Medicine and Health Sciences Commons^™

Neural Correlates Of Fear Extinction: Investing The Impact Of Puberty And Sex In Children And Adolescents Through Neuroimaging, Sneha Bhargava, Clara Zundel, Samantha Ely, Carmen Carpenter, Reem Tamimi, Leah Gowatch, Mackenna Shampine, Emilie-Clare O'Mara, Jovan Jande, Shravya Chanamolu, Ahmad Almaat, Hilary Marusak

Medical Student Research Symposium

Fear-based disorders, including anxiety and posttraumatic stress disorder, are more prevalent in females than males. Steroid hormones (e.g., estradiol) are involved in fear extinction learning and later recall—a process implicated in the pathophysiology of fear-based disorders. Fear-based disorders commonly emerge during the transition from childhood to adolescence, a period marked by the onset of puberty and a natural increase of steroid hormones. Here, we examined the effects of puberty, sex, and their interaction on extinction recall and underlying neural circuitry in youth. Eighty-five youth (6-17 years, 46% female) completed a two-day Pavlovian fear extinction paradigm while undergoing functional magnetic resonance …

Mental Health Attitudes And Perspectives Of Arab Americans: Beliefs Associated With Stigma, Treatment, And The Origins Of Pathology, Sadie Knill, Liam Browning, Nicole Oska, George Kidess, Liza Hinchey, Arwa Saleem, Malaak Elhage, Arash Javanbakht

Medical Student Research Symposium

Purpose:

Arab Americans are one of the largest ethnic groups in the United States. Despite elevated incidence of mental illness and diminished rates of treatment within this community, the mental health of Arab Americans, along with their attitudes towards mental health, has not received adequate study. Unique cultural interpretations of mental illness may engender stigma, exacerbating disparities in treatment. This study aimed to assess the attitudes and perspectives of Arab Americans concerning mental illness, with the goal of identifying and addressing barriers to treatment.

Methods:

Using an anonymous bilingual Qualtrics survey, we assessed Arab and non-Arab participants (n = 294; …

Amniotic Bladder Therapy In Covid-Associated Cystitis (Cac), Michael C. Wang, Jack Vercnocke Md, Codrut Radoiu, Cullen Hudson, Emma Ross, Raghav Madan, Steve Lucas, Nivedita C. Dhar

Medical Student Research Symposium

Introduction:

SARS-coV-2 is linked to genitourinary symptoms of overactive bladder (OAB), marked by increased frequency, urgency, and nocturia, and has been recently labeled COVID-associated cystitis (CAC). The predominant pathophysiology is proposed to be overexpression of pro-inflammatory cytokines causing bladder inflammation, fibrosis, and bothersome urinary symptoms. Research supports that amniotic membrane (AM) can be used to induce apoptosis of pro-inflammatory cells, inhibit differentiation of pro-fibrotic cells, and expedite wound healing. We investigated the therapeutic response and safety of AM in 5 CAC patients with resistant OAB symptoms.

Methods:

All study patients were admitted for treatment of COVID-19 in spring 2019 and …

Addressing Barriers To Black Americans Participation In Clinical Trials: A Faith-Based Community Survey, Alexandra Stone, Lydell Lettsome Md, Brian A. Stone Md, Clinical Diversity Solutions

Medical Student Research Symposium

Background: The underrepresentation of high-risk minority groups in clinical trials remains a crisis in American healthcare. Despite pressures from the NIH to increase Black-American participation in trials, recruitment and retention in this group rarely match population demographics. Our company launched an opinion survey polling 260 Blacks regarding their thoughts and awareness about clinical trial participation.

Methods: We created a web-based survey consisting of 38 items and subdivided it into three main sections: (1) cultural affinity, (2) trust, and (3) background information. The survey was conducted using Jotform, a HIPAAcompliant web-based application. Our target population was Black Americans in central Alabama. …

Investigating Arab American Perspectives On Barriers To Mental Health Treatment, Arwa Saleem, Liam Browning, Nicole Oska, George Kidess, Liza Hinchey, Sadie Knill, Malaak Elhage, Arash Javanbakht

Medical Student Research Symposium

Purpose: Compared to the general population, Arab Americans experience higher rates of mental illness and lower rates of mental health treatment. While some causes of this discrepancy have been suggested, there are many gaps in the literature since Arab Americans are not recognized as an ethnic group in the United States. This study aims to analyze Arab-Americans’ outlook on mental health by identifying and addressing the barriers to receiving mental health treatment.

Methods: An anonymous bilingual Qualtrics survey was conducted and responses were collected from Arab and non-Arab participants (n=294, ages 18+). The participants’ viewpoints on barriers between Arabs and …

The Roles Of Lower Glycolytic Enzymes And Transporters In Regulating The Integrity Of Retinal Vascular Endothelial Cell Barrier, Nicole Oska, Shaimaa Eltanani, Mohamed Shawky, Thangal Yumnamcha, Ahmed S. Ibrahim

Medical Student Research Symposium

Purpose: Damage to the retinal endothelial cells (RECs) is implicated in the progression of retinal degenerative diseases, including diabetic retinopathy and diabetic macular edema. While the role of glycolysis in glucose homeostasis is well-established, its contribution to REC barrier assembly remains unclear. In this study we investigated the importance of lower glycolytic components in maintaining the barrier integrity of human RECs (HRECs). Methods: Electric cell-substrate impedance sensing (ECIS) technology was employed to analyze the real-time impact of various glycolytic enzymes and transporters on the maintenance of HREC barrier integrity, represented by resistance (R) across the cells. Heptelidic acid was used …

Trauma And Anxiety: The Narratives Of Syrian Youth Resettled As Refugees, Jessica Declercq, Lana Ruvolo Grasser, Rasheed Alahmad, Bassem Saad, Hiba Abu Suhaiban, Dalia F. Mammo, Celine Bazzi, Ragda Izar, Noor Abou-Rass, Ayat Abed Ali, Raya Nashef, Tanja Jovanovic, Arash Javanbakht

Medical Student Research Symposium

Background

Civilian war trauma and forced migration are among the most traumatic life experiences. There are approximately 36.4 million refugees worldwide; 40% are children. There is a paucity of mixed methods approaches that quantify properties of trauma narratives of refugee youth. This approach could assist in identifying individuals who could benefit from early clinical care.

Methods

Participants were 68 youth resettled as refugees of Syria in Southeast Michigan ages 7-17 (31F, M_age = 12.85), originally recruited from clinics during health screenings within one month of arrival in the United States. Those enrolled in this study consented to additional data …

The Long-Term Economic Implications Of Burn Injury For Burn Survivors, Jacob M. Dougherty Bs, Hannan A. Maqsood Mbbs, Zhaohui Fan Md Mph, Stewart C. Wang Md Phd, Mark R. Hemmila Md, Naveen F. Sangji Md Mph

Medical Student Research Symposium

Introduction: The long-term economic implications of burn injury on patients and payors has not been well described. Burn injury can be costly due to prolonged intensive care, wound care, rehabilitation, psychological care, and reconstructive surgery that may be required well after the initial injury. We investigated index and post-acute payor and out-of-pocket (OOP) costs related to burn injury for in-patient care at 30 days, and up to 36 months post-discharge to understand the long-term economic implications for burn survivors.

Methods: An observational cohort study was conducted using a commercial claims database from IBM Watson Health® Marketscan. Patients age ≤ …

Natural Spaces, A Social Determinant Of Health, And Self-Rated Health Among Medical Students, Josiah P. Stryd, Anil N. F. Aranha

Medical Student Research Symposium

Background and Purpose: Natural spaces are areas which have a majority of natural ground cover such as vegetation or water. These spaces have positive effects on both physical and mental health. The purpose of this study was to investigate whether medical students who have greater accessibility and use of natural spaces have better self-rated health.

Methods: M2-M4 students from Wayne State University School of Medicine received an email link to the Qualtrics-based study. Variables evaluated included: sociodemographics, residence zip code, natural spaces access frequency, distance, and transportation method. Self-rated physical and mental health was measured using the Healthy Days measure …

A Quantitative Analysis Of Microglia Morphology In Adult Zebrafish Retinas, Yasmeen Berry, Ashley Kramer, Justin Carthage, Ryan Thummel

Medical Student Research Symposium

No abstract provided.

Interpatient Differences In Neural Recruitment Patterns During Pudendal Nerve Stimulation – A Computational Investigation, Amolak S. Jhand, Luis C. Ruiz, Nystha Baishya, Ehsan Mirzakhalili, Gaurang Shah, Priyanka Gupta, Tim M. Bruns, Scott F. Lempka

Medical Student Research Symposium

Bladder dysfunction impairs the quality of life for millions of individuals around the world. Common causes of bladder dysfunction include aging, trauma, and neurological disorders. Due to inadequacies in conventional treatments, neuromodulation therapies to address bladder dysfunction, such as sacral nerve stimulation, have emerged. However, patient needs still remain unmet. Pudendal nerve stimulation (PNS) has recently gained clinical interest as a promising treatment for bladder dysfunction. While PNS has been extensively investigated in preclinical settings, there is a gap in our understanding of the mechanisms of action and efficacy of PNS as limited studies of PNS have been performed on …

Purine And Pyrimidine Monophosphate Vs Polyphosphate Homeostasis In Human Retinal Endothelial Cells, Andrew Gregory, Jenna Hart, Thangal Yumnamcha, Mohamed Shawky, Shaimaa El Tanani, Ahmed Ibrahim

Medical Student Research Symposium

Introduction: A major cause of blindness is proliferative diabetic retinopathy (PDR), and there is limited data on the nucleic acid (NA) profiles in PDR. We characterized the profiles of NAs in human retinal endothelial cells (HRECs) subjected to high glucose (HG) and hypoxia (Hyp) - common risk factors associated with PDR.

Methods: HRECs were treated with osmotic control (Mannitol, 25 mM) or high glucose (HG, 25 mM) for 5 days, followed by normoxia or hypoxia (Hyp, 2% O2) for 24 hours. Pathway enrichment analysis from the significant metabolites in the Hyp+HG vs control comparison was subsequently performed.

Results: The precursors …

Amniotic Bladder Therapy In Patients With Interstitial Cystitis/Bladder Pain Syndrome, Jack Considine, Codrut Radoiu, Sophie Wittenberg, Nivedita Dhar Md, Raghav Madan Md, Jack Vernocke Md, Aron Liaw Md, Alaa Hamada Md

Medical Student Research Symposium

Introduction and Objectives: Our study hypothesis postulates that if patients with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) bladders exhibit increased inflammation, fibrosis, and urothelial dysfunction, then treatment modalities that modulate inflammation and fibrosis, while promoting a regeneration may have a therapeutic effect in such patients. Amniotic membrane (AM) has been shown to foster a regenerative wound-healing environment. This study investigates the safety and efficacy of bladder injections of AM in patients with treatment resistant IC/BPS.

Methods: Fifteen consecutive treatment resistant IC/BPS patients (mean age 50.7 ± 14.4 years) with a median disease duration of 7 years (5-12 years) were …

Cidofovir In The Treatment Of Bk Virus–Associated Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation; A Medication Use And Safety Analysis, Ryan Nazareno, Lea Monday Md, Pharmd, Dhaval Edward Macdonald Patel

Medical Student Research Symposium

BK virus hemorrhagic cystitis (BKV-HC) is a complication after allogeneic hematopoietic stem cell transplant (AlloHCT) for which optimal management is uncertain. Intravenous (IV) and intravesicular (IVES) cidofovir have been used with varying degrees of success in small case series of six to 33 patients. While some series have investigated side effects, none have examined medication errors. A retrospective single-center case series of AlloHCT patients with BKV-HC given IV or IVES cidofovir (CDV) from 2018 to 2022 at an urban cancer center in Detroit, MI. Our primary objective was to determine the incidence of CDV related medication errors (ME) and perform …

Regional And Socioeconomic Factors Impacting Pediatric Victims Of Cranial Gunshot Wounds: Analysis Of The Kids’ Inpatient Database (Kid), Michael Melhem, Elise Yoon, Matthew Brennan, Enoch Kim, Yasmeen Berry, Michael Cools, Leopold Arko

Medical Student Research Symposium

Introduction

Injury by firearms among the pediatric population is a growing concern in the United States. This paper investigates demographic factors associated with pediatric cranial gunshot wounds (GSW).

Methods

A query of the KID databases from 1997-2019 was run for cranial GSW and craniotomy ICD-9 and ICD-10 codes. ANOVA and chi-squared tests were performed to analyze demographics and outcomes by injury type.

Results

Our query resulted in 2990 cranial GSW patients; 86.1% were male. Mean age was 16.48 years; accidental victims were the youngest and intentional the oldest (14.88±5.2, 17.2±2.3, p< 0.001). Blacks, Hispanics, and Asian-Pacific-Islanders (minorities) were most commonly victims of assault; Whites were most commonly victims of intentional GSW (p< 0.001). Victims mostly had Medicaid except for intentional victims who were more likely to have private insurance (p< 0.001). Assault was the predominant injury type in all regions, especially in the West (33.7%). The South had the most accidental (51.9%) and intentional (44.6%) injuries. In 1997 and 2019 the predominant GSW type was accidental; in all other years assault predominated. Accidental victims were most likely to undergo craniotomy and intentional were least likely (p< 0.001). Inpatient mortality was 46.4% with intentional victims having the highest rate (68.6%) then undetermined (60.3%) and law enforcement-related (57.7%).

Conclusion

Victims of assault were more likely to be …

Six-Month Report Assessing The Feasibility And Effectiveness Of Amniotic Membrane Injections In Patients With Short, Anterior, Urethral Strictures, Nicholas Pryde, Jack Vernocke, Aron Liaw, Michael Sessine, Nivedita Dhar

Medical Student Research Symposium

Introduction: Urethral stricture treatment has high recurrence rates and adjunct injectable agents have been explored. Amniotic membranes (AM) promote apoptosis of pro-inflammatory cells, prevent differentiation of pro-fibrotic cells, and decrease scar formation. These tissues generated interest in reconstructive urethral surgery. Thus, we performed urethral dilation combined with micronized AM injection in urethral scar tissue for treatment of urethral stricture.

Materials and Methods: Adult males with strictures ≤12Fr in diameter and ≤2 cm in length, International Prostate Symptom Score (IPSS) ≥11 and maximum flowrate <15 ml/s. Reconstituted 100mg micronized AM was injected at the time of urethral dilation. Primary study end point was anatomical success (≥14Fr by cystoscopy) at 6 months. Secondary end points were questionnaires, flow rate, and post void residual. Outcomes assessed at baseline, 5 days, 14 days, 3 months, and 6 months post-injection. Safety was analyzed.

Results: Ten men, mean age of 52 ± 15 years, were included. There were 7 patients with …

Breast Cancer And Colorectal Cancer Screening In Arab Americans From 2021-2023, Nicole Oska, Hasti Nema, Deni Peterson, Kendall Brothers, Mohammed Najeeb Al Hallek

Medical Student Research Symposium

Breast Cancer and Colorectal Cancer Screening in Arab Americans from 2021-2023

Nicole Oska¹, Hasti Nema¹, Deni Peterson¹, Kendall Brothers¹, Mohammed Najeeb Al Hallak^1,2

¹Department of Oncology, School of Medicine, Wayne State University, Detroit, MI, USA; ²Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA

Introduction:

Breast cancer (BC) and colorectal cancer (CRC) are among the most commonly diagnosed cancers in the United States^1,2; screening for these cancers is a pivotal component of preventative healthcare. Arab Americans represent a diverse, yet understudied, patient population that may encounter distinct barriers …

Efficacy Of Hypnosis As A Treatment For Alopecia, Haya Beydoun, Meena Moossavi

Medical Student Research Symposium

Title:

Efficacy of Hypnosis as a treatment for Alopecia

Introduction:

Hypnosis is an altered state of consciousness in which someone is more receptive to suggestions and modeling, and it can address psychological and physical symptoms that are aggravated by conscious and unconscious triggers.The intended outcome is a change in certain behaviors or patterns of thinking that patients have which can mitigate their stress load. Stress can induce and exacerbate alopecia, and patients often suffer increased stress due to the psychosocial burden of having a dermatological disease. A study showed that high levels of cortisol releasing hormones (CRH) were found to …

Tendon Rupture And Tendonitis In Low-Profile Dorsal Versus Volar Plating For Distal Radius Fractures: A Systematic Review And Meta-Analysis, Matthew Myhand, Shreya Balusu, Alex Lindahl Bs, Hardy Evans Md, Charles Day Dr., Eric Jiang Dr.

Medical Student Research Symposium

Tendon Rupture and Tendonitis in Low-Profile Dorsal versus Volar Plating for Distal Radius Fractures: A Systematic Review and Meta-Analysis

Background: Dorsal plating of distal radius fractures has historically been associated with high rates of hardware removal, tendonitis, and tendon rupture. Newer generation low-profile dorsal plates are thinner (<1.6mm thick) with improved characteristics. We examine whether low-profile dorsal plates still have higher rates of tendon complications than volar locking plates.

Methods: We searched Ovid MEDLINE, Web of Science, and EMBASE for published literature describing tendon complications in association with plating of distal radius fractures. Inclusion criteria encompasses any primary study of low-profile dorsal plates that included data on tendon complications. Studies that included both low-profile dorsal and volar plating arms were included …

Biological Sex Is A Predictor Of Pretibial Subcutaneous Tissue Depth For Intraosseous Catheter Insertion, Alex Duvall, Thomas Sprys-Tellner, Tristan Lemon, Ryan Kelly, Andrew Stefan, James Paxton

Medical Student Research Symposium

Introduction

Intraosseous (IO) vascular access is most commonly used when critical patients need rapid establishment of vascular access. They have shown high rates of successful placement, with the proximal tibia showing the highest first-attempt success rates. Proper establishment of vascular access requires a needle properly sized to enter the bony cortex and stay there. In this study, we analyzed demographic associations with pre-tibial subcutaneous tissue depth (PTSTD).

Methods

The PTSTD was calculated using computed tomography (CT) images of adult (³ 18 years old) patients. Variables including side, age, sex, height, weight, BMI, hypertension, diabetes mellitus, atherosclerosis, coronary artery disease, and …

Utilizing Bibliometrics To Understand The Role Of Machine Learning In The Current Orthopedic Arthroplasty Literature, Matthew Corsi Bs., Fong Nham Md., Mouhanad El-Othmani Md

Medical Student Research Symposium

Background: Machine learning technology has been demonstrated to be a very useful tool in current orthopedic research. Furthermore, machine learning has shown to be quite impactful in the field of arthroplasty solving many clinical and scientific problems, leading to greater utilization in retrospective studies. This current study aims to identify machine learning arthroplasty research and predict future hotspots. We hypothesize that the production of current scientific literature on machine learning will be produced by US-based national institutions and will have exponentially grown in the past 5 years.

Methods: Machine learning arthroplasty publications between 1996 and 2023 were identified using the …

Assessing Mentor And Coordinator Professional Development In The Context Of Medical School Learning Communities, Chelsea Yu, Alyssa Fabrizio, Gretchen Swift, Brianna Regan, Jack Considine, Carline Dugue

Medical Student Research Symposium

Background
Learning communities (LCs) create a bridge for senior students to engage with peers to provide advice and support. Anecdotally, LC leaders gain confidence in communication, empathy, and leadership - well received traits for residency. We aim to describe and quantify the growth of LC leaders over time.

Methods
This study aims to elucidate an objective measure of student leader growth and development. We will evaluate opinions on the LC’s ability to foster professional and personal growth, and we will assess areas for improvement. Through Qualtrics self-rated queries using a Likert scale, we will survey 32 Coordinators from classes 2023-2026 …

Fueling Survival: Adipocyte-Mediated Modulation Of Iron Metabolism And Oxidative Stress Pathways In Bone Metastatic Prostate Cancer, Shrila Rajendran, Alexis Wilson, Shane Mecca, Mackenzie Herroon, Laimar Garmo, Izabela Podgorski

Medical Student Research Symposium

Fueling survival: Adipocyte-mediated modulation of iron metabolism and oxidative stress pathways in bone metastatic prostate cancer

Authors: Shrila Rajendran^1*, Alexis Wilson^1,2, Shane Mecca¹, Mackenzie Herroon¹, Laimar Garmo¹, and Izabela Podgorski^1,2

Department of Pharmacology, Wayne State University School of Medicine¹ and Cancer Biology Graduate Program, Wayne State University School of Medicine and Karmanos Cancer Institute²

Prostate cancer (PCa) commonly metastasizes to the bone marrow, where cancer cells interact with a variety of cell types that compose the bone tumor microenvironment. The interaction of interest for this research is …

Exploring The Effects Of Amniotic Bladder Therapy On Female Sexual Dysfunction In Interstitial Cystitis/Bladder Pain Syndrome Patients, Jonathan D. Lutchka, Jack Vercnocke Md, David Pearlman Md, Aron Liaw Md, Nivedita Dhar Md

Medical Student Research Symposium

Introduction and Objectives: Female sexual dysfunction (FSD) is commonly associated with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). FSD manifests as abnormalities in sexual desire, arousal, orgasm, pain, distress, and satisfaction. Our primary objective was to assess the impact of micronized amniotic membrane injections (AM) on FSD and lower urinary tract symptoms using comprehensive measures, including the multi-domain Female Sexual Function Index (FSFI), the Pain Visual Analog Scale (VAS), and the Interstitial Cystitis Symptom Index (ICSI) and Interstitial Cystitis Problem Index (ICPI).

Methods: Study participants included patients diagnosed with IC/BPS and FSD refractory to traditional therapies. Under general anesthesia, these …

Flash Radiation Ultra-High Dose Rate Radiation With Potential For Sensitization By Platinum, Abigail A. Jaczkowski, Stephen Brown Ph.D.

Medical Student Research Symposium

External beam radiation therapy, a cornerstone in cancer treatment for 50% of patients, poses challenges due to its toxicity to both cancer and healthy cells. Seeking to mitigate side effects, the emerging FLASH radiation technology employs ultra-high dose rates, promising quicker treatments with reduced impact on surrounding normal tissue. Platinum, recognized as a radiation sensitizer, enhances the effectiveness of radiation therapy by increasing sensitization at higher energy levels through pair-production.

This study explores the hypothesis that Cisplatin, a platinum-based chemotherapy agent, will exhibit a synergistic effect when combined with FLASH radiation. Using A549 cells from non-small cell lung cancer, the …

The Efficacy And Frequency Of Early Left Heart Catheterization After Out Of Hospital Cardiac Arrest Over The Last Decade, Shobi Mathew, Robert Welch, Robert Swor, Robert R. Ehrman, Anthony Lagina, Brian O'Neil

Medical Student Research Symposium

Introduction:

The efficacy of early coronary intervention after return of spontaneous circulation (ROSC) from out of hospital cardiac arrest (OHCA) is debated. We aimed to nationally study the effect of early LHC on survival with good neurological outcome and describe the rate and timing of LHC in OHCA.

Methods:

The observational study included patients enrolled in the national CARES registry from 2013-21. Outcome was cerebral performance category, (CPC) (good <3 vs. poor > 3) at hospital discharge. For the outcome of LHC by year, chi square analysis was performed. A propensity score (PS) model was constructed using variables predictive of LHC and good outcome …

Exploring The Relationship Of Varying Hydrocephalus Severity On Csf Dynamics In A Pediatric Hydrocephalus Rodent Model, Parker R. Fitzgerald, Grant Zydeck, Jeff Horbatiuk, Enoch Kim, Arjun Muralidharan, Carolyn A. Harris Phd

Medical Student Research Symposium

Hydrocephalus causes neurological effects and high intracranial pressure (ICP) in the pediatric condition. Studies observing the relationship between ICP and cerebrospinal fluid (CSF) production in an electrical resistance model have been performed, but less has been done to define this relationship in living organisms. This study explored CSF flow dynamics as a consequence of hydrocephalus severity utilizing a novel model.

The model induced hydrocephalus in rats through injecting 30-50 micrometers of 25% (w/v) kaolin into the cisterna magna to obstruct CSF outflow. After 15-16 days of acclimation, the rats were anesthetized with isoflurane. A Transonic SP200 pressure transducer was inserted …

A Pilot Study Assessing The Efficacy Of Amniotic Bladder Therapy In Spinal Cord Injury Patients With Female Sexual Dysfunction, Kyle P. O'Hollaren, Emma Ross, Codrut Radoiu, Lincoln Erickson, Michael Bush-Arnold, Ali Bitar, Steven Lucas, Nivedita Dhar

Medical Student Research Symposium

Introduction and Objectives: Female sexual dysfunction (FSD) following spinal cord injury (SCI) presents with abnormalities in sexual desire, arousal, orgasm, pain, distress, and dissatisfaction. FSD negatively impacts quality of life and is often refractory to available treatment options. Previously, we reported preliminary benefits of intra-detrusor micronized amniotic membrane (AM) on detrusor dysfunction following SCI. In this study, we evaluated the effect of intra-detrusor micronized AM injection on FSD symptoms in SCI patients using the multi-domain female sexual function index (FSFI) and pain visual analog scale (VAS).

Methods: Five SCI females (mean age: 32 ± 12 years) with FSD recalcitrant to …

Examining Vaccine Hesitancy Trends In An Underserved Population At A Student-Run Free Clinic, John Pum, Cameron Bear, Dhiraj Tadikamalla, Hasti Nema

Medical Student Research Symposium

Title: Examining Vaccine Hesitancy Trends in an Underserved Population at a Student-Run Free Clinic

Authors: John Pum, Cameron Bear, Dhiraj Tadikamalla, Hasti Nema, Robert Sherwin M.D.

Introduction:

The global debate surrounding the safety and efficacy of COVID-19 vaccines has triggered widespread vaccination hesitancy, impacting not only COVID-19 immunizations but also other vaccines. This study investigates whether a parallel trend exists within a Student-Run Free Clinic (SRFC), focusing on an underserved population disproportionately affected by the pandemic.

Methods:

Retrospective analysis was conducted by coordinators of Cass Clinic, a Detroit-based SRFC. Patients included were individuals 18 or older who received the influenza …

Six- Month Report Assessing The Feasibility And Effectiveness Of Amniotic Bladder Therapy In Patients With Chronic Radiation Cystitis, Samy Shelbaya, Raghav Madan, Nick Pryde, Jack Vercnocke, Codrut Radoiu, Julian Julian Jeberaeel, Nitin Vaishampayan, Nivedita Dhar

Medical Student Research Symposium

Introduction: In view of the pathophysiology of chronic radiation cystitis (CRC) that is mainly caused by activation of an inflammatory cascade leading to chronic inflammation, vascular damage and fibrosis, amniotic membrane (AM) based therapy has emerged as a potential therapeutic approach for radiation-induced tissue injury due to its immunomodulatory, vasculogenic and anti-fibrotic properties. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory CRC patients for up to 3 months. Herein, we evaluated the durability of ABT up to 6 months.

Methods: CRC patients recalcitrant to multiple therapies were eligible for the study and …