Medicine and Health Sciences Commons^™

The Effect Of Luteolin On Human Glioblastoma, David M. Anson, Samson Amos, Robert L. Paris, Denise S. Simpson

The Research and Scholarship Symposium (2013-2019)

Glioblastoma multiforme (GBM) is widely recognized as the most common and lethal of the malignant gliomas. Few effective therapeutic treatments are available as five-year survival rates of diagnosed individuals are less than five percent. Luteolin, a common flavonoid found in a variety of fruits and vegetables, has demonstrated significant promise in combating cancers of the breast, colon, liver, lung, and bone. In this study, we investigated the effects of luteolin on glioblastoma multiforme cell lines U-251, U-87, and U-1242. Cell viability was assessed using cell count with trypan blue exclusion and MTT assays. Results revealed that luteolin reduces GBM cell …

A Systematic Review Of The Cost-Effectiveness Of Chemotherapy Regimens, Chelsea R. Manion, Eric Blizzard, Emily Bruce, Hannah Chittenden, David Fisher, Lia G. Hickinbotham, Abigail Moon, Nicholas Rudy, Aleda Chen, Kristi Coe

The Research and Scholarship Symposium (2013-2019)

Background: The rising cost of chemotherapy dramatically increases the burden on healthcare and presents new challenges in achieving optimal patient outcomes. New treatments, in general, are more specialized but show minor progress in regards to efficacy. Accordingly, the threat of overpaying for chemotherapy regimens has increased. There is a need for a comprehensive review to compile relevant studies in order to inform clinician decisions on the basis of cost-effectiveness and quality of life.

Objectives: The objective of this project is to assess the cost-effectiveness of anticancer medications with a special focus on the quality of life of patients undergoing chemotherapy, …

The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson

The Research and Scholarship Symposium (2013-2019)

Glioblastoma multiforme (GBM) is a WHO grade IV brain tumor. These tumors are highly proliferative, infiltrative, necrotic, angiogenic, and resistant to apoptosis. One major characteristic of GBM is the overexpression of epidermal growth factor receptor (EGFR), which leads to cell growth and proliferation when activated. GBM is very difficult to treat due to its location, heterogeneity, and invasiveness; an effective treatment is therefore needed. The use of flavonoids, which are natural compounds found in many fruits and vegetables, has been studied in the treatment of many different tumor types. Apigenin is a specific flavonoid that has previously been shown to …

Effects Of High-Fidelity Simulation On Student Perceptions Of Interprofessional Education, Trevor Stump, Mckenzie Shenk, Karissa C. Chow, Becky Brown

The Research and Scholarship Symposium (2013-2019)

Background: Interprofessional education is gaining momentum in healthcare education through the accreditation standards for various health professions and requirements from government initiatives like the Affordable Care Act. The role of high-fidelity simulation in healthcare education is growing and serves as a mechanism to implement interprofessional education.

Purpose: Assess the change in healthcare students’ perceptions of interprofessional education following a high-fidelity emergency medicine simulation.

Methods: Students from a medical, nursing, and pharmacy school participated in a high fidelity simulation event. There was first a brief presentation on interdisciplinary teamwork. The Student Perceptions of Interprofessional Clinical Education-Revised 2 (SPICE-R 2) was administered …

Preventing Pressure Ulcers In Adults: An Integrative Review, Abram Bassinger, Kara Kistler, Melissa Soule

The Research and Scholarship Symposium (2013-2019)

Introduction and Background: Pressure ulcers (PU’s) are a preventable healthcare concern which can impede the health quality and recovery for adult patients.

Purpose: To determine if in the adult population, the use of alternative mattresses or standard mattresses reduces the risk of pressure ulcers more effectively.

Framework: The Iowa Model of Evidence-Based Practice.

Results: Of the 10 articles reviewed, 7 articles had significant focus on the comparison between alternative versus standard mattresses while 3 articles discussed alternative versus standard mattresses but concentrated on other interventions for PU’s. Of the 7 focused on alternative versus standard mattresses, 5 have significant evidence …

The Impact Of An 8-Hour Versus 12-Hour Shift For Registered Nurses: An Integrative Review, Jenna Classen, Shannon Davis, Emily Sutter

The Research and Scholarship Symposium (2013-2019)

More hospitals are eliminating the traditional 8 hour shift and replacing it with the 12 hour shift. The aim of this study was to review literature about the effects of shift length on nurses and patients. Cedarville University's OneSearch was used to collect the 12 articles reviewed. Some studies indicated nurses working 12 hour shifts were at a greater risk of experiencing burnout compared to nurses working 8 hour shifts. Nurses working 12 hour shifts were more likely to experience chronic fatigue related to inadequate amounts of sleep. Furthermore, when a nurse’s shift exceeded 13 hours, patients became more dissatisfied …

The Impact Of A Flipped Classroom Compared To Lecture-Based Teaching On Achieving Course Outcomes, Melissa J. Beck, Akwasi Appiah, Jasmine Gunti, Victoria Bumgardner, Caleb Tang

The Research and Scholarship Symposium (2013-2019)

Education is one of the most vital components that compose a modern society and as such, its improvement and optimization is always sought. This study investigates the efficacy between two learning methods in a graduate level biochemistry course: complete active learning and a hybrid of active and passive learning. Active learning is one method of achieving course outcomes with an emphasis on student responsibility through self-studying of course material followed by classroom discussion. In comparison, passive learning emphasizes instructor responsibility through didactic lecturing of course material. The aftermath results following a hybrid form of active and passive learning (in-class didactic …

The Impact Of Free Health Screenings At Community Pharmacies On Diabetes, Anna Smith, Jacques Allou, Jeniffer George, Jessica Amtower, Nicholas Daniels, Jeb Ballentine, Emily M. Laswell

The Research and Scholarship Symposium (2013-2019)

Diabetes is a prevalent issue in the United States, with an estimated 8.1 million people un-diagnosed as of 2012. Health screenings have been proven to identify diseases earlier, thereby resulting in earlier and more satisfactory treatment. Community pharmacies can offer many of the same screenings as those in doctor offices. The objective of this study was to assess the impact of free health screenings in community pharmacies on patient follow-up, perceptions, and knowledge of diabetes through blood glucose screenings and patient education. The study design was a pre-post observational study using surveys, blood sugar screenings, and patient education on diabetes. …

Effects Of Social Support On Compliance In Rehabilitating Athletes, Sarah E. Orr, Hannah L. Stedge

The Research and Scholarship Symposium (2013-2019)

The purpose of the study was to better understand if social support has an effect at all on the athlete’s compliance in coming in to do their rehabilitation during an injury. Those who participated in this study were from the colleges and universities in the state of Ohio. The participants were collegiate athletes who were in a rehabilitation program for six or more weeks and had returned to play. Of the 56 surveys returned, 18 (32.14%) of those were fully completed, and nine (16.07%) of those, consisting of seven (77.78%) females and two (22.22%) males, met the criteria set. Athletes …

Investigation Of The Effects Of Growth Environment On The Ferric Reducing Antioxidant Power Of Selected Plant Species, Denise S. Simpson, Marshall C. Johnson, David T. Bancroft, Robert L. Paris

The Research and Scholarship Symposium (2013-2019)

Metabolism within the human body creates multiple oxidant by-products. These oxidants may cause cell injury, damage to DNA, and other complications leading to the development of chronic disease. Antioxidants are important dietary components which defend against oxidative damage by scavenging the oxidant by-products. Research has shown that diets rich in antioxidants offer protection against various chronic diseases.

The goal of this research is to determine the effects of varying growing conditions on the production of antioxidants, and to ultimately find the best possible plant-growth environment for maximum production of antioxidants. Each plant was grown under three different environmental conditions; positive, …

College Student Awareness Of Fetal Alcohol Spectrum Disorders, Micah F. Bernard, Kale Hanavan, Vineeta Rao, Jacob Shaffer, Katherine Woodard, Dominic Yeboah, Phillip L. Thornton

The Research and Scholarship Symposium (2013-2019)

Fetal alcohol spectrum disorders (FASDs) result from women drinking alcohol during pregnancy. This objective of this project is to assess college students’ awareness of FASDs and determine if education improves self-reported attitudes towards drinking while pregnant or when pregnancy is possible. Previously conducted studies have equipped healthcare professionals to provide education to at-risk mothers and to intervene in pregnant mothers. However, little research has been done on informing those who are not yet pregnant but who may become pregnant about this disease and its prevention. This study will attempt to add to the literature on FASDs prevention by targeting college …

Validation Of Humanized Mouse Antibodies, Meiling G. Norfolk, Rocco J. Rotello

The Research and Scholarship Symposium (2013-2019)

Antibody therapy is being developed and tested as one of the most promising agents for treatment of various human diseases. As of March 2016, 350 antibody candidates are in clinical trials. Many of these antibodies have been taken from animals and “humanized” by genetic modification. Our experiment tests monoclonal antibodies that have been harvested from mouse hybridoma (spleen-derived) cells and cloned until the heavy and light chains of the antibody can be recognized by human cells. Because of this “humanization” procedure, basic antibody assays are needed to demonstrate that the binding, specificity and functional parameters of the antibodies are not …

The Effect Of Andrographolide On The Metabolism Of Carbamazepine In Rats, Elizabeth Aziz, Samuel Franklin, Ankit Pandav, Abigail Savino, Caleb Thompson, Caleb Vandyke, Ruth Choi, Elisha R. Injeti

The Research and Scholarship Symposium (2013-2019)

Objective: To determine if andrographolide (AND) impacts the pharmacokinetics of carbamazepine (CBZ).

Background: CBZ is an anticonvulsant medication that is metabolized in the liver by cytochrome P450 (CYP) enzymes. AND is an over-the-counter medication that is common in Eastern cultures to treat inflammation and is a CYP enzyme inhibitor. Because CBZ is metabolized in the liver by these specific CYP enzymes, coadministration of andrographolide and CBZ could result in a herb-drug interaction. Methods: Sprague-Dawley rats (N=12) aged between 3 months and 6 months (250-350 g) will be split into control (N=6) and treatment (N=6) groups. The treatment group will receive …

2016 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

Click the "Download" button in the top right corner to view the abstract booklet.

Evaluating Interprofessional Fast Forward Rounds For Transition Of Care Education, Laura Cummings, Ashley J. Smith, Mike Pelyhes, Zachary Jenkins, Phillip L. Thornton, Maurice Lee, William Matcham

The Research and Scholarship Symposium (2013-2019)

Background: Interprofessional Education is gaining recognition by key pharmacy organizations for its value in healthcare education, producing various models for implementation among healthcare students and professionals. Unfolding cases incorporating transitions of care may improve student skills and attitudes toward interprofessional collaboration.

Objectives: This project assessed the efficacy of unfolding cases in improving interprofessional skills and attitudes among pharmacy, nursing, and social work students. The ultimate goal is to integrate this model, if proven effective, into the curricula of multiple health science centers.

Methodology: First, pharmacy, nursing, and social work students completed a pre-intervention survey regarding interprofessional skills and attitudes before …

Nutritional Knowledge Among Athletic Teams, Hannah F. Gualtieri, Ellen L. Thompson, Hannah L. Stedge

The Research and Scholarship Symposium (2013-2019)

The topic of sports nutrition has often been undermined in the athletic world. Practicing good nutritional habits has the ability to both improve performance and health. Several studies have examined nutritional knowledge among athletic teams; however very few have compared this knowledge among athletic teams. The purpose of this study was to determine the extent of various athletes’ nutritional knowledge and evaluate the differences in this knowledge among NCAA Division II Athletic teams. A secondary purpose was to discover athlete’s confidence level in their nutritional knowledge as well as gain their opinion on how they would improve nutritional knowledge among …

Chiropractic Physicians' Knowledge Of Pediatric Concussions, Rachel A. Lamb, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Recent legislation in the state of Ohio now allows chiropractic physicians who possess certain credentials to both diagnose and clear young patients who have sustained concussions. Unfortunately, little if any existing research examines the knowledge and abilities of chiropractic physicians regarding the management of this condition. Therefore, the purpose of this study was to provide a general overview of chiropractic physicians’ knowledge regarding the diagnosis and management of pediatric concussions. A survey was emailed to 1,344 chiropractors in the state of Ohio. Of those who were contacted, 71 completed the survey. The survey included questions regarding demographics, patient scenarios, and …

Factors Contributing To Professional Self-Efficacy Levels In Recently Graduated Certified Athletic Trainers, Matthew Kuo, Hannah L. Stedge, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Self-efficacy is an important factor for job success, but it has been cited as a missing factor in new athletic training graduates. Therefore, the objective of this study was to find what factors affect the development of self-efficacy in the recently graduated certified athletic trainer. A qualitative survey method was utilized that involved questions aimed to extract as much personal opinion and experiences as possible. Online surveys were sent out electronically to 1,000 prospective participants. A total of 64 survey responses were received but only 52 surveys were qualified for inclusion into the study. Data was collected via the online …

Effects Of Olfactory Sense On Chocolate Craving, Michael W. Firmin, Aubrey Gillette, Taylor E. Hobbs

The Research and Scholarship Symposium (2013-2019)

Chocolate has been referred to as one of the most socially acceptable addictions. It is one of America’s most craved foods, and women tend to crave it more frequently than men. Kemps and Tiggemann (2013) conducted an innovative experiment to reconcile the ideas of mental imagery, scent, and craving. After presenting images of sweet foods and having female undergraduate students smell a neutral scent, the researchers found that the neutral smell decreased craving for sweet foods.

In the present study, researchers sought to replicate many aspects of Kemps and Tiggemann’s design. This new study went one step further, though: in …

Predictive Value Of The Functional Movement Screen As It Relates To Anterior Cruciate Ligament Injury, Daniel A. Herring, Kyle D. Cherry, Hannah L. Stedge

The Research and Scholarship Symposium (2013-2019)

Introduction: Anterior cruciate ligament injuries occur over 200,000 times annually in the United States alone (Brophy, et al. 2009). This injury strains the healthcare system and affects the players, teams, parents, and the organization they are a part of. There have been, however, clinically researched risk factors that predispose athletes to ACL injury (Gignac, et al. 2015; Laible, et al. 2014). As a result, there is a clinical need for an effective screening tool to identify those athletes at risk for ACL injury. The Functional Movement Screen has been shown to be an effective screening tool for detecting athletes who …

Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg

The Research and Scholarship Symposium (2013-2019)

Individuals with intellectual and developmental disabilities (IDD) are commonly prescribed antiepileptic drugs (AEDs) to manage seizures, manage behavior, and stabilize mood. Though research has been done on the effects of antiepileptic medications in patients with epilepsy, little study has been done on the persons with intellectual and developmental disabilities population. After surveying IDD patients with a history and current use of AEDs on osteoprotective behaviors, we were unable to use SPSS due to incomplete surveys and low sample sizes. However, we were still able to analyze for common themes, and we found that the most prevalent use of AEDs was …

Hydration And Fluid Replacement Knowledge In High School Football Athletes, Megan Anderson

The Research and Scholarship Symposium (2013-2019)

The primary purpose of this study was to investigate the knowledge of hydration and fluid replacement among high school football players. Secondary purposes of this investigation included identifying the athletes’ current sources of nutrition information and to identify the players’ perception of the adequacy of their fluid intake and barriers that prevent them from obtaining enough fluid before, during, and after exercise. A total of 29 athletes completed the survey. The mean ages of the athletes participated in this study was 16.4 years. The mean number of seasons played on the high school football team was 3.1 seasons. The mean …

The Effects Of Faith-Based Therapy Versus Secular Therapy On Substance Abuse Treatment, Lydia Cook, Brittany Humphreys, Jennifer Stallard

The Research and Scholarship Symposium (2013-2019)

Substance abuse can affect anyone. The consequences are significant and may lead to death. Substance abuse also puts a great financial burden on the healthcare system. The purpose of this review of literature was to investigate the effect of faith-based therapy compared to secular therapy on substance abuse treatment. The data sources used were: PsychINFO, CINAHL, and OneSearch. Results showed multiple factors of faith-based therapy such as: cultural pressure, fear of judgment, and social support may correlate with recovery. A positive correlation was found between faith-based therapy and substance abuse recovery when compared with secular therapy (Al-Omari, Hamed, & Abu …

Risk Factors For Concussion In Collegiate Ncaa Division Ii Men's And Women's Soccer Athletes, Isaac S. Beckler, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Background: Certain risk factors may predispose athletes to an increased risk of concussion.

Purpose: To identify risk factors for concussion among men's and women's college soccer athletes, and determine the likelihood of concussion based on those risk factors.

Methods: A short electronic survey was sent out to NCAA Division II universities in Ohio. Survey questions included demographics, soccer-related questions, and concussion-related questions. Participants were women's and men's soccer athletes participating in either varsity or junior varsity soccer at their respective universities.

Results: Of the concussions sustained while playing soccer, 29.4% of female participants sustaining a concussion compared to only 17.4% …