Medicine and Health Sciences Commons^™

Overview Of Healthcare Quality: Hospitals And Public Health Trends: Rural Vs. Urban, Sandy S. Lee

Social Sciences

No abstract provided.

Wiihopp, Jeff Christian, Ben Hoselton, Derek Simon

Mechanical Engineering

Childhood obesity is becoming a growing problem in the United States. According to the CDC, childhood obesity has more than tripled in the past 30 years [7]. It can lead to health problems previously reserved for adults, such as diabetes, high blood pressure, and high cholesterol. For the team WiiHopp project, we plan to turn a JumpSport mini-trampoline into a controller for the Nintendo Wii console. The hope is to help turn the problem of video games and the laziness surrounding them into an active solution to combat the problem of childhood obesity.

Our goal is to produce an add-on …

Vesicular Stomatitis Virus In The Treatment Of Hepatocellular Carcinoma, Celene Joza

Animal Science

No abstract provided.

Discovery Of An Apoptosis Inducing Ligand For Burkitt Lymphoma, Carolyn Laymon, Kyla Bradylong, Mary Saunders, David Olivos, Kit Lam

STAR Program Research Presentations

One-bead two-compound (OB2C) combinatorial chemistry libraries enable the discovery of novel synthetic compounds which can be used to evoke specific signaling response in cells. The library configuration is composed of a fixed known cell adhesion ligand and a random chemical library displayed on the surface of Tentagel beads. The cell adhesion ligand binds to specific receptors located on the surface of cells enabling the random immobilized chemical molecules on each bead resin bead to evoke specific cellular responses such as apoptosis or cell death. To validate this concept, a OB2C combinatorial library comprised of an α4β1 integrin targeting ligand, LLP2A, …

Life As A Swimmer, Danielle N. Coville

Chemistry and Biochemistry

No abstract provided.

An Exploratory Investigation Of The Effects Of Dragon Boating On The Psychosocial Well-Being Of Female Cancer Survivors, Clara Therese Louise Vanherweg

Master's Theses

The purpose of this study was to prospectively examine the effects of dragon boat participation on the psychosocial well-being of female cancer survivors over time and compared with the population-based norms. Nine female cancer survivors belonging to the dragon boat team, SurvivOars, participated in the initial measurement process. The measurement packet was 21 page compilation of psychosocial questionnaires capturing demographics, quality of life, moods, depressive symptoms, perceived stress, self-esteem, self-efficacy, social support, physical activity levels, body image, and sedentary behaviors. After 8 weeks, 8 subjects completed the same follow-up questionnaire to assess changes in psychosocial variables over time. Scores were …

Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers

Master's Theses

Functional vasodilation in arterioles is impaired with chronic ischemia. We sought to examine the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice and the profunda femoris artery diameter was measured at rest and following gracilis muscle contraction 14 days later using intravital microscopy. Functional vasodilation was significantly impaired in ischemic mice (14.4±4.6% vs. 137.8±14.3%, p<0.0001 n=8) and non-ischemic adult mice (103.0±9.4% vs. 137.8±14.3%, p=0.05 n=10). In order to analyze the cellular mechanisms of the impairment, a protocol was developed to apply pharmacological agents to the experimental preparation while maintaining tissue homeostasis. Endothelial and smooth muscle dependent vasodilation were impaired with ischemia, 39.6 ± 13.6% vs. 80.5 ± 11.4% and 43.0 ± 11.7% vs. 85.1 ± 10.5%, respectively. From this data, it can be supported that smooth muscle dysfunction is the reason for the observed impairment in arterial vasodilation.

Determining A Method For Rendering Low Cost Cdse(Zns) Core(Shell) Quantum Dots Aqueous Soluble Via Amphiphilic Polymer Wrapping, Patrick Mcbride

Materials Engineering

Herein is described the procedure of two amphiphilic polymer wrapping techniques that may be employed for obtaining aqueous soluble quantum dots (QDs) for use in biological fluorescent imaging applications. The advent of QDs has led to new nanoscale fluorescent materials that exhibit unparalleled quantum yields (QYs), high resistance to photobleaching, tunable emissions, and
absorption over a large optical range. However, the QD synthesis employed here at Cal Poly to obtain bright, photostable CdSe(ZnS) core(shell) QDs involves the use of organic solvents and surfactants, leading to hydrophobic QDs. Since all of biology relies on aqueous solubility, this hydrophobicity creates a major …

Rfid Techniques For Passive Electronics, Ryan Behr, David Cobos

Electrical Engineering

No abstract provided.

Characterization Of Amino Acid Residues Integral To Neuronal Binding Of Amyloid Beta Protein In Alzheimer’S Disease, Nicole C. Olson

Chemistry and Biochemistry

Purpose: Alzheimer’s Disease is a neurodegenerative disease resulting from over-production and neuronal accumulation of amyloid-beta proteins (Aβ40/Aβ42). The glycine residue at position 33 and histidine residues at positions 13 and 14 are involved with binding and internalization of these proteins, actions potentially inhibited by substituting or sterically hindering these residues with an antibody specific to positions 2-11 (IgG-4.1). Rat pheochromocytoma (PC12) cells differentiated with nerve growth factor were used as a neuronal model to determine whether substitution and/or antibody block amyloid-beta’s neuronal interactions.

Methods: PC12 cells were incubated with fluorescein-labeled-amyloid-beta-40 (F-Aβ40) or substituted F-Aβ40 derivatives (F-Aβ40-H13,14G, F-Aβ40-H13,14G;G33A), with or without …

Effects Of Exercise On Brain Activation In Response To Visual Food Cues, Laura Hackett

Kinesiology and Public Health

No abstract provided.

Alzheimer's Disease, Sophie Walsh

Kinesiology and Public Health

No abstract provided.

The Effects Of Carbohydrate, Caffeine, And Protein On Endurance Performance, Tony Zapata

Kinesiology and Public Health

No abstract provided.

Perceived Benefits Of Yoga Participants Enrolled In Different Yoga Styles, Jennifer Lovas

Recreation, Parks, and Tourism Administration

Yoga affects the lifestyles of many individuals ranging from child and teen to senior. The Yoga Centre studios in San Luis Obispo and Arroyo Grande provide a variety of classes conducive to the yoga practice for all ages and levels. The purpose of this study was to examine the perceived benefits of participants enrolled in different styles of yoga at the Yoga Centre. The 163 participants completed the survey using self-administered and electronic questionnaires distributed in January of 2011. Stress relief was the highest perceived benefit. Most participants started yoga for health and fitness reasons and most were fearful of …

Angiostatin Like Peptides In Milk: Potential Development For Dairy Products Capable Of Cancer Prevention, Erin Stefanutti

Master's Theses

For the past 40 years, antiangiogenic approaches have been of major interest in the development of methods to cure and prevent cancer. Angiogenesis, the development of blood vessels from pre-existing vascularization, is essential for cancer growth and spread of metastasis through the delivery of nutrients and oxygen essential to sustain the metabolic activity of these malignant cells. Blocking access to blood will cause cancerous cells to assume a dormant state creating inactive micro-tumors innocuous to the host. Angiostatin, the internal fragment of the fibrinolytic zymogen plasminogen, has shown great potential in reducing cancer size and number of metastatic colonies in …

The Use Of Non-Steroidal Anti-Inflammatory Drugs (Nsaids) In Treating Delayed Onset Muscle Soreness (Doms), Tiffany Windju

Kinesiology and Public Health

No abstract provided.

Combating Childhood Obesity In California, Janelle Borelli

Social Sciences

Childhood obesity has become a major problem in Corporate America. Our youth’s health is at risk, the statistics are alarming, and childhood obesity is largely preventable. In order to solve the childhood obesity epidemic, government action, both state and federal, needs to be taken by passing nutrition standard laws. Also, the built environment should support an active lifestyle rather than one based on fast food and lack of exercise. Families should adopt a healthy lifestyle including having adequate fruits and vegetables at home along with exercising daily.

Approximation Of Anterolateral Curvature Of Lumbar Vertebra, Ben A. Friesem

Biomedical Engineering

The study of lateral interbody lumbar spinal surgery and designing an optimal intervetebral device is a complex endeavor. Interbody spinal fusion is performed for a variety of clinical situations, including back pain, vertebral fractures, and tumor conditions that require stabilization of the vertebral segments. The fundamental goal of spinal fusion is to attain a solid fixation at the implant-vertebral interface.
Replacement of a degenerated vertebral disc with an artificial intervertebral disc (AID) is currently possible, but poses problems mainly in the force distribution through the vertebral column. Data on the intervertebral disc space geometry will provide a better fit of …

Laser Etched Pmma Microfluidic Chip Design And Manufacture With Applications In Capillary Zone Electrophoresis, Evan Allen Barbre

Master's Theses

This thesis encompasses a feasibility study of using low-cost materials to manufacture microfluidic chips that can perform the same functions as chips manufactured using traditional methods within an acceptable range of efficiency of chips created with more exotic methods and materials. The major parts of the project are the selection and characterization of the fabrication methods for creating the channels for fluid flow, the methods for sealing the channels to create a usable chip and the electrophoretic separations of carboxylated microspheres of different potentials. In this work we seek to answer the question if laser-etched PMMA microfluidic chips are comparable …

Low-Cost Prosthetic Leg For The Vida Nueva Prosthesis Clinic, Sarah M. Baker, Justin G. Lekos, Jen Van Donk, Kevin Yamauchi

Mechanical Engineering

The Piernas de Vida team partnered with the Vida Nueva Clinic of Prostheses and Orthoses in Choluteca, Honduras to design, plan, and implement a prosthetic foot that could be manufactured entirely by the technicians at the clinic in order to reduce their costs and ultimately allow them to serve more patients each year. Currently, the clinic uses a prefabricated prosthetic lower limb provided by the International Committee of the Red Cross (ICRC) which can be adapted to both transDfemoral and transDtibial patients. The team has successfully developed a foot, currently called the Layer Foot, which can be used by the …