Medicine and Health Sciences Commons^™

The Underrecognized Prothrombotic Vascular Disease Of Covid-19., Kp Cohoon, G Mahé, Ac Spyropoulos

Journal Articles

No abstract provided.

A Cross-Disease Meta-Gwas Identifies Four New Susceptibility Loci Shared Between Systemic Sclerosis And Crohn’S Disease, D. González-Serna, E. Ochoa, E. López-Isac, A. Julià, F. Degenhardt, N. Ortego-Centeno, T. R. Radstake, P. K. Gregersen, A. T. Lee, A. Gabrielli, +78 Additional Authors

Journal Articles

© 2020, The Author(s). Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases …

Letter: Considerations For Performing Emergent Neurointerventional Procedures In A Covid-19 Environment., As Pandey, Aj Ringer, A Rai, Pt Kan, Pm Jabbour, A Siddiqui, E Levy, Kv Snyder, Ha Riina, D Langer, +9 Additional Authors

Journal Articles

No abstract provided.

Patient Attitudes Toward Telepsychiatry During The Covid-19 Pandemic: A Nationwide, Multisite Survey., D. Guinart, P. Marcy, M. Hauser, M. Dwyer, J. M. Kane

Journal Articles

Background

The COVID-19 pandemic and its associated movement restrictions forced a rapid and massive transition to telepsychiatry to successfully maintain care continuity.

Objective

The aim of this study is to examine a large number of patients' experiences of, use of, and attitudes toward telepsychiatry.

Methods

An anonymous 11-question survey was delivered electronically to 14,000 patients receiving telepsychiatry care at 18 participating centers across 11 US states between the months of April and June 2020, including questions about their age and length of service use, as well as experience and satisfaction with telepsychiatry on a 5-point Likert scale. Descriptive statistics were …

'Whatsapp (R)' Ening In Nephrology Training, K. D. Jhaveri, B. Pascarelli, A. Hasan, A. Kozikowski, S. Fishbane, R. Pekmezaris

Journal Articles

No abstract provided.

Does Increasing Packing Density Using Larger Caliber Coils Improve Angiographic Results Of Embolization Of Intracranial Aneurysms At 1 Year: A Randomized Trial, J. Raymond, J. Ghostine, B. A. Van Adel, J. J. Shankar, D. Iancu, A. P. Mitha, P. Kvamme, R. D. Turner, H. H. Woo, T. E. Darsaut, +13 Additional Authors

Journal Articles

© 2020 American Society of Neuroradiology. All rights reserved. BACKGROUND AND PURPOSE: The impact of increased aneurysm packing density on angiographic outcomes has not been studied in a randomized trial. We sought to determine the potential for larger caliber coils to achieve higher packing densities and to improve the angiographic results of embolization of intracranial aneurysms at 1 year. MATERIALS AND METHODS: Does Embolization with Larger Coils Lead to Better Treatment of Aneurysms (DELTA) was an investigator-initiated multicenter prospective, parallel, randomized, controlled clinical trial. Patients had 4- to 12-mm unruptured aneurysms. Treatment allocation to either 15- (experimental) or 10-caliber coils …

Atypical Presentation Of Panhypopituitarism., H. K. Rai, G. John, M. Anton

Journal Articles

Hypopituitarism is a rare disorder. Hypopituitarism can present as a deficiency of individual anterior pituitary hormones (e.g., adrenocorticotropic hormone, thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, prolactin, growth hormone) or posterior pituitary hormones (e.g., oxytocin, vasopressin) or as the deficiency of all these pituitary hormones, also known as panhypopituitarism. Here, we discuss a 59-year-old man who presented with two episodes of unwitnessed syncope after an episode of vomiting. On admission, the patient was hypotensive to 88/54 mmHg, afebrile, and with a leukocyte count of 21.43 K/µL (reference range: 3.80 to 10.50 K/µL). CT scan of the head revealed a hyperdensity in …

A Randomized Phase Ii Trial Of Epigenetic Priming With Guadecitabine And Carboplatin In Platinum-Resistant, Recurrent Ovarian Cancer, A. M. Oza, U. A. Matulonis, A. A. Secord, J. Nemunaitis, L. D. Roman, S. P. Blagden, S. Banerjee, W. P. Mcguire, B. Schwartz, D. Matei, +18 Additional Authors

Journal Articles

© 2020 American Association for Cancer Research Inc.. All rights reserved. Purpose: Platinum resistance in ovarian cancer is associated with epigenetic modifications. Hypomethylating agents (HMA) have been studied as carboplatin resensitizing agents in ovarian cancer. This randomized phase II trial compared guadecitabine, a second-generation HMA, and carboplatin (GþC) against second-line chemotherapy in women with measurable or detectable platinum-resistant ovarian cancer. Patients and Methods: Patients received either GþC (guadecitabine 30 mg/m2 s.c. once-daily for 5 days and carboplatin) or treatment of choice (TC; topotecan, pegylated liposomal doxorubicin, paclitaxel, or gemcitabine) in 28-day cycles until progression or unacceptable toxicity. The primary endpoint …

Consortium Of Otolaryngology Journal Editors: Collegiality And Contributions, R. T. Sataloff, R. Chandra, E. W. Fisher, D. Goldenberg, E. Y. Hanna, J. Johnson, D. W. Kennedy, D. H. Kraus, J. H. Krouse, D. B. Welling, +12 Additional Authors

Journal Articles

No abstract provided.

Seizures Induce Obstructive Apnea In Dba/2j Audiogenic Seizure-Prone Mice: Lifesaving Impact Of Tracheal Implants, R. Irizarry, D. Sukato, R. Kollmar, S. Schild, J. Silverman, K. Sundaram, S. Stephenson, M. Stewart

Journal Articles

Wiley Periodicals, Inc. © 2020 International League Against Epilepsy The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. We hypothesized that DBA/2J mice, which display lethal audiogenic seizures, would be protected from death by implanting a tracheal T-tube as a surrogate airway. In a 2 × 2 design, mice were implanted with either open or closed tracheal T-tubes and treated with either low-dose ketamine/xylazine to …

Brucella Exposure Risk Events In 10 Clinical Laboratories, New York City, Usa, 2015 To 2017, J. Ackelsberg, A. Liddicoat, T. Burke, W. A. Szymczak, M. H. Levi, B. Ostrowsky, E. A. Mitchell, W. Lowe, R. Khare, M. Layton, +34 Additional Authors

Journal Articles

Copyright © 2020 American Society for Microbiology. All Rights Reserved. From 2015 to 2017, 11 confirmed brucellosis cases were reported in New York City, leading to 10 Brucella exposure risk events (Brucella events) in 7 clinical laboratories (CLs). Most patients had traveled to countries where brucellosis is endemic and presented with histories and findings consistent with brucellosis. CLs were not notified that specimens might yield a hazardous organism, as the clinicians did not consider brucellosis until they were notified that bacteremia with Brucella was suspected. In 3 Brucella events, the CLs did not suspect that slow-growing, small Gram-negative bacteria might …

Cd4 T Follicular Helper Cells Prevent Depletion Of Follicular B Cells In Response To Cecal Ligation And Puncture, M. D. Taylor, M. R. Brewer, A. Nedeljkovic-Kurepa, Y. Yang, K. S. Reddy, M. N. Abraham, B. J. Barnes, C. S. Deutschman

Journal Articles

No abstract provided.

Early Oral Colostrum Administration In Preterm Infants, D. Maffei, M. Brewer, C. Codipilly, B. Weinberger, R. J. Schanler

Journal Articles

No abstract provided.

The Irresponsible Use Of Social Media Among Medical Students, M. Curato, A. Husain, K. Shah, M. Kanter, D. Egan, H. Thompson, M. Silverberg, M. Jones, T. Dulani, P. Mukherji, +8 Additional Authors

Journal Articles

No abstract provided.

Are We Responding Effectively To Bone Mineral Density Loss And Fracture Risks In People With Epilepsy?, A. S. Miller, V. Ferastraoaru, V. Tabatabaie, T. R. Gitlevich, R. Spiegel, S. R. Haut

Journal Articles

© 2020 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. Objective: A 2007 study performed at Montefiore Medical Center (Bronx, NY) identified high prevalence of reduced bone density in an urban population of patients with epilepsy and suggested that bone mineralization screenings should be regularly performed for these patients. We conducted a long-term follow-up study to determine whether bone mineral density (BMD) loss, osteoporosis, and fractures have been successfully treated or prevented. Methods: In the current study, patients from the 2007 study who had two dual-energy absorptiometry (DXA) scans performed at least …

Fetal Loss And Malformations In The Monead Study Of Pregnant Women With Epilepsy, K. J. Meador, P. B. Pennell, R. C. May, L. Van Marter, T. F. Mcelrath, C. Brown, E. E. Gerard, L. Kalayjian, S. Hwang, R. H. Finnell, +7 Additional Authors

Journal Articles

No abstract provided.

Editorial: The Role Of Hmgb1 In Immunity, M. Son, B. Diamond, J. Shin

Journal Articles

No abstract provided.

A Pilot Study Testing A Novel 3d Printed Amphibious Lower Limb Prosthesis In A Recreational Pool Setting, T. Goldstein, A. Oreste, G. Hutnick, A. Chory, V. Chehata, J. Seldin, M. D. Gallo, O. Bloom

Journal Articles

No abstract provided.

Ultrasound Powered Piezoelectric Neurostimulation Devices: A Commentary., T. Sun, J. Wright, T. Datta-Chaudhuri

Journal Articles

Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piezoelectric neural stimulators work by converting ultrasound energy to electrical charge for neural stimulation. In addition to the benefits of wireless powering and miniaturization leading to less traumatic surgery, piezoelectric neural stimulators can also exhibit prolonged operational lifetimes for a long-term stable neural interface, and show promise for clinical translation. As one of first steps to demonstrate the value of ultrasound-powered piezoelectric neural interface, Li et al. developed a piezoelectric stimulator to …

In Utero Exposure To Endogenous Maternal Polyclonal Anti-Caspr2 Antibody Leads To Behavioral Abnormalities Resembling Autism Spectrum Disorder In Male Mice, C. Bagnall-Moreau, P. T. Huerta, D. Comoletti, A. La-Bella, R. Berlin, C. Zhao, B. T. Volpe, B. Diamond, L. Brimberg

Journal Articles

© 2020, The Author(s). The concept that exposure in utero to maternal anti-brain antibodies contributes to the development of autism spectrum disorders (ASD) has been entertained for over a decade. We determined that antibodies targeting Caspr2 are present at high frequency in mothers with brain-reactive serology and a child with ASD, and further demonstrated that exposure in utero to a monoclonal anti-Caspr2 antibody, derived from a mother of an ASD child, led to an-ASD like phenotype in male offspring. Now we propose a new model to study the effects of in utero exposure to anti-Caspr2 antibody. Dams immunized with the …

Pathophysiology And Pathology Of Acute Kidney Injury In Patients With Covid-19, J. H. Ng, V. Bijol, M. A. Sparks, M. E. Sise, H. Izzedine, K. D. Jhaveri

Journal Articles

© 2020 National Kidney Foundation, Inc. Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. The variability in the occurrence of AKI has been attributed to the difference in geographic locations, race/ethnicity, and severity of illness. AKI among hospitalized patients is associated with increased length of stay and in-hospital deaths. Even patients with AKI who survive to hospital discharge are at risk of developing chronic kidney disease or end-stage kidney disease. An improved knowledge of the pathophysiology of AKI in COVID-19 is crucial to …

Estimating The Predictive Value Of Negative Sars-Cov-2 Results: A Prospective Study, D. Hirschwerk, M. Foley, M. Lesser, B. Farber, J. M. Crawford, K. W. Davidson, G. J. Berry, E. Smith, C. Kast, T. Mcginn, +1 Additional Author

Journal Articles

© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved. We performed a prospective study of 501 patients, regardless of symptoms, admitted to the hospital, to estimate the predictive value of a negative Nasopharyngeal swab for SARS-CoV-2. At a positivity rate of 10.2%, the estimated Negative Predictive Value (NPV) was 97.2% and NPV rose as prevalence decreased during the study.

Increased Inpatient Mortality For Cardiovascular Patients During The First Covid-19 Epidemic In New York, S. Richardson, J. S. Hirsch, M. Narasimhan, J M. Crawford, T Mcginn, K W. Davidson, V. Singh

Journal Articles

No abstract provided.

The Paradox Of Stemi Regionalization: Widened Disparities Despite Some Benefits, R. O. Roswell, R. Brown, S. Richardson

Journal Articles

No abstract provided.