Medicine and Health Sciences Commons^™

Potential Role Of Protein Kinase Cbeta In High Fat Diet-Induced Adipose Dysfunction By Regulating Autophagy Levels, Neil Mehta

Williams Honors College, Honors Research Projects

Obesity is the most common nutritional disorder in the United States and worldwide. Public health efforts and other anti-obesity measures clearly have not controlled the obesity epidemic. There is a great need to understand the pathogenic mechanisms underlying fat accumulation. Research of the past decade supports a prominent role for diet-induced adipose tissue dysfunction in the development and/or progression of obesity and associated insulin resistance. Potential mechanisms for the development of adipose tissue dysfunction include ectopic (visceral) fat accumulation, genetic factors, and alterations in autophagy and inflammatory processes. However, the molecular mechanisms linking dietary fat intake with alterations in adipose …

Role Of The Physical Therapist In Reducing Postoperative Complications In Type 2 Diabetics, Angela M. Formanik

Williams Honors College, Honors Research Projects

This article examines current research on the topic of reducing postoperative complications in patients with type 2 diabetes mellitus. Type 2 diabetes is a metabolic condition with rapidly increasing prevalence. Patients with type 2 diabetes are twice as likely to undergo surgery for comorbid conditions compared to individuals without the disease (Zantidis, Iliadis, & Didangelos, 2011). Aside from higher instances of surgical intervention, type 2 diabetic patients experience a higher rate of perioperative complications compared to individuals without the disease (Holt, 2012). Concurrent conditions such as peripheral neuropathy and hyperglycemia put diabetic patients at a higher risk of surgical complications …

Tactical Medicine: An Examination Of Medical Training In Law Enforcement, Brian J. Woods Jr.

Williams Honors College, Honors Research Projects

In recent years, there has been a trend towards making law enforcement officers more well-rounded first responders by increasing their required medical competencies. The required medical competencies of six law enforcement agencies of varying sizes in Northeast Ohio were examined by interviews conducted with a representative from each agency. Interview question topics included information on current training requirements and the types of medical equipment issued to officers. The study found that all six of the agencies surveyed offered medical training to officers as part of required continuing education, and all six agencies currently issued, or planned to issue in the …

Sharp Rna Recognition Motif Optimizations, Extensions, And Mutations For Use In 2d And 3d Nmr Experiments, Shaun M. Christie

Williams Honors College, Honors Research Projects

SMRT/HDAC Associated Repressor Protein interacts with the long noncoding RNA, produced by SRA, by binding at the RRMs. Three projects were done to prepare the truncated proteins for use in 2D and 3D NMR experiments. The first focuses on RRM 3 and its optimization during the purification process. The second focuses on RRM 2-4, which was found to be missing two alpha helices that may be important for protein stability. These helices can also interact with RRM 3 as well due to the tight association of RRMs 3 and 4. The two step PCR extension of RRM 2-4 was assumed …

Literature Review: Effects Of Myofascial Release On Range Of Motion And Athletic Performance, Alex Zazac

Williams Honors College, Honors Research Projects

No abstract provided.

Preliminary Nutritional Profile Analysis Of Box Tops 4 Education Food Products, Hannah Griffith

Williams Honors College, Honors Research Projects

The marketing of unhealthy food to children is often cited as a cause of the obesity epidemic.¹ However, most studies that examine this issue evaluated the marketing of food through print or television advertising. This project investigates the marketing of food products to children through incentive based programs, specifically General Mill’s Box Tops 4 Education. This study undertakes a preliminary systematic analysis of Box Tops food items to determine their healthfulness. A subset of all Box Tops food products was selected for review and a basic quantitative content analysis of priority nutrients was performed. Priority nutrients were identified …

The Relationship Among Math Anxiety, Mathematical Performance, And Math Education In Undergraduate Nursing Students, Joshua D. Beall, Troy Roebuck, Paul Penkalsky

Williams Honors College, Honors Research Projects

Although nurses spend up to 40% of their day calculating and administering medication doses, undergraduate nursing students often perform poorly on nursing math exams. The purpose of this study was (a) to examine the relationship among mathematical education, performance, and anxiety and (b) to compare the mathematical education, performance, and anxiety in sophomore and senior baccalaureate nursing students at a public university in the Midwest. This cross-sectional, descriptive study was guided by Bandura's self-efficacy theory. Math performance was measured with an 11-item math instrument, math education was measured with number of math courses, and math anxiety was measured with Fennema–Sherman …

Women's Fitness Week, Claire T. Lucas, Tiffany M. Finch

Williams Honors College, Honors Research Projects

This project addressed women’s wellness. Many women experience physical and mental health issues related to a lack of physical activity or psychological support. Women’s Fitness Week was offered to women of the University of Akron and the outside community, providing opportunities to learn more about and improve upon the various dimensions of wellness – emotional, environmental, financial, intellectual, occupational, physical, social/cultural, and spiritual. Events were held at the University’s Student Recreation and Wellness Center and encompassed topics such as nutrition, weight training, and self-defense. The goals of this project were to: increase knowledge levels of fitness, health, and wellness, increase …

The Effects Of Instructional Strategies On Adherence To A Flexibility Program And Physiological Outcomes, Taylor M. Graham

Williams Honors College, Honors Research Projects

Health care professionals construct exercise prescriptions for clients and patients to complete on their own. Exercise specialists, physical therapists, occupational therapists, and exercise physiologists are all considered health care professionals for this study. Furthermore, the importance of flexibility and stretching is commonly overlooked. The purpose of this research study was to compare whether or not different instructional techniques affect adherence to a stretching routine, and if followed were improvements gained in quadriceps and hamstring flexibility. Thirty-one students from The University of Akron between the ages of 18 and 37 with an average height of 66.7 inches and average weight of …

Shotblocker® - Bionix® Senior Design, Samuel Dockery

Williams Honors College, Honors Research Projects

No abstract provided.

Review Of The Accuracy Of Two Pain Assessment Tools In Nonverbal Adult Patients, Mackenzie Mosley, Emily Hartman, Kristen Tankovich, James Galantis

Williams Honors College, Honors Research Projects

Intensive care units frequently have patients that are unable to verbally communicate their pain, thus negating conventional pain assessment techniques and making pain assessment difficult. Pain management is often a priority in all patients’ circumstances and therefore, assessment and reassessment are included in the plan of care. Different observational pain scales have been used in intensive care units, but often times these scales must be adapted to fit the patient’s circumstances. Pain scales that are used for nonverbal patients typically include behavioral indicators and some are adapted to incorporate physiologic indicators such as vital signs. The aim of this review …

Morphometric Analysis Of Left & Right Tonsils In Adult Symptomatic Type 1 Chiari Patients And Healthy Controls, Louis J. Konstan

Williams Honors College, Honors Research Projects

Historically, CMI has been radiographically defined by cerebellar tonsillar descent below the foramen magnum (FM) more than 5 mm (2). This measurement is typically made with a single sagittal plane T1-or T2-weighted MR image. Studies have obtained additional morphometric measurements to help diagnose CMI, and establish normal values (3,4). These studies were somewhat These studies were somewhat successful in differentiating CMI patients from healthy subjects. However, results from these studies have shown that the standard TD measurement does not necessarily correlate with neurological symptom severity as patients with CMI-like symptoms have been found with a TD of less than 5 …

Kangaroo Care And Preterm Infants, Natalie Schindler, Kathryn Lynn

Williams Honors College, Honors Research Projects

Infants that are born near-term or before they reach their full gestational age of 40 weeks are at risk for facing future health problems and disparities in terms of proper development (Ladewig, London, & Davidson, 2012). This has been a major concern in the medical realm because of the high cost of managing preterm newborns and the complications that can develop. However, kangaroo care may aid in physical growth and cognitive development of these infants. The purpose of this integrative review was to determine if current research shows that kangaroo care has a positive effect on preterm infants in the …

A Systematic Review: Non-Pharmacological Interventions For Chemotherapy-Induced Nausea And Vomiting, Miranda L. Ayers, Olateju F. Olowe

Williams Honors College, Honors Research Projects

Around 70-80% of patients receiving chemotherapy are at risk of chemotherapy-induced nausea and vomiting (CINV), which can interfere with appetite and the ability to perform normal activities for daily living. When CINV is severe, psychological distress, depression, and physiological impairment occur. Patients may also stop chemotherapy treatments, which can lead to untimely deaths. The aim of this systematic review was to identify, describe, and evaluate the evidence about the use and effectiveness of non-pharmacological interventions, compared to no use of non-pharmacological interventions, on self-reported episodes of CINV among the cancer patients. Twenty articles were reviewed on the use of acupressure, …

Relationship Between Stages Of Change And Hpv Vaccine Attitudes And Beliefs In Baccalaureate Nursing Students, Megan M. Stein, Michael Sabo, Julia Caverly

Williams Honors College, Honors Research Projects

The purpose of this study was to: (a) determine if there is a relationship between attitudes/beliefs about Human papillomavirus (HPV) vaccination and stages of change and (b) investigate gender differences in attitudes/beliefs and stages of change in undergraduate baccalaureate nursing students. The study employs a cross-sectional and descriptive correlational design and it was guided by the Trans-theoretical Model of Change (TMC). The convenience sample was comprised of 131 participants at a large urban public university in Midwest United States. Data were collected with online surveys distributed via university email. A positive, moderate relationship was found between HPV vaccination attitudes/beliefs and …

A Survey Of Speech-Language Pathologists On Facilitating Support Groups For Those With Communication Disorders, Danielle A. Hower, K. Todd Houston Ph.D

Williams Honors College, Honors Research Projects

Support groups are used in a variety of settings and can be helpful for group members to develop coping strategies. This research aims to evaluate Ohio Speech-Language Pathologists’ perceived knowledge of planning and implementing support groups. Another goal for this research is to gain information on how many Speech-Language Pathologists are using this knowledge to conduct a support group, what type of populations are benefiting, and in what setting type utilizes support groups.

The Effects Of Vitamin D Supplementation On Influenza, Jonah M. Spoerndle

Williams Honors College, Honors Research Projects

Recently the role of vitamin D in other non-classical capacities has been evaluated. One of these non-classical vitamin D roles is assisting in maintaining proper immune system health. One disease that has a great effect on the immune system is influenza. Vitamin D helps to prevent and limit influenza by moderating the inflammatory cytokines as well as promoting the production of monocytes that help destroy the invading materials. Through the use of vitamin D supplementation the recommended daily amount of vitamin D can be assured and optimal health could be achieved. The purpose of this project was to design a …

Induced And Spontaneous Labor Education: Evaluation, Knowledge, And Intent To Discuss Options In Pregnant Women, Kathleen Hartzell, Katherine Bartolotta

Williams Honors College, Honors Research Projects

Labor inductions are increasing worldwide, with rates continuing to rise each year. Currently 30% of labors in the United States result from inductions. The purpose of the study was to examine the effect of an educational intervention about induced and spontaneous labor on knowledge and intent to discuss options with health providers in pregnant women. This study was guided by the health-belief model which explains that people’s beliefs about how a health care decision may affect their lives affect how they make the decisions. This study was conducted using a quantitative and descriptive design with pre and post paper and …

The Effect Of An Educational Hunger Cues Intervention On Awareness In Mothers With Infants, Juliana F. Gill, Ellen A. Vierheller

Williams Honors College, Honors Research Projects

Stress to an infant can inhibit the ability to properly feed and gain the nutrients that are essential for efficient growth. Mothers who are unaware of early hunger cues from their infant have the potential to stress the infant if their early hunger cues are not attended to. The purpose of this study was to examine the effect of an educational hunger cues intervention on awareness in mothers with an infant. The following research question will be answered: Will new mothers who complete an educational intervention show increased awareness of hunger cues in their infants, in comparison to before the …

Transmedial Documentation For Non-Visual Image Access, Melody J. Mccotter

Proceedings from the Document Academy

In my doctoral studies on information accessibility for the individual who is blind or visually impaired, I’ve been exploring the ways we can make image documents more accessible. This requires using an alternative sensory modality, and translating the document into a different format. The questions that arise when we consider this process are many, but among them are:

• Is it the same document once we’ve converted it to an audio narrative about the work, or a 3D topographic map of an artwork, or a musical interpretation?
• If it is not the same document, how truthful can the “trans-medial” translation be …

Hepatic Carboxylesterase 1 Is Induced By Glucose And Regulates Postprandial Glucose Levels, Jiesi Xu, Liya Yin, Yang Xu, Yuanyuan Li, Munaf Zalzala, Gang Cheng, Yanqiao Zhang

Chemical, Biomolecular, and Corrosion Engineering Faculty Research

Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke. Carboxylesterase 1 (CES1) is an enzyme that hydrolyzes triglycerides and cholesterol esters, and is important for lipid metabolism. Our previous data show that over-expression of mouse hepatic CES1 lowers plasma glucose levels and improves insulin sensitivity in diabetic ob/ob mice. In the present study, we determined the physiological role of hepatic CES1 in glucose homeostasis. Hepatic CES1 expression was reduced by fasting but increased in diabetic mice. Treatment of mice with glucose induced hepatic CES1 expression. Consistent with the in vivo study, …

Alterations In Gene Array Patterns In Dendritic Cells From Aged Humans, Jia-Ning Cao, Anshu Agrawal, Edward Sharman, Zhenyu Jia, Sudhir Gupta

Statistics Faculty Research

Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs decline with age. The purpose of this study was to define the age-associated molecular changes in DCs by gene array analysis using Affymatrix GeneChips. The expression levels of a total of 260 genes (1.8%) were significantly different (144 down-regulated and 116 upregulated) in monocyte-derived DCs (MoDCs) from aged compared to young human donors. Of the 260 differentially expressed genes, 24% were down-regulated by more than 3-fold, …

The Impact Of Spinal Cord Nerve Roots And Denticulate Ligaments On Cerebrospinal Fluid Dynamics In The Cervical Spine, Soroush Heidari Paylavian, Theresia Yiallourou, R. Shane Tubbs, Alexander C. Bunck, Francis Loth, Bryn A. Martin, Mark Goodin, Mehrdad Raisee

Mechanical Engineering Faculty Research

Cerebrospinal fluid (CSF) dynamics in the spinal subarachnoid space (SSS) have been thought to play an important pathophysiological role in syringomyelia, Chiari I malformation (CM), and a role in intrathecal drug delivery. Yet, the impact that fine anatomical structures, including nerve roots and denticulate ligaments (NRDL), have on SSS CSF dynamics is not clear. In the present study we assessed the impact of NRDL on CSF dynamics in the cervical SSS. The 3D geometry of the cervical SSS was reconstructed based on manual segmentation of MRI images of a healthy volunteer and a patient with CM. Idealized NRDL were designed …

Evaluation Of Tissue-Engineered Tendon Enthesis Polymer Constructs, Joshua A. Bundy Bs, Mary Beth Wade Phd, Hitomi Nakao Md, Phillip Mcclellan Phd, Qing Yu Phd, Robin Jacquet-Childs Ms, William J. Landis Phd

Williams Honors College, Honors Research Projects

Both scientists and clinicians have proposed tissue engineering as the future of medicine. The possibilities for tissue engineering, that is, fabrication of tissues and organs in the laboratory and their translation to patients, appear to be endless, and many believe that this new approach in medicine will result in abolishing many common ailments, injuries, and congenital defects. Injuries to a tendon enthesis, the normal tissue connection between tendon and bone, are of particular concern to clinicians because of their frequency and failure to repair as a result of surgery. While these injuries may not be life threatening, they can certainly …

Intellectual Property And Public Health – A White Paper, Ryan G. Vacca, Jim Chen, Jay Dratler Jr., Tom Folsom, Timothy Hall, Yaniv Heled, Frank Pasquale, Elizabeth Reilly, Jeff Samuels, Kathy Strandburg, Kara Swanson, Andrew Torrance, Katharine Van Tassel

Akron Law Faculty Publications

On October 26, 2012, the University of Akron School of Law’s Center for Intellectual Property and Technology hosted its Sixth Annual IP Scholars Forum. In attendance were thirteen legal scholars with expertise and an interest in IP and public health who met to discuss problems and potential solutions at the intersection of these fields. This report summarizes this discussion by describing the problems raised, areas of agreement and disagreement between the participants, suggestions and solutions made by participants and the subsequent evaluations of these suggestions and solutions.

Led by the moderator, participants at the Forum focused generally on three broad …