Medicine and Health Sciences Commons^™

“I Have A Lot Of Pvcs And I Need To See A Cardiologist”, Ravi Choxi, Arun Kundra

Transformative Medicine (T-Med)

No abstract provided.

Forest Therapy For Anxiety, Fiteh Yelekal, Nipa Doshi

Transformative Medicine (T-Med)

No abstract provided.

Multidisciplinary Retreatment Of Skeletal Class Ii Malocclusion With Obstructive Sleep Apnea And Multiple Prosthesis, Si-Rong Chen, Cheng-Hui Lin, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

Obstructive sleep apnea (OSA) is a common sleep disorder syndrome, especially in the middle-aged, obese men population. Patients suffer from an interrupted sleep at night, which could be life-threatening. Treatment alternatives include continuous positive airway pressure, mandible advanced device, nasal surgery and maxillo-mandibular advancement surgery. This article presented a patient who came with chief complaints of lower jaw retrusion, poor sleep quality, unsatisfactory occlusion and old prosthesis. The patient had declined the surgical-orthodontics in 12 years ago, and went for another camouflage orthodontic treatment with extraction of teeth and multiple prosthesis. He presented with skeletal Class II with retrognathic mandible …

Camouflage Treatment Of Skeletal Anterior Open Bite With Tongue Training, Cheng-Han Sie, Wen-Ken Tai, Chih-Chen Chou, Po-Yu Yang, Jung-Chun Yeh, Chun-Te Ho, Chia-Tze Kao

Taiwanese Journal of Orthodontics

The aim of this case report was to present an adult patient who suffered from poor occlusal function and poor aesthetic appearance due to skeletal anterior open bite. After orthodontic treatment, she was satisfied with improvements of mastication and esthetics. A case of 20-year-old female with skeletal Class II jaw relationship, mandible retrognathism and anterior open bite without signs and symptoms of temporomandibular disorder. Intraoral examination showed premature contact over bilateral posterior teeth and the forward resting position of tongue. Our treatment plan was orthodontic camouflage with extraction of all first premolars and tongue training. As forward resting position of …

Quality Of Life Changes In Taiwanese Patients With Dentofacial Deformities Undergoing Orthognathic Surgery, Jing Hao Ng, I-Chen Lee, Becky Chiang-Lin Liu, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

Objectives: The evaluation of orthognathic surgery (OgS) is shifting towards a coherent approach for patient care that balances objective clinician-defined measures with patient-centred outcome assessments, including health-related quality of life (QoL). This aim of this study adds to the pool of literature in East Asian subjects by studying the longitudinal QoL changes in Taiwanese patients with dentofacial deformities (DFD) undergoing OgS, using two standardized questionnaires at three different treatment stages. Materials and Methods: This prospective cohort study comprised 113 consecutive Taiwanese OgS patients who underwent surgical-orthodontic treatment between 2015 and 2018. The subjects completed SF-36 and OHIP-14 standardized questionnaires with …

Comparison Of Bone Thickness In Infrazygomatic Crest Area At Various Miniscrew Insertion Angles: A Cone-Beam Computed Tomographic Study, Rajju Dangal, Rabindra Man Shrestha, Jyoti Dhakal, Sujita Shrestha, Alka Gupta, Shreya Shah

Taiwanese Journal of Orthodontics

Introduction: The infrazygomatic crest (IZC) is an alternative site for miniscrew anchorage. It is important to analyze the anatomy of the region during preoperative planning to minimize the risk of unwanted tooth movement and injury to the vital structures. The literatures on the clinical application of miniscrew in IZC is scarce. Objective: To determine bone thickness, height and angle of insertion of miniscrew in the IZC region. Materials and methods: This cross-sectional observational comparative study included 44 patients above18 years. IZC bone thickness and height of miniscrew insertion were measured on cone-beam computed tomographic (CBCT) records. Student t-test was done …

Cephalometric Analysis: History And Clinical Application, Ib Leth Nielsen

Taiwanese Journal of Orthodontics

When roentgen cephalometry was first introduced to the orthodontic profession in 1931 by Broadbent in the USA and Hofrath in Germany it was a major milestone in terms of new diagnostic tools available to orthodontists. Until that time only clinical observation and study casts of the patients had been available to the clinician but now a more in depth understanding of the facial makeup became possible. This meant that each patient’s malocclusion could now be related to their facial skeletal and dental morphology. The dentoalveolar components could now be studied in detail and better treatment plans could be developed that …

2022-12-27_Michiganoverview_Isdreporting, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The K-12 Aged ISD Reporting page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/k-to-12-aged-isd-reporting.

This report is created from data reported by the Michigan Disease Surveillance System (MDSS) the Michigan Department of Health and Human Services' web-based communicable disease reporting system. Data is updated every week.

The purpose of the dashboard is to report the 7 day average of COVID-19 cases in Michigan school students aged 5 through 18 at the intermediate school district and school district levels, as well as display trends over time to better illustrate the changing nature of the COVID-19 pandemic. Cases are attributed to …

2022-12-27_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

2022-12-27_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/stats.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

Financing Benefits And Barriers To Routine Hiv Screening In Clinical Settings In The United States: A Scoping Review, Hani Serag, Isabel Clark, Cherith Naig, David Lakey, Yordanos M. Tiruneh

School of Medicine Faculty Publications and Presentations

The Centers for Disease Control and Prevention recommends everyone between 13--64 years be tested for HIV at least once as a routine procedure. Routine HIV screening is reimbursable by Medicare, Medicaid, expanded Medicaid, and most commercial insurance plans. Yet, scaling-up HIV routine screening remains a challenge. We conducted a scoping review for studies on financial benefits and barriers associated with HIV screening in clinical settings in the U.S. to inform an evidence-based strategy to scale-up routine HIV screening. We searched Ovid MEDLINE®, Cochrane, and Scopus for studies published between 2006-2020 in English. The search identified 383 Citations; we screened 220 …

Can The Inhibition Of Natural Manifestations In Pandemics Cause Chronic Diseases Later?, Indu Shukla

Indian Journal of Research in Homoeopathy

Recent publications in various medical journals have focused on coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has gravely impacted the entire world. But hardly anyone discusses the consequences of its suppression by the widespread use of covid vaccines as a mandatory measure in almost all countries of the world. Through your esteemed journal, I would like to draw the attention of the entire homoeopathy fraternity towards this, in light of the Hahnemannian philosophy and propose anti-miasmatic treatment of the same.

Covid-19 Vaccination: Hesitancy, Side Effects And Homoeopathy, Subhash Kaushik

Indian Journal of Research in Homoeopathy

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Lycopodium Clavatum As An Inhibitor Of Monosodium Urate Crystallisation In Gout: An In Vitro Study, Sithara Perveen P, Kr Mansoor Ali, Sheeba Veluthoor, Jijith U.S, Nithya T, Afiya Alloor, Shijil V K

Indian Journal of Research in Homoeopathy

Background: Hyperuricaemia plays a significant role in the development and pathogenesis of several metabolic and systemic disorders including metabolic syndrome, hypertension, stroke and atherosclerosis. Lycopodium clavatum is the most widely used drug in homoeopathy for treating hyperuricaemia and gout. However, its mechanism of action in reducing serum uric acid remains uncertain. Objective: The objective of the study was to study the potential role of homoeopathic preparation of Lycopodium clavatum in different potencies on monosodium urate crystallisation in vitro. Methods: Spectrophotometric crystallisation assay was carried out on a stock solution of 5 ml of uric acid after its …

Scope Of Homoeopathy In The Treatment Of Depression: A Narrative Synthesis, Karunakara Moorthi, Radhika P, Manu Chandran, K.C. Muraleedharan

Indian Journal of Research in Homoeopathy

Background: Depression is a disorder of major public health importance, in terms of its prevalence and suffering, dysfunction, morbidity and economic burden. Depression is one of the most common conditions for which people seek homoeopathic treatment. Objective: This study is aimed to understand the scope of homoeopathy in depression based on the results of previous studies. Methods: A study was done to evince the scope of homoeopathic medicines in the treatment of depression. Searches were done in both general and specialised databases. The data were collected from peer-reviewed journals published between January 2001 and January 2021. Efforts …

Covid-19 Vaccines And Homoeopathy – An Integrative Review, Deepthi Gilla, S R Sreelakshmy, Bsj Raja Kumar

Indian Journal of Research in Homoeopathy

Background: The COVID-19 pandemic has brought millions of people at risk. Clinical trials of several known antiviral drugs and vaccines have been done. Homoeopathy is known to be effective in the prevention and treatment of infectious diseases as well as in overcoming some adverse effects of vaccination. Objectives: The objectives of this review were to identify the adverse effects of COVID-19 vaccination from the published literature and doing homoeopathic repertorisation to find out indicated remedies for alleviating the ill effects of COVID-19 vaccines. Methods: Published literature was searched for ‘Covid-19’, ‘Vaccination’ and ‘Adverse events’ in PubMed between …

Homoeopathy In Plantar Psoriasis: An Evidence-Based Case Report, Gr Kiranmayee Rompicherla, Hima Bindu Ponnam

Indian Journal of Research in Homoeopathy

Introduction: Plantar psoriasis is a variant of psoriasis and accounts for 3–4% of total cases of psoriasis. Psoriasis, an autoimmune and chronic inflammatory disease of the skin, can leave the patient in agony with its distressing infection episodes. The homoeopathic system of medicine offers a wide range of medicines that can have a beneficial role in managing cases of psoriasis as depicted in the previous studies. Case summary: A distinct case of plantar psoriasis treated with homoeopathic remedies of ultra-high dilution has been presented here. The evidence-based illustrations were done before and after the treatment and the periodical objective …

Homoeopathic Treatment Of A Diabetic Covid-19 Patient With The Complication Of Bronchitis And Pleural Effusion - A Case Report, Alok Ghosh, Sadia Kamal

Indian Journal of Research in Homoeopathy

Introduction: COVID-19 is a novel SARS-CoV-2 disease that has caused a worldwide pandemic. It is highly contagious and produces severe acute respiratory syndrome. Many homoeopathic medicines have been suggested for treatment of COVID cases and reports have also been published. Case Summary: The present case report is of a 61-year-old COVID-positive, male, presenting with complications such as bronchitis and pleural effusion. He was treated for COVID-19 with a suitable homoeopathic medicine, based on the totality of symptoms, while the patient continued his regular regime of conventional medicine for diabetes mellitus and hypertension. The indicated remedy led to immediate relief …

Homeopathic Management Of Reinke’S Edema In A Non-Smoker: A Case Report, Aditya Pareek

Indian Journal of Research in Homoeopathy

Introduction: Reinke’s edema, also known as polypoid degeneration of vocal cords, is a bilateral, symmetrical swelling of the whole of the membranous part of the vocal cords. Surgery has been the mainstay of treatment for Reinke’s edema. Thus, patients are often left with practically no non-invasive treatment option. Case Summary: This is the case of a 40-year-old male, teacher, who presented with hoarseness of voice for 1 year and opted for homeopathic treatment when he was advised surgery. A rapid improvement in the symptoms, as well as significant objective improvement as confirmed with video laryngoscopy. The results were …

A Scientific Convention On The World Homoeopathy Day: ‘Homoeopathy: People’S Choice For Wellness’ – A Conference Report, Babita Rani Kondle, Divya Taneja, Subhash Kaushik

Indian Journal of Research in Homoeopathy

Three apex bodies, namely the Central Council for Research in Homoeopathy, the National Commission for Homoeopathy and the National Institute of Homoeopathy, jointly organised a scientific convention on the occasion of the World Homoeopathy Day to commemorate the 267th birth anniversary of the founder of Homoeopathy, Dr Christian Fredrich Samuel Hahnemann which was held on 9 and 10 April 2022 at New Delhi on the theme ‘Homoeopathy: People’s Choice for Wellness’. Over the 2 days, scientific sessions and interactive meets were held. This convention was an opportunity to review the developments in the field of Homoeopathy and formulate future strategies …

Reply To Hahnemann's Position On Vaccination: A Call To Rethink., Rudi Verspoor

Indian Journal of Research in Homoeopathy

There is a debate on the merits of modern vaccination in relation to Hahnemann’s position regarding this practice in his time. The authors of a recent Letter to the Editor argue that Hahnemann was in favour of vaccination and that we need to assess vaccination objectively. I agree with both of these positions, but disagree as to the details regarding what is meant by these two conclusions. I argue that Hahnemann made clear that vaccination did not provide immunity, and never can. I further argue that there are better alternatives to vaccination in terms of boosting the immune system, and …

Acknowledgement To Our Reviewers (2022), Ijrh Editorial Board

Indian Journal of Research in Homoeopathy

Indian Journal of Research in Homoeopathy editorial team duly acknowledges the following reviewers, who reviewed the articles in the year 2022. Their invaluable and timely efforts enabled a fair and rigorous peer review process. Also, the valued recommendations of the Editorial Advisory Board members are also deeply acknowledged.

2022-12-27_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

Aa And Dha Are Decreased In Paediatric Ad/Hd And Inattention Is Ameliorated By Increased Plasma Dha, John J. Miklavcic, Ellen Ivity, Ian M. Macdonald, Liana Urichuk, Vera C. Mazurak, Christina Rinaldi, Michael T. Clandinin

Food Science Faculty Articles and Research

The purpose of this study was to assess long chain polyunsaturated fatty acid (LCPUFA) status in relation to socio-behavioral outcomes in children with Attention Deficit/Hyperactivity Disorder (AD/HD). In a case-control design, plasma phospholipid fatty acid content was assessed in children aged 5–12 years with AD/HD and in typically functioning children. Dietary intakes of LCPUFAs arachidonic acid (AA; 20:4n6) and docosahexaenoic acid (DHA; 22:6n3) were quantified using a four-day food record, polymorphisms were determined in FADS1 and FADS2, and socio-behavioral outcomes were assessed using the Conners 3 Parent Rating Scales in a cross section of children with AD/HD. Compared to …

Structure-Based Rational Design Of Small Α-Helical Peptides With Broad-Spectrum Activity Against Multidrug-Resistant Pathogens, Sandeep Lohan, Anastasia G. Konshina, Roman G. Efremov, Innokentiy Maslennikov, Keykavous Parang

Pharmacy Faculty Articles and Research

A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal activity and selectivity toward the bacterial cells. The analysis identified a lead 12-mer peptide 8b with broad-spectrum activity against Gram-positive (MIC = 3.1–6.2 μg/mL) and Gram-negative (MIC = 6.2–12.5 μg/mL) bacteria and selectivity toward prokaryotic versus eukaryotic cells (HC50 = 280 μg/mL, >75% cell viability at 150 μg/mL). The rapid membranolytic action of 8b was demonstrated by a calcein dye leakage assay and confirmed using scanning electron microscopy. According to circular dichroism and NMR spectroscopy, the peptides have an …

The Performance Of Plasma Amyloid Beta Measurements In Identifying Amyloid Plaques In Alzheimer's Disease: A Literature Review, Abby L Brand, Paige E Lawler, James G Bollinger, Yan Li, Suzanne E Schindler, Melody Li, Samir Lopez, Vitaliy Ovod, Akinori Nakamura, Leslie M Shaw, Henrik Zetterberg, Oskar Hansson, Randall J Bateman

2020-Current year OA Pubs

The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD). Detection of Aβ pathology is essential for AD diagnosis and for identifying and recruiting research participants for clinical trials evaluating disease-modifying therapies. Currently, AD diagnoses are usually made by clinical assessments, although detection of AD pathology with positron emission tomography (PET) scans or cerebrospinal fluid (CSF) analysis can be used by specialty clinics. These measures of Aβ aggregation, e.g. plaques, protofibrils, and oligomers, are medically invasive and often only available at specialized medical centers or not covered by medical insurance, and PET …

The Diagnostic Performance Of Ultrasonography In The Evaluation Of Extrathyroidal Extension In Papillary Thyroid Carcinoma: A Systematic Review And Meta-Analysis, Peter P. Issa, Aaron L. Albuck, Eslam Hossam, Mohammad Hussein, Mohamed Aboueisha, Abdallah S. Attia, Mahmoud Omar, Seif Abdelrahman, Gehad Naser, Robert D.E. Clark, Eman Toraih, Emad Kandil

School of Medicine Faculty Publications

Extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) is an indication of disease progression and can influence treatment aggressiveness. This meta-analysis assesses the diagnostic accuracy of ultrasonography (US) in detecting ETE. A systematic review and meta-analysis were performed by searching PubMed, Embase, and Cochrane for studies published up to April 2022. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated. The areas under the curve (AUC) for summary receiver operating curves were compared. A total of 11 studies analyzed ETE in 3795 patients with PTC. The sensitivity of ETE detection was 76% (95%CI = 74–78%). The …

Diverse Monogenic Subforms Of Human Spermatogenic Failure, Liina Nagirnaja, Wu-Lin Charng, Christina A Gurnett, Kenan R Omurtag, Et Al.

2020-Current year OA Pubs

Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable. Defining the genetic basis of NOA has proven challenging, and the most advanced classification of NOA subforms is not based on genetics, but simple description of testis histology. In this study, we exome-sequenced over 1000 clinically diagnosed NOA cases and identified a plausible recessive Mendelian cause in 20%. We find further support for 21 genes in a 2-stage burden test with 2072 cases and 11,587 fertile controls. The disrupted genes are primarily on the autosomes, enriched for undescribed human "knockouts", and, for the most part, have …

Patient Factors Impacting Perioperative Outcomes For T1b-T2 Localized Renal Cell Carcinoma May Guide Decision For Partial Versus Radical Nephrectomy, Yash B Shah, Rishabh K Simhal, Kerith Wang, Hanan Goldberg, Costas D. Lallas, Thenappan Chandrasekar

Department of Urology Faculty Papers

There remains debate surrounding partial (PN) versus radical nephrectomy (RN) for T1b-T2 renal cell carcinoma (RCC). PN offers nephron-sparing benefits but involves increased perioperative complications. RN putatively maximizes oncologic benefit with complex tumors. We analyzed newly available nephrectomy-specific NSQIP data to elucidate predictors of perioperative outcomes in localized T1b-T2 RCC. We identified 2094 patients undergoing nephrectomy between 2019-2020. Captured variables include surgical procedure and approach, staging, comorbidities, prophylaxis, peri-operative complications, reoperations, and readmissions. 816 patients received PN while 1278 received RN. Reoperation rates were comparable; however, PN patients more commonly experienced 30-day readmissions (7.0% vs. 4.7%, p = 0.026), bleeds …

Role Of Adenylyl Cyclase Type 7 In Functions Of Bv-2 Microglia, Yawen Hu, Rebecca A. Hill, Masami Yoshimura

School of Medicine Faculty Publications

To assess the role of adenylyl cyclase type 7 (AC7) in microglia’s immune function, we generated AC7 gene knockout (AC7 KO) clones from a mouse microglial cell line, BV-2, using the CRISPR-Cas9 gene editing system. The ability of BV-2 cells to generate cAMP and their innate immune functions were examined in the presence or absence of ethanol. The parental BV-2 cells showed robust cAMP production when stimulated with prostaglandin-E1 (PGE1) and ethanol increased cAMP production in a dose-dependent manner. AC7 KO clones of BV-2 cells showed diminished and ethanol-insensitive cAMP production. The phagocytic activity of the parental BV-2 cells was …