkable holoclone-forming capabilities, which can be suppressed by an antibody-mediated ABCB5 blockade. The cell sheets are generated from ABCB5+ hiPSCs that first emerge in 2D eye-like organoids around six weeks of differentiation and display …

Foveal Avascular Zone And Choroidal Thickness Are Decreased In Subjects With Hard Drusen And Without High Genetic Risk Of Developing Alzheimer’S Disease, Inés López-Cuenca, Rosa De Hoz, Celia Alcantara-Rey, Elena Salobrar-García, Lorena Elvira-Hurtado, José A. Fernández-Albarral, Ana Barabash, Federico Ramírez-Toraño, Jaisalmer De Frutos-Lucas, Juan J. Salazar, Ana I. Ramírez, José M. Ramírez

Research outputs 2014 to 2021

A family history (FH+) of Alzheimer’s disease (AD) and ɛ4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ɛ4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ɛ4−, HD+) group compared with …

Physical Activity And Self-Reported Metabolic Syndrome Risk Factors In The Aboriginal Population In Perth, Australia, Measured Using An Adaptation Of The Global Physical Activity Questionnaire (Gpaq), Tuguy Esgin, Deborah Hersh, Kevin G. Rowley, Rona Macniven, Kristen Glenister, Alan Crouch, Robert U. Newton

Research outputs 2014 to 2021

Background: Complex, ongoing social factors have led to a context where metabolic syndrome (MetS) is disproportionately high in Aboriginal Australians. MetS is characterised by insulin resistance, abdominal obesity, hypertension, hypertriglyceridemia, high blood-sugar and low HDL-C. This descriptive study aimed to document physical activity levels, including domains and intensity and sedentary behaviour, and MetS risk factors in the Perth Aboriginal (predominately Noongar) community. Methods: The Global Physical Activity Questionnaire (GPAQ), together with a questionnaire on self-reported MetS risk factors, was circulated to community members for completion during 2014 (n = 129). Results: Data were analysed using chi-squared tests. The average (SD) …

An Early Collaborative Intervention Focusing On Parent-Infant Interaction In The Neonatal Period. A Descriptive Study Of The Developmental Framework, Charlotte Sahlén Helmer, Ulrika Birberg Thornberg, Evalotte Mörelius

Research outputs 2014 to 2021

Moderate to late preterm infants are at risk of developing problems later in life. To support attachment and infants’ development, high quality parent-infant interaction is important. Parent-infant interaction is known to improve through intervention programs but since no such intervention program is addressed directly to moderate to late preterm infants, a tailor-made intervention was developed. The aim was to describe the rationale, development, framework and practical provision of a new early collaborative intervention program. This study has a descriptive design and the intervention is described using the Template for Intervention Description and Replication. During an intervention-session, the preterm infant’s cues …

Wellbeing Of Breastfeeding Women In Australia And New Zealand During The Covid‐19 Pandemic: A Cross‐Sectional Study, Vanessa S. Sakalidis, Alethea Rea, Sharon L. Perrella, Jacki Mceachran, Grace Collis, Jennifer Miraudo, Stuart A. Prosser, Lisa Y. Gibson, Desiree Silva, Donna T. Geddes

Research outputs 2014 to 2021

During the COVID‐19 pandemic, breastfeeding women have experienced restricted access to support, placing them at increased risk of mental health concerns and limited breastfeeding assistance. This study investigated the effect of the pandemic on feeding choices and maternal well-being amongst breastfeeding mothers living in Australian and New Zealand. We conducted a cross-sectional online survey that examined feeding methods, maternal mental wellbeing, worries, challenges, and positive experiences during the pandemic. Most women were exclusively breastfeeding (82%). Partial breastfeeding was associated with perceived low milk supply and longer pregnancy duration during the pandemic. Reduced mental health and wellbeing was associated with lower …

Does Accurate Data, Identifying Obese Patients Impact Nurse Safety And Hospital Finances?, Kim Mcclean

Theses: Doctorates and Masters

Healthcare staff who manage obese patients are at increased risk of sustaining patient handling injuries, and this risk is anticipated to intensify as projected Australian obesity rates increase to 42% by the year 2035 and obese patients admitted to hospitals also increase. High cost burdens to healthcare organisations will result due to increased funding requirements for bariatric risk management solutions and growing costs of workers’ compensation claims of injured staff. Five (5) studies explored if identification of obese patients impacts the safety of nurses and other healthcare staff who manage obese patients and investigated the accuracy of obesity data recorded …

Unravelling The Potential Applications Of Extracellular Vesicles For The Clinical Management Of Melanoma Patients, Michael Edward Clark

Theses: Doctorates and Masters

Metastatic melanoma is the third most common cancer in Australia with global incidence increasing. After decades without effective systemic treatments for advanced melanoma, the advent of targeted and immune therapies has substantially improved patient survival. While this is encouraging, further research is needed as the majority of patients treated with targeted therapy ultimately develop drug resistance. Immunotherapy can achieve durable responses in many patients however, not all patients respond to current single or a combination of immune checkpoint inhibitors. Considering the cost and potential toxicities to patients being treated with these therapies, there is an urgent need to develop biomarkers …

The Coaches’ Eye: Exploring Coach Decision-Making During Talent Identification, Alexandra Hannah Roberts

Theses: Doctorates and Masters

For decades, researchers and practitioners interested in talent identification have discussed the coaches’ eye: the elusive ability that allows some coaches to ‘see’ qualities in an athlete that point to their talent or future potential. While there is significant anecdotal evidence of coaches who possess this ability, there is little empirical research supporting the validity or reliability of the coaches’ eye. Guided by ecological dynamics, this thesis employs mixed methodologies to explore the decision-making that underpins how high-level coaches identify talent in Olympic combat sports. These four studies captured the processes of thirty- four coaches during the talent identification process, …

An Exploration Of The Relationship Between Aphasia Therapy, Depression And Quality Of Life In Post-Stroke Patients After Rehabilitation At 12 And 26 Weeks After Stroke: A Verse Sub-Study, Alia Rashid Khan

Theses: Doctorates and Masters

Background: Depression is a common consequence of stroke, and people with aphasia (PWA) post-stroke have a higher risk of developing depression compared to stroke survivors without aphasia. However, current stroke interventions featuring aphasia therapy tend to neglect the effect of the treatment on mood. There is also a lack of evidence on the impact of stroke education and counselling on PWA in early stroke recovery. Additionally, the research on post-stroke depression often excludes or insufficiently describes PWA in study populations. The influence of direct aphasia therapy on depression in PWA is undetermined. This sub-study investigated: i) the effect of …

The Adherence To Group B Streptococcus Screening Guidelines Amongst Pregnant Women In Western Australia – A Quantitative Descriptive Analysis, Sabine Pangerl

Theses: Doctorates and Masters

Colonisation with Group B Streptococci (GBS) is a major risk factor for neonatal infection acquired via vertical transmission during pregnancy, labour, or birth, potentially resulting in significant morbidity and mortality. Universal screening at 35 – 37 weeks gestation for maternal GBS colonisation and the use of intrapartum antibiotic prophylaxis has resulted in substantial reductions in the burden of neonatal Early-Onset GBS Disease (EOGBSD). Women in Western Australia (WA) are offered GBS screening in pregnancy and intrapartum antibiotic prophylaxis. Anecdotal evidence suggests variations in viewpoints and thus low adherence to relevant clinical guidelines amongst midwives and pregnant women in the midwifery …

Delegation Practices Between The Registered Nurse And The Assistant In Nursing In The Acute Care Setting In Western Australia, Carol Crevacore

Theses: Doctorates and Masters

Background:

Delegation is an essential skill that allows the Registered Nurse (RN) to allocate aspects of patient care to other team members including the unregulated Assistant in Nursing (AIN). Concerns have been raised about the activities delegated to AINs in the acute care environment.

Aim:

The aim of this research was to explore the practice of delegation between the RN and the AIN in the acute care environment. This delegation practice was examined through the lens of both the RN and the AIN.

Methodology:

This study used a mixed method explanatory sequential design. The participants were RNs and AINs working …

Change In Mental Health, Physical Health, And Social Relationships During Highly Restrictive Lockdown In The Covid-19 Pandemic: Evidence From Australia, Shane Rogers, Travis Miles Cruickshank

Research outputs 2014 to 2021

Background

A novel coronavirus first reported in Wuhan City in China in 2019 (COVID-19) developed into a global pandemic throughout 2020. Many countries around the world implemented strict social distancing policies to curb the spread of the virus. In this study we aimed to examine potential change in mental/physical health and social relationships during a highly restrictive COVID-19 lockdown period in Australia during April 2020.

Methods

Our survey (n = 1, 599) included questions about concerns, social behaviour, perceived change in relationship quality, social media use, frequency of exercise, physical health, and mental health during COVID-19 lockdown (April, 2020). …

Overview Of Aboriginal And Torres Strait Islander Health Status, 2020, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

The Overview of Aboriginal and Torres Strait Islander health status (the Overview) aims to provide a comprehensive outline of the most recent indicators of the health and current health status of Australia's Aboriginal and Torres Strait Islander people. The initial sections of the Overview provide information about the context of Aboriginal and Torres Strait Islander health, social determinants, the Aboriginal and Torres Strait Islander population and measures of population health status including births, mortality and hospitalisation...

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2020, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

The Summary of Aboriginal and Torres Strait Islander health status - selected topics 2020 is a useful source of the most recent national information for health workers and those studying in the field. It provides general information regarding the health status of Aboriginal and Torres Strait Islander people across the following topics:

• social and cultural determinants
• births and deaths
• hospitalisations
• chronic conditions (including CVD, cancer, diabetes and kidney health)
• sexually transmitted infections
• environmental health
• social and emotional wellbeing
• alcohol and other drug use.

The Summary is based on the Overview of Aboriginal and Torres Strait Islander health status 2020 and …

Construct Validity Of The Suboptimal Health Status Questionnaire-25 In A Ghanaian Population, Eric Adua, Ebenezer Afrifa-Yamoah, Kwasi Frimpong, Esther A. Adama, Shantha P. Karthigesu, Enoch Odame Anto, Emmanuel Aboagye, Yuxiang Yan, Youxin Wang, Xuerui Tan, Wei Wang

Research outputs 2014 to 2021

Background

The Suboptimal Health Status Questionnaire-25 (SHS-Q-25) developed to measure Suboptimal Health Status has been used worldwide, but its construct validity has only been tested in the Chinese population. Applying Structural Equation Modelling, we investigate aspects of the construct validity of the SHS-Q-25 to determine the interactions between SHS subscales in a Ghanaian population.

Methods

The study involved healthy Ghanaian participants (n = 263; aged 20–80 years; 63% female), who responded to the SHSQ-25. In an exploratory factor and parallel analysis, the study extracted a new domain structure and compared to the established five-domain structure of SHSQ-25. A confirmatory factor …

Summary Of Sexual Health Links With Chronic Disease In Aboriginal And Torres Strait Islander Males, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

This Summary is based on the Review of sexual health issues linked with cardiovascular disease and type 2 diabetes mellitus in Aboriginal and Torres Strait Islander males (the ‘Review’) published by the Australian Indigenous HealthBulletin in 2021. It provides information about the male sexual health conditions of erectile dysfunction (ED) and low testosterone, and their links to chronic disease, specifically cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). It outlines:

• the causes and symptoms of ED and low testosterone
• how common ED and low testosterone are among the Australian male population (there are limited data available about Aboriginal and …

Hypogonadism Induced By Surgical Stress And Brain Trauma Is Reversed By Human Chorionic Gonadotropin In Male Rats: A Potential Therapy For Surgical And Tbi-Induced Hypogonadism?, Rastafa I. Geddes, Amita Kapoor, Kentaro Hayashi, Ryan Rauh, Marlyse Wehber, Quinn Bongers, Alex D. Jansen, Icelle M. Anderson, Gabrielle Farquhar, Sivan Vadakkadath-Meethal, Toni E. Ziegler, Craig S. Atwood

Research outputs 2014 to 2021

Introduction: Hypogonadotropic hypogonadism (HH) is an almost universal, yet underappreciated, endocrinological complication of traumatic brain injury (TBI). The goal of this study was to determine whether the developmental hormone human chorionic gonadotropin (hCG) treatment could reverse HH induced by a TBI. Methods: Plasma samples were collected at post-surgery/post-injury (PSD/PID) days -10, 1, 11, 19 and 29 from male Sprague-Dawley rats (5- to 6-month-old) that had undergone a Sham surgery (craniectomy alone) or CCI injury (craniectomy + bilateral moderate-to-severe CCI injury) and treatment with saline or hCG (400 IU/kg; i.m.) every other day. Results: Both Sham and CCI injury significantly decreased …

Cardiovascular Safety Of Antifracture Medications In Patients With Osteoporosis: A Narrative Review Of Evidence From Randomized Studies, Alexander J. Rodríguez, Bo Abrahamsen

Research outputs 2014 to 2021

Osteoporosis and cardiovascular (CV) disease share common risk factors and pathophysiology. Low bone mineral density (BMD) and fractures appear to increase the risk for multiple CV diseases. Equally, prevalent CV disease appears to predispose to bone loss and increase fracture rates. This relationship has naturally provoked the hypothesis that stopping bone loss may result in some CV benefit. Secondary analyses of safety and adverse event data from many randomized controlled trials (RCTs) have attempted to clarify this putative association. Recently, the discontinuation of odanacatib (anti-cathepsin K monoclonal antibody) over stroke concerns and the imbalance in ischemic events in romosozumab-treated (anti-sclerostin …

A Cross Sectional Survey Of International Horse-Racing Authorities On Injury Data Collection And Reporting Practices For Professional Jockeys, Siobhán O'Connor, Peta L. Hitchens, Charlotte Bolwell, Rachel Annan, Adrian Mcgoldrick, Lauren V. Fortington

Research outputs 2014 to 2021

Jockey injuries are common in professional horse-racing and can result in life-threatening or career-ending outcomes. Robust injury data are essential to understand the circumstances of injury occurrence and ultimately identify prevention opportunities. This study aimed to identify jockey injury surveillance practices of international horse-racing authorities (HRAs) and the specific data items collected and reported by each HRA. A cross-sectional survey of representatives (e.g. Chief Medical Officer) from international HRAs was conducted. An online and paper questionnaire was designed comprised of 32 questions. Questions considered the barriers and facilitators to data collection within each HRA, and where available, what data were …

Utility And Limitations Of Hepascore And Transient Elastography To Detect Advanced Hepatic Fibrosis In Hfe Hemochromatosis, Sim Y. Ong, Tiffany Khoo, Amanda J. Nicoll, Lyle Gurrin, Thomas Worland, Puraskar Pateria, Louise E. Ramm, Adam Testro, Gregory J. Anderson, Richard Skoien, Lawrie W. Powell, Grant A. Ramm, John K. Olynyk, Martin B. Delatycki

Research outputs 2014 to 2021

Aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 Index (Fib4) have been validated against liver biopsy for detecting advanced hepatic fibrosis in HFE hemochromatosis. We determined the diagnostic utility for advanced hepatic fibrosis of Hepascore and transient elastography compared with APRI and Fib4 in 134 newly diagnosed HFE hemochromatosis subjects with serum ferritin levels > 300 µg/L using area under the receiver operator characteristic curve (AUROC) analysis and APRI- ( > 0.44) or Fib4- ( > 1.1) cut-offs for AHF, or a combination of both. Compared with APRI, Hepascore demonstrated an AUROC for advanced fibrosis of 0.69 (95% CI 0.56–0.83; sensitivity = 69%, specificity …

Vaginal Microbial Profiling In A Preterm Birth High-Risk Cohort Using Shallow Shotgun Metagenomics, Alishum Ali, Claus T. Christophersen, Jeffrey A. Keelan

Research outputs 2014 to 2021

Preterm birth (PTB) is a significant health problem globally, with an estimate of 15 million cases annually. Approximately 10% of neonates born early will die prematurely, while a subset will develop severe life-long morbidities. Unfortunately, preterm birth's syndromic nature has evaded prevention strategies, and it continues to impose a high burden on healthcare systems and families. The role of vaginal bacteria in triggering biomolecular causes of PTB has been recognised for years. However, translating this knowledge to practical diagnostic and therapeutic strategies has remained elusive. New techniques in high-throughput sequencing have improved our understanding of the nature and role of …

Epidemiological Overview Of Multidimensional Chromosomal And Genome Toxicity Of Cannabis Exposure In Congenital Anomalies And Cancer Development, Albert Stuart Reece, Gary K. Hulse

Research outputs 2014 to 2021

Cannabis and cannabinoids are implicated in multiple genotoxic, epigenotoxic and chromosomal-toxic mechanisms and interact with several morphogenic pathways, likely underpinning previous reports of links between cannabis and congenital anomalies and heritable tumours. However the effects of cannabinoid genotoxicity have not been assessed on whole populations and formal consideration of effects as a broadly acting genotoxin remain unexplored. Our study addressed these knowledge gaps in USA datasets. Cancer data from CDC, drug exposure data from National Survey of Drug Use and Health 2003–2017 and congenital anomaly data from National Birth Defects Prevention Network were used. We show that cannabis, THC cannabigerol …

Using Realist Approaches In Nutrition And Dietetics Research, Gemma Jenkins, Isabella Maugeri, Claire Palermo, Rebecca Hardwick

Research outputs 2014 to 2021

Aim: The aim of this study was to explore the use and future potential of realist approaches to research in nutrition and dietetics. Methods: A targeted literature review was used to search key journals (n = 7) in nutrition and dietetics to identify existing research using a realist approach. A narrative synthesis was conducted to explore findings in relation to the research aim. Results: Nine research papers (four realist evaluations, five realist reviews) describing seven nutrition interventions were found, which revealed the application of realist research in nutrition and dietetics has focused on public health interventions. Realist research provided a …

Estimating The Economic Cost Of Nurse Sensitive Adverse Events Amongst Patients In Medical And Surgical Settings, Aileen Murphy, Peter Griffiths, Christine Duffield, Noeleen M. Brady, Anne Philomena Scott, Jane Ball, Jonathan Drennan

Research outputs 2014 to 2021

Aims: To identify the costs associated with nurse sensitive adverse events and the impact of these events on patients’ length of stay. Design: Retrospective cohort study using administrative hospital data. Methods: Data were sourced from patient discharge information (N = 5544) from six acute wards within three hospitals (July 2016–October 2017). A retrospective patient record review was undertaken by extracting data from the hospitals’ administrative systems on inpatient discharges, length of stay and diagnoses; eleven adverse events sensitive to nurse staffing were identified within the administrative system. A negative binomial regression is employed to assess the impact of nurse sensitive …

Effect Of Occupational Therapy Home Visit Discharge Planning On Participation After Stroke: Protocol For The Home Rehab Trial, Natasha A. Lannin, Lindy Clemson, Avril Drummond, Mandy Stanley, Leonid Churilov, Kate Laver, Sophie O'Keefe, Ian Cameron, Maria Crotty, Tim Usherwood, Nadine E. Andrew, Laura Jolliffe, Dominique A. Cadilhac

Research outputs 2014 to 2021

Introduction: After first stroke, the transition from rehabilitation to home can be confronting and fraught with challenges. Although stroke clinical practice guidelines recommend predischarge occupational therapy home visits to ensure safe discharge and provision of appropriate equipment, there is currently limited evidence to support this recommendation. Methods and analysis: The HOME Rehab trial is a national, multicentre, phase III randomised controlled trial with concealed allocation, blinded assessment and intention-to-treat analysis being conducted in Australia. The trial aim is to determine the effect and potential cost-effectiveness of an enhanced occupational therapy discharge planning intervention that involves pre and postdischarge home visits, …

Bridging The Research To Practice Gap: A Systematic Scoping Review Of Implementation Of Interventions For Cancer-Related Fatigue Management, Oluwaseyifunmi Andi Agbejule, Nicolas H. Hart, Stuart Ekberg, Koczwara Bogda, Rahul Ladwa, Camilla Simonsen, Elizabeth P. Pinkham, Raymond Javan Chan

Research outputs 2014 to 2021

Background: Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in people with cancer. Although efficacy of interventions for CRF have been extensively investigated, less has been done to ensure successful translation into routine clinical practice. The aim of this systematic scoping review was to synthesise knowledge surrounding the implementation of CRF interventions, summarise the processes and outcomes of implementation strategies used, and identify opportunities for further research. Methods: PubMed, Cochrane CENTRAL, EMBASE and CINAHL databases were searched (up to December 2020). The Cochrane Effective Practice and Organisation of Care (EPOC) Group taxonomy and the RE-AIM Framework …

Association Of Tyg Index And Tg/Hdl-C Ratio With Arterial Stiffness Progression In A Non-Normotensive Population, Zhiyuan Wu, Di Zhou, Yue Liu, Zhiwei Li, Jinqi Wang, Ze Han, Xinlei Miao, Xiangtong Liu, Xia Li, Wei Wang, Xiuhua Guo, Lixin Tao

Research outputs 2014 to 2021

Background: Cross-sectional studies have reported that insulin resistance (IR) is associated with arterial stiffness. However, the relationship between IR and arterial stiffness progression remains unclear. This study aims to evaluate the association of triglyceride glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio with arterial stiffness progression in a non-normotensive population. Methods: A total of 1895 prehypertensive (systolic pressure 120–139 mmHg or diastolic pressure 80–90 mmHg) or hypertensive (systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg or using antihypertensive medication) participants were enrolled in 2013 and 2014, and followed until December 31, 2019. Arterial stiffness …

Patterns Of Immunotherapy-Induced Pneumonitis In Patients With Non-Small-Cell Lung Cancer: A Case Series, Sarah Picard, Desiree Goh, Ashley Tan, Nisha Sikotra, Eli Gabbay, Tim Clay

Research outputs 2014 to 2021

Background: Immunotherapy has become an efficacious option in the management of solid organ malignancies. Immune-related adverse events including pneumonitis are well described and may be particularly of concern in patients receiving immunotherapy for non-small-cell lung cancer. Case presentations: In this paper, we describe three cases of immunotherapy-induced pneumonitis occurring in the management of lung malignancy. Our cases include a 54-year-old Caucasian woman with squamous cell lung cancer who was successfully rechallenged with immunotherapy after prior significant pneumonitis, a 65-year-old Caucasian man with metastatic squamous cell lung cancer who developed pneumonitis after multiple cycles of uneventful immunotherapy, and a 73-year-old Caucasian …