Medicine and Health Sciences Commons^™

Fighting Fatigue With Caffeine: Exploring Perceptions On Patient Safety, Camille Quitangon

Honors Theses

Objective: To examine the association between fatigue and caffeine consumption, and explore nurses’ perceptions of the impact of these factors on patient safety.

Background: Many people consume caffeine for its benefits, such as stimulating the central nervous system to feel more awake. Health professionals, such as nurses, commonly experience fatigue and often will drink coffee to get through their long shifts.

Methods: A comprehensive literature review was conducted. Studies were split into two categories – fatigue and patient safety or caffeine's effect on human performance.

Results: Fatigue causes nurses to be impaired; it affects their ability to be alert, vigilant, …

Resilience Interventions In Higher Education: Surveying The Research Landscape, Caroline Umeda, Anne Browning, Helen Mach

Occupational Therapy | Faculty Conference Presentations

Learning Objectives

1. Describe scoping review purpose, objectives, and methods
2. Describe key findings on range and nature of resilience programming for college students
3. Explore current resilience programming and research among session participants’ home institutions
4. Identify next steps for resilience research and evidence-based programming

Effectiveness Of A Modified Lifestyle-Integrated Functional Exercise Program In Residential Retirement Communities—A Pilot Study, Kitsum Li, Kayla Comer, Tiffany Huang, Kelly Schmidt, Matthew Tong

Occupational Therapy | Faculty Scholarship

Aims: This study explored the effectiveness of a modified Lifestyle-integrated Functional Exercise program for increasing community-dwelling older adults’ lower body strength and balance to decrease fall risk.

Methods: Purposive sampling of men and women aged 65 years and older, with or without a history of falls, living at retirement communities yielded 19 older adult participants, and 16 of the participants completed the 26-week integrated exercise program. The program consisted of five-group training sessions focused on how to integrate individualized exercises into everyday activities, followed by 20 weeks of independent practice with a booster session at Week 10 and two phone …

Antimalarial Proteasome Inhibitor Reveals Collateral Sensitivity From Intersubunit Interactions And Fitness Cost Of Resistance., Laura A. Kirkman, Wenhu Zhan, Joseph Visone, Alexis Dziedziech, Pradeep K. Singh, Hao Fan, Xinran Tong, Igor Bruzual, Ryoma Hara, Masanori Kawasaki, Toshihiro Imaeda, Rei Okamoto, Kenjiro Sato, Mayako Michino, Elena Fernandez Alvaro, Liselle F. Guiang, Laura M. Sanz, Daniel J. Mota, Kavitha Govindasamy, Rong Wang, Yan Ling, Patrick K. Tumwebaze, George Sukenick, Lei Shi, Jeremie Vendome, Purnima Bhanot, Philip J. Rosenthal, Kazuyoshi Aso, Michael A. Foley, Roland A. Cooper, Bjorn Kafsack, J Stone Doggett, Carl F. Nathan, Gang Lin

Natural Sciences and Mathematics | Faculty Scholarship

We describe noncovalent, reversible asparagine ethylenediamine (AsnEDA) inhibitors of the Plasmodium falciparum proteasome (Pf20S) β5 subunit that spare all active subunits of human constitutive and immuno-proteasomes. The compounds are active against erythrocytic, sexual, and liver-stage parasites, against parasites resistant to current antimalarials, and against P. falciparum strains from patients in Africa. The β5 inhibitors synergize with a β2 inhibitor in vitro and in mice and with artemisinin. P. falciparum selected for resistance to an AsnEDA β5 inhibitor surprisingly harbored a point mutation in the noncatalytic β6 subunit. The β6 mutant was resistant to the species-selective Pf20S β5 inhibitor but remained …

Open Ears, Open Mind, Open Heart: Active Listening, Mia Nguyen

Service-Learning | Student Scholarship

Active listening is the act of listening with all senses– the body, the mind, and the soul. It means empathizing with another person and finding that place within ourselves where we can listen beyond our initial judgements and personal feelings. It is listening beyond words and allowing our souls to understand, connect, and accept one another. Active listening sparks internal purity eliminating all types of judgement and allowing us to truly take in what another person has to offer. It is “an experience of language as a bodily felt process” in which we have a felt understanding rather than a …

Strategies For Bridging Gaps Between Diversity, Academics, And Community/Clinical Partnerships, Joseph Morris Rn, Phd, Mary Dickow Mpa, Faan, Sharon Goldfarb Rn, Msn, Fnp

Community Engagement Theme

The academic‐practice gap has been well documented for over four decades in the literature, and current literature suggests the viewpoints of academic and practice leaders remain divergent. Closing this gap will require a dedicated and coordinated response from both academia and the clinical practice institutions. Additionally, diversity in the Nursing field is essential because it provides opportunities to administer quality care to patients. Goals: The panelists will share their unique perspectives and offer Strategies for Bridging Gaps between Diversity, Academics, and Community/Clinical Partnerships.

A Comical Look At Occupational Therapy, Karen Mccarthy, Kira Kuwada

Collected Faculty and Staff Scholarship

n 2015, I attended the Association of Occupational Therapists of Ireland Conference and was inspired by the keynote address given by Sue Baptiste, MHSc, OT(C). Baptiste explored how she viewed the profession of occupational therapy as moving away from its roots in occupation and becoming more reductionistic in its practice. The profession of occupational therapy has seen many paradigm shifts—from a paradigm of occupation, to a mechanistic paradigm, and then toward a contemporary paradigm, which embraces (1) emphasizing the importance of occupation to health and well-being, (2) recognizing occupational problems and/or challenges as the focus of occupational therapy, and (3) …

Survey Of Sensory Diet Use Among California Occupational Therapy Practitioners, Morganne Peterson, Allison Hunt, Emily White

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to examine the use of sensory diets in the field of occupational therapy. This study investigated the use of sensory diets among California occupational therapy practitioners. A mixed-methods design was used to collect data through an online survey. The survey was sent out to members of the Occupational Therapy Association of California (OTAC) and received 98 respondents within one month. Participants worked among various clinical settings and implemented sensory diets with various client populations. Practitioners reported using terms such as “sensory strategies,” “sensory tools,” and “sensory supports” which indicates an overall misunderstanding associated with …

Resilience And Protective Factors In Older Adults, Jessica Mcclain, Katelyn Gullatt, Caroline Lee

Dissertations, Masters Theses, Capstones, and Culminating Projects

Evidence suggests resilience promotes successful aging in place and protective factors promote resilience. This study sought to investigate whether or not the combination of three protective factors, physical health, social support, and self-efficacy are all of equal importance in predicting resilience among Marin County older adults, or if some individual protective factors have a greater impact on resilience than the others. Fifty-eight participants ages 62 and higher were recruited from senior community programs and personal contacts. Four self-report questionnaires were completed by the participants in this exploratory, cross-sectional, quantitative design. SPSS was used for a descriptive and multivariate analyses to …

Measuring Physiological Responses To Sensation In Typical Adults, Sarah Button, Kristen Christensen, Emily Minor

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective: Sensory processing issues can have a large negative impact on the ability to participate in daily occupations such as ADLs, access to work, school and leisure environments, and social interactions (Dunn, 2001). The evidence documenting sensory processing issues in adults is sparse. Physiological information can be used as objective evidence to support the claim that those with over-responsivity to sensations are experiencing their environment differently than the typical population. Understanding more about sensory processing in adults may lead to increased recognition of the problem and more opportunities for intervention to increase occupational participation. The purpose of this quantitative study …

Different Methodologies To Characterize And Diagnose Sickle Cell Disease In Both Developed And Developing Nations, Mohammed Alharbi

Dissertations, Masters Theses, Capstones, and Culminating Projects

Sickle cell disease (SCD) is a genetic blood disorder that causes the RBC to become sickle shaped due to a mutation in the β-globin gene encoding the protein hemoglobin. This disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection susceptibility. SCD affects around 100,000 individuals in USA alone and 14 million people globally. SCD affected individuals have high mortality rates. Early detection and constant monitoring of this disease is essential. The following review focuses on various methodologies that have emerged in the diagnosis of SCD. Also, low cost methods that can be easily …

Implementation Plan To Integrate The Nanosphere Verigene Assay In A High-Volume Reference Laboratory And The Anticipated Workflow Benefits To Adopting Rapid Blood Culture Testing, Sofia Nazar

Dissertations, Masters Theses, Capstones, and Culminating Projects

Laboratory processing pathways have a significant impact on the overall management of patients with sepsis. Retrieval and isolation of the suspected pathogen from a patient blood culture specimen is required for a definitive diagnosis of bacterial septicemia. Reference laboratories are high-volume facilities most often located some distance away from the collecting facility. Given the lengthy work up already required for blood culture pathogen analysis, reference laboratories must identify ways to optimize every step of the blood culture pathway in the effort to decrease turnaround time and mitigate lag time to final pathogen identification incurred by prolonged collection-to-incubation times. Rapid molecular …

Determination Of The Feasibility Of Using Cell-Free Dna (Cfdna) In The Q-Clamp Kras Codon Specific Mutation Test, Manuel Garcia

Dissertations, Masters Theses, Capstones, and Culminating Projects

KRAS is a proto-oncogene which was first identified in Kirsten rat sarcoma virus. The normal KRAS protein performs an essential function in normal tissue signaling and a mutation of a KRAS gene is an essential step in the development of many cancers. Q-Clamp® KRAS codon specific mutation test is an in vitro real-time qualitative PCR assay for the detection of mutations in the targeted regions and KRAS mutation often serves as a useful marker in drug response. The Q-Clamp® KRAS codon specific mutation test experiment was performed using cell-free extracted DNA (cfDNA) instead of FFPE extracted DNA. The results of …

Combinational Therapy To Mitigate Α-Dicarbonyl Toxicity, Jessica Ramirez

Dissertations, Masters Theses, Capstones, and Culminating Projects

Diabetes mellitus is a metabolic disease characterized by hyperglycemia that affects 30 million children and adults in the United States alone. Patients suffering from diabetes have high concentrations of reactive α-dicarbonyls (α-DCs) like, methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, nephropathy and cardiomyopathy. A recently discovered TRPA-1-Nrf-2 pathway is a conserved mechanism in vertebrates and invertebrates that detoxifies α-DCs; however, regulators that activate the detoxification mechanism are currently unknown. Several supplement grade compounds were screened for TRPA-1-Nrf2 induced …

Poct Testing And Importance Of Operator Lock-Out, Nuha Fadlalla

Dissertations, Masters Theses, Capstones, and Culminating Projects

Point-of-Care Testing (POCT) is usually performed at the patient’s bedside by healthcare providers other than laboratory- trained professionals. Rapid growth of POCT is supported by numerous factors which include healthcare provider efficiency, improving diagnostic insight and better patient outcomes. This project study is done to make sure POCT users have adequate training to ensure and enhance the quality and patient safety. The individual performing these tests to be trained properly before he/she is approved to operate the POC devices. One method to ensure POCT operators have met the required training is the lock out approach which will not allow them …

A Change Of Heart: Internal Narratives, Forgiveness & Health, Keiko Ehret

Dissertations, Masters Theses, Capstones, and Culminating Projects

In this thesis I investigate the interconnectedness of forgiveness as a narrative, as a philosophical, religious and cultural phenomenon, and the ways in which forgiveness is increasingly being used as a vehicle for improving health and psychological well-being. By threading together how scholars in a variety of fields have approached these areas of study, we can better understand the way the interdisciplinary nature of forgiveness grants access to heal not merely relationships with others, but also our bodies, our minds, and our relationship with ourselves.

Important to my investigation is understanding that the life circumstances that prompt forgiveness consist of …

Older Adults’ Perspective: Exploring The Experience Of Owning A Guide Dog, Jeffrey Kou, Yvonne Lam, Patricia Lyons, Susan Nguyen

Dissertations, Masters Theses, Capstones, and Culminating Projects

Guide dogs have been shown to be an effective assistive device that can help older adults with low vision navigate their community and improve overall well-being. Despite vast research conducted on pet therapy and dog companionship, limited research exists on the facilitators and barriers of owning a dog guide among older adults with low vision. The purpose of this qualitative phenomenological study is to explore the facilitators and barriers of owning a guide dog as experienced by older adults with low vision participating in Guide Dogs for the Blind (GDB) organization. Data were gathered among seven participants using semi-structured phone …

Measuring The Outcomes Of Therapeutic Listening In Children With Learning And Developmental Disabilities, Hannah Tashjian, Donielle Hair, Phoebe Taasan

Dissertations, Masters Theses, Capstones, and Culminating Projects

Anecdotal reports of the Therapeutic Listening ®-Quickshifts (TL-Q) technique report positive effects on child behavior but the individualized approach requires further supporting evidence. TL-Q is an individualized sound-based program used to facilitate sensory processing skills and is believed to improve interpersonal, social, and cognitive skills (Frick & Hacker, 2001). This study examines the use of a standardized protocol to measure the specific outcomes of the TL-Q program using a practice-based evidence (PBE) approach for the purpose of aggregating data for clinical practice. The protocol was used to measure the outcomes of the TL-Q program in a convenience sample of 23 …

Living With Fragile X Syndrome: Occupations As An Outcome Measure In A Clinical Trial, Theresa Chase, Ty Duong, Ana Baldinger, Kaylee Gothelf

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of …

Evaluating The Effectiveness Of A Formal Dementia Care Training Program: Abilities Care Experts™, Carmen Joaquin, Michelle D'Amato, April Perez, Louiza Alexandria Villarina, Sophie E. Miller

Dissertations, Masters Theses, Capstones, and Culminating Projects

Overview: Abilities Care Experts™ (ACE™) is an educational training program for nursing staff who care for individuals with dementia in skilled nursing facilities (SNF). The objective of the program is to provide the nursing staff with knowledge, and methods to engage residents’ remaining abilities in order to maximize occupational participation using a stage-specific dementia care approach. ACE™ training has yet to be evaluated for effectiveness in a controlled study design.

Objectives: This study sought to evaluate the effectiveness of the ACE™ training.

Design: The study employed a quantitative, cross-sectional, quasi-experimental design.

Participants: A total of 29 CNAs, 13 ACE™ trained …

Identification Of Substrate-Selective Histone Deacetylases And Their Inhibitors That Mediate Her2 Transcript Stability, Mariah Alejo

Dissertations, Masters Theses, Capstones, and Culminating Projects

Breast cancer is the most common malignancy diagnosed in women. 15-20% of these cancers overexpress the HER2 (ERRB2) oncoprotein. HER2-positive breast cancers are generally aggressive and are associated with poor prognosis. Unfortunately, only a mere 30% of HER2-positve patients respond to therapies when they are used as a single agent. Combining therapeutics can potentially lead to synergy and improved anticancer efficacy, and there is clearly a need for the development of new HER2-directed therapeutics. Newer approaches include the utilization of histone deacetylase (HDAC) inhibitors. It has been observed that HDAC inhibitors can induce the rapid decay of oncogenic transcripts such …

Pilot Study: Assistive Technology As A Vocational Support For Individuals With Autism Spectrum Disorder, Erin Chaffee, Tina Ho, Kevin Ng

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this pilot study was to determine the effectiveness of video-based instruction (VBI) to support completion of vocational tasks. A mixed-method approach was utilized to explore the use of VBI on a personal digital assistant with individuals with autism spectrum disorder (ASD). Using two assembling cooking tasks, researchers investigated the level of independence with task completion through written instruction versus VBI. The results indicated a small non-significant increase in the level of independence with task completion during the VBI task independent of intelligence quotient (IQ) levels. Participant’s feedback of VBI was also noted as positive to help learn …

Collaborative Practices In Special Education: An Exploratory Study, Blanka Pentek, Katherine Sadoff, Evelyn Tang

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective: This exploratory survey study examined collaborative practices of professionals working in special education. The basis for the survey was the Conceptual Model of Collaboration (CMC), created by Hess and colleagues (2017).

Methods: 27 professionals who work in special education participated. Cross tabulation tests and Pearson's correlation tests were run to determine relationships between the variables.

Results: The findings indicated that the majority of participants value collaboration for student outcomes and professional development. Most participants agreed on common facilitators and barriers to collaboration. Collaboration primarily takes place in IEP meetings, through email and text messaging and is frequent in all …

Functional Cognitive Activities For Adults With Traumatic Brain Injury: Pilot Case Studies, Ajay Pala, Karen Huang, Ashley Cook

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of these pilot case studies were to investigate the effectiveness of the Functional Cognitive Activities for Adults with Brain Injury: A Sequential Approach (FCA) in generalizing functional cognitive skills across meaningful occupations for adults with traumatic brain injury (TBI). This study was a pretest-posttest design consisted of two participants with TBI.

Both participants attended 14 out of the 16 intervention sessions, twice-a-week for eight-weeks. Pretest-posttest measurements, including the Canadian Occupational Performance Measure (COPM), Kohlman Evaluation of Living Skills, and Goal Attainment Scale (GAS), were used to measure changes in occupational performance. Additionally, a four-month follow-up phone interview using …

Age-Related Changes In Visual Processing Speed: A Pilot Study Using The Motor Free Visual Perception Test- 4, Amber Zadravecz, Kassidy Ha, Lauren Gollnick, Stephanie Pawek, Zoe Studer

Dissertations, Masters Theses, Capstones, and Culminating Projects

Older adults are at a significantly increased risk of being involved in motor vehicle accidents. Evidence reveals that visual processing speed decreases with age, which may impact driving. The Motor-Free Visual Perception Test- Third Edition (MVPT-3) is used as a pre-driving assessment and has an age-normed Response Time Index that measures visual processing speed. In 2015, a new version, the new Motor-Free Visual Perception Test- Fourth Edition (MVPT-4), was published. The new MVPT-4 does not yet demonstrate its utility in measuring visual processing speed. The purpose of this study was to explore if differences in visual processing speed between younger …

Managing Fatigue With Technology For Individuals With Multiple Sclerosis, Janie Grant, May Anne Gamueda, America Ortega, Jordan Song

Dissertations, Masters Theses, Capstones, and Culminating Projects

OBJECTIVE: The purpose of this study was to investigate whether the use of a mobile health application (mHealth app) in conjunction with energy conservation management techniques will result in a decrease in fatigue for adults with multiple sclerosis.

METHOD: Using a quantitative, exploratory, pre-posttest design, we examined outcomes associated with the use of the mHealth app, Pace My Day, by seven participants during one chosen task over two weeks. The app reinforced the use of energy conservation management techniques during the chosen task. Outcome measures included Modified Fatigue Impact Scale (MFIS) and Canadian Occupational Performance Measure (COPM).

RESULTS: There was …

Optimization Of Braf V600 Assay As A 2-Step Real-Time Pcr Protocol, Mimi Phuong

Dissertations, Masters Theses, Capstones, and Culminating Projects

The QClamp® BRAF Codon Specific Mutation Detection Kit is a real-time PCR assay for the detection of somatic mutations in codon 600 Valine at exon 15 in the BRAF gene which encodes the serine/threonine protein kinase, using purified DNA. The V600E mutation is the most common BRAF gene mutation found in human cancers. This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell growth and division. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even …

Nurses’ Perception Of The Relationship Between Socioeconomic Status, Incidence Rates And Complications Of A Type 2 Diabetes Diagnosis In The Adult Population, Malia Mcdowell

Honors Theses

The objective of this paper was to review the literature that reflects studies conducted on lower socioeconomic patients at risk for diabetes. These studies targeted the prevalence, medication adherence, chronic complications, and socioeconomic levels and the risk of incidence. The concluding evidence supports the research studies regarding diabetes and socioeconomic levels in that an adults’ socioeconomic level has a direct negative relationship between level of finance and the overall life time risk of a new diagnosis of Type 2 diabetes and its complications such as retinopathy, neuropathy and poor clinical outcomes. Furthermore, economic status also has a direct negative correlation …

Do People Who Are More Aggressive Sustain More Injuries Than Their Less Aggressive Counterparts: A Study Of Participants Of Medieval Combat Games In The United States?, Christopher Sanchez

Honors Theses

Today people are being encouraged to be more active for the sake of their health, but in becoming more active people are getting more sports related injuries. There are many risk factors that may increase the likelihood of a sports related injury. Aggression in particular may be contributing factor to a higher likelihood of injury. The goal of this study is to look at the relationship between aggressive personalities and injury occurrence.

Measuring The Outcomes Of Therapeutic Listening® In Children With Learning And Developmental Disabilities, Donielle Hair, Phoebe Taasan, Hannah Tashjian, Julia L. Wilbarger

Student Research Posters

A practice-based evidence (PBE) approach was used to explore the outcomes of the Therapeutic Listening® technique. PBE examines how effective clinical practice is within the actual clinical context. PBE capitalizes on using customary procedures and measures to establish clinical outcomes. (Horn & Gassaway, 2010; Swisher, 2010).

Therapeutic Listening® (TL®) is a sound-based intervention broadly used by pediatric OTs as a complement to sensory integration interventions for children with sensory processing disorders.