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Assessment Of Soil Transmitted Helminth Infection (Sthi) In School Children, Risk Factors, Interactions And Environmental Control In El Salvador., Sharad Suryakant Malavade Sep 2015

Assessment Of Soil Transmitted Helminth Infection (Sthi) In School Children, Risk Factors, Interactions And Environmental Control In El Salvador., Sharad Suryakant Malavade

USF Tampa Graduate Theses and Dissertations

Background:

Soil transmitted helminth infections (STHI) are important Neglected Tropical Diseases (NTD). The three main STHI are infections with Ascaris lumbricoides, Trichuris trichiura and hookworms. STHI have a significant effect on the growth and development of children. A national survey for STHI in El Salvador by Pan American Health Organization and Ministry of Health in 2012 in school children aged 8years to 10 years. The survey collected data on age, gender, behavioral habits, and source of drinking water, type of toilet facility used and ecological zone of residence.

A) We did an analyses of the data with an aim to …


Validity Of A Nonspeech Dynamic Assessment Of Phonological Awareness In Children From Spanish-Speaking Backgrounds, Bianca Angelica Loreti Sep 2015

Validity Of A Nonspeech Dynamic Assessment Of Phonological Awareness In Children From Spanish-Speaking Backgrounds, Bianca Angelica Loreti

USF Tampa Graduate Theses and Dissertations

Literacy development in Spanish-speaking children is a growing concern in the United States (Invernizzi, 2009). Phonological awareness is a predictor of literacy achievement in most alphabetic languages (Anthony et al., 2011; Davison & Brea-Spahn, 2012; Durgunoğlu, Nagy, & Hancin-Bhatt, 1993; Goikoetxea, 2005). Bilingual children with complex communication needs (CCN) demonstrate increased difficulties in speaking, reading, and writing, making learning two languages a difficult task (Toppelberg, Snow, & Tager-Flusberg, 1999). Literacy attainment in bilingual individuals who have CCN is important to improve their overall language development and communication interaction skills (Harrison-Harris, 2002). A valid and reliable phonological awareness assessment that does …


Energy Production And Effluent Quality In Tubular Digesters Treating Livestock Waste In Rural Costa Rica, Maureen Njoki Kinyua Sep 2015

Energy Production And Effluent Quality In Tubular Digesters Treating Livestock Waste In Rural Costa Rica, Maureen Njoki Kinyua

USF Tampa Graduate Theses and Dissertations

Use of tubular anaerobic digesters to treat livestock waste in developing countries has energy, agricultural, health, social and environmental benefits. However, careful use of digester effluent as a soil amendment is required due to the potential presence of protozoan parasites Cryptosporidium parvum and Giardia lamblia. This research investigated the performance of four tubular digesters in the Monteverde region of Costa Rica. High (>75%) volatile solids and BOD5 removal efficiencies were observed, which was attributed to the formation of a biologically active floccular sludge layer. Computational fluid dynamics (CFD) and bioprocess models were developed to evaluate the transport and transformation …


Using Self-Monitoring And Goal Setting To Increase Swimming In Adults, Sarah Rose Abraham Sep 2015

Using Self-Monitoring And Goal Setting To Increase Swimming In Adults, Sarah Rose Abraham

USF Tampa Graduate Theses and Dissertations

Many people in the United States do not engage in the recommended levels of physical activity. Self-management strategies, including self-monitoring and goal setting, are among the interventions that have been used to increase physical activity in adults. Visual feedback has also been incorporated into interventions to increase physical activity. Minimal research has focused on increasing swimming behavior. The current study investigated the effectiveness of self-management strategies to increase swimming activity in adults. An automated recording device (watch) was used to collect data on participants’ swimming behavior. The effect of self-monitoring in the form of a self-graphing intervention to increase swimming …


Perspective From Two Professions: Two Professionals Making Meaning Of The Clinical Educator Role, Tara Payor Aug 2015

Perspective From Two Professions: Two Professionals Making Meaning Of The Clinical Educator Role, Tara Payor

USF Tampa Graduate Theses and Dissertations

The purpose of this phenomenological study was to describe how professional educators make sense of their role in helping novice practitioners make meaning from authentic clinical practice. Simultaneously studying a clinical educator from teacher and graduate medical education, and subsequently setting their stories side by side, speaks to the interest both professions have in learning from the other. Both clinical educators were Board certified in their respective area of practice. In-depth phenomenological interviewing was used as the study’s methodology, and the professional formation construct served as the study’s conceptual framework. Data corroborate findings in the literature that there is a …


Race/Ethnic Disparities In Treatment Patterns Among Newly Diagnosed Primary Prostate Cancer Patients In Florida, Vonetta L. Williams Apr 2015

Race/Ethnic Disparities In Treatment Patterns Among Newly Diagnosed Primary Prostate Cancer Patients In Florida, Vonetta L. Williams

USF Tampa Graduate Theses and Dissertations

Study Purpose: The purpose of this study was to examine whether there were differences in patterns of care between African American (AA) and Non-Hispanic White (NHW) men newly diagnosed with prostate cancer in Florida, and how the treatment patterns compare with the National Comprehensive Cancer Network (NCCN) initial treatment recommendations.

Materials and Methods: This retrospective cohort study utilized data from the Florida Cancer Data System (FCDS), to identify incident cases of prostate cancer diagnosed between 1982 and 2012. The variables of interest included: race/ethnicity, marital status, age at diagnosis, stage at diagnosis, tumor grade, year of diagnosis, and treatment modality …


Slope Settlement And Post-Disaster Health Needs Of Urban Displacement In La Paz, Bolivia, James Steven Arango Apr 2015

Slope Settlement And Post-Disaster Health Needs Of Urban Displacement In La Paz, Bolivia, James Steven Arango

USF Tampa Graduate Theses and Dissertations

In 2011, a landslide displaced approximately six thousand people from the urbanized mountain slopes of La Paz, Bolivia. The municipal government of La Paz (GAMLP) managed the displacement by housing thousands of people in displacement camps throughout the city. By 2013, residents were attempting to return to still damaged lands. This research used participant observation and interviews with residents over eight weeks in 2013 to address the following questions: 1) What social, cultural, economic or historic factors influence the settling and then resettling of at-risk slope neighborhoods in La Paz, Bolivia? 2) What are the most pressing health needs of …


The Impact Of The Veterans Health Administration's Home Based Primary Care On Health Services Use, Expenditures, And Mortality, Melissa Castora-Binkley Mar 2015

The Impact Of The Veterans Health Administration's Home Based Primary Care On Health Services Use, Expenditures, And Mortality, Melissa Castora-Binkley

USF Tampa Graduate Theses and Dissertations

Background: Among patients with multiple chronic conditions, care coordination and integration remains one of the major challenges facing the U.S. health care system. A home-based, patient-centered primary care program has been offered through the Veterans Health Administration (VHA) since the 1970s for frail veterans who have difficulty accessing VHA clinics. The VHA Home Based Primary Care (VHA HBPC) aims to integrate primary care, rehabilitation, disease management, palliative care, and coordination of care for frail individuals with complex, chronic diseases within their homes. Early research suggested that VHA HBPC was associated with positive outcomes (e.g., reduced resource use and patient satisfaction). …


Gene Expression Analysis Of Upregulated Genes By 20-Oh Ecdysone In Brugia Malayi, Monica Lazaro Mar 2015

Gene Expression Analysis Of Upregulated Genes By 20-Oh Ecdysone In Brugia Malayi, Monica Lazaro

USF Tampa Graduate Theses and Dissertations

Brugia malayi is a filarial nematode causing lymphatic filariasis in humans characterized by swelling of the lower extremities. The aim of this study was to conduct a real time PCR (qRT-PCR) to verify gene expression levels of Brugia malayi nematodes treated with 20 hydroxyecdysone. Transcriptome analysis was previously performed resulting in the identification of 44 genes that were upregulated by exposure to 20-hydroxyecdysone. Based on transcriptome results, known GO Terms and functions, four genes and one endogenous housekeeping gene were chosen for validation by RT-PCR. Induced samples showed a mean increase of microfilarie by 2.2 fold. Induced wells exhibited a …


Food Insecurity And Hunger Experiences And Their Impact On Food Pantry Clients In The Tampa Bay, Nora Brickhouse Arriola Mar 2015

Food Insecurity And Hunger Experiences And Their Impact On Food Pantry Clients In The Tampa Bay, Nora Brickhouse Arriola

USF Tampa Graduate Theses and Dissertations

Since 1999, there has been a significant increase in the number of food insecure individuals in the United States. The Great Recession (2007-2009) and slow economic recovery has led to additional increases in rates of food insecurity and the usage of emergency food assistance programs. Thirty qualitative interviews with individuals seeking emergency food assistance at a Tampa Bay food pantry were conducted. Interviews focused on collecting the life experiences of participants, the barriers they face in having food security, their strategies to cope with limited food budgets, and how food insecurity impacts their household's overall health and wellbeing. Recommendations for …


Embedded System Design For Real-Time Monitoring Of Solitary Embedded System Design For Real-Time Monitoring Of Solitary, Robert Philip O'Brien Mar 2015

Embedded System Design For Real-Time Monitoring Of Solitary Embedded System Design For Real-Time Monitoring Of Solitary, Robert Philip O'Brien

USF Tampa Graduate Theses and Dissertations

Alzheimer's disease and other forms of dementia cause cognitive disabilities in the afflicted person. As a result, the person with dementia often requires assistance from a primary caregiver. However, while the caregiver is away from the home they are unaware of the person's status and may not be able to find out without returning to the home due to dementia's effects on cognition.

In this thesis work, a system of embedded devices is presented which tracks a solitary dementia patient in the home in real-time. The system is composed of three main hardware components. Multiple passive and active sensors are …


The Relationship Between Hearing Status And Cognitive Performance And The Influence Of Depressive Symptoms In The Older Adult, Julie A. Daugherty Mar 2015

The Relationship Between Hearing Status And Cognitive Performance And The Influence Of Depressive Symptoms In The Older Adult, Julie A. Daugherty

USF Tampa Graduate Theses and Dissertations

Hearing loss and cognitive impairment are significant health problems, threatening the independent function of older adults. While there appears to be a strong relationship between the two conditions, the mechanisms underlying this association are complex and are not fully elucidated.

The purpose of this secondary analysis was to explore the relationship between hearing ability and cognitive performance in older adults. In addition, this study attempted to examine the role of depressive symptoms in the relationship between hearing loss and cognitive performance. Comprehensive measures of peripheral hearing, central auditory processing and cognitive performance were utilized to examine these relationships in a …


Reproductive Health Seeking Behaviors Among Female University Students: An Action Oriented Exploratory Study, Robin Emily Mowson Feb 2015

Reproductive Health Seeking Behaviors Among Female University Students: An Action Oriented Exploratory Study, Robin Emily Mowson

USF Tampa Graduate Theses and Dissertations

The focus of this research was to: 1) study the perceptions of female students attending the university Student Health Center, concerning available services, 2) learn how they describe their decisions to obtain care, and 3) identify perceived barriers to reproductive health care and contraception. This exploratory study used a mixed-methods approach that included clinic public-space observations, interviews with health care providers and staff at Student Health Services (SHS), surveys distributed to clients of the campus clinic, and in-depth interviews to contextualize emergent themes. Topics addressed included sexual health behaviors and perceptions, influence of peers and partners, the propagation of health …


5-Aminolevulinate Synthase: Characterization Of The Enzymatic Mechanism, Reaction Selectivity, And Structural Plasticity, Bosko M. Stojanovski Feb 2015

5-Aminolevulinate Synthase: Characterization Of The Enzymatic Mechanism, Reaction Selectivity, And Structural Plasticity, Bosko M. Stojanovski

USF Tampa Graduate Theses and Dissertations

5-Aminolevulinate synthase (ALAS) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation between glycine and succinyl-CoA to generate coenzyme A (CoA), CO2, and 5-aminolevulinate (ALA). The chemical mechanism of this reaction, which represents the first and regulated step of heme biosynthesis in mammals, involves the formation of a short-lived glycine quinonoid intermediate and an unstable 2-amino-3-ketoadipate intermediate. Using liquid chromatography coupled with tandem mass spectrometry to analyze the products from the reaction of murine erythroid ALAS (mALAS2) with O-methylglycine and succinyl-CoA, we directly identified the chemical nature of the inherently unstable 2-amino-3-ketoadipate intermediate, which predicates the glycine quinonoid species as …


The Association Of Cognitive Endophenotypes And Risky Single Nucleotide Polymorphisms Of Alzheimer's Disease Within The Alzheimer's Disease Neuroimaging Initiative (Adni) Database, Kyle Joseph Jennette Feb 2015

The Association Of Cognitive Endophenotypes And Risky Single Nucleotide Polymorphisms Of Alzheimer's Disease Within The Alzheimer's Disease Neuroimaging Initiative (Adni) Database, Kyle Joseph Jennette

USF Tampa Graduate Theses and Dissertations

Objective: The purpose of this study was to assess the influence of three single nucleotide polymorphisms (SNP) previously associated with Alzheimer's disease on specific domains of cognition, when controlling for Apolipoprotein E gene (APOE), in a sample of individuals with Alzheimer's disease. Methods: The data were drawn from the Alzheimer's Disease Neuroimaging Initiative database, a comprehensive, longitudinal database of controls, persons with mild cognitive impairment, and persons with mild Alzheimer's disease. Each subject has a full neuropsychological assessment, neuroimaging, genetic sequencing, and physical evaluation. For the purposes of this study, individuals were selected based on the presence of the three …


A Comparative Evaluation Of The Learner Centered Grading Debriefing Method In Nursing Education, Marisa J. Belote Jan 2015

A Comparative Evaluation Of The Learner Centered Grading Debriefing Method In Nursing Education, Marisa J. Belote

USF Tampa Graduate Theses and Dissertations

The nursing discipline lacks a consensus on a best practice method for debriefing students following simulation-based training. A recognized, standardized method does not exist and various methods are utilized within the domain. The similarities between aviation and healthcare are well documented. Training members of both disciplines require standardization and methods of best practice. The aviation industry through the Federal Aviation Administration has found Learner Centered Grading (LCG) to be a successful educational format. The utilization of the LCG Debriefing method in simulation-based training is the standardized debriefing format for a technologically dynamic industry.

The aim of this research was to …


Neuroinflammatory Alterations Via Cd-36 In Traumatic Brain Injury, Diana G. Hernandez-Ontiveros Jan 2015

Neuroinflammatory Alterations Via Cd-36 In Traumatic Brain Injury, Diana G. Hernandez-Ontiveros

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) has become an increasingly unmet clinical need due to intense military conflicts worldwide. Directly impacted brain cells suffer massive death, with neighboring cells succumbing to progressive neurodegeneration accompanied by inflammatory and other secondary cell death events. Subsequent neurodegenerative events may extend to normal areas beyond the core of injury, thereby exacerbating the central nervous system’s inflammatory response to TBI. Recently CD-36 (cluster of differentiation 36/fatty acid translocase (FAT), a class B scavenger receptor of modified low-density lipoproteins (mLDLs) in macrophages, has been implicated in lipid metabolism, atherosclerosis, oxidative stress, and tissue injury in cerebral ischemia, and …


An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis Jan 2015

An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis

USF Tampa Graduate Theses and Dissertations

Research misconduct has been generally considered a limited issue, occurring in a small percentage of research studies. Studies of the number of article retractions use retraction percentages to perpetuate the idea that research misconduct is not a common event, and use information in the retraction notice to quantify types of research misconduct and types or research error. However, retractions appear to be the wrong variable with which to assess misconduct rates and characteristics. Using final misconduct findings in hard science research from the Office of Research Integrity (ORI) for investigations closed from 1993 through 2013, the number of publications and …


Hesitation Rate As A Speaker-Specific Cue In Bilingual Individuals, Jamie Lynn Armbrecht Jan 2015

Hesitation Rate As A Speaker-Specific Cue In Bilingual Individuals, Jamie Lynn Armbrecht

USF Tampa Graduate Theses and Dissertations

Hesitation use is common among all speakers, regardless of whether they are engaged in their dominant or non-dominant language (Fehringer & Fry, 2007; Reed, 2000). The question is whether a bilingual speaker will engage in the same types of hesitations in both languages. If hesitation patterns can be identified consistently across speakers regardless of language, their use as an acoustic cue for speaker identification may be possible. This study examines differences in hesitation use across languages and speaking contexts (reading vs. conversation) in bilingual speakers.

Twenty Spanish-English bilinguals (ages 19 -31 years) were tested as part of a larger speaker …


Sound Attenuation Performance Of Fiber-Reinforced Polymer Composite Circumaural Hearing Protection Devices, Steven Christopher Augustine Jan 2015

Sound Attenuation Performance Of Fiber-Reinforced Polymer Composite Circumaural Hearing Protection Devices, Steven Christopher Augustine

USF Tampa Graduate Theses and Dissertations

Personnel who work on the flight deck of an aircraft carrier are exposed to extreme levels of jet engine noise often in excess of 140 decibels (dB). The current circumaural hearing protective devices (CAHPD) employed by flight deck crewmen are inadequate for the level of protection required for these extreme levels of noise. Fiber-reinforced thermoset polymer composite (FRPC) materials such as aramid fibers used in body armor, have high theoretical values of acoustic impedance due to a fundamentally high modulus of elasticity and may offer a superior level of hearing protection over original equipment (OE) thermoplastic CAHPDs. The objective of …


Anticipatory Coarticulation And Stability Of Speech In Typically Fluent Speakers And People Who Stutter Across The Lifespan: An Ultrasound Study, Alissa Joy Belmont Jan 2015

Anticipatory Coarticulation And Stability Of Speech In Typically Fluent Speakers And People Who Stutter Across The Lifespan: An Ultrasound Study, Alissa Joy Belmont

USF Tampa Graduate Theses and Dissertations

This study uses ultrasound to image onset velar stop consonant articulation in words. By examining tongue body placement, the extent of velar closure variation across vowel contexts provides for the measurement of anticipatory coarticulation while productions within the same vowel context provide measurement of extent of token-to-token variation. Articulate Assistant Advanced 2.0 software was used to semi-automatically generate midsagittal tongue contours at the initial point of maximum velar closure and was used to fit each contour to a curved spline. Patterns of lingual coarticulation and measures of speech motor stability, based on curve-to-curve distance (Zharkova, Hewlett, & Hardcastle, 2011), are …


Sigma Receptor Activation Mitigates Toxicity Evoked By The Convergence Of Ischemia, Acidosis And Amyloid-Beta, Adam Alexander Behensky Jan 2015

Sigma Receptor Activation Mitigates Toxicity Evoked By The Convergence Of Ischemia, Acidosis And Amyloid-Beta, Adam Alexander Behensky

USF Tampa Graduate Theses and Dissertations

Stroke is the fifth leading cause of death in the United States and a major cause of long-term disability in industrialized countries. The core region of an ischemic stroke dies within minutes due to activation of necrotic pathways. Outside of this core region is the penumbral zone, where some perfusion is maintained via collateral arteries. Delayed cell death occurs in this area due to the triggering of apoptotic mechanisms, which expands the ischemic injury over time. The cellular and molecular events that produce the expansion of the ischemic core continue to be poorly understood. The increases in the amyloid precursor …


Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck Jan 2015

Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck

USF Tampa Graduate Theses and Dissertations

Evidence suggests comorbidity of ADHD and eating disorders (EDs) among females. Capitalizing on the comorbidity of ADHD and EDs and subsequent obesity could lead to improved prevention and treatment of all three conditions. However, additional information regarding the comorbidity is necessary to develop such interventions, as little is known about how or why this co-occurrence exists. A comprehensive model of the underlying mechanisms associated with comorbid ADHD and EDs is needed to improve understanding of the development of the comorbidity. Moreover, while there are gender differences within each disorder, literature is limited regarding to the comorbidity among males, leading to …


Validity Testing Of A Preschool Reading Screening Device For Pediatricians, Erika Elaine Blue Jan 2015

Validity Testing Of A Preschool Reading Screening Device For Pediatricians, Erika Elaine Blue

USF Tampa Graduate Theses and Dissertations

Despite efforts to improve access to early literacy intervention in the United States, there are still children entering kindergarten that are not adequately prepared for school and are unlikely to catch up to their peers (National Education Association, 2014). Preschool programs are actively involved in screening their students for potential literacy difficulties; however, there are children who do not attend preschool and may not have their literacy development assessed. One solution to this problem is to involve other individuals who routinely see preschool age children. Pediatricians are one such group as children come to them for their wellness visits and …


Sleep, Depressive Symptoms And Cognition In Older Adults And Caregivers Of Persons With Dementia, Glenna Shemida Brewster Jan 2015

Sleep, Depressive Symptoms And Cognition In Older Adults And Caregivers Of Persons With Dementia, Glenna Shemida Brewster

USF Tampa Graduate Theses and Dissertations

Caregivers of persons with dementia, who are often older adults, report sleep disturbance, high rates of depressive symptoms and may be at risk for impaired cognition. This dissertation examined sleep, depressive symptoms, and cognition in older adults and caregivers of persons with dementia. The aims of the review of literature were to understand, in community dwelling adults 60 years and older, the relationships among sleep parameters (sleep onset latency, wake after sleep onset, sleep efficiency, total sleep time, and general sleep complaints), and the domains of cognition (Executive Function, Attention, Episodic Memory, Working Memory, Processing Speed), and global cognition. Based …


The Relation Between Adiposity And Anxiety In Youth: Analysis Of Peer Victimization, Teasing, Sociocultural Influences, And Internalization Of Appearance Ideals As Explanatory Variables, Natasha L. Burke Jan 2015

The Relation Between Adiposity And Anxiety In Youth: Analysis Of Peer Victimization, Teasing, Sociocultural Influences, And Internalization Of Appearance Ideals As Explanatory Variables, Natasha L. Burke

USF Tampa Graduate Theses and Dissertations

The purpose of the current study was to examine putative mediators and moderators in the association between adiposity and anxiety in a sample of overweight and obese youth. In addition, anxiety was examined as a potential moderator between adiposity and health-related quality of life (HRQOL). Participants were youth (N = 137) between 8 and 17 years old (M = 13.09, SD = 2.61) and their legal caregivers recruited from four medical clinics affiliated with the University of South Florida. Youth were primarily overweight (28.5%) or obese (64.2%) and ethnically diverse. Data were analyzed by path analysis. Weight-related teasing significantly mediated …


Latino Immigrant Workers’ Search For Justice After Occupational Injury, Carla Gabriela Castillo Jan 2015

Latino Immigrant Workers’ Search For Justice After Occupational Injury, Carla Gabriela Castillo

USF Tampa Graduate Theses and Dissertations

Latino immigrants encounter an entanglement of rights and policies after occupational injury or illness. In collaboration with an immigrant worker center, ethnographic research and a survey are used to analyze injured workers’ experiences. The center uses survey results to identify common threads and systematic problems, and to explore potential direct action. Through interviews with workers and medical and legal professionals, I investigate the barriers Latino immigrants face following occupational injury or illness, how their lived experiences relate to the greater medicolegal frameworks that demarcate most formal processes of compensation and treatment, and the experiences of professionals who mediate these structures. …


Effects Of Occupational Stressors On Nurses’ Safety Performance And Well-Being: A Within-Individual Study, Xinxuan Che Jan 2015

Effects Of Occupational Stressors On Nurses’ Safety Performance And Well-Being: A Within-Individual Study, Xinxuan Che

USF Tampa Graduate Theses and Dissertations

Occupational stressors have been extensively studied as predictors of safety performance and employee well-being in previous research. However, many newly introduced organizational constructs that have the characteristics of an occupational stressor have rarely been studied as such, especially from a within-person perspective. The current study focused on three occupational stressors in relation to safety performance. Based on previous literature, I proposed that within individuals, compulsory citizenship behavior, illegitimate tasks, and interpersonal conflict at work as occupational stressors would have negative effects on employees well-being and safety performance through negative emotions (anger), job attitudes (job satisfaction and organizational commitment) and role …


Script Training: The Role Of Written Cues, Hallie Cohen Jan 2015

Script Training: The Role Of Written Cues, Hallie Cohen

USF Tampa Graduate Theses and Dissertations

Script training is a technique that allows persons with acquired speech and language disorders, such as nonfluent aphasia, to have islands of fluent speech during which they can speak about a topic without pausing or having word-finding errors. Scripts relevant to specific functional situations are written and practiced until memorized. Script training delivered verbally has been effective with clients with aphasia but the role of written cues in the training has not been explored. Therefore the purpose of this study was to compare the effectiveness of script training taught verbally, or verbally with a written script, in persons with aphasia. …


Strategies For Preventing Age And Neurodegenerative Disease-Associated Mitochondrial Dysfunction, Vedad Delic Jan 2015

Strategies For Preventing Age And Neurodegenerative Disease-Associated Mitochondrial Dysfunction, Vedad Delic

USF Tampa Graduate Theses and Dissertations

Mitochondrial dysfunction plays a pivotal role in the development of aging phenotypes and aging-associated neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS). Strategies that restore mitochondrial dysfunction may rescue the deficits of central metabolism in these disorders and improve cell survival. For example, we found that modulating the mTOR signaling pathway in a tissue culture model of aging-induced mitochondrial DNA mutation enhanced mitochondrial function as evidenced by increased oxygen consumption. Our previous melatonin studies also led us to hypothesize that caloric restriction and the hormone melatonin would reverse brain mitochondrial dysfunction in animal …