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Full-Text Articles in Medicine and Health Sciences
Patients With Breast Cancer: Screening Of The Disease Among Their Families In Menoufia University Hospital, Egypt, Hala M. Shaheen, Naser M. Abd El-Bary, Nora A. Khalil, Taghreed M. Farahat, Yasmin H. Hassan Hussein
Patients With Breast Cancer: Screening Of The Disease Among Their Families In Menoufia University Hospital, Egypt, Hala M. Shaheen, Naser M. Abd El-Bary, Nora A. Khalil, Taghreed M. Farahat, Yasmin H. Hassan Hussein
Menoufia Medical Journal
Objective To assess the frequency of breast cancer (BC) among families of diagnosed cases and to determine BC risk factors among the screened relatives. Background BC is the most common malignancy among women. The family history of BC increases the risk of the disease. Screening with mammography reduces BC mortality. Patients and methods The study included 150 women from first-degree and second-degree relatives of diagnosed BC cases attending Oncology Outpatient Clinics, Menoufia University Hospital, during the period from January 2016 to February 2017. The participated relatives were subjected to history taking and clinical breast examination. Sonomammography was done for those …
Androgen Receptor Expression In Estrogen Receptor-Negative Breast Cancer, Belal M. Meligy, Eman A. Tawfik, Enas A. El Khouly, Hagar Alagizy, Mohamed A. Shehata, Noha M. Elkady
Androgen Receptor Expression In Estrogen Receptor-Negative Breast Cancer, Belal M. Meligy, Eman A. Tawfik, Enas A. El Khouly, Hagar Alagizy, Mohamed A. Shehata, Noha M. Elkady
Menoufia Medical Journal
Objective The aim of this study was to estimate the expression of androgen receptors (ARs) in patients with estrogen receptor (ER)-negative breast cancer. Background Growth of breast cancer is hormone dependent. Estrogen and progesterone play a fundamental role in the pathogenesis and treatment of patients with ER-positive breast cancer and those with progesterone receptor-positive breast cancer. Patients who lack the expression of these receptors receive no benefit from hormonal treatment and are considered to have a poor prognosis. AR is a member of nuclear steroid receptors with ambiguous role in patients with breast cancer. There is growing evidence about its …
Cell-Free Dna As A Biomarker Of Breast Cancer, Ahmed S. El Gamaal, Hala H. El Said, Marwa M. M. Omar, Rasha I. Noreldin, Rawheyia H. El Edel
Cell-Free Dna As A Biomarker Of Breast Cancer, Ahmed S. El Gamaal, Hala H. El Said, Marwa M. M. Omar, Rasha I. Noreldin, Rawheyia H. El Edel
Menoufia Medical Journal
Background Circulating plasma cell-free DNA (CFDNA) is comprised of nucleic acids in fringe blood of healthy persons and patients with several diseases that start from cell death. Apoptotic tumor cells may discharge DNA into the peripheral blood, and this may hold possibilities for the early detection of breast cancer. Objective This study aimed to assess CFDNA (glyceraldehyde 3-phosphate dehydrogenase) concentration in patients with malignant and benign breast lesions and healthy controls to investigate its role as a noninvasive marker for early detection of breast cancer. Patients and methods This study included 50 patients divided into three groups: group I included …
Predictive Significance Of Stromal-Associated Lymphocytes In Response To Neoadjuvant Chemotherapy In Breast Cancer, Abeer H. Anter, Afaf T. Ibrahiem, Hala A. Mouhamed
Predictive Significance Of Stromal-Associated Lymphocytes In Response To Neoadjuvant Chemotherapy In Breast Cancer, Abeer H. Anter, Afaf T. Ibrahiem, Hala A. Mouhamed
Menoufia Medical Journal
Objective In this work, we aimed to assess whether the high stromal-associated lymphocytes and their subtypes in pretreatment core biopsies from patients with invasive breast carcinoma have a predictive role in pathologic response to neoadjuvant chemotherapy (NACT). Background Tumor-infiltrating lymphocytes including stromal-associated lymphocytes in breast cancer are considered a form of the host immune response to malignancy. Several studies suggested that tumor-infiltrating lymphocytes could predict better response to NACT, but their roles in predicting complete pathologic response (pCR) rate after NACT still needs further evaluation. Patients and methods Stromal-associated lymphocytes were evaluated in 100 pretreatment core biopsies from primary breast …