Medicine and Health Sciences Commons^™

Intracranial Aneurysms In Sickle Cell Disease Are Associated With Hemodynamic Stress And Anemia, Yan Wang, Jared S Garland, Slim Fellah, Martin N Reis, Matthew S Parsons, Kristin P Guilliams, Melanie E Fields, Amy E Mirro, Josiah B Lewis, Chunwei Ying, Rachel A Cohen, Monica L Hulbert, Allison A King, Yasheng Chen, Jin-Moo Lee, Hongyu An, Andria L Ford

2020-Current year OA Pubs

Although hemodynamic stress plays a key role in aneurysm formation outside of sickle cell disease (SCD), its role is understudied in patients with SCD. We hypothesized that tissue-based markers of hemodynamic stress are associated with aneurysm presence in a prospective SCD cohort. Children and adults with SCD, with and without aneurysms, underwent longitudinal brain magnetic resonance imaging/magnetic resonance angiography (MRA) to assess cerebral blood flow (CBF) and oxygen extraction fraction (OEF). Baseline characteristics were recorded. In the subgroup of adults, stepwise mixed-effect logistic regression examined clinical variables, CBF, and OEF as predictors of aneurysm presence. Cumulative rates of new aneurysm …

Evaluating The Impact Of A Year-Long External Mentorship Pilot Program In Classical Hematology, Zoya Qureshy, Pooja Nair, Sara K Vesely, Allison A King, Alfred I Lee, Nathan T Connell, Annette Von Drygalski, Ida Wong-Sefidan, Martina C Murphy, Ronak H Mistry, Rebecca L Zon, Erin G Reid, Josel Fritz, Soo J Park

2020-Current year OA Pubs

Effective mentorship is a pivotal factor in shaping the career trajectory of trainees interested in classical hematology (CH), which is of critical importance due to the anticipated decline in the CH workforce. However, there is a lack of mentorship opportunities within CH compared with medical oncology. To address this need, a year-long external mentorship program was implemented through the American Society of Hematology Medical Educators Institute. Thirty-five hematology/oncology fellows interested in CH and 34 academically productive faculty mentors from different institutions across North America were paired in a meticulous process that considered individual interests, experiences, and background. Pairs were expected …

Characterizing Undiagnosed And Incident Stis In An Hiv Vaccine Trial Cohort In South Africa (Hvtn 702), Hermione Yamyo Monie, Adrienne Shapiro, Fatima Laher, Ayman Osman

Research Colloquium

Background: According to the World Health Organization (WHO), sub-Saharan Africa leads the world in incidence rates of chlamydia, gonorrhea, and trichomonas1. Sexually transmitted infections (STIs) are associated with reduced quality of life, neonatal deaths and increased disease susceptibility. Despite efforts in public health, among those with STIs, the risk of contracting HIV remains at an all-time high2.

The aim of this secondary analysis was to extrapolate the prevalence and incidence of STIs, within a cohort, as supporting evidence to guide future public health efforts and resources.

Methods This analysis was conducted as a cross-sectional and longitudinal examination of the data …

Nmosd Mitochondrial Fluorescence Correlates With Ganglion Cell Layer Loss Consistent With Retinal Vasculitis, Francesco Cappellani, Md, Daniel M. Markowitz, Bs, Elizabeth Affel, Ms, Jose S. Pulido, Md, Brian Fernandez, Md, Robert C. Sergott, Md

Farber Institute for Neuroscience Staff Papers and Presentations

Introduction

• Fluorescence lifetime imaging ophthalmoscopy (FLIO, Heidelberg Engineering, Figures 1 and 2), a novel in vivo retinal imaging biomarker, generates fluorescence decay lifetimes in 2 spectral channels corresponding to mitochondrial metabolic processes
• Short Spectral Channel (SSC): 498 – 560 nm Ø Corresponds to flavin adenine dinucleotide (FAD) and oxidative phosphorylation.
• Long Spectral Channel (LSC): 560 – 720nm Ø Corresponds to predominantly lipofuscin and lysosomal function
• Based upon animal experimental models and clinical data, mitochondrial dysfunction has a role in the pathophysiology of NMOSD

How Do Older Adults Define A Good Death? A Scoping Review, Ellen L. Csikai, Quentin R. Maynard

Midwest Social Sciences Journal

A scoping literature review of the concepts of ‘good death’ and ‘dying well’ among older adults was conducted. The purpose was to identify aspects that older adults specifically considered important in defining a ‘good death’. The search revealed five articles published between 2005 and 2019 that met inclusionary criteria for the review. Primary among the views of the older adults in these studies of a ‘good death’ was the desire to avoid being a burden to families; done so by dying pain-free/peacefully (preferably in sleep) and preparing in advance by involving family in decisions and funeral/estate planning. Family support throughout …

Providing End-Of-Life Counseling: A Narrative Inquiry, Carol Hecht, Sibyl West

Adultspan Journal

This qualitative study aimed to address the gap in the research related to end-of-life counseling by exploring the experiences of counselors working with clients at end of life. While counseling literature and education are lacking regarding end of life, many counselors will work alongside clients approaching death. The purpose of this study was twofold: (a) to better understand the nuanced experiences of counselors providing end-of-life counseling and (b) to explore the supports and preparations helpful for counselors to provide end-of-life counseling. A narrative approach, using the Listening Guide (Gilligan, 2015), was employed to analyze and present the stories of three …

Physical Activity: A Comparison Of Rural And Urban Older Adults' Needs And Preferences, Annette Contrady, Sarah L. Francis, Elgloria Harrison, Doris Montgomery, Catherine Rudolph, Lillie Monroe-Lord, Phd, Rdn, Ld, Elmira Asongwed, Anne Marie Jean Baptiste, Tiffany Johnson-Largent Phd Rdn Ld, B. Michelle Harris, Tia D. Jeffery, Pier Broadnax

The Journal of Extension

Physical activity (PA) rates among older adults are low. We examined and compared the PA needs, preferences, and practices of 118 rural- and urban-residing older adults through focus groups and surveys. The sample was diverse (White = 42.4%, Black = 37.3%), mostly female, food-secure, and not meeting PA recommendations (38.1%). PA rates were lower for rural-residing older adults (p < 0.05). PA motivators were health benefits and socialization, while barriers were cost, pain, low motivation, and health limitations. Preferred PA programs were described as age-appropriate, expert-led, and group-based. These findings provide insight regarding what to consider when planning PA programming for community-residing older adults.

Music Therapy In The Pacu: An Evidence Based Practice Project On Multimodal Postoperative Pain Interventions, Rachael Addison Spruell, Pamela D. Hardesty

Graduate Publications and Other Selected Works - Doctor of Nursing Practice (DNP)

BACKGROUND: Postoperative patients come to the PACU where pain and anxiety are priorities in care. Creating healing environments in PACU is often difficult due to open bays and constant movement and patient transports from operating rooms. Medication is often offered to relieve patients’ unrest in the anxiety-provoking environment, which leads to increased medication needs and prolonged admissions. Studies demonstrate how music therapy with current care practices effectively decrease pain, anxiety, and medication requirements in the PACU.

LOCAL PROBLEM: The setting was the main PACU of a Level I trauma hospital in Tennessee. The PACU nurse manager identified increased …

Considerations Of Medicare Telehealth Services With Older Adults, Sonah Kho, Amanda Dediego

Adultspan Journal

The onset of the COVID-19 pandemic set in motion a rapid expansion of mental health services offered via telehealth. With this rapid expansion came the need to examine how policy and practice should be shaped in a future where telehealth is considered common in counseling practice. For counselors to understand how to support older adult clients in using telehealth services, they must understand telehealth policy. Following the eligibility of licensed counselors to participate in Medicare, counselors need to stay abreast of regulatory changes regarding restrictions and regulations on use of telehealth for mental and behavioral health services, including video and …

Long-Term Clinical Outcome Of Corneal Endothelial Degeneration Managed With Keratoleptynsis In A Chihuahua Dog, Manbok Jeong

The Thai Journal of Veterinary Medicine

A 9-year-old spayed female Chihuahua presented with a 2-month history of progressive corneal edema in the left eye. Slit lamp biomicroscopy showed moderate corneal edema, instability of the axial corneal epithelial surface, and an anterior cortical opacity of the lens. Based on these results, a diagnosis of canine endothelial degeneration was made with the incidental finding of an incipient cataract in the left eye. Keratoleptynsis successfully managed the corneal edema for 28 months after surgery without corneal ulceration. This case study underscores the need for an early surgical approach using keratoleptynsis for dogs with a progressive nature of canine endothelial …

An Undetermined Osteoporotic Disease Managed With Im Rod In A Dog, Hyejong Oh, Byoungho An, Dongwook Kim, Heesoo Ahn, Dongwoo Chang, Gonhyung Kim

The Thai Journal of Veterinary Medicine

Osteoporosis is a systemic bone disorder characterized by decreased bone density, which can weaken bone strength and increase the risk of fractures. Osteogenesis imperfecta (OI), one of the main causes of osteoporosis in children, results in fragile bones and multiple fractures. The present study documented the case of a dog with an undetermined osteoporotic disease managed with intramedullary rod fixation. A 3-month-old intact male Alaskan Malamute dog, weighing 11.6 kg, was presented with lameness in the left pelvic limb. Radiography revealed left pelvic and femoral fractures, and the cortex of the long bones was thin. On CT scanning, a significant …

Synchronous Tri-Cavitary Biphasic Malignant Mesothelioma In A Dog Presenting With Dyspnea, Nawarus Prapaiwan, Tawewan Issarankura Na Ayudhaya, Poonavit Pichayapaiboon, Onrampha Tanglakmankhong

The Thai Journal of Veterinary Medicine

Malignant mesothelioma is an uncommon tumor that has a challenging diagnosis and a tendency for late diagnosis. A 7-year-old intact male dog presented with respiratory distress. Thoracic radiography revealed pleural effusion and bone reactions at multiple ribs. A computerized tomography scan with rib biopsy was suggested as a diagnosis plan. Unfortunately, the dog died. Gross pathological findings demonstrated multifocal to coalescing, pinkish-white firm masses scattered over the parietal pleural surface, extended to the serosa of the diaphragm and the pericardium, making them adhere to each other and causing the coalescence of a white irregular mass at the diaphragm. Multiple white …

Long-Term Tapering Regimen Use Of Oclacitinib For The Control Of Pruritus In An Atopic Dog, Piyarat Chansiripornchai

The Thai Journal of Veterinary Medicine

Abstract

Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory skin disease with a global distribution, yet it is incurable. A key clinical sign of CAD is pruritus. Oclacitinib has proven effective in managing pruritus in atopic dogs. This case report details the long-term administration of oclacitinib every other day for controlling pruritus in an atopic dog. An 8-year-old atopic Bangkaew dog presented with pruritus, alopecia, and recurrent Malassezia pachydermatis infection. To control the pruritus, the dog received oclacitinib at a dose of 0.4 mg/kg orally every 24 hours for 30 weeks. The pruritus visual analog scale (PVAS) decreased from …

Fatal Disseminated Toxoplasmosis In Captive Red Kangaroo (Macropus Rufus) And Parma Wallaby (Macropus Parma): Pathological And Immunohistochemical Investigations, Sawang Kesdangsakonwut

The Thai Journal of Veterinary Medicine

Abstract

Toxoplasmosis is a protozoan zoonosis caused by Toxoplasma gondii. Marsupials are considered a susceptible intermediate host. T. gondii is mainly transmitted to intermediate hosts via the fecal-oral route. A captive red kangaroo was diagnosed with disseminated toxoplasmosis based on clinicopathological and immunohistochemical (IHC) investigations. Two years later, a five-year-old Parma wallaby was kept in the same area as the red kangaroo and showed clinical signs of depression, withdrawal from the troop, and weakness. The wallaby died within two days after showing the clinical signs. Pathological findings in this wallaby were compatible with disseminated toxoplasmosis. Tachyzoites and tissue cysts …

The Importance Of Community Rehabilitation: Evaluating Effectiveness Of Tennessee Interventions, Sarah Grace Knight

Masters Theses

Rehabilitation for offenders has been a topic of discussion for decades. While the system expresses that rehabilitation is the best method of practice, statistics show that these individuals still struggle to reenter society successfully. This study addresses environmental factors and barriers that can make the reentry process difficult and increase chances of recidivism. Additionally, this article takes a look at the state of Tennessee in particular, considering its high crime and recidivism rates. While many states have programs in place, it is apparent that the government needs to focus on creating more stable financial budgets for both community and prison …

Designing A Novel Approach To Cadaveric Dissection And Evaluation Of The Lacrimal Gland Anatomy, Maresa Joanna Mcdowell

Doctoral Dissertations and Projects

During our study, the orbital dissections of 44 cadavers were analyzed, and the lacrimal gland's condition after dissection was evaluated. Medical students previously dissected twenty-two of the cadavers using the dissection steps outlined in Grant’s Dissector. From these, 21 student groups performed orbital dissection using the two approaches outlined in Grant’s Dissector. Post-evaluation of Grant’s anterior approach (GAA) showed that 50% of the lacrimal glands had signs of damage to the orbital lobe, and 88.89% of the palpebral lobe were damaged. When Grant’s supraorbital approach (GSA) was used, 70% of the palpebral lobes showed signs of damage compared to the …

A Holistic Approach To Music For Stress Management During Pregnancy, Danielle Emily Dixon

Doctoral Dissertations and Projects

Pregnancy is a transformative journey for women, but amidst the excitement and anticipation that most women experience, pregnancy often raises stress levels to profound heights for various reasons, which may include hormonal fluctuations, physical discomforts, concerns about the baby’s health, financial pressures, relationship changes, fear of labor and birth, life adjustments, and societal expectations. The purpose of this qualitative hermeneutic phenomenological study was to examine how music interventions impacted stress levels during pregnancy. This two-week study employed an in-person group experiment involving pregnant women. The study sample was selected via voluntary response sampling, where pregnant women volunteered to participate in …

Exploring The Correlation Between Climate Change And Influenza Activity In The Northeast United States, 2003-2023, Emily M. Posadas

Doctoral Dissertations and Projects

The influenza virus is influenced by a myriad of complex interactions with human and environmental factors, with changing climate patterns having significant effects on the health status of a population. This study investigates the correlation between climate change and influenza activity in the northeast United States from 2003 to 2023, providing insight and understanding into the interaction between the two variables. The anthropogenic factors that have contributed to climate change are recognized, and circulating seasonal and avian influenza viruses are discussed within the context of climate change. The investigation of the correlation between climate change and influenza activity across this …

A Qualitative Examination Of Food Choice Among Division Iii Student Athletes Using Grounded Theory, Paul Webster Craig

Doctoral Dissertations and Projects

The determinants of food choice among the general population have been extensively investigated, but studies of food choice in collegiate student athletes are limited. Student athletes make food choices daily, and the selection of foods is an integral part of an athlete’s training regimen. National Collegiate Athletic Association (NCAA) Division III (DIII) student athletes are a comparatively unstudied population, particularly in terms of their food choices; therefore, assessing and understanding the influences of food choices in this population can enable and support optimal eating behavior. To assess different determinants of food choice in athletes, this qualitative study developed a theoretical …

The Effects Of High-Fidelity Bereavement Simulation On Perinatal Nurse Attitude And Comfort With Providing Bereavement Care For Patients Experiencing Perinatal Loss, Victoria Jule Johnson

Doctoral Dissertations and Projects

Perinatal loss is a global phenomenon that requires holistic and individualized care of patients. Nurses are responsible for providing most bereavement care after the loss of a pregnancy or infant; however, nurses commonly experience a lack of education and exposure to ways to promote high-quality bereavement care, leading to nurse discomfort providing perinatal bereavement care. The purpose of the study is to examine if high-fidelity perinatal bereavement simulation is an effective method to increase nurse comfort and improve nurse attitudes toward providing perinatal bereavement care. Data was collected using a quantitative quasi-experimental one-group pretest-posttest research design using a sample of …

Building Confidence, Diminishing Stress: A Clinical Incivility Management Initiative For Nursing Students, Younglee Kim, Phoebe (Yeon) S. Kim, Henrietta Nwamu, Anne Lama

Nursing Faculty Publications

Objective: The aim of this study was to evaluate the effectiveness of an interactive program designed to reduce nursing students’ perceived stress and improve self-efficacy and readiness to professionally address incivility during clinical practice. Background: Incivility in clinical settings adversely impacts learners, educators, institutions, and healthcare systems, undermining safety and the teaching–learning process. Despite its increasing global prevalence, effective interventions remain largely unexplored. Methods: Our mixed-methods study, conducted from March to April 2024, involved senior baccalaureate pre-licensure nursing students (N = 35) from a California State University. The three-week, one-hour-per-week, interactive clinical incivility management program was developed through an extensive …

Economic Impacts Of Establishing A Neutron Source Facility In Windsor, Abdur Rahman

Major Papers

Cancer poses a significant health challenge in Canada, with two in five individuals likely to develop the disease. This paper explores the economic impacts of establishing a prototype compact accelerator-based neutron source (PC-CANS) facility in Windsor that will produce medical isotopes locally in Windsor, Ontario, rather than relying on centralized production and transportation from London, Ontario. Fluorine-18 medical isotopes, crucial for positron emission tomography (PET) scans, experience significant decay losses during transportation due to their short half-life of 109.8 minutes, increasing costs and restricting availability. Using a differential analysis approach, the study quantifies economic benefits, focusing on three main impacts: …

Lingual Histiocytic Sarcoma In A Dog: A Case Report, Seulgi Bae

The Thai Journal of Veterinary Medicine

An 8-year-old spayed Maltese dog was presented for the evaluation of a lingual mass. The dog had excessive drooling and dysphagia. Oral examination revealed a soft, fluctuating mass at the left side of the tongue. Computed tomography showed a 21 × 32 × 66 mm lingual mass and enlarged left medial retropharyngeal lymph node. On cytology of the lingual mass, a round cell tumor was suspected; however, it was not responsive to glucocorticoid therapy. Because of severe complications, glossectomy and lymphadenectomy were performed; unfortunately, the patient died because of dyspnea in the postoperative period. Histopathologic examination and immunohistochemistry revealed lingual …

Removal Of Common Antimicrobial Agents By Sustained Low- Efficiency Dialysis, Joanna Q. Hudson Pharmd, Bcps, Fasn, Fccp, Madelyn N. Hilgers Bs, Pharmd Candidate, Elvira O. Gosmanova Md

Faculty Publications

Adequate dosing of antimicrobials is paramount for treating infections in critically ill patients undergoing kidney replacement therapy; however, little is known about antimicrobial removal by sustained low-efficiency dialysis (SLED). The objective was to quantify the removal of cefepime, daptomycin, meropenem, piperacillin–tazobactam, and vancomycin in patients undergoing SLED. Adult patients ≥18 years with acute kidney injury (AKI) or end-stage kidney disease receiving one of the select antimicrobials and requiring SLED were included. Blood and dialysate flow rates were maintained at 250 and 100 mL/min, respectively. Simultaneous arterial and venous blood samples for the analysis of antibiotic concentrations were collected hourly for …

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods For Peripheral Nerve Regeneration, Jacob Lee Carter

Theses and Dissertations

Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A …

Efficiency Of One Against One Game Situations In Polish Soccer National Team And Their Opponents During Uefa European Championship Matches, Andrzej Szwarc, Krzysztof Kromke, Henryk Duda, Andrzej Soroka, Lukasz Radziminski

Baltic Journal of Health and Physical Activity

Introduction: The purpose of this study was to assess the efficiency in one against one (1v1) game situations of Polish national team soccer players and their opponents in 12 matches of the group stage in 4 consecutive cup finals at the European Championship in the years 2008–2021. Material and methods: Audio-visual records of matches were analysed and data about the game were recorded on a self-developed observation sheet. Activity, effectiveness and reliability of individual offensive and defensive actions were assessed in the context of implementation of the game objectives. Results: It was found that the Polish players were involved in …

Wmdds Bulletin Winter 2021

West Michigan District Dental Society Bulletin

In the Winter 2021 issue, the reader will find the following feature articles:

• Seeking Out COVID-19 Vaccine Information
• Dentists Beyond the Chair: Trap and Skeet Shooting, Judd Carroll, DMD

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Spring 2021

West Michigan District Dental Society Bulletin

In the Spring 2021 issue, the reader will find the following feature articles:

• Be Part of the Solution: The Dental Needs of Refugee and Immigrant Youth
• Dentists Beyond the Chair: Monoskiing, Jeffrey Heinz, DDS, MSD

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Summer 2021

West Michigan District Dental Society Bulletin

In the Summer 2021 issue, the reader will find the following feature articles:

• Doppelgangers: Katie Swan and Katie Swanson
• GRCC 2021 Graduation Highlights

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Holiday 2021

West Michigan District Dental Society Bulletin

In the Holiday 2021 issue, the reader will find the following feature articles:

• Spectrum Health Youth Behavioral Health Initiatives: Increasing Dental Provider Awareness
• Dentists Doing Good: Local WMDDS Dentists Doing GREAT
• Free CE and Certification: Penn Dental Medicine’s Person with Disabilities Series

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.