Medicine and Health Sciences Commons^™

Clinical Evaluation 32 Patients With Jme In Southern Khorasan, Hamid Riasi, Fariba Nakhaei, Kavian Ghandehari, Frood Salehi, Zahra Toraby, Mojtaba Teimoori

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Intrathecal Use Of Polyrnyxinb For Multiresistant Acineobacter Meningitis, Atta-Ul Aleem Bhatti, Aslam Khan, Syed Ather Enam, Rashid Jooma

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

16th Annual Psn Meeting, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Central Corneal Thickness Of Pakistani Adults, Roomasa Channa, Fazia Mir, Mahnaz Naveed Shah, Azam Ali, Khabir Ahmad

Section of Ophthalmology

Objective: To determine the average central corneal thickness (CCT) of healthy adults in the ophthalmology clinic of a tertiary care hospital of Pakistan.
Methods: This was a cross-sectional study conducted in the ophthalmology clinics of Aga Khan University Hospital, Karachi Pakistan. One hundred normal subjects (200 eyes) were studied. An ultrasound pachymeter was used to measure CCT.
Results: The mean (+/- SD) age of the study population was 44.29 +/- 15.18 years with a median of 47 years (range: 16-73). Twenty three percent of the subjects had diabetes mellitus, 29% hypertension and 6% had history of ischaemic heart disease. The …

Gender Differences And Delay In Presentation Of Childhood Squint, Tanveer Anjum Chaudhry, Aziz Khan, Muhammad Bilal Salman Khan, Khabir Ahmad

Section of Ophthalmology

Objective: To assess gender differences and delay in presentation of childhood squint in a tertiary care hospital.
Methods: It was a series of children presenting with squint at the Aga Khan University Hospital, Karachi, Pakistan. We retrospectively studied the cases presenting between February 2000 and July 2007.
Results: A total of 107 children with squint were seen. Of these, 55 (52.4%) were girls. A statistically significant difference was observed between the mean age at presentation (+/- SD) of boys and girls (3 years and 5 months vs 4 years and 5 months p: < 0.05). Girls had a greater mean (SD) and median (range) delay in squint presentation than had boys (2 year 4 months +/- 3 years vs 3 years +/- 2 year 8 months) and 2 year 3 months (1 month to 12 years) vs 1 year 3 months (1 month to 14 years), respectively. Overall amblyopia was present in 25.3% (23/91) children. Girls also had a higher burden of amblyopia compared with their male counterparts though the difference was not statistically significant (P = 0.09).
Conclusion: There was a significant gender difference …

Overview Of Surgical Management Of Infectious Non-Suppurative Brain Lesions (Part 1), Muhammad Shahzad Shamim, Ather Enam, Rushna Pervez Ali, Syed Faizan Ali, Mohammad Wasay

Section of Neurosurgery

No abstract provided.

Knowledge Of Emergency Contraception Among Women Of Childbearing Age At A Teaching Hospital Of Karachi, Farhana Irfan, Syed Irfan Karim, Saman Hashmi, Sajid Ali, Syed Arif Ali

Department of Family Medicine

OBJECTIVES: To assess knowledge and attitudes about Emergency Contraception among women of childbearing age in Karachi, Pakistan.

METHODS: A questionnaire based survey was conducted on 400 married women, attending the family practice clinics at a teaching hospital in Karachi, Pakistan from July to December 2006. Questionnaire was administered to women at the family practice clinic-seeking level of knowledge of emergency contraception (EC) and attitudes towards its use, Ethical requirements of informed consent and confidentiality were ensured Data was entered into Epi data and analyzed in SPSS.RESULTS: Eighty-eight percent of women were not aware of EC. 83% were housewives. Only a …

Pharmacy Newsletter : April 2009, Pharmacy Department

Department of Pharmacy Archives

Content:

• Pharmacy News
• FDA Alerts
• Interaction Update
• Establishment of a New Anti-H.pylori Regimen

Cerebral Palsy In Adolescents, Rehan Ali, Shakeel Ahmed, Maqbool Qadir

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Changing Patterns Of Visual Hallucinations, Mubashira Hashmi, Ashfaq A. Sharif, Shaista A. Siddiqui, Muhammad Shahid Mustafa

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Gliosarcoma, Rafael Cincu, Juan F. Martín Lázaro, José Luis Capablo Liesa, Jose Eiras

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

External Ventricular Drains — Can Morbidity Be Reduced, Ansar Hayat, Desi Rodrigues, Peter Crawford, David Mendelow

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Diagnostic Accuracy Of Ct Angiography And Surgical Outcome Of Cerebral Aneurysms, Nozaina Khan, Naveed Ashraf, Abdul Hameed, Akmal Muhammed

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Cases Of Subconjunctival Hemorrhage After A Joy Ride, Roomasa Channa, Sana Shoukat Memon, Tanveer Anjum Chaudhry, Khabir Ahmad

Department of Surgery Docs

No abstract provided.

Assessment Of Knowledge & Practice Of Contraceptives In Females Of Reproductive Age Group At A Tertiary Care Hospital, Nabeela Fazal Babar, Mahmood Ahmed, Muhammad Babar Khan, Muhammad Wasif Khan

Department of Surgery Docs

Abstract

Objectives: To assess the knowledge & practice of contraceptives in females of reproductive age group.
Study Design: Cross sectional descriptive.
Place and Duration of Study: OPD of Fauji Foundation Hospital from February 2008 – September 2008.
Subjects and Method: 339 Females of age b/w of 15 – 49 years attending OPD of Fauji Foundation Hospital were included in study. A structured questionnaire was used to collect data.
Results: Eighty eight percent of the females in our study sample were familiar with one or more methods of contraception (72.7%were familiar with combined oral contraceptive pill (COCP), 60.7% were aware of …

Spectrum Of Tamoxifen Associated Endometrial Pathology In Breast Cancer Patients, Asim Qureshi, Farhan Bukhari, Shahid Pervez

Department of Pathology and Laboratory Medicine

The objective of the study was to determine the incidence and type of endometrial abnormalities in long-term users of tamoxifen with breast cancer. All patients with a diagnosis of Oestrogen Receptor positive breast cancer on Tamoxifen therapy who had also undergone endometrial biopsy for abnormal bleeding or other symptoms were included. Among the 37 cases that had long-term follow up available, 21(57%) had evidence of endometrial pathology. There were seven cases of simple hyperplasia and thirteen of endometrial polyp. Only one case of endometrial carcinoma was seen. These findings support the association between prolonged tamoxifen therapy and endometrial pathology of …

Evaluation Of Suspected Renal Colic Patients With Unenhanced Low-Dose Multi-Detector Computed Tomography, N. Twahirwa, J. Rees

Imaging & Diagnostic Radiology, East Africa

Objectives: To determine the proportion of correctly diagnosed ureteric calculi and alternate diagnoses using unenhanced low dose multidetector CT KUB.

Design: Descriptive – prospective study.

Setting: Aga Khan University Hospital, Nairobi between November 2006 and October 2007.

Subjects: One hundred and four patients underwent low dose multi-detector computed tomography (MDCT) KUB.

Results: Ninety (47 males and 43 females with age range of 17 - 79 years, mean 40 years) were included in the statistical analysis while 14 were excluded. Eighteen out of ninety (20%) were classified as definitely having ureteric calculi on the composite reference. Among the 18, 17 were …

Cancer Of The Penis: Case Report, D. K. Kiptoon, P. M. Ngugi, F. S. Rana

Pathology, East Africa

Two patients with penile carcinoma are presented after management at a district hospital in Kenya. Both had undergone ritual circumcision as teenagers and presented late. HR was a 73 year old who presented with a fungating penile mass for which a partial penectomy was performed after wedge biopsy confirmed malignancy. He thereafter declined to have the surgical specimen sent for histology and took the amputated stump for burial in his compound to avoid bad omen. GK was 25 years old and presented with a fungating mass and underwent partial penectomy after a histological diagnosis was made. He absconded from follow-up …

Antiretroviral Therapy Dose Adjustments Based On Calculated Creatinine Clearance, J. Shavadia, G. Tesfaldet, Majid Twahir

Internal Medicine, East Africa

Background: Whereas therapy for HIV is dependent on level of creatinine clearance, most laboratories locally only report an absolute creatinine value. There is likelihood that the patients already on antiretroviral therapy (ART) may have required dosage adjustment at the time of initiation of therapy or sometime during ongoing therapy. This paper explores a group of patients who are already on ART to determine their creatinine clearance and assess the need for ART dose adjustment.

Objective: To determine the proportion of stable HIV outpatients who have a documented creatinine clearance (CrCI) and the proportion requiring antiretroviral drug dose adjustments depending on …

A Case Of Finger Clubbing Associated With Nasopharyngeal Carcinoma In A Young Girl, And Review Of Pathophysiology, Nasir Ali, Ahmed Nadeem Abbasi, Farook Karsan, Raheel Hashmi, Quratul-Ain Badar, Asim Jamal Sheikh

Department of Radiation Oncology

Hypertrophic osteoarthropathy is characterized by clubbing of the digital tips and periosteal reaction of long bones. Most of the cases are associated with malignancy or other conditions such as congenital heart disease, liver cirrhosis, pulmonary fibrosis, biliary atresia and gastrointestinal polyps. Hypertrophic osteoarthropathy associated with malignancy is rare in children. A few cases of hypertrophic osteoarthropathy in children with nasopharyngeal carcinoma have been reported. This is a case of hypertrophic osteoarthropathy associated with nasopharyngeal carcinoma with lung and bone metastasis in a 16 year old girl. In this case, lung metastases progressed after intensive chemotherapy and hypertrophic osteoarthropathy (Clubbing) persisted.

Management Of Allergic Fungal Sinusitis With Postoperative Oral And Nasal Steroids: A Controlled Study., Mubasher Ikram, Akbar Abbas, Anwar Suhail, Maisam Abbas Onali, Shabbir Akhtar, Moghira Iqbal

Section of Otolaryngology, Head & Neck Surgery

In Patients with allergic fungal sinusitis, the mainstay of treatment remains surgical removal of allergic mucin and fungal debris. But as a single modality, surgery is associated with high rates of recurrence, so a number of adjunctive medical modalities have been tried, including postoperative corticosteroid therapy. We conducted a study of 63 Patients with allergic fungal sinusitis who underwent endoscopic sinus surgery with or without postoperative steroid therapy. A group of 30 Patients who had been treated prior to January 2000 had undergone surgery only, their cases were reviewed retrospectively, and they served as historical controls. Another 33 Patients who …

Fight Against Chronic Diseases (High Blood Pressure, Stroke, Diabetes And Cancer) In Pakistan; Cost-Effective Interventions, Mohammad Wasay, Abdul Jabbar

Department of Medicine

No abstract provided.

Asian Cerebral Venous Thrombosis Registry: Study Protocolv, Mohammad Wasay, Ayeesha Kamal, Bhojo Khealani

Department of Medicine

Introduction:

Cerebral venous thrombosis (CVT) is a well known but poorly reported entity. Most of the studies and registries related to CVT are reported from European countries. No large multi-center or multi- national data base or registry has been reported from Asian countries. CVT is not uncommon in Asia especially in south Asian subcontinent including India, Pakistan and Bangladesh. One study reported from India that CVT accounted for half of all strokes in the young and 40% of strokes in women. Review of CVT cases from Asian countries is suggestive of differences in risk factors profile and outcome in these …

Moyamoya Disease: A Clinical Spectrum, Literature Review And Case Series From A Tertiary Care Hospital In Pakistan., Sana Shoukat, Ahmed Itrat, Ather M. Taqui, Moazzam Zaidi, Ayeesha Kamran Kamal

Department of Medicine

Background: Moyamoya is a rare cerebrovascular disease of unknown etiology. The data on moyamoya disease from Pakistan is sparse. We report a case series of 13 patients who presented with moyamoya disease to a tertiary care hospital in Pakistan with a national referral base.

Methods: We conducted a retrospective review of thirteen patients who presented to The Aga Khan University and diagnosed with "Moyamoya Disease" during the period 1988 – 2006. These patients were identified from existing hospital database via ICD-9 codes. A predesigned questionnaire containing information about clinical presentation, management and neuroimaging was administered to all identified patients. Results: …

What Do Young Adults Know About The Hiv/Aids Epidemic? Findings From A Population Based Study In Karachi, Pakistan., Syed Farid-Ul-Hasnain, Eva Johansson, Gunilla Krantz

Community Health Sciences

Background: HIVAIDS is spreading globally, hitting the younger generations. In Pakistan, the prevalence of HIV in high-risk subpopulations is five per cent or higher. This poses a serious threat of a generalised epidemic especially among the younger population. In the wake of HIVAIDS epidemic this is worrying as a well informed younger generation is crucial in restricting the spread of this epidemic. This study investigated Pakistani young adults' (male and female) knowledge and awareness of the HIV/AIDS disease. Methods: A population-based, cross-sectional study of 1,650 male and female adults aged 17-21 years living in Karachi was conducted using a structured …

Prevalence Of Obesity In School-Going Children Of Karachi., Haider Javed Warraich, Faisal Javed, Mohammed Faraz-Ul-Haq, Fariha Batool Khawaja, Sarah Saleem

Community Health Sciences

Background: Obesity is an emerging problem in Pakistan. The authors sought to determine prevalence of obesity and malnutrition in school-going children, from grades 6(th) to 8(th) of different schools of Karachi and assess associations that affect the weight of the children.
Methodology/Principal Findings: A cross sectional Study Design with children studying in grades 6(th) to 8(th) grade, in different schools of Karachi. We visited 10 schools of which 4 consented, two subsidized government schools and two private schools. A questionnaire was developed in consultation with a qualified nutritionist. Height and weight were measured on calibrated scales. A modified BMI criterion …

Cytokine Gene Polymorphisms Across Tuberculosis Clinical Spectrum In Pakistani Patients., Ambreen Ansari, Najeeha Talat, Bushra Jamil, Zahra Hasan, Tashmeem Razzaki, Ghaffar Dawood, Rabia Hussain

Department of Pathology and Laboratory Medicine

Background:Pakistan ranks 7(th) globally in terms of tuberculosis (TB) disease burden (incidence 181/100000 pop./yr, prevalence of 329/pop./yr). Reports from different populations show variable associations of TB susceptibility and severity with cytokine gene polymorphisms. Tuberculosis clinical severity is multi-factorial and cytokines play a pivotal role in the modulation of disease severity. We have recently reported that the ratio of two key cytokines (IFNgamma and IL10) show significant correlation with the severity spectrum of tuberculosis. The objective of the current study was to analyze the frequency of cytokine gene polymorphisms linked to high and low responder phenotypes (IFNgamma +874 T(hi)-->A(lo) …

Assessment Of Asthma Control Using The Asthma Control Test At A Tertiary Care Centre In Karachi, Pakistan, Sana Shoukat, Saqib Ali Gowani, Ameer Ali Khowaja, Javaid Khan

Section of Pulmonary & Critical Care

The aim of our study was to assess asthma control among asthmatics at a tertiary care setting in Karachi using ACT questionnaire. The ACT questionnaire was filled by known asthmatics in January 2007. A total of 150 questionnaires were filled of which, 61 (40%) were males and 89 (60%) females. Mean ACT score was 17.71 +/- 4.41. Association between sex and asthma control was not statistically significant. Significant association was seen with asthma control and Ipratropium bromide inhaler. Asthma control among patients at a tertiary care centre is moderate. ACT can be used to follow patients in the hospital.

Early Ischemic Stroke Presentation In Pakistan, Ayeesha Kamran Kamal, Bhojo A Khealani, Sajjad Ahmed Ansari, Maria Afridi, Nadir Ali Syed

Department of Medicine

Introduction: There are no studies from Pakistan that describe stroke presentation rates or factors associated with early or delayed presentation. This is important to know because current clinical protocols limit the use of recombinant tissue plasminogen activator (rtPA), the only available therapy for acute ischemic stroke, to a three-hour window from symptom onset.
Methods: All patients aged 14 years or above with acute ischemic stroke of < or = 48 hours duration were prospectively identified from the Aga Khan University Stroke Data Bank over a 22-month period ending May 2001.
Results: 269 ischemic stroke patients presented within 48 hours of stroke onset. 55 out of 269 (21%) presented within first three hours and 110 out of 269 (41%) within first six hours. Unawareness of …

Predictors Of Recurrence Of Urethral Stricture Disease Following Optical Urethrotomy, Ali Akbar Zehri, M. H. Ather, Q. Afshan

Faculty of Health Sciences, East Africa

Objective:

To assess the predictors of recurrence in Optical urethrotomy (OU) for male urethral strictures.

Methods: 148 male patients treated with OU with intent to treat during the period of January 2003– December 2008 were included in the study. Charts were reviewed for demographics, cause of stricture, stricture length and need for ancillary procedure following OU. The time to recurrence following OU was noted. All patients were evaluated postoperatively with uroflowmetry monthly for the first 3 months, every 3 months during year 1 and every 6 months during year 2. After year 2 most patients were followed annually.

Results:

139 …