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First Trimester Metformin In Polycystic Ovary Syndrome Patients With History Of Recurrent Early Pregnancy Loss: Randomized Controlled Trial, Farid Ibrahim Hassan, Muhamed Ahmed Abdelmoaty, Ahmed Hamdy Muhammed Saad

Al-Azhar International Medical Journal

Background: Women with polycystic ovarian syndrome (PCOS) who take metformin throughout their pregnancies have lower rates of miscarriage, labour, and foetal development restriction. Positive benefits of metformin on insulin sensitivity, plasma glucose concentration, and lipid profile have been shown in patients with polycystic ovary syndrome.

Aim and objectives: to the disparity in the occurrence of miscarriage between two patient cohorts who will get or not receive Metformin in the first trimester, to determine the efficacy of Metformin in preventing early pregnancy loss in pregnant patients with PCOs.

Subjects and methods: This was a randomised controlled trial that was conducted on …