Medicine and Health Sciences Commons^™

The Effects Of Thc On Hiv Tat Protein-Mediated Neuroinflammation, Camille Martin

Honors Theses

Although antiretroviral therapies have allowed people living with human immunodeficiency virus (HIV) to achieve normal life expectancies, they cannot cure HIV nor the neurological symptoms associated with infection, termed neuroHIV. NeuroHIV describes a myriad of neurological disorders including mood disorders (depression and anxiety), cognitive impairment, neuropathic pain, and motor disinhibition. The mechanisms by which HIV promotes neurological impairment are not known, but may involve actions of its neurotoxic proteins. One such protein that has been well-characterized is the HIV trans-activator of transcription (Tat). Tat exerts neurotoxic effects via various means, one of which is to activate microglia, the macrophages of …

Student Engagement And Performance Assessment As Associated With Three Types Of Integument System Laboratory Activities, Sophie Deoliveira

Honors Theses

Students participating in anatomy education, specifically an Anatomy and Physiology classroom, have shown difficulty in learning and retaining information on the various systems of the body. This study sought to assess the benefits of different learning activities associated with student engagement and performance on subsequent examinations regarding the integumentary system. For this study, three different hands-on laboratory activities (i.e., treatments) were given during different laboratory sessions. These hands-on activities included labeling a three-dimensional model, illustrating a model, or building a model of the integumentary system using materials provided. Students then completed a post-laboratory questionnaire regarding their enjoyment of their particular …

Lc-Ms Identification Of Serum Proteins Adsorbed Onto Ionic Liquid-Coated Nanoparticles, Anh M. Hoang

Honors Theses

Nanocarriers are promising candidates for drug delivery due to their size and tunable surface characteristics. However, when they are intravenously injected, few particles make it to their designated location. This is because upon entering the bloodstream, the serum in the blood, which is rich with a diversity of proteins, adsorbs onto the particles’ surfaces forming a protein corona. Many of the attached proteins trigger the mobile immune system and are removed by macrophages, and many particles are then filtered out by the liver and kidneys. Ionic Liquids (ILs), which consist of asymmetric, bulky components that are liquid

Rates And Perceptions Of Covid-19 Vaccination From University Of Mississippi Students, Josie Parham

Honors Theses

The trials, tribulations and triumphs of the global COVID-19 pandemic are impacted by and are a product of behaviors that occur at the level of nations, states, cities and, ultimately, communities. In the wake of the development of safe and effective vaccines against SARS-CoV2, the virus responsible for the pandemic, the significance of the vaccine is closely linked to the number of individuals that receive the vaccine. To date, surveys have measured sizable variations in vaccination rates between nations, states, cities, and communities. Focusing on events that have transpired in one such local community, the present study (i) measured the …

The Efficacy Of The Student Communication Repair Inventory And Practical Training Program On Adolescent’S Self-Advocacy Skills In Communication Breakdowns, Karlye Tolbird

Honors Theses

Purpose

Hearing loss can affect several aspects of an adolescent’s life, particularly their self-advocacy skills and ability to communicate their needs in the classroom. Literature shows that adolescents between the ages of 12 and 18 years have a prevalence of hearing loss between 14.9 percent and 19.5 percent (Shargorodsky et al., 2010). Therefore, early identification and intervention of hearing loss are necessary to reduce the adverse effects on the development of cognition, verbal communication skills, and self-advocacy skills (Michael & Zidan, 2018). This research study aimed to determine if the implementation of the SCRIPT program changes the communication repair behavior …

Synthetic Investigations In Chemical Probe Development Part 1: Design And Synthesis Of Novel Triton X-405 Adenosine Conjugates; Part 2: Synthesis Of 2,8-Dihydroxychrysene, Rachel Irene Hammond

Honors Theses

Although not drugs themselves, chemical probes are a necessary tool in biomedical research for the interrogation of biological systems. In the present synthetic investigation, two chemical probes were developed – a Triton X-405 adenosine conjugate (TX-405A) and 2,8-dihydroxychrysene. The designed TX-405A conjugate was generated in four steps through tosylation and amination of TX-405 such that EDC-coupling of TX-amine with 2’,3’-Isopropylidene adenosine-5’-carboxylic acid afforded TX-405A following acetonide deprotection. The development of TX-405A represents the first report of the synthesis and utilization of a detergent-linked dosimeter. The synthesis of 2,8-dihydroxychrysene provided an in-depth exploration on the unique reactivity of chrysene. The desired …

A Systematic Review Of Music Therapy For Children With Autism Spectrum Disorder, Alana Andrus

Honors Theses

Music therapy has been suggested to be effective in Autism. The purpose of this systematic review was to assess the effectiveness of music therapy as a potential treatment option for individuals with autism spectrum disorder, or ASD. To obtain published records, a PubMed search was conducted with the search term “music therapy autism,” which generated 187 studies. Each study was evaluated for relativity to the topic at hand. The remaining 151 articles were assessed for support status, as well as other later suggested research, in order to more confidently support music therapy as a treatment option for ASD patients. Approximately …

Trends In Prenatal Care Accessibility In Rural Mississippi And How These Trends Affect Unfavorable Birth Outcomes, Maura Isabella Webb

Honors Theses

This thesis investigated the level of accessibility to prenatal care in rural Mississippi areas and how this affects or has affected Mississippi’s high rates of unfavorable birth outcomes. The research questions included specifically looked at how lack of prenatal care in rural areas of Mississippi plays a role, if any, in extremely high rates of unfavorable birth outcomes as well as what policy can be implemented to expand education regarding unfavorable birth outcomes. To understand the effects of accessibility and eligibility of rural women’s health care, seven women were interviewed. Interviews were conducted with these women who met the criteria …

Isolation Of Sphingolipids From Sphingomonas Echinoides B-3126 And Their Characterization By Ms/Ms Analysis, Edgar David Uribe Sanchez

Honors Theses

EDGAR DAVID URIBE SANCHEZ: Isolation of Sphingolipids from Sphingomonas echinoides B-3126 and their Characterization by MS/MS Analysis

Sphingolipids are important components in human cellular lipid membranes and are differentiated by the incorporation of serine with an amide bond between the amino acid and a lipid tail. Sphingolipids produced by bacteria differ in both headgroups attached to the serine alcohol and the architecture of the lipid backbone. While the synthesis of sphingolipids in mammalian cells is well studied, only a handful of steps in the pathway are described in bacteria.¹ The observations that although sphingolipid synthesis is rare in bacteria, …

The Effects Of Astrocytic Derived Insulin-Like Growth Factor (Igf-1) On Cognition And Astrocytes, Destiny Wilson

Honors Theses

Insulin-like growth factor 1 (IGF-1) is a neuroendocrine signaling hormone that plays a vital role in growth and development, as well as learning and memory. Inhibition of this hormone results in cognitive impairments like those seen with age-related decline. While a majority of research has focused on the role of IGF-1 on neurons, the role of astrocytes still needs to be explored. Our research investigates how astrocytes and cognition are affected as a result of direct regulation of localized IGF-1 production in early development and after puberty. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary …

The Synthesis And Characterization Of Ionic Liquids Using Nitrogen-Based Cations For Transdermal Delivery, Jo Galloway

Honors Theses

The purpose of this research was to explore the synthesis mechanisms of water-soluble ionic liquids with nitrogen-containing cationic bases for future use in transdermal drug delivery and forensic science applications. Ionic liquids are salts with an organic cation and either an organic or inorganic anion. They have asymmetric structures, which means that the molecules don’t pack together as neatly as other salts do, therefore, they don’t crystallize as easily, and their melting points are lower. Ionic liquids have melting points below 100°C, and many are liquid at room temperature. Mechanistic studies reveal that the potency of ILs in enhancing transdermal …

Resilience Training & Parental Support For Children Who Stutter - A Systematic Review, Rachel Elizabeth Davis

Honors Theses

The objective of this study was to investigate the relationship between emotional resilience and family/parental/caregiver support for children who stutter, and to review existing research on resilience training and family support relative to enhancing the quality of life in children who stutter. Thus, A systematic review of appropriate published studies was conducted utilizing the electronic databases PubMed and Google Scholar. Analysis revealed that there is an abundance of research supporting parental support and resilience training; however, there was limited direct clinical application relative to the unification of these concepts. Data indicates that the clinical application of emotional resilience and cognitive …

Intensive, Interprofessional Therapy: A Case Approach, Emma C. Schrotenboer

Honors Theses

This research looks at the impacts of intensive, interprofessional therapy for children with disabilities. There is very little literature currently published on this topic, although what is available generally finds that more intense therapy is more beneficial. The child who was studied was a camper at Adam’s Camp therapy camp, a week-long program that involves six hours of therapy each day with therapists from five different fields. Her progress over the week, as well as her retention of skills several weeks later, were determined by pre- and post-camp surveys sent to the mother and the therapists’ notes from during the …

The Effects Of Short-Term Indoor And Personal Exposure To Fine Particulate Matter (Pm2.5) On Cardiovascular Health: A Review, Whitley Cagle

Honors Theses

Fine Particulate Matter (PM2.5), a component of air pollution, has known effects on human health. However, there is limited research surrounding the specific cardiovascular impacts associated with these small particles entering into the bloodstream. This literature review aims to make associations between indoor and personal exposures to PM2.5 and cardiovascular health. An online search was conducted to obtain scholarly articles using various key terms, and the articles were filtered through based on specific selection criteria. In the final review, we focused on 37 research articles which discussed PM2.5 and its effects on the human cardiovascular system. Positive associations between PM2.5 …

Lectin-Glycan Complexes: A Comprehensive Analysis Of Docking Calculations, Ashton Custer

Honors Theses

Lectins are a type of glycan-binding protein that noncovalently bind glycans. Carbohydrates are molecules consisting of sugar units joined together. Glycans are carbohydrates. Hence, glycans are also sugars. Lectins and lectin-glycan complexes have a range of biological roles and can be found in animals (including humans), plants, bacteria, viruses, and yeasts and fungi.¹ Many scientists focus on the computational study of these complexes due to their intricate roles in many living organisms. Computational study is important in furthering our knowledge of lectin-glycan complexes and other such protein complexes. However, computational study is not perfect. There are many challenges in …

Effects Of Music Exposure On Autobiographical Memory In Alzheimer's Patients: A Systematic Review And Meta-Analysis, Gregory Vance

Honors Theses

The progression of Alzheimer’s disease is primarily characterized by a loss of memory concerning past events, as well as a lack in ability to create new memories. While this spans across many subsets of memory, such as recognition, recall, and autobiographical memory, there seems to be a lesser impact on musical memory in those with Alzheimer’s. Multiple studies have suggested that exposure to music and introduction of music therapy can even improve other aspects of memory in Alzheimer’s patients. This systematic review and meta-analysis sought to examine the relationship between music exposure and autobiographical memory specifically. A pool of electronic …

Effects Of Waterborne Benzo[A]Pyrene Embryonic Exposure On Development, Behavior, Reproduction, And Mitochondrial Bioenergetics In Zebrafish, Megha Patel

Honors Theses

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is a known carcinogen leading to adverse effects in the development of both humans and animals. BaP is also continuously present in the environment leading to regular exposure via inhalation or ingestion. Because organisms’ early life stages can be more susceptible to contaminant exposure, our focus was on BaP’s adverse impacts on survival, length, weight, behavior, bioenergetic state, and fecundity following developmental exposures. To study BaP’s impacts, zebrafish (Danio rerio) were used as a model organism. BaP is a ligand for the aryl hydrocarbon receptor (AHR in humans; Ahr in …

Comparing Intuitive Eating Behaviors Between Student Athletes And College Students Enrolled At The University Of Mississippi, Mary Mckennon Pierce

Honors Theses

Intuitive eating strives to consciously listen to the internal hunger and fullness cues our body provides, as humans often practiced long before counting calories and dieting existed. Rational thought, instinct, and emotion influence an intuitive eater’s decision-making and allow for full capability in navigating food decisions. While intuitive eating habits can benefit any individual, little research has compared the intuitive eating habits between collegiate students and student-athletes. measures unconditional permission to eat, eating for physical rather than emotional reasons, reliance on hunger and fullness cues, and body-food choice congruence. Student-athletes presented a significantly higher overall intuitive eating score (3.53±0.54, p=0.003) …

Ageism, Eldercare, And Healthcare: An Examination Of Growing Old In Costa Rica, Akshaya Vijayasankar

Honors Theses

The world’s aging population and the Covid-19 pandemic have revealed the high level of ageism against older adults around the globe, which has resulted in an overall decreased quality of life for elders. Societies are now faced with the challenge of creating a suitable and equitable model of care to support their aging population. Despite the recent publication of the World Health Organization's Global Report on Ageism, there is still a large gap in the literature regarding ageism. This paper addresses the issues of institutional ageism in the eldercare and healthcare sector. I argue that Costa Rica serves as a …

Determining The Distribution Of Elemental Compounds And Oxidative Potential Across Fine Particulate Matter (Pm2.5) Filters, Allie Michelle Sidwell

Honors Theses

Fine particulate matter (PM_2.5) is a complex mixture of particles and sorbed chemicals that poses serious, adverse effects on human health such as increasing cardiovascular and respiratory morbidity and mortality. There is ongoing research into the impacts of PM_2.5 of differing chemical compositions, sampling location, and the mechanisms for the observed health effects. To conduct these analytical and toxicology studies of PM_2.5, researchers often split filters into sections. This process allows multiple, often destructive, assays to be performed. Our previous research showed chemical composition differences across PM_2.5 filters. The goal of our study was …

Assessment Of Spatial Skills In Human Anatomy And Physiology Students, Abigail Carroll

Honors Theses

Visual spatial skills are an individual’s ability to mentally and manipulate the shapes, forms and positions of objects. Spatial skills are necessary for adequate learning in many settings. Few studies have assessed spatial skills compared to success in Anatomy and Physiology in undergraduate students. Most students in this course are on a health profession track. Due to the increasing health care demands and need for competent health care professionals, this study assesses the innate spatial skill ability in students and acquired additional learned spatial skills. This study tests 17 students with the paper-folding test, blank page test, and two surveys …

Food Insecurity In Collegiate Athletes During Covid-19, Elizabeth Swindell

Honors Theses

A study done by Georgetown University in 2019 found that one-fourth of NCAA, D1 collegiate athletes experience food insecurity. The study purpose was to examine food security levels in student athletes at a southern university and the impact of the COVID-19 pandemic on food security in these students. A survey was completed by student athletes to determine their food security levels during the 2020 academic year at the onset of the COVID-19 pandemic. The survey included questions relating to food security based on the USDA’s food insecurity module as well as questions specifically related to the impact of food security …

Finding The Optimal Ionic Liquid To Target White Blood Cell Subpopulations Using Nanoparticles, Meghan Gorniak

Honors Theses

Disorders and diseases of the immune system have become more prevalent in recent decades and can have life-threatening effects on those afflicted. Granulocyte disorders disproportionately affect infants and children, while chronic lymphocytic leukemia is the most common type of leukemia in adults. Unfortunately, current treatments have many drawbacks such as everyday injection, short-lived efficacy, and unknown levels of safety and effectiveness. It is imperative to find more effective treatment options that could allow for easier drug delivery to specific populations of white blood cells (WBCs). Nanoscale medicine shows promising application, but complications remain in reaching the desired target site and …

Investigation Into The Detection Of Drug Metabolites In Latent Fingerprints, Paige Oden

Honors Theses

Fingerprinting has proved a useful mode of identification for thousands of years. Following numerous technological advancements, it has become a technique for categorizing and keeping track of people over large geographical spaces for almost half of a century. Those living in the beginnings of fingerprinting used them as a form of signature as it was something completely unique to each individual that could not be replicated. Although they are no longer used as the primary form of signature, it certainly remains a biomarker of identity. Over the past century the practice has been heavily refined in order to identify people …

The Role Of Age Ligand And Rap1a In Myofibroblast Signaling Cascade In Type 2 Diabetes Mellitus-Induced Cardiomyopathic Conditions, Camilla Puglia

Honors Theses

Diabetes is one of the leading causes of death in the United States, taking more than 90,000 lives annually. Type 2 diabetes mellitus-induced cardiac fibrosis is a common condition seen in diabetic patients. The AGE/RAGE signaling cascade has been strongly associated with this supposed cardiac fibrosis along with hyperactive myofibroblasts which excessively remodel extracellular matrix tissue, leading to damaged and enlarged heart muscle tissue. In diabetic patients, Advanced Glycation End Products (AGEs) are produced in abundance and accumulate in the extracellular matrix of heart tissue. To investigate the role of of the AGE ligand on fibroblast behavior, increasing amounts of …

Mississippi Pharmacists’ Perceptions Of Dietary Supplements, Emory Booth

Honors Theses

Dietary supplements are often a controversial topic among healthcare professionals. Many view supplements positively and appreciate the health benefits they can provide. Others are wary of the decreased regulation dietary supplements are subject to and believe that the benefits of supplements do not outweigh the risks. Dietary supplements are of particular interest to pharmacists, as they are often sold at their place of work, and pharmacists have to consolidate their patients’ supplement use with their medication use. The purpose of this thesis is to evaluate the viewpoints of Mississippi pharmacists in relation to dietary supplements. A survey was sent to …

Sources Of Patient Information For Type 2 Diabetes Self-Care In Northern Mississippi, Minh-Sang La

Honors Theses

Given the prevalence of Type 2 Diabetes Mellitus in the United States and the continuous rise of cases, especially within Mississippi, there is an increasing need to identify if, and how, patients with Type 2 Diabetes receive information about self-care. While there is data available on the topic of where patients receive their information and the influence it has on their health in other countries of the world, the research on the source of Type 2 Diabetes education in the United States is scarce. Therefore, this study aims to bridge the gap of understanding where patients with Type 2 Diabetes …

Content Analysis Of Vitiligo Portrayal On Social Media, Mary Miller

Honors Theses

Given that vitiligo affects a small percentage of the world population, and its affects are not widely known, there is an increasing need to learn of its effects on those with vitiligo, both physical and psychological. Social media has become an influential platform to spread awareness and build confidence in those with vitiligo. This study aims to find how vitiligo is portrayed through social media using content analysis procedures. This is a cross-sectional content analysis that utilized a codebook to analyze Instagram posts. The results were analyzed by interrater reliability and frequency for each coder. The findings of this content …

The Effect Of Age Concentration And Glucose Levels In Rage-Mediated Cardiac Fibroblast Migration In Type 2 Diabetes, Lorral Kanauss

Honors Theses

Diabetes is one of the largest health concerns in the United States. Its continuous increase in prevalence has led to it being one of the largest healthcare costs and consistently listed as one of the leading causes of death. That being said, diabetes also increases the risk of other health conditions, one of which is cardiovascular disease. Left ventricle hypertrophy resulting in the stiffening of the left ventricle and diastolic dysfunction is one form of cardiovascular disease associated with diabetes. Thought to be impacted by decreased fibroblast migration in the extracellular matrix, the experiments performed in this study seek to …

Firsthand Experience In A Community Pharmacy Through The Lens Of A Pharmacy Technician, Khamariah Patrice Yelder-Anderson

Honors Theses

In the first chapter, I discussed three of the major issues in a community pharmacy which are rude customers, phones, and shorter hours. Technicians have to deal with very opinionated customers who can come off as insolent. The phones are a popular mode of communication for both the patients and physicians but that doesn’t account for the added demands it places on pharmacy workers. Lastly, the pharmacy has experienced later openings with earlier closings that have left filled queues and unhappy customers. The next chapter, interpersonal dynamic, takes a deeper look into how various roles of the pharmacy engage with …