Medicine and Health Sciences Commons^™

Mental Health In Sports Media, Samuel Ridgley

Communication & Media Studies | Senior Theses

This paper looks at the increasingly popular conversation surrounding mental health in sports. It provides a glimpse into how common the struggle of mental health can be for many high-level athletes while also examining the narrative and expectations that society and the media have created. The paper also provides examples of prominent athletes from a variety of different sports and delves into their personal mental health experiences in the eyes of the media. The goal of this paper is to show the progression and change of how the media portrays mental health amongst athletes in today’s ever-changing world.

The Influence Of Apoe Genotype On Lipid Droplet Dynamics, Cassi Friday

Theses and Dissertations--Physiology

Excess lipid droplet (LD) accumulation is associated with several pathological states, including neurodegenerative disorders such as Alzheimer’s disease (AD). However, the mechanism(s) by which changes in LD composition and dynamics may contribute to the pathophysiology of AD remains unclear. Apolipoprotein E (ApoE) is a droplet-related protein with a common variant (ApoE4) that confers the largest increase in genetic risk for late-onset AD. Interestingly, ApoE4 is associated with both increased neuroinflammation and excess LD accumulation. This dissertation work seeks to quantitatively profile the lipid and protein composition of LDs between the ‘neutral’ ApoE3 and ‘risk’ ApoE4 isoforms, in order to gain …

Role Of Autophagy In Aortic Aneurysms, Aida Javidan

Theses and Dissertations--Pharmacology and Nutritional Sciences

Abdominal Aortic Aneurysms (AAAs) are permanent dilations of the abdominal aorta with greater than 80% mortality after rupture. Currently, there are no proven non-surgical therapeutics to blunt expansion or rupture, which highlights the need to gain mechanistic insights into AAA formation. AAA formation involves a complex process of destruction of aortic media through activation of matrix metalloproteinases (MMPs), loss of smooth muscle cells, degradation of extracellular matrix proteins like elastin and collagen, and inflammation. Autophagy is a well-conserved cellular process whereby damaged cytoplasmic organelles and long-lived proteins are degraded. Cellular autophagic activity is usually low under normal conditions but can …

Mitochondria As Causes Of And Therapeutic Targets In Chronic Post-Sepsis Skeletal Muscle Weakness, Meagan Scott Kingren

Theses and Dissertations--Pharmacology and Nutritional Sciences

Sepsis, or the organ damage that ensues after the body fails to properly contain a local infection, is the leading cause of in-patient hospitalization in the United States. Advances in critical care medicine over the last 20 years have enabled most sepsis patients to survive the life-threatening dysregulated immune response. However, a majority of survivors report chronic weakness and fatigue years after sepsis, and the cause of this weakness remains largely unknown. This dissertation work focused first on elucidating the major causes of post-sepsis muscle weakness (Aim 1). This aim involved a time-course study to determine when muscle weakness was …

Exploring Risk Factors Associated With Post-Traumatic Stress Disorder Symptomatology In Police, Lori Camacho

Electronic Theses and Dissertations, 2020-

Mental health outcomes, especially post-traumatic stress disorder (PTSD), in police have become more of a concern for law enforcement administrators, peers, family and friends. Using culture as a theoretical framework, the current cross-sectional, convergent mixed methods study explored the relationship between personal cumulative exposure to different types of critical incidents and likelihood of reporting PTSD symptoms in a sample of officers (n=71) from one municipal police department. This study also examined how personal cumulative exposure to different types of critical incidents and likelihood of reporting symptoms of PTSD may be moderated by the degree of perception of social support from …

A Digitally Enhanced Virtual Cognitive Behavior Skill Building Intervention To Reduce Parent Stress And Family Obesogenic Behaviors, Sharlene Smith

Electronic Theses and Dissertations, 2020-

Parental stress is associated with increased obesogenic family lifestyle behaviors contributing to childhood obesity. Novel interventions are needed to reduce parental stress and improve healthy lifestyle behaviors for preschool-age children and families. The primary study aim was to analyze preliminary effects of a digitally enhanced evidence-based cognitive- behavior skill-building (CBSB) intervention on parental stress and healthy lifestyle behaviors (diet and physical activity) among parents of preschool-age children. A secondary aim was to evaluate feasibility/acceptability of this school-based virtual intervention during the COVID-19 pandemic. The 12-week intervention involved text messaging and three pre-recorded CBSB educational video presentations accessed by parents of …

Role Of Vitamin D, Folate, And Cobalamin Deficiency In Mycobacterium Avium Paratuberculosis Infection And Inflammation, Joseph Vaccaro

Electronic Theses and Dissertations, 2020-

Vitamin D, folate, and cobalamin (vitamin B12) are crucial micronutrients in human physiology that are necessary for healthy calcium, phosphorus, and single-carbon metabolism. Recent studies have indicated that these vitamins also affect the inflammatory response in ways unrelated to their well-characterized deficiencies. Accordingly, analysis of their effect on chronic inflammatory diseases like Crohn's disease (CD) is warranted. This investigation examines the effects of vitamin deficiency on macrophages and intestinal epithelial cells upon exposure to Mycobacterium avium paratuberculosis (MAP,) a pathogen capable of triggering CD, to model the inflammatory response in clinical CD patients. ELISA analysis of CD patient plasma established …

Discharge Education Protocol To Improve Patient Satisfaction, Courtney Banzon

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background: Discharge education that is patient-centered and started in a timely manner provides patients with the knowledge to care for themselves in the home setting and prevent adverse outcomes from occurring.
Methods: A discharge education protocol was implemented on a cardiology inpatient unit. The registered nurses were given a discharge checklist that focused on education and discharge planning with the patient within 24 hours of admission. Patients completed a survey that measured satisfaction of staff education. Surveys were collected for 10 weeks pre-intervention and compared with surveys 10 weeks post-intervention. Data was collected on the time of discharge with the …

Implementation Of A Suicide Prevention Program In A Rural School, Mackenzie Wieser

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Introduction: Suicide is a leading cause of death among today's youth. One in six youth have seriously considered attempting suicide, and one in 13 have attempted suicide at least once. Timely identification of those at risk and connection with appropriate help are critical. Elementary, middle, and high school teachers are ideally positioned to act as gatekeepers through early recognition of students in psychological distress and timely response and referral when appropriate.
Evidence Summary: Teachers report a sense of responsibility for providing indirect mental health services to youth but have a lack of sufficient training and preparedness. Kognito online simulations have …

The Effects Of Positive Behavioral Interventions And Supports On Emotional Regulation In Preschool Children, Alyssa Richardson

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Purpose: Positive Behavioral Interventions and Support (PBIS) is an evidence-based three-tiered framework that supports children and their behavioral needs including emotional behaviors. Emotional behavioral problems (EBP) seen at an early age have a major connection to their preschool setting and a significant effect on future long-term mental and physical health outcomes. 11
Methods: Preintervention, teachers completed PBIS and Teacher Observations of Classroom Adaptation-Checklist (TOCA-C) training. The teachers evaluated and assigned each student to a PBIS tier group using TOCA-C. Tier appropriate interventions were then implemented. TOCA-C was used 3 months post intervention to reevaluate each months post intervention to …

The Implementation Of A Palliative Needs Screening Intervention In A Neuro Critical Care Unit:, Marcus Goodfellow

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Purpose: Palliative care (PC) is an important and yet underutilized discipline in neuro critical care units (NCCUs). The purpose of this project was to integrate and improve PC in a NCCU by implementing a Palliative Needs Screening Intervention (PNSI). A PNSI consists of a list of criteria used to screen patients to identify family and patient PC needs.
Methods: A quality improvement project using a PNSI was implemented in a NCCU. Nurses completed 2 hours of pre-implementation PC education and a palliative perceived self-efficacy scale pre/post-implementation. A PNSI was developed and integrated into the NCCU’s daily rounding process.
Results: PNSI …

Impact Of A Respiratory Health Program On Attitudes, Knowledge, And Behaviors Related To Respirator Use In Farmers And Ranchers, Rebecca White

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background: Studies show an association between agricultural occupational hazards and respiratory illnesses. Personal protective equipment (PPE) has protective effects, but limited education and inadequate respiratory protection are common among agricultural workers.
Methods: A demographic questionnaire and two pre-intervention surveys were initially administered to farmers and ranchers. The surveys measured attitude, knowledge, and behaviors related to respiratory safety and PPE practices. Pulmonary function testing, educational handouts, and respirator fit testing was provided in a variety of settings, and one N95 mask was given to each participant. Two surveys were distributed 3 months post-intervention.
Results: The pre- and post-intervention surveys were matched …

Chronic Pain Assessment And Documentation Protocol Implementation In Home Health Care, Lannese Purtell

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background/Purpose: Chronic pain management protocols are necessary in all aspects of health care to reduce negative perceptions and improve knowledge and comfort when caring for patients with chronic pain.
Methods: A pre-implementation Simplified Knowledge and Attitude Survey Regarding Pain (KASRP) and Comfort Survey were administered to rural Midwest home health nursing staff followed by implementation of a chronic pain management protocol. The protocol included an educational session on understanding and managing chronic pain, the use of the OPQRST handout to guide proper documentation, Pain Risk Factors Assessment Form, and a Managing Chronic Pain handout. The Simplified KASRP and Comfort Surveys …

Improving Unlicensed Staff And Nurses’ Knowledge, Attitudes, And Practices Associated With Fluid Status Monitoring By The Utilization Of A Fluid Status Monitoring Protocol, Brittni Roberts

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background: Monitoring fluid status may prevent adverse patient outcomes. Nurses and unlicensed staff are responsible for inpatient fluid status monitoring and documentation.
Methods: Registered nurses and unlicensed staff completed a pre-intervention questionnaire measuring their knowledge, attitudes, and practices related to fluid status monitoring. They then completed an education session on fluid status monitoring and the new protocol. This protocol includes use of a fluid balance chart, a standardized daily weight process, and allowed patient participation. The protocol was implemented for 2 months, and the questionnaire was completed again post implementation.
Results: The results were analyzed using a Wilcoxon signed-rank test …

For “Them”, Not Us: A Qualitative Study Of Asian American Pacific Islander Perceptions Of Substance Use And Harm Reduction, Winnie Ho

Public Health Theses

Background: Asian American Pacific Islander (AAPI) substance use data is typically aggregated in a way that not only produces overly generalized results, but also potentially perpetuates stereotypes created by the Model Minority Myth (MMM). This has mutually reinforced a lack of representation and understanding of AAPI substance use experiences and needs. This presents a public health concern that is both excluding them from consideration by the field of harm reduction, but also themselves from considering harm reduction. Disaggregated data shows rising rates of substance use and associated harms that are often hidden or not taken as seriously as a public …

"Hair-Esteem Toolkit For Black Girls": The Development Of A Self-Esteem Toolkit For Black Adolescent Girls Centering Hair As A Tool For Empowerment, Sydney Hussett-Richardson

Public Health Theses

Background: For Black adolescent girls, hair is a strong staple of gender and ethnic identity, influencing intrapersonal and interpersonal interactions. Gendered racism and Eurocentric beauty standards pathologize Black girls and their hair, leading them to experience high rates of hair harassment and discrimination. These experiences negatively impact the self-esteem of Black girls, which has important implications for a host of health behaviors. The purpose of this study was to explore the relationship between self-esteem and hair among Black girls and integrate findings into a culturally relevant digital toolkit to promote and develop hair-esteem and self-esteem among Black girls.Methods: This study …

“I Was Reaching Out For Help And They Did Not Help Me”: Mental Healthcare In The Carceral State, Anna Grace Preston

Public Health Theses

Background: Despite the limitations the carceral environment may impose on mental wellness, mental healthcare is increasingly becoming a carceral endeavor. Over the course of the last several decades, prisons and jails have become the de facto mental healthcare provider for thousands of incarcerated individuals. Furthermore, practices like mandated mental healthcare for supervised individuals further broaden the population experiencing mental healthcare within the criminal legal system at large. This study examines the perspectives of nine individuals who experienced mental healthcare within the carceral state, whether in prison or on parole or probation, with a special focus on how attributes of the …

“To Live In The Body Of A Survivor ”: Unique And Cumulative Disaster Exposure And Mental Health In A Sample Of Hurricane Katrina Survivors, Noelle Serino

Public Health Theses

Introduction: Fueled by the escalation of climate change, weather-related disasters are increasing in frequency and severity. Existing research has documented the extensive harm induced by such disasters, yet few studies have examined how individuals’ psychological well-being fares when exposed to multiple, diverse threats, including other weather-related and public health disasters (e.g., COVID-19). As such, the present study explores posttraumatic and psychological distress in the context of unique and cumulative disaster exposure.Methods: The data utilized for this study came from the Resilience in Survivors of Katrina (RISK) Project. The sample was comprised of 381 predominantly Non-Hispanic Black (84.5%) women who experienced …

“For The Future, For Him, And For Our Life Together”: The Relationship Goals And Well-Being Of Persons Living With Dementia And Their Spousal Care Partners, Claire Leigh Szapary

Public Health Theses

Background. Identities and dynamics in relationships can change when one spouse develops dementia. This study aimed to understand the various types of goals both spousal care partners and persons living with dementia (PLWD) have for their relationship, and to explore whether approach or avoidance goals were associated with individual wellbeing and relational support – as well as their partners’ wellbeing and support.

Methods. A secondary analysis of data from sixty-two spousal dyads where one partner has dementia was conducted. Thematic goal-type categories were determined through a card-sort content analysis methodology using participants’ brief qualitative responses to a question asking about …

Surgical Outcomes Following Posterior Spinal Fusion For Adolescent Idiopathic Scoliosis, Wyatt Benajmin David

Yale Medicine Thesis Digital Library

Surgical Outcomes Following Posterior Spinal Fusion for Adolescent Idiopathic ScoliosisWyatt B. David and Michael DiLuna. Section of Pediatric Neurosurgery, Department of Neurosurgery, Yale University, School of Medicine, New Haven, CT. Hospital size has previously been shown to impact outcomes in adult spine surgery. However, there is a paucity of studies assessing the impact of hospital size on outcomes in adolescent spine surgery. Furthermore, gender-based differences have been suggested in disease progression and outcomes of adolescent idiopathic scoliosis (AIS), though only a few studies have investigated these disparities. The aim of this study was to determine the impact of hospital size …

International Academic Partnerships In Orthopaedic Surgery, Michael Jesse Flores

Yale Medicine Thesis Digital Library

Abstract: INTERNATIONAL ACADEMIC PARTNERSHIPS IN ORTHOPAEDIC SURGERY. Michael J. Flores. Department of Orthopaedics & Rehabilitation, Yale University, School of Medicine, New Haven, CT.

Introduction: Orthopaedic-related disease (ORD) is one of the leading health challenges faced worldwide and is a significant cause of global morbidity and mortality, especially in low- and middle-income countries (LMICs). In recent years, international orthopaedic outreach to address the global burden of ORD has received greater attention due to initiatives such as the Lancet Commission on Global Surgery (LCGS). Many strategies have been considered to address the global burden of ORD, most commonly though volunteer trips by …

Incarcerated Patients Have Higher Mortality After Trauma: An Unreported Healthcare Disparity, Harry Newmanplotnick

Yale Medicine Thesis Digital Library

While the U.S. has the highest incarceration rate in the world, at nearly 1% of the adult population, or over 2 million people, insight regarding health disparities in this population remains limited, particularly for traumatic injuries and surgical care. Our aims with this paper were two-fold. First, we sought to perform the largest national database analysis of criminal-justice system involved (CJI) trauma patients (specifically incarcerated patients). Second, we planned to investigate if incarceration status was associated with differences in a variety of outcomes after trauma for U.S. adults.To accomplish these aims we analyzed data from the National Trauma Data Bank …

Almajiri Health; A Scoping Review On Disease, Health Literacy And Space For Participatory Research, Muzzammil Imran Muhammad

Yale Medicine Thesis Digital Library

Introduction

Almajirai are male children who leave the care of their parents to learn the Qur’an and study Islam under the tutelage of a Mallam or Imam at a Tsangaya. Almajiranci refers to the system of education based on this relationship between almajiri and mallam, and which was the dominant mode of education in precolonial Hausaland – Northern Nigeria and Southern Niger. This system remains widespread and popular in both countries. In recent years, discourse around almajirai has featured prominently in media from and about this region, and has associated almajiranci with non-participation in formal education, abuse, poverty, and underdevelopment. …

More Than Meets The Eye: Improving Recognition Of Child Abuse In Emergency Departments, May Shum

Yale Medicine Thesis Digital Library

Background: Child abuse guidelines exist to help emergency department (ED) providers evaluate injured children for suspected child abuse. Little is known about the impact of these guidelines on provider decision-making in pediatric (PED) and community EDs (CEDs). Objective: To evaluate the impact of a child abuse guideline in pediatric and community EDs through three primary studies: 1. To examine guideline adherence and the appropriateness of decision-making by CED providers. 2. To determine the impact of the guideline on differences in evaluations of infants for abuse between a PED and three CEDs. 3. To implement and assess the use of a …

Análisis In-Silico Y Clínico De Los Cambios En La Superficie Ocular En Individuos Con Queratocono, María Fernanda Quesada Portela

Maestría en Ciencias de la Visión

Introducción: El queratocono (KC) es la ectasia corneal más frecuente, que afecta la salud visual y ocular de los pacientes que la padecen; por este motivo se han desarrollado diversos tratamientos como en el caso de los lentes de contacto que han demostrado ser eficaces en mejorar el rendimiento visual de los pacientes y retardar el progreso del queratocono, pero no se ha enfatizado en la influencia de estos a nivel de la superficie ocular, y en menor medida en el análisis mediante biomarcadores. Objetivo: identificar biomarcadores de KC mediante análisis Insilico y el estado de la superficie ocular en …

Función Visual Como Marcador Clínico Del Glaucoma, Jenifer Castro Buitrago

Maestría en Ciencias de la Visión

El glaucoma consiste en una neuropatía óptica en la cual se ven afectadas las células ganglionares de la retina y sus axones, en esta patología se encuentran diversas funciones visuales alteradas tales como el campo visual, la sensibilidad al contraste, y la visión cromática. Además, es una de las principales causas de ceguera a nivel mundial, siendo una causa evitable si se trata a tiempo con un diagnóstico temprano. Existe la posibilidad de realizar diferentes pruebas que permiten detectar un daño funcional o estructural que pueden estar asociados al glaucoma como lo son la tomografía óptica coherente, la tonometría, la …

Medical Emergency Preparedness Among Undergraduate Students, Savannah L. Finigan

Honors Theses

Knowing how to respond to a medical emergency is a valuable life skill that college students ought to have the opportunity to attain in order to save lives. This study aims to understand how prepared and confident local students are to respond to a medical emergency. Participants consisted of undergraduate students who had no healthcare or nursing school experience. A survey was distributed that asked students to rank and describe their own confidence to respond to medical emergencies. The survey also questioned how much former training or experience they had with medical emergencies. The results of the survey show that …

Generation Of Chimeric Rhinoviruses Presenting Sars-Cov-2 Broadly Neutralizing Epitopes And Their Antigenicity Characterization, Danish Ansari

Biotechnology Theses

The global COVID pandemic is not yet fully under control as there were over 21 million new cases of SARS-CoV-2 infections and over 50,000 deaths globally as of January of 2022. A heavily mutated variant of concern, Omicron is responsible for most of these cases which demands an urgency for a new vaccine. NIH reports over 180 vaccine candidates that use various strategies currently in development. However, a recurring concern with these vaccines is that the continuous viral mutations decrease the efficacy of vaccines. Therefore, we proposed to construct a human rhinovirus (HRV) based chimeric virus containing highly conserved, broadly …

High Body Mass Index Changes Peri-Tumor Adipose Tissue Which In Turn Promotes Triple Negative Breast Cancer, Cora Elizabeth Miracle

Theses, Dissertations and Capstones

Cancer is one of the leading causes of death worldwide, responsible for over half a million deaths each year. There are multiple risk factors associated with the development of cancer. Some of these risks include genetics, smoking, and most recently, obesity (Lewandowska et al., 2019) (De Pergola & Silvestris, 2013). Research has shown that obesity is linked to the promotion of fourteen different cancers, including aggressive triple negative breast cancer (TNBC). Patients that are obese are more likely to develop cancer (Park et al., 2014). In addition, if the patient is obese at the time of a cancer diagnosis, they …

Prenatal Buprenorphine Exposure Reduces Expression Of Myelin Proteins In Neonatal Longs-Evans Rat, Christopher James Grahe

Theses, Dissertations and Capstones

In the USA and especially in WV, there has been a surge in the rise of opioid use disorder (OUD), and with it a rise in neonatal abstinence syndrome (NAS). What makes this rise in NAS so unfortunate is that the Medications for OUD (MOUD) do not prevent the development of NAS. Although the relationship between MOUD and NAS is still unclear, it is thought that buprenorphine, one of the main substances used to treat OUD in pregnant women, may feed into the development of NAS, which may affect mental and physiological development and cause other health problems. Via understanding …