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Articles 1 - 15 of 15
Full-Text Articles in Medicine and Health Sciences
Biological Evaluation Of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives As Anti-Agents, Amandeep Singh, Snigdha Chennamaneni
Biological Evaluation Of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives As Anti-Agents, Amandeep Singh, Snigdha Chennamaneni
Undergraduate Research Posters 2012
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. A series of new nimesulide analogs were evaluated with cell proliferation assay based on a non-small lung cancer cell line H292. The results showed that several derivatives were very active to against H292 cell growth with IC50s of sub nano mole. These results suggest the possibility of using these nimesulide derivatives as chemo preventive agents.
Simulation And Control Of An Intelligent Prosthetic Knee With Biogeography-Based Optimization, George L. Thomas
Simulation And Control Of An Intelligent Prosthetic Knee With Biogeography-Based Optimization, George L. Thomas
Undergraduate Research Posters 2012
Traditional, passive leg prostheses for transfemoral amputees require the user to produce unnaturally large actuations in order to walk. The resulting motions can cause joint degeneration and arthritis. To avoid this, a semi-active prosthetic knee using hydraulics to store and release energy has been developed. In our work this summer, we have improved upon a previous simulation model for this leg, and we have developed preliminary valve control results in this simulation software with BBO.
Normalizing For Noise Removal From Electrocardiogram Signals, Dominique Diamond Brooks, Daniel J. Simon
Normalizing For Noise Removal From Electrocardiogram Signals, Dominique Diamond Brooks, Daniel J. Simon
Undergraduate Research Posters 2012
Electrocardiography (ECG) measures the electrical impulse of the heart over time using electrodes that attached to the body. Designing a computational program using a synthetic ECG to test Normalized Least Mean Square (NLMS) filter serves as a basis to remove noise from the signal.
Investigating Axonal Biology Using Microfluidic Devices, James Deyling, Brittany Kastan
Investigating Axonal Biology Using Microfluidic Devices, James Deyling, Brittany Kastan
Undergraduate Research Posters 2012
During nervous system development, various diffusing biomolecules play a critical role in neurite outgrowth and guidance, resulting in the formation of a complex circuitry. However, the precise mechanism by which these molecules are spatio-temporally delivered to the growing tip of the neurites is unclear. Overall, the results suggest to the utility of this device for studying neurobiology, tissue engineering and cell migration.
Anti-Cancer Drug Screening Of Dual Tubulin And Hsp27 Inhibitors With 2d And 3d Lung Cancer Cell Assays, Janine Maria Naim, Rati Lama
Anti-Cancer Drug Screening Of Dual Tubulin And Hsp27 Inhibitors With 2d And 3d Lung Cancer Cell Assays, Janine Maria Naim, Rati Lama
Undergraduate Research Posters 2012
Cancer is the leading cause of death worldwide. The current treatment options available for lung cancer are limited and have drawbacks such as poor bioavailability, numerous side effects, poor efficacy and drug resistance. 3D model serve as a novel approach for drug screening purposes and the evaluation of compounds in the platform can help identify potent compounds for further in vivo xenograft studies.
Obtaining A Pure Protein Using An Elp-Tagged Tev Protease, Teisha L. Mullins
Obtaining A Pure Protein Using An Elp-Tagged Tev Protease, Teisha L. Mullins
Undergraduate Research Posters 2012
We present here use of GLGVP for tagging and purifying a gadolinium binding protein domain.
Key Players In Reverse Cholesterol Transport: The Plasma Enzyme Lcat, Christopher J. Pechura
Key Players In Reverse Cholesterol Transport: The Plasma Enzyme Lcat, Christopher J. Pechura
Undergraduate Research Posters 2012
Lecithin cholesterol acyltransferase (LCAT) is a plasma enzyme that remodels nascent high density lipoprotein (HDL) into a mature form called spherical HDL. The model will be used in the future to map the amino acid residues from LCAT and the protein component of nascent HDL (apoA1) involved in mutual interaction, and to identify LCAT residues interacting with the lipid phase of nascent HDL.
Understanding The Structure Of High Density Lipoprotein, Dmitriy Parshakov, Kayla T. Tran
Understanding The Structure Of High Density Lipoprotein, Dmitriy Parshakov, Kayla T. Tran
Undergraduate Research Posters 2012
The high-density lipoprotein (HDL), the carrier of ‘good cholesterol’, transports cholesterol from periphery cells to liver for catabolism, a process termed reverse cholesterol transport. In this project we focused on obtaining and characterizing HDL particles.
Caregivers’ Incongruence: Emotional Strain In Caring For Persons With Stroke, Linda L. Pierce, Teresa L. Thompson, Amy L. Govoni, Victoria Steiner
Caregivers’ Incongruence: Emotional Strain In Caring For Persons With Stroke, Linda L. Pierce, Teresa L. Thompson, Amy L. Govoni, Victoria Steiner
Nursing Faculty Publications
Purpose:Guided by Friedemann's framework, the purpose of this study was to examine the dimensions of new family caregivers’ emotional strain in caring for persons with stroke. Method: Seventy-three caregivers who were new to that role participated in an interview every 2 weeks for a year as part of a NIH project. Of these caregivers, 36 participants were randomly assigned and had access to a Web-based intervention and its e-mail discussion. In this secondary data analysis, 2,148 e-mail discussion messages plus 2,455 narrative interview entries were used to examine dimensions of caregivers’ emotional strain. Rigorous content analysis was applied to these …
The Ethics Of Vaginal Birth After Cesarean, Sonya Charles
The Ethics Of Vaginal Birth After Cesarean, Sonya Charles
Philosophy and Religious Studies Department Faculty Publications
The decline in providers and facilities that will allow a trial of labor after cesarean forces many women to choose a repeat cesarean. The choice is frequently not much of a choice, however, since the full range of options are often not on the table. This limited 'choice' violates obstetricians' obligations both to respect patients' autonomy and to offer them good care. There has been a vigorous but so far not very fruitful debate in the last few years about the lack of access to a trial of labor after cesarean. Some recently released documents express concern about the limited …
Discerning Reported Suicide Attempts Within A Youthful Offender Population, Christopher A. Mallett, Leaanne Derigne, Linda M. Quinn, Patricia A. Stoddard Dare
Discerning Reported Suicide Attempts Within A Youthful Offender Population, Christopher A. Mallett, Leaanne Derigne, Linda M. Quinn, Patricia A. Stoddard Dare
Social Work Faculty Publications
With suicide being the third leading cause of death among young people, early identification of risk is critical, particularly for those involved with the juvenile courts. In this study of court-involved youth (N = 433) in two Midwest counties, logistic regression analysis identified some expected and unexpected findings of important demographic, educational, mental health, child welfare, and juvenile court-related variables that were linked to reported suicide attempts. Some of the expected suicide attempt risk factors for these youth included prior psychiatric hospitalization and related mental health services, residential placement, and diagnoses of depression and alcohol dependence. However, the most unexpected …
Public Awareness Of Aphasia, Sarah Jane Jenkins
Public Awareness Of Aphasia, Sarah Jane Jenkins
ETD Archive
Aphasia is an acquired communication disorder that affects portions of the brain responsible for language processing and production. It is a disorder that occurs secondary to strokes and other traumatic brain injuries. It is estimated that almost 1 million people in the United States have aphasia. However, there has been very little research regarding public awareness of aphasia, particularly among service-industry workers. The purpose of this study was to analyze the level of public awareness of aphasia in Cleveland, Ohio. This study investigated 100 individuals' knowledge of aphasia by way of a questionnaire, with a focus on respondents who were …
Acoustic And Perceptual Analyses Of The Fundamental Frequencies Of African American And Caucasian Males And Females, Rose A. Vargo
Acoustic And Perceptual Analyses Of The Fundamental Frequencies Of African American And Caucasian Males And Females, Rose A. Vargo
ETD Archive
Normative data compiled by Hixon and Abbs (1980) continue to serve as guidelines for fundamental frequency (F0). These normative data were collected solely from Caucasian participants and may not accurately reflect norms for other ethnicities. According to published literature regarding pitch differences among racial groups, African Americans are believed to have a lower F0 than their Caucasian counterparts.This study investigated differences in F0 between African American and Caucasian young adults. Twenty adults between the ages of 18 and 30 were examined along three vocal parameters: sustained vowel phonation, a speaking task, and a reading task. Three experienced speech-language pathologists and …
Significant Race Differences In Factors Related To The Detention Recidivism Of Youthful Offenders, Christopher A. Mallett, Miyuki Fukushima, Patricia A. Stoddard Dare, Linda M. Quinn
Significant Race Differences In Factors Related To The Detention Recidivism Of Youthful Offenders, Christopher A. Mallett, Miyuki Fukushima, Patricia A. Stoddard Dare, Linda M. Quinn
Social Work Faculty Publications
A significant number of youthful offenders in the United States are held in juvenile court detention centers. Of broad concern is the disproportionate impact these placements have on minority youth, with African American and Hispanic youth much more frequently detained in these facilities compared to Caucasian youth. This U.S. study of a 2-county youthful offender population in the Midwest (1 urban, 1 rural) investigated racial differences in both extralegal (demographic, educational, mental health, and history of abuse or neglect) and court-related legal variables that predict detention placement upon recidivism—in other words, a second detention placement. Findings from logistic regression analysis …
Improved Left Ventricular Mass Quantification With Partial Voxel Interpolation – In-Vivo And Necropsy Validation Of A Novel Cardiac Mri Segmentation Algorithm, Noel C.F. Codella, Hae Yeoun Lee, David S. Fieno, Debbie W. Chen, Sandra M. Hurtado Rua, Minisha Kochar, John Paul Finn, Robert Judd, Parag Goyal, Jesse Schenendorf, Matthew D. Cham, Richard B. Devereux, Martin Prince, Yi Wang, Jonathan W. Weinsaft
Improved Left Ventricular Mass Quantification With Partial Voxel Interpolation – In-Vivo And Necropsy Validation Of A Novel Cardiac Mri Segmentation Algorithm, Noel C.F. Codella, Hae Yeoun Lee, David S. Fieno, Debbie W. Chen, Sandra M. Hurtado Rua, Minisha Kochar, John Paul Finn, Robert Judd, Parag Goyal, Jesse Schenendorf, Matthew D. Cham, Richard B. Devereux, Martin Prince, Yi Wang, Jonathan W. Weinsaft
Mathematics and Statistics Faculty Publications
Background—CMR typically quantifies LV mass (LVM) via manual planimetry (MP), but this approach is time consuming and does not account for partial voxel components - myocardium admixed with blood in a single voxel. Automated segmentation (AS) can account for partial voxels, but this has not been used for LVM quantification. This study used automated CMR segmentation to test the influence of partial voxels on quantification of LVM. Methods and Results—LVM was quantified by AS and MP in 126 consecutive patients and 10 laboratory animals undergoing CMR. AS yielded both partial voxel (ASPV) and full voxel (ASFV) …